Satoshi Takahashi

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Leukemia: cord blood for allogeneic stem cell transplantation
    Satoshi Takahashi
    Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Curr Opin Oncol 19:667-72. 2007
  2. ncbi request reprint Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies
    Satoshi Takahashi
    Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, 6 1, Shirokanedai 4, Minato ku, Tokyo 108 8639 Japan
    Blood 104:3813-20. 2004
  3. ncbi request reprint Posttransplantation engraftment and safety of cord blood transplantation with grafts containing relatively low cell doses in adults
    Satoshi Takahashi
    Division of Molecular Therapy, Advanced Clinical Research Center, School of Health Sciences and Nursing, University of Tokyo, Tokyo, Japan
    Int J Hematol 84:359-62. 2006
  4. ncbi request reprint Comparative single-institute analysis of cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem-cell transplants from related donors in adult patients with hematologic malignancies after myeloablative conditioning regim
    Satoshi Takahashi
    Division of Molecular Therapy, Institute of Medical Science, Department of Biostatistics Epidemiology and Preventive Health Sciences, School of Health Sciences and Nursing, University of Tokyo, Japan
    Blood 109:1322-30. 2007
  5. doi request reprint Unrelated cord blood transplantation after myeloablative conditioning in adults with acute myelogenous leukemia
    Jun Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Biol Blood Marrow Transplant 14:1341-7. 2008
  6. ncbi request reprint Varicella-zoster virus encephalitis in a patient undergoing unrelated cord blood transplantation for myelodysplastic syndrome-overt leukemia
    Kenji Fukuno
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Shirokanidae, Tokyo
    Int J Hematol 84:79-82. 2006
  7. doi request reprint Second myeloablative allogeneic stem cell transplantation (SCT) using cord blood for leukemia relapsed after initial allogeneic SCT
    Takaaki Konuma
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Leuk Res 33:840-2. 2009
  8. ncbi request reprint Cord blood transplantation for acute myelogenous leukemia using a conditioning regimen consisting of granulocyte colony-stimulating factor-combined high-dose cytarabine, fludarabine, and total body irradiation
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Eur J Haematol 77:46-50. 2006
  9. ncbi request reprint Unrelated cord blood transplantation for adult patients with advanced myelodysplastic syndrome
    Jun Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Japan
    Blood 101:4711-3. 2003
  10. ncbi request reprint Unrelated cord blood transplantation after myeloablative conditioning for adult patients with refractory anemia
    Jun Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int J Hematol 81:424-7. 2005

Detail Information

Publications91

  1. ncbi request reprint Leukemia: cord blood for allogeneic stem cell transplantation
    Satoshi Takahashi
    Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Curr Opin Oncol 19:667-72. 2007
    ..Immunological analysis of T cell recovery processes and approaches to cellular therapy using cord blood-derived immune cells are also discussed...
  2. ncbi request reprint Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies
    Satoshi Takahashi
    Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, 6 1, Shirokanedai 4, Minato ku, Tokyo 108 8639 Japan
    Blood 104:3813-20. 2004
    ..01, respectively), despite the higher human leukocyte antigen mismatching rate and lower number of infused cells. These data strongly suggest that CBT could be safely and effectively used for adult patients with hematologic malignancies...
  3. ncbi request reprint Posttransplantation engraftment and safety of cord blood transplantation with grafts containing relatively low cell doses in adults
    Satoshi Takahashi
    Division of Molecular Therapy, Advanced Clinical Research Center, School of Health Sciences and Nursing, University of Tokyo, Tokyo, Japan
    Int J Hematol 84:359-62. 2006
    ..Based on these preliminary results, cord blood grafts containing less than 2.0 X 10(7) cells/kg may be useful for cases where no grafts with higher cell doses or other stem cell sources are available...
  4. ncbi request reprint Comparative single-institute analysis of cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem-cell transplants from related donors in adult patients with hematologic malignancies after myeloablative conditioning regim
    Satoshi Takahashi
    Division of Molecular Therapy, Institute of Medical Science, Department of Biostatistics Epidemiology and Preventive Health Sciences, School of Health Sciences and Nursing, University of Tokyo, Japan
    Blood 109:1322-30. 2007
    ..These data suggest that unrelated cord blood could be as safe and effective a stem-cell source as related bone marrow or mobilized peripheral blood for adult patients when it is used as a primary unrelated stem-cell source...
  5. doi request reprint Unrelated cord blood transplantation after myeloablative conditioning in adults with acute myelogenous leukemia
    Jun Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Biol Blood Marrow Transplant 14:1341-7. 2008
    ..These results suggest that unrelated CBT after myeloablative conditioning could be safely and effectively used for adult patients with AML...
