Hirokazu Takahashi

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Multiple neural origins of early auditory evoked potential of rat
    H Takahashi
    Research Center for Advanced Science and Technology, The University of Tokyo, 4 6 1 Komaba, Meguro ku, Tokyo 153 8904, Japan
    Neuroscience 148:845-56. 2007
  2. pmc Response variance in functional maps: neural darwinism revisited
    Hirokazu Takahashi
    Graduate School of Information Science and Technology, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    PLoS ONE 8:e68705. 2013
  3. doi request reprint Light-addressed single-neuron stimulation in dissociated neuronal cultures with sparse expression of ChR2
    Hirokazu Takahashi
    Research Center for Advanced Science and Technology, The University of Tokyo, Komaba 4 6 1, Meguro ku, Tokyo 153 8904, Japan
    Biosystems 107:106-12. 2012
  4. ncbi request reprint Selective activation of distant nerve by surface electrode array
    Hirokazu Takahashi
    Research Center for Advanced Science and Technology, The University of Tokyo, 4 6 1 Komaba, Meguro ku, Tokyo 153 8904, Japan
    IEEE Trans Biomed Eng 54:563-9. 2007
  5. doi request reprint Progressive plasticity of auditory cortex during appetitive operant conditioning
    Hirokazu Takahashi
    Research Center for Advanced Science and Technology, The University of Tokyo, Meguro ku, Tokyo, Japan
    Biosystems 101:37-41. 2010
  6. ncbi request reprint Intra-oral pressure-based voicing control of electrolaryngeal speech with intra-oral vibrator
    Hirokazu Takahashi
    Research Center for Advanced Science and Technology, The University of Tokyo, 4 6 1 Komaba, Meguro ku, Tokyo 153 8904, Japan
    J Voice 22:420-9. 2008
  7. doi request reprint Learning-stage-dependent, field-specific, map plasticity in the rat auditory cortex during appetitive operant conditioning
    H Takahashi
    Research Center for Advanced Science and Technology, The University of Tokyo, Komaba 4 6 1, Meguro ku, Tokyo 153 8904, Japan
    Neuroscience 199:243-58. 2011
  8. doi request reprint Light-addressed stimulation under Ca(2+) imaging of cultured neurons
    Jun Suzurikawa
    Graduate School of Information Science and Technology, University of Tokyo, Tokyo, Japan
    IEEE Trans Biomed Eng 56:2660-5. 2009
  9. ncbi request reprint Easy-to-prepare assembly array of Tungsten microelectrodes
    Hirokazu Takahashi
    Department of Engineering Synthesis, Graduate School of Engineering, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    IEEE Trans Biomed Eng 52:952-6. 2005
  10. ncbi request reprint Accessing ampli-tonotopic organization of rat auditory cortex by microstimulation of cochlear nucleus
    Hirokazu Takahashi
    Department of Engineering Synthesis, Graduate School of Engineering, The University of Tokyo, Tokyo 113 8656, Japan
    IEEE Trans Biomed Eng 52:1333-44. 2005

Collaborators

Detail Information

Publications82

  1. ncbi request reprint Multiple neural origins of early auditory evoked potential of rat
    H Takahashi
    Research Center for Advanced Science and Technology, The University of Tokyo, 4 6 1 Komaba, Meguro ku, Tokyo 153 8904, Japan
    Neuroscience 148:845-56. 2007
    ..In such conditions, e.g. in human scalp-recording experiments or routine clinical screenings, our idea is specifically worth considering for the interpretation of signals...
  2. pmc Response variance in functional maps: neural darwinism revisited
    Hirokazu Takahashi
    Graduate School of Information Science and Technology, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    PLoS ONE 8:e68705. 2013
    ..Thus, functional maps and map plasticity are likely to play essential roles in Darwinian computation, serving as effective, but not absolutely necessary, structures to generate diverse response properties within a neural population. ..
  3. doi request reprint Light-addressed single-neuron stimulation in dissociated neuronal cultures with sparse expression of ChR2
    Hirokazu Takahashi
    Research Center for Advanced Science and Technology, The University of Tokyo, Komaba 4 6 1, Meguro ku, Tokyo 153 8904, Japan
    Biosystems 107:106-12. 2012
    ..These results suggest that organized activation of a very small population of neurons can provide better control over global activity of neuronal circuits than can single-neuron activities by themselves...
  4. ncbi request reprint Selective activation of distant nerve by surface electrode array
    Hirokazu Takahashi
    Research Center for Advanced Science and Technology, The University of Tokyo, 4 6 1 Komaba, Meguro ku, Tokyo 153 8904, Japan
    IEEE Trans Biomed Eng 54:563-9. 2007
    ..We then applied the lateral gating stimulation on the rat spinal cords and obtained a preliminary support for the feasibility...
