Sadao Takahashi

Summary

Affiliation: University of Fukui
Country: Japan

Publications

  1. ncbi request reprint The very low-density lipoprotein (VLDL) receptor: characterization and functions as a peripheral lipoprotein receptor
    Sadao Takahashi
    The Third Department of Internal Medicine, University of Fukui, 23 3, Matsuokacho, Fukui, 910 1193, Japan
    J Atheroscler Thromb 11:200-8. 2004
  2. ncbi request reprint The very low density lipoprotein (VLDL) receptor--a peripheral lipoprotein receptor for remnant lipoproteins into fatty acid active tissues
    Sadao Takahashi
    The Third Department of Internal Medicine, Fukui Medical University, Fukui, Japan
    Mol Cell Biochem 248:121-7. 2003
  3. doi request reprint Comparative reactivity of remnant-like lipoprotein particles (RLP) and low-density lipoprotein (LDL) to LDL receptor and VLDL receptor: effect of a high-dose statin on VLDL receptor expression
    Michiko Imagawa
    Third Department of Internal Medicine, University of Fukui, Faculty of Medical Science, Japan
    Clin Chim Acta 413:441-7. 2012
  4. ncbi request reprint New therapeutic target for metabolic syndrome: PPARdelta
    Sadao Takahashi
    Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Japan
    Endocr J 54:347-57. 2007
  5. doi request reprint Glucose deprivation accelerates VLDL receptor-mediated TG-rich lipoprotein uptake by AMPK activation in skeletal muscle cells
    Yasuo Zenimaru
    Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Eiheiji cho, Fukui 910 1193, Japan
    Biochem Biophys Res Commun 368:716-22. 2008
  6. ncbi request reprint Function of hormone-sensitive lipase in diacylglycerol-protein kinase C pathway
    Hideo Kanehara
    Third Department of Internal Medicine, Faculty of Medical Science, University of Fukui, Fukui 910 1193, Japan
    Diabetes Res Clin Pract 65:209-15. 2004
  7. doi request reprint Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and fibrosis in streptozotocin diabetic mice
    Masami Ueno
    Third Department of Internal Medicine, Faculty of Medical Science, University of Fukui, Fukui, Japan
    Am J Physiol Endocrinol Metab 294:E1109-18. 2008
  8. ncbi request reprint Peroxisome proliferator-activated receptor delta (PPARdelta), a novel target site for drug discovery in metabolic syndrome
    Sadao Takahashi
    Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui 910 0063, Japan
    Pharmacol Res 53:501-7. 2006
  9. doi request reprint Species differences of macrophage very low-density-lipoprotein (VLDL) receptor protein expression
    Sadao Takahashi
    Third Department of Internal Medicine, University of Fukui, Faculty of Medical Science, Japan
    Biochem Biophys Res Commun 407:656-62. 2011
  10. ncbi request reprint Cardiac gene expression profile and lipid accumulation in response to starvation
    Jinya Suzuki
    Third Department of Internal Medicine, Fukui Medical University, Fukui 910 1193, Japan
    Am J Physiol Endocrinol Metab 283:E94-E102. 2002

Collaborators

  • Jinya Suzuki
  • Wen Jun Shen
  • Masafumi Takahashi
  • Toshiya Tanaka
  • FREDRIC KRAEMER
  • Greer M Murphy
  • Takashi Ito
  • Kazuya Yamada
  • Takashi Suzuki
  • Mitsuyo Okazaki
  • Mitsuru Emi
  • Katsuyuki Nakajima
  • W L Olszewski
  • Tadao Iwasaki
  • Hiroaki Hattori
  • Tokuo T Yamamoto
  • Takahiro Fujino
  • Yasuo Zenimaru
  • Isamu Miyamori
  • Juro Sakai
  • Takeshi Kujiraoka
  • Kenta Magoori
  • Ryoichi X Ioka
  • Akihisa Kamataki
  • Michiko Imagawa
  • Masami Ueno
  • Mitsuaki Ishihara
  • Joji Yamamoto
  • Makoto Nagano
  • Norman E Miller
  • Hiroshi Asaba
  • Man Jong Kang
  • Dong Ho Kim
  • Lijing Jia
  • Uichi Ikeda
  • Hideo Kanehara
  • Masashi Yanagisawa
  • Satoshi Iwasaki
  • Hironobu Naiki
  • Yukio Ikeda
  • Masako Sasaki
  • Tohru Egashira
  • Yumiko A Takei
  • Masato Nose
  • Mayumi Ito
  • Shinichi Usui
  • Masao Ono
  • Irina P Stepanova
  • Tomoko Kimura
  • Takamitsu Nakano
  • Tsutomu Koizumi
  • Osamu Yamaguchi
  • Sakon Noriki
  • Kinya Otsu
  • Hajime Morimoto
  • Kou Juey Wu
  • Hirohiko Ise
  • Atsushi Izawa
  • Tatsuhiko Kodama
  • Toshiyuki Mori
  • Hiroshi Sakaue
  • Kazuyuki Shimada
  • Sadayoshi Ito
  • Haruhisa Iguchi
  • Koji Oida
  • Izumi W Kaneko
  • Katsumi Imaizumi
  • Akito Kawaguchi
  • Jun Ishi
  • Hajime Kakuuchi
  • M Nazeem Nanjee
  • Mitsuko R Ito
  • Hiroko Tomoyori
  • Shin Kamiyama
  • Hisashi Oishi
  • Tomoichiro Oka
  • Yuichiro Ito
  • Masahiro Tsuji
  • Jinny S Wong
  • Hironobu Sasano
  • Hideyuki Sone
  • Shinji Takada
  • Yoshiharu Miyamoto
  • Toshio Murase
  • Robert L Hamilton
  • Minoru Okubo
  • C Justin Cooke
  • Katsuhiko Masamura