  6. ncbi request reprint Varicella-zoster virus encephalitis in a patient undergoing unrelated cord blood transplantation for myelodysplastic syndrome-overt leukemia
    Kenji Fukuno
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Shirokanidae, Tokyo
    Int J Hematol 84:79-82. 2006
    ..MRI scans showed substantial resolution but with mild residual lesions. The present report indicates that VZV should be considered as a possible causative agent in patients who develop multifocal neurologic symptoms of the CNS after SCT...
  7. doi request reprint Second myeloablative allogeneic stem cell transplantation (SCT) using cord blood for leukemia relapsed after initial allogeneic SCT
    Takaaki Konuma
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Leuk Res 33:840-2. 2009
    ..We conclude that second myeloablative allo-SCT using CB may be feasible in selected patients with the relatively younger age, less organ damage and longer time interval between first and second allo-SCT...
  8. ncbi request reprint Cord blood transplantation for acute myelogenous leukemia using a conditioning regimen consisting of granulocyte colony-stimulating factor-combined high-dose cytarabine, fludarabine, and total body irradiation
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Eur J Haematol 77:46-50. 2006
    ..Large-scale studies will be needed to determine the efficacy and safety of the conditioning regimen in CBT...
  9. ncbi request reprint Unrelated cord blood transplantation for adult patients with advanced myelodysplastic syndrome
    Jun Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Japan
    Blood 101:4711-3. 2003
    ..The probability of disease-free survival at 2 years was 76.2%. These results suggest that adult advanced MDS patients without suitable related or unrelated bone marrow donors should be considered as candidates for CBT...
  10. ncbi request reprint Unrelated cord blood transplantation after myeloablative conditioning for adult patients with refractory anemia
    Jun Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int J Hematol 81:424-7. 2005
    ..All patients are alive and free of disease at between 17 and 39 months after CBT. These results suggest that adult MDS-RA patients without suitable related or unrelated bone marrow donors should be considered as candidates for CBT...
  11. doi request reprint Recipient-derived cells after cord blood transplantation: dynamics elucidated by multicolor FACS, reflecting graft failure and relapse
    Nobukazu Watanabe
    FACS Core Laboratory, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Biol Blood Marrow Transplant 14:693-701. 2008
    ..Multicolor HLA-fFlow analysis and cell sorting in early diagnosis of graft failure and relapse was confirmed as valuable in 14 patients who had received HLA-mismatched CBT...
  12. ncbi request reprint Resolution of Behçet's disease after HLA-mismatched unrelated cord blood transplantation for myelodysplastic syndrome
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Japan
    Ann Hematol 83:464-6. 2004
    ..These observations suggest that allogeneic hematopoietic stem cell transplantation, which encompasses CBT, may be an effective therapy in patients with high-risk aggressive BD...
  13. ncbi request reprint Unrelated cord blood transplantation for adult patients with de novo acute myeloid leukemia
    Jun Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Blood 103:489-91. 2004
    ..The probability of disease-free survival at 2 years was 76.6%. These results suggest that adult AML patients without suitable related or unrelated bone marrow donors should be considered as candidates for CBT...
  14. ncbi request reprint Impact of cytomegalovirus serostatus on outcome of unrelated cord blood transplantation for adults: a single-institute experience in Japan
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Eur J Haematol 80:251-7. 2008
    ..This might be due to effective antiviral therapy for CMV infection. Large-scale studies are needed to determine the impact of recipient CMV serostatus on the outcome of CBT for adults...
  15. ncbi request reprint Using related donors other than genotypically HLA-matched siblings in allogeneic hematopoietic stem cell transplantation for hematologic disease: a single institution experience in Japan
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Int J Hematol 76:354-9. 2002
    ....
  16. ncbi request reprint Varicella-zoster virus infection in adult patients after unrelated cord blood transplantation: a single institute experience in Japan
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Br J Haematol 122:802-5. 2003
    ..01). These results suggest that recovery of VZV-specific immune responses after CBT is delayed even in patients without severe acute GVHD...
  17. ncbi request reprint Hemorrhagic cystitis in adults after unrelated cord blood transplantation: a single-institution experience in Japan
    Akira Tomonari
    Department of Hematology Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Int J Hematol 84:268-71. 2006
    ..8% at 1 year. The incidence of AdV-induced severe HC after CBT may be relatively low among Japanese adults. The role of other viruses, including BK virus, in the pathogenesis of HC after CBT needs to be examined...
  18. doi request reprint Myeloablative unrelated cord blood transplantation for acute leukemia patients between 50 and 55 years of age: single institutional retrospective comparison with patients younger than 50 years of age
    Takaaki Konuma
    Department of Hematology Oncology, University of Tokyo, Tokyo, Japan
    Ann Hematol 88:581-8. 2009
    ..These results suggest that, in patients with acute leukemia, myeloablative CBT might be as safe and effective in patients aged between 50 and 55 years as in younger patients...