  5. doi request reprint Progressive plasticity of auditory cortex during appetitive operant conditioning
    Hirokazu Takahashi
    Research Center for Advanced Science and Technology, The University of Tokyo, Meguro ku, Tokyo, Japan
    Biosystems 101:37-41. 2010
    ..Thus, the progressive plasticity in the present study reflects a shift from identification to storage of a behaviorally relevant auditory object, which is potentially associated with a habitual behavior...
  6. ncbi request reprint Intra-oral pressure-based voicing control of electrolaryngeal speech with intra-oral vibrator
    Hirokazu Takahashi
    Research Center for Advanced Science and Technology, The University of Tokyo, 4 6 1 Komaba, Meguro ku, Tokyo 153 8904, Japan
    J Voice 22:420-9. 2008
    ..5 gf/cm2 and during the 35 milliseconds that followed, proved efficient to improve the voiceless/voiced contrast...
  7. doi request reprint Learning-stage-dependent, field-specific, map plasticity in the rat auditory cortex during appetitive operant conditioning
    H Takahashi
    Research Center for Advanced Science and Technology, The University of Tokyo, Komaba 4 6 1, Meguro ku, Tokyo 153 8904, Japan
    Neuroscience 199:243-58. 2011
    ....
  8. doi request reprint Light-addressed stimulation under Ca(2+) imaging of cultured neurons
    Jun Suzurikawa
    Graduate School of Information Science and Technology, University of Tokyo, Tokyo, Japan
    IEEE Trans Biomed Eng 56:2660-5. 2009
    ..To provide patterned illumination for light addressing, a digital micromirror device was installed in the system as an active photomask. The system could induce pinpoint neuronal activation at a cellular level...
  9. ncbi request reprint Easy-to-prepare assembly array of Tungsten microelectrodes
    Hirokazu Takahashi
    Department of Engineering Synthesis, Graduate School of Engineering, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    IEEE Trans Biomed Eng 52:952-6. 2005
    ..Copying the groove pattern onto polystyrene mass-produced a replica substrate. Tungsten probes were then aligned on the substrate, and the tips of probes were finely processed in the block...
  10. ncbi request reprint Accessing ampli-tonotopic organization of rat auditory cortex by microstimulation of cochlear nucleus
    Hirokazu Takahashi
    Department of Engineering Synthesis, Graduate School of Engineering, The University of Tokyo, Tokyo 113 8656, Japan
    IEEE Trans Biomed Eng 52:1333-44. 2005
    ..We also found that the cortical dynamic range was wider for the DCN than VCN stimulation and for the low-frequency than for the high-frequency pathway. The present results have great implications for improved ABI performance...
  11. ncbi request reprint Microelectrode array on folding polyimide ribbon for epidural mapping of functional evoked potentials
    Hirokazu Takahashi
    Department of Engineering Synthesis, Graduate School of Engineering, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656, Japan
    IEEE Trans Biomed Eng 50:510-6. 2003
    ..Our in vivo experiments then successfully achieved synchronized neuronal activity and evoked potential patterns useful for understanding brain function and for finding cortical function...
  12. ncbi request reprint Cortical mapping of auditory-evoked offset responses in rats
    Hirokazu Takahashi
    Department of Engineering Synthesis, Graduate School of Engineering, The University of Tokyo, Tokyo 113 8656, Japan
    Neuroreport 15:1565-9. 2004
    ..Thus, the rebound after the inhibition in the presence of a stimulus is likely to be a major cause of offset responses in the auditory cortex...
  13. ncbi request reprint Distributed representation of sound intensity in the rat auditory cortex
    Hirokazu Takahashi
    Department of Engineering Synthesis, Graduate School of Engineering, The University of Tokyo, Tokyo, 113 8656, Japan
    Neuroreport 15:2061-5. 2004
    ..Each field represents the intensity information differently, particularly at the off-CF locations. These results suggest that intensity information is distributed in various aspects in the multiple auditory fields...
  14. ncbi request reprint Interfield differences in intensity and frequency representation of evoked potentials in rat auditory cortex
    Hirokazu Takahashi
    Department of Engineering Synthesis, Graduate School of Engineering, The University of Tokyo, 7 3 1 Hongo, Tokyo 113 8656, Japan
    Hear Res 210:9-23. 2005
    ..These results suggest that each field modifies the representation to handle a different aspect of sound information, which can be better analyzed than the cochlear representation...