Detail Information

Publications23

  1. ncbi request reprint The very low-density lipoprotein (VLDL) receptor: characterization and functions as a peripheral lipoprotein receptor
    Sadao Takahashi
    The Third Department of Internal Medicine, University of Fukui, 23 3, Matsuokacho, Fukui, 910 1193, Japan
    J Atheroscler Thromb 11:200-8. 2004
    ..Beyond its function as a peripheral lipoprotein receptor, possibilities of its physiological function have been extended to include signal transduction, angiogenesis and tumor growth...
  2. ncbi request reprint The very low density lipoprotein (VLDL) receptor--a peripheral lipoprotein receptor for remnant lipoproteins into fatty acid active tissues
    Sadao Takahashi
    The Third Department of Internal Medicine, Fukui Medical University, Fukui, Japan
    Mol Cell Biochem 248:121-7. 2003
    ..The gene therapy of VLDL receptor into the LDL receptor knockout mice liver showed a benefit effect for lipoprotein metabolism and atherosclerosis. Further researches about the VLDL receptor function will be needed in the future...
  3. doi request reprint Comparative reactivity of remnant-like lipoprotein particles (RLP) and low-density lipoprotein (LDL) to LDL receptor and VLDL receptor: effect of a high-dose statin on VLDL receptor expression
    Michiko Imagawa
    Third Department of Internal Medicine, University of Fukui, Faculty of Medical Science, Japan
    Clin Chim Acta 413:441-7. 2012
    ..Comparison of the reactivity of remnant-like lipoprotein particles (RLP) and LDL particles to LDL receptor and VLDL receptor has not been investigated...
  4. ncbi request reprint New therapeutic target for metabolic syndrome: PPARdelta
    Sadao Takahashi
    Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Japan
    Endocr J 54:347-57. 2007
  5. doi request reprint Glucose deprivation accelerates VLDL receptor-mediated TG-rich lipoprotein uptake by AMPK activation in skeletal muscle cells
    Yasuo Zenimaru
    Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Eiheiji cho, Fukui 910 1193, Japan
    Biochem Biophys Res Commun 368:716-22. 2008
    ..Our study suggests that the VLDL-R-mediated uptake of TG-rich lipoproteins might compensate for glucose shortfall through AMPK activation in skeletal muscle...
  6. ncbi request reprint Function of hormone-sensitive lipase in diacylglycerol-protein kinase C pathway
    Hideo Kanehara
    Third Department of Internal Medicine, Faculty of Medical Science, University of Fukui, Fukui 910 1193, Japan
    Diabetes Res Clin Pract 65:209-15. 2004
    ....
  7. doi request reprint Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and fibrosis in streptozotocin diabetic mice
    Masami Ueno
    Third Department of Internal Medicine, Faculty of Medical Science, University of Fukui, Fukui, Japan
    Am J Physiol Endocrinol Metab 294:E1109-18. 2008
    ..In conclusion, since HSL overexpression inhibits cardiac steatosis and fibrosis by apparently hydrolyzing toxic lipid metabolites, cardiac HSL could be a therapeutic target for regulating diabetic cardiomyopathy...
  8. ncbi request reprint Peroxisome proliferator-activated receptor delta (PPARdelta), a novel target site for drug discovery in metabolic syndrome
    Sadao Takahashi
    Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui 910 0063, Japan
    Pharmacol Res 53:501-7. 2006
    ....
  9. doi request reprint Species differences of macrophage very low-density-lipoprotein (VLDL) receptor protein expression
    Sadao Takahashi
    Third Department of Internal Medicine, University of Fukui, Faculty of Medical Science, Japan
    Biochem Biophys Res Commun 407:656-62. 2011
    ....
  10. ncbi request reprint Cardiac gene expression profile and lipid accumulation in response to starvation
    Jinya Suzuki
    Third Department of Internal Medicine, Fukui Medical University, Fukui 910 1193, Japan
    Am J Physiol Endocrinol Metab 283:E94-E102. 2002
    ..These data provide a broad perspective of the molecular events occurring physiologically in the heart in response to starvation...
  11. ncbi request reprint The important role for betaVLDLs binding at the fourth cysteine of first ligand-binding domain in the low-density lipoprotein receptor
    Tadao Iwasaki
    Department of Advanced Medical Technology and Development, BML, Inc, Saitama, Japan
    J Hum Genet 49:622-8. 2004
    ....
  12. ncbi request reprint Remnant lipoprotein particles are taken up into myocardium through VLDL receptor--a possible mechanism for cardiac fatty acid metabolism
    Akihisa Kamataki
    Tohoku University Gene Research Center, Sendai, Japan
    Biochem Biophys Res Commun 293:1007-13. 2002
    ..Thereby, we showed that the cardiac VLDL receptor pathway for delivery of remnant lipoprotein particles might be part of a cardiac fatty acid metabolism...