  19. ncbi request reprint Ganciclovir-related neutropenia after preemptive therapy for cytomegalovirus infection: comparison between cord blood and bone marrow transplantation
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, 4 6 1, Shirokanedai, Minato ku, 108 8639 Tokyo, Japan
    Ann Hematol 83:573-7. 2004
    ..No risk factors for GCV-related neutropenia were found in BMT patients. These results suggest that GCV may be less toxic to myeloid progenitor cells from cord blood than those from bone marrow...
  20. doi request reprint Unrelated cord blood transplantation after myeloablative conditioning regimen in adolescent and young adult patients with hematologic malignancies: a single institute analysis
    Yasuhiro Ebihara
    Department of Pediatric Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Leuk Res 36:128-31. 2012
    ..2% and 48.6%, respectively, comparable to adult or childhood cases. Adolescents and young adult patients with hematologic malignancies who have no HLA-matched adult donors could be considered as candidates for CBT...
  21. ncbi request reprint Early renal injury after myeloablative cord blood transplantation in adults
    Hiroshi Mae
    Department of Pharmacy, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Leuk Lymphoma 49:538-42. 2008
    ..01). Our result suggests that it is important to monitor VCM dosing more strictly with pharmacokinetic assessment, especially in days 11 - 20, when the most frequently observed declining renal function...
  22. ncbi request reprint Human herpesvirus 6 variant B infection in adult patients after unrelated cord blood transplantation
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Int J Hematol 81:352-5. 2005
    ..05). In contrast, positive HHV-6B DNAemia at week 2 was associated with neither skin rash nor aGVHD. Prospective large-scale studies are needed to determine the role of HHV-6 infection in CBT patients...
  23. ncbi request reprint Pancreatic hyperamylasemia and hyperlipasemia in association with cytomegalovirus infection following unrelated cord blood transplantation for acute myelogenous leukemia
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Int J Hematol 84:438-40. 2006
    ..The present report indicates that CMV infection should be included in the differential diagnosis for patients with pancreatic hyperamylasemia after SCT...
  24. ncbi request reprint Bacterial bloodstream infection in neutropenic adult patients after myeloablative cord blood transplantation: experience of a single institution in Japan
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Int J Hematol 85:238-41. 2007
    ..Early diagnosis of bacterial BSI and prompt treatment with effective antibiotics are necessary for neutropenic adult patients after myeloablative CBT...
  25. ncbi request reprint Early-onset thyrotoxicosis after unrelated cord blood transplantation for acute myelogenous leukemia
    Takaaki Konuma
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Japan
    Int J Hematol 83:348-50. 2006
    ..The present study shows that thyrotoxicosis can occur during very early periods after CBT...
  26. ncbi request reprint A clinical comparison of unrelated cord blood transplantation and unrelated bone marrow transplantation for adult patients with acute leukaemia in complete remission
    Jun Ooi
    Department of Haematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Br J Haematol 118:140-3. 2002
    ..The probability of 2 year disease-free survival was similar between the two groups. These results suggest that adult acute leukaemia patients in CR without a suitable donor should be considered as candidates for UCBT...
  27. ncbi request reprint Unrelated cord blood transplantation after myeloablative conditioning in patients over the age of 45 years
    Jun Ooi
    Department of Haematology and Oncology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Br J Haematol 126:711-4. 2004
    ..4%. These results suggest that patients over 45 years of age without suitable related or unrelated bone marrow donors should be considered as candidates for CBT...
  28. ncbi request reprint Cytomegalovirus infection following unrelated cord blood transplantation for adult patients: a single institute experience in Japan
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Br J Haematol 121:304-11. 2003
    ..024, 0.032 and 0.017 respectively). These results suggest that recovery of CMV-specific immunity after CBT is delayed when compared with BMT...
  29. ncbi request reprint Unrelated cord blood transplantation with a reduced-intensity conditioning regimen following autologous transplantation for multiple myeloma
    Toshiki Yamada
    Department of Hematology Oncology, The Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Int J Hematol 80:377-80. 2004
    ..These results suggested that CBT with a reduced-intensity conditioning regimen after high-dose chemotherapy with ASCT is a new promising approach for the treatment of multiple myeloma...
  30. ncbi request reprint Prospective multicenter study of single-unit cord blood transplantation with myeloablative conditioning for adult patients with high-risk hematologic malignancies
    Takehiko Mori
    Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Biol Blood Marrow Transplant 19:486-91. 2013
    ..These results suggest that the IMSUT CBT procedures can safely provide a high disease-free survival rate in patients with high-risk hematologic malignancies...
  31. ncbi request reprint Fatal acute tumor lysis syndrome following intrathecal chemotherapy for acute lymphoblastic leukemia with meningeal involvement
    Takaaki Konuma
    Department of Hematology Oncology, Institute of Medical Science, University of Tokyo, Tokyo
    Intern Med 47:1987-8. 2008
    ..This case indicates that intrathecal chemotherapy alone may be sufficient to induce ATLS. Close monitoring and prevention of ATLS are also warranted following intrathecal chemotherapy alone...