  15. ncbi request reprint Light-addressable planar electrode with hydrogenated amorphous silicon and low-conductive passivation layer for stimulation of cultured neurons
    Jun Suzurikawa
    Dept of Mechano Informatics, The University of Tokyo, Japan
    Conf Proc IEEE Eng Med Biol Soc 1:648-51. 2006
    ..Moreover, the focused illumination to the electrode resulted in the selective activation of neurons around the illuminated area...
  16. ncbi request reprint Spatial and temporal strategy to analyze steady-state sound intensity in cortex
    Hirokazu Takahashi
    Departments of Engineering Synthesis, Graduate School of Engineering, The University of Tokyo, Tokyo 113 8656, Japan
    Neuroreport 16:137-40. 2005
    ..In addition, the optimal combination that can distinguish between the two states differs across auditory fields, suggesting robust analyses of sound intensity in the auditory cortex...
  17. doi request reprint Distributed representation of tone frequency in highly decodable spatio-temporal activity in the auditory cortex
    Akihiro Funamizu
    Graduate School of Information Science and Technology, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8656, Japan
    Neural Netw 24:321-32. 2011
    ..These findings support the hypothesis that the auditory cortex adopts a distributed code in tone frequency representation, in which high- and low-spike-rate activities play mutually complementary roles...
  18. ncbi request reprint Separation of subcortical component from cortical auditory evoked potential by independent component analysis
    Hirokazu Takahashi
    Graduate School of Information Science and Technology, University of Tokyo, Japan
    Conf Proc IEEE Eng Med Biol Soc 1:2284-7. 2006
    ..The ICA results suggest that the deflection appears when subcortical contribution to AEP is equal to or larger than cortical contribution...
  19. doi request reprint Dissociated neuronal culture expressing ionotropic odorant receptors as a hybrid odorant biosensor--proof-of-concept study
    Norio Tanada
    Research Center for Advanced Science and Technology, The University of Tokyo, Komaba 4 6 1, Tokyo 153 8904, Japan
    Analyst 137:3452-8. 2012
    ..These results provide the proof-of-concept of the proposed hybrid odorant biosensor...
  20. ncbi request reprint Alaryngeal speech aid using an intra-oral electrolarynx and a miniature fingertip switch
    Hirokazu Takahashi
    Department of Engineering Synthesis, Graduate School of Engineering, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656, Japan
    Auris Nasus Larynx 32:157-62. 2005
    ..These results placed the intra-oral electrolarynx as a useful option of alaryngeal speech aids and encouraged the further development of the intra-oral electrolarynx...
  21. doi request reprint Voltage-sensitive-dye imaging of microstimulation-evoked neural activity through intracortical horizontal and callosal connections in cat visual cortex
    Jun Suzurikawa
    Graduate School of Information Science and Technology, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8656, Japan
    J Neural Eng 6:066002. 2009
    ..This finding indicates that our experimental system can serve for the investigation of cortical functional connectivity...
  22. doi request reprint State-dependent precursors of seizures in correlation-based functional networks of electrocorticograms of patients with temporal lobe epilepsy
    Hirokazu Takahashi
    Research Center for Advanced Science and Technology, The University of Tokyo, Komaba 4 6 1, Tokyo, 153 8904, Japan
    Neurol Sci 33:1355-64. 2012
    ..In addition to stationary network properties we characterized in the present study, dynamic interactions of epileptic activities with the network might be taken into account to predict the spread of a seizure...
  23. ncbi request reprint Delta-9 fatty acid desaturase gene containing a carboxyl-terminal cytochrome b5 domain from the red alga Cyanidioschyzon merolae
    R Itoh
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo, Tokyo 113 0033, Japan
    Curr Genet 33:165-70. 1998
    ..The discovery of CmFAD9 indicates the existence of a novel type of plant delta-9 fatty acid desaturase that may function in the endoplasmic reticulum, but not in the plastid...
  24. ncbi request reprint The use of magnetic resonance images to investigate the influence of recruitment on the relationship between torque and cross-sectional area in human muscle
    H Akima
    Department of Life Sciences, Sports Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Japan
    Eur J Appl Physiol 83:475-80. 2000
    ..05). These results suggested that muscle recruitment affects the PCSA-torque relationship...
  25. ncbi request reprint Three new nuclear genes, sigD, sigE and sigF, encoding putative plastid RNA polymerase sigma factors in Aarabidopsis thaliana
    M Fujiwara
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi, Bunkyo ku, 113 0032, Japan
    FEBS Lett 481:47-52. 2000
    ..Finally, the amino-terminal sequence of the sigF gene product was shown to function as a plastid-targeting signal using green fluorescent protein fusions...