  13. ncbi request reprint Expression cloning and characterization of a novel glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein, GPI-HBP1
    Ryoichi X Ioka
    Tohoku University Gene Research Center, Sendai 981 8555, Japan
    J Biol Chem 278:7344-9. 2003
    ..In situ hybridization revealed the accumulation of GPI-HBP1 transcripts in cardiac muscle cells, hepatic Kupffer cells and sinusoidal endothelium, and bronchial epithelium and alveolar macrophages in the lung...
  14. ncbi request reprint Severe hypercholesterolemia, impaired fat tolerance, and advanced atherosclerosis in mice lacking both low density lipoprotein receptor-related protein 5 and apolipoprotein E
    Kenta Magoori
    Tohoku University Gene Research Center, Aoba, Sendai 981 8555, Japan
    J Biol Chem 278:11331-6. 2003
    ..These data suggest that LRP5 mediates both apoE-dependent and apoE-independent catabolism of plasma lipoproteins...
  15. ncbi request reprint [PPARalpha, PPARgamma, PPARdelta]
    Sadao Takahashi
    Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui
    Nihon Rinsho 64:259-62. 2006
  16. ncbi request reprint Changes in cardiac lipid metabolism during sepsis: the essential role of very low-density lipoprotein receptors
    Lijing Jia
    Department of Organ Regeneration, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    Cardiovasc Res 69:545-55. 2006
    ..In the present study, we explored lipid accumulation and VLDL-R expression in the lipopolysaccharide (LPS)-stimulated heart in vivo and regulation of VLDL-R expression in vitro...
  17. ncbi request reprint Deficiency of the very low-density lipoprotein (VLDL) receptors in streptozotocin-induced diabetic rats: insulin dependency of the VLDL receptor
    Tadao Iwasaki
    Department of Advanced Medical Technology and Development, BML, Inc, Kawagoe, Japan
    Endocrinology 146:3286-94. 2005
    ..These results suggest that the combination of VLDL-R deficiency and reduced plasma lipoprotein lipase activity may be responsible for severe hyperlipidemia in insulin-deficient diabetes...
  18. ncbi request reprint Interleukin-1beta attenuates beta-very low-density lipoprotein uptake and its receptor expression in vascular smooth muscle cells
    Masafumi Takahashi
    Department of Organ Regeneration, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    J Mol Cell Cardiol 38:637-46. 2005
    ..These results indicate that IL-1beta attenuates uptake of VLDL through downregulation of its receptor in VSMCs, and that this downregulation is mediated through a benzoquinone ansamycin-dependent but c-Src-independent pathway...
  19. ncbi request reprint A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2
    Joji Yamamoto
    Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, the Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    J Biol Chem 279:16954-62. 2004
    ..Furthermore, KLF15 overexpression induced the levels of AceCS2 transcripts both in myoblasts and in myotubes, indicating that AceCS2 gene expression in vivo is indeed induced by KLF15...
  20. ncbi request reprint Effects of intravenous apolipoprotein A-I/phosphatidylcholine discs on LCAT, PLTP, and CETP in plasma and peripheral lymph in humans
    Takeshi Kujiraoka
    Department of Advanced Medical Technology and Development, BML, Inc, 1361 1 Matoba, Kawagoe, Saitama 350 1101, Japan
    Arterioscler Thromb Vasc Biol 23:1653-9. 2003
    ....
  21. ncbi request reprint Altered distribution of plasma PAF-AH between HDLs and other lipoproteins in hyperlipidemia and diabetes mellitus
    Takeshi Kujiraoka
    Department of Advanced Medical Technology and Development, BML, Inc, Saitama, Japan
    J Lipid Res 44:2006-14. 2003
    ....
  22. pmc Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion
    Takahiro Fujino
    Gene Research Center and Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University, Sendai 980 8574, Japan
    Proc Natl Acad Sci U S A 100:229-34. 2003
    ..In contrast, LRP5-deficient islets lacked the Wnt-3a-stimulated insulin secretion. These data suggest that WntLRP5 signaling contributes to the glucose-induced insulin secretion in the islets...
  23. ncbi request reprint beta-very low density lipoprotein enhances inducible nitric oxide synthase expression in cytokine-stimulated vascular smooth muscle cells
    Masafumi Takahashi
    Department of Internal Medicine, Division of Cardiology, Jichi Medical School, Minamikawachi Machi, 329 0498, Tochigi, Japan
    Atherosclerosis 162:307-13. 2002
    ..Our results suggest that beta-VLDL enhances iNOS expression and nitrite accumulation in IL-1beta-stimulated VSMC through tyrosine kinase(s)-dependent mechanisms...