  32. ncbi request reprint Anti-NK cell treatment induces stable mixed chimerism in MHC-mismatched, T cell-depleted, nonmyeloablative bone marrow transplantation
    Seok Goo Cho
    Division of Molecular Therapy, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo 4 6 1, Shirokanedai, Minatoku, Tokyo, Japan
    Exp Hematol 32:1246-54. 2004
    ....
  33. ncbi request reprint Effect of conditioning regimen on the outcome of bone marrow transplantation from an unrelated donor
    Yoshinobu Kanda
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo, Hongo, Tokyo, Japan
    Biol Blood Marrow Transplant 11:881-9. 2005
    ..48; P = .0003) and inferior survival (RR, 1.45; P < .0001). The results of this retrospective study suggested that the Cy-TBI regimen was superior to other regimens in unrelated BMT...
  34. ncbi request reprint Nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan
    Ryoichi Hamasuna
    Urogenital Sub committee and the Surveillance Committee of Japanese Society of Chemotherapy JSC, The Japanese Association for Infectious Diseases JAID and The Japanese Society for Clinical Microbiology JSCM, Tokyo, Japan
    J Infect Chemother 19:571-8. 2013
    ..The MIC of azithromycin in 2 strains was 2 μg/ml, but no high-level resistance to macrolides was detected. ..
  35. doi request reprint Feasibility of reduced-intensity cord blood transplantation as salvage therapy for graft failure: results of a nationwide survey of adult patients
    Fusako Waki
    Hematopoietic Stem Cell Transplantation Division, National Cancer Center Hospital, Tokyo, Japan
    Biol Blood Marrow Transplant 17:841-51. 2011
    ..In conclusion, in an older population of patients, our data support the feasibility of CBT with a reduced-intensity conditioning regimen for GF...
  36. ncbi request reprint Atypical hypersensitivity to mosquito bites without natural killer cell proliferative disease in an adult patient
    Takaaki Konuma
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Int J Hematol 82:441-4. 2005
    ..Peripheral NK cell lymphocytosis and EBV-associated lymphoproliferative disease did not develop. These findings suggest that some patients with chronic EBV infection may develop HMB without NK cell proliferative disease...
  37. doi request reprint Effect of ABO blood group incompatibility on the outcome of single-unit cord blood transplantation after myeloablative conditioning
    Takaaki Konuma
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan Electronic address
    Biol Blood Marrow Transplant 20:577-81. 2014
    ..These data suggested that donor-recipient ABO incompatibility does not have a significant impact on outcome after myeloablative CBT for hematological malignancies...
  38. ncbi request reprint Intracranial germ cell tumors: efficacy of neoadjuvant chemo-radiotherapy without surgical biopsy
    Satoshi Takahashi
    Department of Neurosurgery, School of Medicine, Keio University, Tokyo, Japan
    Keio J Med 60:56-64. 2011
    ..With our current treatment protocol comprising neoadjuvant chemo-radiotherapy without surgical biopsy, prognoses of patients with GCTs have improved compared to historical controls at our institution...
  39. ncbi request reprint Cytogenetic remissions induced by interferon alpha and imatinib mesylate are immunologically distinct in chronic myeloid leukemia
    Shin Nakayama
    Department of Hematology Oncology, Research Hospital, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Int J Hematol 86:208-11. 2007
    ..Collectively, the 2 therapeutic agents induce a distinct immunologic status in CML patients whose hematopoiesis has returned to normal levels...
  40. doi request reprint Single-unit cord blood transplantation after granulocyte colony-stimulating factor-combined myeloablative conditioning for myeloid malignancies not in remission
    Takaaki Konuma
    Department of Hematology Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan Electronic address
    Biol Blood Marrow Transplant 20:396-401. 2014
    ..These data demonstrate that CBT after G-CSF-combined myeloablative conditioning is a promising curative option for patients with myeloid malignancies not in remission. ..
  41. ncbi request reprint Long-term follow-up of allogeneic bone marrow transplantation after reduced-intensity conditioning in patients with chronic myelogenous leukemia in the chronic phase
    Shinichiro Okamoto
    Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Int J Hematol 75:493-8. 2002
    ..In summary, this reduced-intensity conditioning resulted in a cure with markedly reduced regimen-related toxicities in this relatively older cohort of patients with CML...
  42. ncbi request reprint Comparable Long-Term Outcome of Unrelated Cord Blood Transplantation with Related Bone Marrow or Peripheral Blood Stem Cell Transplantation in Patients Aged 45 Years or Older with Hematologic Malignancies after Myeloablative Conditioning
    Takaaki Konuma
    Department of Hematology Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan Electronic address
    Biol Blood Marrow Transplant 20:1150-5. 2014
    ..These data suggest that CBT could be as safe and effective as BMT/PBSCT from older related donors for relatively older patients when it is used as a primary unrelated stem cell source. ..
  43. doi request reprint Molecular and clinical risk factors for recurrence of skull base chordomas: gain on chromosome 2p, expression of brachyury, and lack of irradiation negatively correlate with patient prognosis
    Yohei Kitamura
    Departments of Neurosurgery, and Pathology, Keio University School of Medicine, Tokyo, Japan
    J Neuropathol Exp Neurol 72:816-23. 2013
    ..Our results suggest that brachyury-negative chordomas arebiologically distinct from brachyury-positive chordomas and that T/brachyury might be an appropriate molecular therapeutic target for chordoma. ..
  44. ncbi request reprint Downregulation of KIF23 suppresses glioma proliferation
    Satoshi Takahashi
    Department of Neurosurgery, Keio University, School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Neurooncol 106:519-29. 2012
    ..Taken together, our results indicate that downregulation of KIF23 decreases proliferation of glioma cells and that KIF23 may be a novel therapeutic target in malignant glioma...
  45. ncbi request reprint Clinical features of adult acute leukemia with 11q23 abnormalities in Japan: a co-operative multicenter study
    Hayato Tamai
    Department of Hematology, Nippon Medical School, Sendagi 1 1 5, Bunkyo ku, Tokyo, Japan
    Int J Hematol 87:195-202. 2008
    ..However, further studies involving a large number of cases are required to assess the effect of allo-HSCT on adult AL with 11q23 abnormalities...
  46. doi request reprint Downregulation of uPARAP mediates cytoskeletal rearrangements and decreases invasion and migration properties in glioma cells
    Satoshi Takahashi
    Department of Neurosurgery, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Neurooncol 103:267-76. 2011
    ..Our present study suggests that uPARAP may be involved in glioma cell invasiveness through actin cytoskeletal rearrangement. downregulation of uPARAP may be a novel anti-invasion therapeutic strategy for malignant gliomas...
  47. ncbi request reprint Chronic graft-versus-host disease following umbilical cord blood transplantation: retrospective survey involving 1072 patients in Japan
    Hiroto Narimatsu
    Divison of Exploratory Research, Institute of Medical Science, The University of Tokyo, Japan
    Blood 112:2579-82. 2008
    ..Although chronic GVHD is a significant problem after CBT, it is associated with improved survival, perhaps due to graft-versus-malignancy effects...
  48. doi request reprint Gene-expression profiles of peripheral blood mononuclear cell subpopulations in acute graft-vs-host disease following cord blood transplantation
    Naoyuki Takahashi
    Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Exp Hematol 36:1760-1770. 2008
    ..However, detailed pathophysiology of acute GVHD developed after CBT has not yet been elucidated. In this study, we aimed to clarify the molecular mechanism of acute GVHD after CBT...
  49. ncbi request reprint One allele deletion of the RB1 gene in a case of refractory anemia with del(13)(q12q14): a fluorescence in situ hybridization study of the RB1 gene
    Fumitaka Nagamura
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, 108 8639 Tokyo, Japan
    Cancer Genet Cytogenet 146:77-80. 2003
    ..6%). Thus, the majority of hematopoietic progenitor cells lacked one allele of the RB1 gene, suggesting that in this particular case the RB1 gene played an important role in abnormal hematopoiesis...
  50. ncbi request reprint Development of testicular alpha-fetoprotein-secreting germ cell tumor 3 years after treatment of intracranial lesion identified as non-secreting germ cell tumor on the basis of clinical data--case report
    Satoshi Takahashi
    Department of Neurosurgery, Keio University School of Medicine, Tokyo, Japan
    Neurol Med Chir (Tokyo) 48:522-5. 2008
    ..Patients may subsequently develop germ cell tumors at other sites in the body. Therefore, follow up should monitor for tumor recurrence not only in the brain but also in other locations...
  51. doi request reprint Dual-view imaging system using a wide-range dichroic mirror for simultaneous four-color single-molecule detection
    Takanobu Haga
    Central Research Laboratory, Hitachi, Ltd, Kokubunji shi, Tokyo, Japan
    Anal Chem 83:6948-55. 2011
    ..The developed system is suitable for detection systems of next-generation DNA sequencers and DNA microarray-chip analyzers...
  52. ncbi request reprint [Cord blood transplantation]
    Satoshi Takahashi
    Institute of Medical Science, University of Tokyo, 6 1, 4 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Gan To Kagaku Ryoho 31:307-13. 2004
    ..Umbilical cord blood is promising alternative to bone marrow-derived stem cells. More prospective studies are needed to establish the role of CBT during various allogeneic HSC transplantations...
  53. doi request reprint Prism-based spectral imaging of four species of single-molecule fluorophores by using one excitation laser
    Takanobu Haga
    Central Research Laboratory, Hitachi, Ltd, Kokubunji shi, Tokyo, Japan
    J Fluoresc 23:591-7. 2013
    ..5 times higher. The approach taken in this study, namely, using BigDye with a prism-type system, is effective for increasing the throughput of DNA microarray-chip analysis and SM real-time DNA sequencing...
  54. ncbi request reprint Second allogeneic hematopoietic stem cell transplantation for leukemia relapse after first allogeneic transplantation: outcome of 16 patients in a single institution
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Japan
    Int J Hematol 75:318-23. 2002
    ..HSCT2 is considered to be beneficial for select patients. Preparative regimens, GVHD prophylaxis, and donor choice for HSCT2 need to be studied to obtain a more successful outcome for HSCT2...
  55. ncbi request reprint Subcortical intracerebral hemorrhage caused by mucormycosis in a patient with a history of bone-marrow transplantation
    Satoshi Takahashi
    Department of Neurosurgery, Keio University School of Medicine, Tokyo, Japan
    J Stroke Cerebrovasc Dis 18:405-6. 2009
    ..Combined with surgical findings, venous occlusion by Mucor mycelium might be the cause of ICH in the patient...
  56. ncbi request reprint Central nervous system leukemia on magnetic resonance imaging
    Takaaki Konuma
    Department of Hematology and Oncology, Institute of Medical Science University of Tokyo
    Intern Med 47:477. 2008
  57. ncbi request reprint Non-Born-Oppenheimer electronic and nuclear wavepacket dynamics
    Takehiro Yonehara
    Department of Basic Science, The University of Tokyo, Komaba, 153 8902 Tokyo, Japan
    J Chem Phys 130:214113. 2009
    ..Thus, the present theoretical framework gives a basic method with which to study non-Born-Oppenheimer electronic and nuclear wavepacket states relevant to ultrafast chemical events...
  58. ncbi request reprint Neuroendoscope-assisted removal of an organized chronic subdural hematoma in a patient on bevacizumab therapy--case report
    Satoshi Takahashi
    Department of Neurosurgery, Mita Hospital, International University of Health and Welfare, Tokyo, Japan
    Neurol Med Chir (Tokyo) 51:515-8. 2011
    ..The present case indicates the possible involvement of bevacizumab in the occurrence of CSDH and the efficacy of the neuroendoscopic approach in the surgical treatment of organized CSDH...
  59. doi request reprint Intrasellar salivary gland-like pleomorphic adenoma: case report
    Satoshi Takahashi
    Department of Neurosurgery, Keio University School of Medicine, Tokyo, Japan
    Neurosurgery 68:E562-5; discussion E566. 2011
    ..We present a rare case of a patient with intrasellar salivary gland-like pleomorphic adenoma and review the 2 previously reported cases of the clinical entity to identify their common clinical features...
  60. ncbi request reprint Focal hand dystonia cured by removal of clinoid meningioma-case report-
    Satoshi Takahashi
    Department of Neurosurgery, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Neurol Med Chir (Tokyo) 49:619-21. 2009
    ..Magnetic resonance imaging after surgery showed that the compression of the surrounding brain was released. This case shows that secondary focal hand dystonia caused by extra-axial brain tumor can be cured by surgical removal...
  61. ncbi request reprint [Cord blood transplantation in adult patients]
    Satoshi Takahashi
    Division of Molecular Therapy, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo
    Nihon Rinsho 65:439-44. 2007
  62. doi request reprint Nationwide surveillance of bacterial pathogens from patients with acute uncomplicated cystitis conducted by the Japanese surveillance committee during 2009 and 2010: antimicrobial susceptibility of Escherichia coli and Staphylococcus saprophyticus
    Hiroshi Hayami
    Urogenital sub committee and the Surveillance Committee of Japanese Society of Chemotherapy JCS, The Japanese Association for Infectious Diseases JAID and The Japanese Society for Clinical Microbiology JSCM, Tokyo, Japan
    J Infect Chemother 19:393-403. 2013
    ..Therefore, these data present important information for the proper treatment of UTIs and will serve as a useful reference for future surveillance studies...
  63. ncbi request reprint Cerebral venous sinus thrombosis in an adult patient presenting as headache and acute subdural hematoma
    Satoshi Takahashi
    Department of Neurosurgery, Eiju General Hospital, Tokyo, Japan
    J Stroke Cerebrovasc Dis 21:338-40. 2012
    ....
  64. ncbi request reprint Chromosome arm 1q gain associated with good response to chemotherapy in a malignant glioma. Case report
    Satoshi Takahashi
    Department of Neurosurgery, Keio University School of Medicine, Tokyo, Japan
    J Neurosurg 106:488-94. 2007
    ....
  65. ncbi request reprint Combined gangliocytoma and prolactinoma of the pituitary gland
    Shuji Mikami
    Division of Diagnostic Pathology, Keio University Hospital, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Endocr Pathol 19:117-21. 2008
    ..The last is that their common origin may be the same stem/progenitor cells in normal adult pituitaries...
  66. doi request reprint Simultaneous four-color imaging of single molecule fluorophores using dichroic mirrors and four charge-coupled devices
    Takanobu Haga
    Central Research Laboratory, Hitachi, Ltd, Tokyo, Japan
    Rev Sci Instrum 82:023701. 2011
    ..The error rates of fluorophore classification were estimated to be less than 3.2% for all the species. Our system is suitable for the biological studies that desire to simultaneously monitor the four colors of SM fluorophores...
  67. ncbi request reprint Prophylactic antimicrobial agents in urologic laparoscopic surgery: 1-day versus 3-day treatments
    Koh Takeyama
    Department of Urology, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, 060 8543, Sapporo, Japan
    J Infect Chemother 10:168-71. 2004
    ..The 1-day use of a prophylactic antimicrobial agent may be recommended for the clean or clean-contaminated urologic laparoscopic surgery described above...
  68. ncbi request reprint Impact of cytogenetics on outcome of stem cell transplantation for acute myeloid leukemia in first remission: a large-scale retrospective analysis of data from the Japan Society for Hematopoietic Cell Transplantation
    Hiroyasu Ogawa
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan
    Int J Hematol 79:495-500. 2004
    ..In multivariate analysis, cytogenetics was found to be an independent predictor of relapse as well as of treatment failure...
  69. ncbi request reprint Early-onset pulmonary complication showing organizing pneumonia pattern following cord blood transplantation in adults
    Akira Tomonari
    Int J Hematol 85:364-6. 2007
  70. doi request reprint Central nervous system relapse of leukemia after allogeneic hematopoietic stem cell transplantation
    Kumi Oshima
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Biol Blood Marrow Transplant 14:1100-7. 2008
    ..Although the outcome of patients with CNS relapse was generally poor, long-term disease-free survival could be achieved in some patients...
  71. ncbi request reprint Impact of human leucocyte antigen mismatch on graft-versus-host disease and graft failure after reduced intensity conditioning allogeneic haematopoietic stem cell transplantation from related donors
    Takanori Teshima
    Centre for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan
    Br J Haematol 130:575-87. 2005
    ..RICT from a one-locus-mismatched donor may represent an effective alternative approach in patients with high-risk malignancies who lack HLA-matched related donors...
  72. ncbi request reprint Detection of human papillomavirus DNA on the external genitalia of healthy men and male patients with urethritis
    Satoshi Takahashi
    Department of Urology, Sapporo Medical University School of Medicine, Japan
    Sex Transm Dis 30:629-33. 2003
    ..We conducted HPV DNA detection among healthy male volunteers and men with urethritis, both having no visible lesions on their external genitalia...
  73. ncbi request reprint Application of real-time polymerase chain reaction technology to detect prostatic bacteria in patients with chronic prostatitis/chronic pelvic pain syndrome
    Satoshi Takahashi
    Department of Urology, University of Washington School of Medicine, 112 GU, VA Puget Sound Health Care System1660 South Columbian Way, WA 98108 1597, Seattle, USA
    World J Urol 21:100-4. 2003
    ..Quantification, speed and specificity make real-time PCR a promising approach for the quantitative detection and identification of prostatic bacteria from CP/CPPS patients...
  74. ncbi request reprint Allogeneic stem cell transplantation for hepatosplenic gammadelta T-cell lymphoma
    Takaaki Konuma
    Leuk Lymphoma 48:630-2. 2007
  75. ncbi request reprint Incidence of sexually transmitted infections in asymptomatic healthy young Japanese men
    Satoshi Takahashi
    Department of Urology, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    J Infect Chemother 11:270-3. 2005
    ..0%. Our study showed that the incidence rates of asymptomatic STIs were not negligible, and that we should provide screening programs for young men with a high risk for such unrecognized infections and study their natural histories...
  76. ncbi request reprint [A case of astrocytoma with extracranial extension after malignant transformation]
    Ikuo Sakuma
    Department of Radiology, Akita University School of Medicine, 1 1 1 Hondo, Akita City, Akita 010 8543, Japan
    No To Shinkei 55:153-6. 2003
    ..After surgery, chemotherapy and radiotherapy were performed. The tumor invades the skull base and extended into the infratemporal fossa 25 months after surgery...
  77. ncbi request reprint [Male genital herpes]
    Satoshi Takahashi
    Department of Urology, Sapporo Medical University School of Medicine
    Nihon Rinsho 64:77-80. 2006
  78. ncbi request reprint Ischemic lesions related to cerebral angiography: Evaluation by diffusion weighted MR imaging
    Koki Kato
    Department of Radiology, Ootawara Red Cross Hospital, 2 7 3 Sumiyoshi cho, Ootawara, Tochigi 324 8686, Japan
    Neuroradiology 45:39-43. 2003
    ..In patients who underwent occlusion tests of the internal carotid artery, the incidence of silent lesions was significantly higher than in patients who did not...
  79. ncbi request reprint National institutes of Health Chronic Prostatitis Symptom Index for Japanese men
    Yasuharu Kunishima
    Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Urology 60:74-7. 2002
    ....
  80. ncbi request reprint Surgical antimicrobial prophylaxis in transurethral ureterolithotripsy
    Satoshi Takahashi
    Department of Urology, Hakodate Goryokaku Hospital, Hakodate, Japan
    J Infect Chemother 11:239-43. 2005
    ..Our study showed that single AMP was effective for patients receiving a TUL operation. In the future, a prospective randomized study will be needed for a large series, with various types of lithotripters being included...
  81. ncbi request reprint Metalloprotease inhibitors block release of soluble CD27 and enhance the immune stimulatory activity of chronic lymphocytic leukemia cells
    Kazunori Kato
    Division of Hematology Oncology, Department of Medicine, UCSD School of Medicine, La Jolla, CA, USA
    Exp Hematol 35:434-42. 2007
    ..In this study, we evaluated whether protease inhibitors could inhibit the release of sCD27 from CLL cells and enhance T-cell activation mediated by CD27-CD70 interaction...
  82. ncbi request reprint Incidence of and risk factors for surgical site infection in patients with radical cystectomy with urinary diversion
    Koh Takeyama
    Department of Urology, Sapporo Medical University School of Medicine, Japan
    J Infect Chemother 11:177-81. 2005
    ..In our study, the incidence of SSI after RC was 33%, although 71% of the infections were superficial. It is necessary to establish more appropriate countermeasures to prevent SSI after RC with UD; in particular, that caused by MRSA...
  83. ncbi request reprint Incidence of sexually transmitted diseases in Hokkaido, Japan, 1998 to 2001
    Satoshi Takahashi
    Department of Urology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, 060 8543, Sapporo, Japan
    J Infect Chemother 10:163-7. 2004
    ..In conclusion, the current study of STDs revealed high incidences of gonococcal and chlamydial infections in the Hokkaido area, and there was no decreasing trend in STD incidence during these 4 years...
  84. ncbi request reprint A novel maxizyme vector targeting a bcr-abl fusion gene induced specific cell death in Philadelphia chromosome-positive acute lymphoblastic leukemia
    Yasushi Soda
    Department of Advanced Molecular and Cell Therapy, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka shi 812 8582, Japan
    Blood 104:356-63. 2004
    ..These results indicate that e1a2Mz kills Ph(+) ALL cells specifically, suggesting that it may be used as a novel gene therapy strategy for Ph(+) ALL...
  85. ncbi request reprint Systemic inflammatory response syndrome in open versus laparoscopic adrenalectomy
    Masatoshi Mutoh
    Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Urology 64:422-5. 2004
    ..To compare the surgical invasiveness of laparoscopic adrenalectomy with that of open surgery when the invasiveness is evaluated by the incidence of systemic inflammatory response syndrome (SIRS)...
  86. doi request reprint Myeloablative unrelated cord blood transplantation for adult acute myeloid leukemia patients with 11q23 abnormalities
    Takaaki Konuma
    Eur J Haematol 80:545-8. 2008
  87. ncbi request reprint [Application of real-time polymerase chain reaction for the detection of prostatic bacteria in patients with chronic prostatitis/chronic pelvic pain syndrome]
    Satoshi Takahashi
    Jpn J Antibiot 58:187-92. 2005
  88. ncbi request reprint [Application of real-time polymerase chain reaction technology to detect prostatic bacteria in patients with chronic prostatitis/chronic pelvic pain syndrome]
    Satoshi Takahashi
    Department of Urology, University of Washington School of Medicine, Seattle, WA, USA
    Jpn J Antibiot 56:338-9. 2003
  89. ncbi request reprint Neutrophil elastase and trastuzumab responsiveness
    Michiko Harao
    Onkologie 30:583-4. 2007
  90. ncbi request reprint Activation of CD1d-independent NK1.1+ T cells in the large intestine by Lactobacilli
    Satoshi Takahashi
    Department of Immunology, Niigata University School of Medicine, Asahimachi dori 1 757, Niigata 951 8510, Japan
    Immunol Lett 102:74-8. 2006
    ..Our results suggest that Lactobacilli selectively activate CD1d-independent NK1.1+ T cells in the large intestine to produce IFN-gamma and therefore modulate Th1 immune responses...
  91. ncbi request reprint Diffusion changes in a tumor and peritumoral tissue after stereotactic irradiation for brain tumors: possible prediction of treatment response
    Noriaki Tomura
    Department of Radiology, Akita University School of Medicine, and Department of Radiology, Akita University Hospital, Japan
    J Comput Assist Tomogr 30:496-500. 2006
    ..Changes in apparent diffusion coefficient (ADC) in a tumor and peritumoral tissue after stereotactic irradiation (STI) were evaluated, and then the therapeutic efficacy of ADC measurement was assessed...