  26. doi request reprint Dosimetric evaluation of neutron capture therapy for local advanced breast cancer
    H Yanagie
    Department of Nuclear Engineering and Management, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan
    Appl Radiat Isot 67:S63-6. 2009
    ..In this study, we showed the possibility to apply BNCT to local recurrent breast cancer. We can irradiate tumors selectively and as safely as possible, reducing the effects on neighboring healthy tissues...
  27. ncbi request reprint Isolation, characterization, and chromosomal mapping of an ftsZ gene from the unicellular primitive red alga Cyanidium caldarium RK-1
    M Takahara
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan
    Curr Genet 37:143-51. 2000
    ..Phylogenetic analysis indicated that C. caldarium RK-1 and other eukaryotic ftsZ genes are the descendants of cyanobacterial ftsZ genes, supporting the current agreement that FtsZ is involved in plastid division...
  28. ncbi request reprint Auditory cortical plasticity induced by intracortical microstimulation under pharmacological blockage of inhibitory synapses
    R Yokota
    Graduate Sch of Inf Sci and Technol, Tokyo Univ, Meguro ku, Tokyo, Japan
    Conf Proc IEEE Eng Med Biol Soc 1:4929-32. 2006
    ..Alternatively, the conventional ICMS had an inadequate timing to control excitatory synaptic inputs, because inhibitory synapse determined the latency of total neural inputs...
  29. doi request reprint Induction of the histidine decarboxylase genes of Photobacterium damselae subsp. damselae (formally P. histaminum) at low pH
    B Kimura
    Department of Food Science and Technology, Faculty of Marine Science, Tokyo University of Marine Science and Technology, Tokyo, Japan
    J Appl Microbiol 107:485-97. 2009
    ..To elucidate the detailed mechanism of histamine production by Photobacterium damselae subsp. damselae...
  30. ncbi request reprint The pH-dependent structural variation of complementarity-determining region H3 in the crystal structures of the Fv fragment from an anti-dansyl monoclonal antibody
    M Nakasako
    Precursory Research for Embryonic Science and Technology PRESTO, Japan Science and Technology Corporation JST Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi, Bunkyoku, Tokyo, 113 0032, Japan
    J Mol Biol 291:117-34. 1999
    ..The side-chain of Tyr96H occupied the site and interacted with Phe27H of H1, giving a clue for the binding mode of the dansyl group in the site...
  31. ncbi request reprint The first isolation of Arthroderma benhamiae in Japan
    R Kano
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Microbiol Immunol 42:575-8. 1998
    ..benhamiae (+) strain. Therefore, the isolate was identified to be A. benhamiae (-), confirming the result of molecular analysis. This is the first report on the isolation of A. benhamiae in Japan...
  32. ncbi request reprint Early phase adaptations of muscle use and strength to isokinetic training
    H Akima
    Department of Life Sciences Sports Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Japan
    Med Sci Sports Exerc 31:588-94. 1999
    ..These results suggest that muscle strength increases after short periods of isokinetic resistance training without muscle hypertrophy would be due to increased muscle contractile activity...
  33. ncbi request reprint A putative mitochondrial ftsZ gene is present in the unicellular primitive red alga Cyanidioschyzon merolae
    M Takahara
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo, Japan
    Mol Gen Genet 264:452-60. 2000
    ..merolae genome. Northern analysis revealed that both CmftsZ1 and CmftsZ2 are transcribed, and accumulate specifically before cell and organelle division. The results of Western analysis suggest that CmFtsZ1 is localized in mitochondria...
  34. ncbi request reprint Cloning of cDNA and expression of the gene encoding rat presenilin-2
    H Takahashi
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Gene 197:383-7. 1997
    ..During brain development, the expression level of both PS-2 and PS-1 increased but decreased in the adult. No remarkable change was observed in neural differentiation of PC12 cells...
  35. ncbi request reprint Lysine decarboxylase of Vibrio parahaemolyticus: kinetics of transcription and role in acid resistance
    Y Tanaka
    Tokyo University of Marine Science and Technology, Minato, Tokyo, Japan
    J Appl Microbiol 104:1283-93. 2008
    ..The aim of this study was to investigate the detailed mechanisms of acid resistance in Vibrio parahaemolyticus...
  36. doi request reprint Microelectrode findings and topographic reorganisation of kinaesthetic cells after gamma knife thalamotomy
    T Terao
    Department of Neurosurgery, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan
    Acta Neurochir (Wien) 150:823-7; discussion 827. 2008
    ..Our findings raise the possibility that the specific properties of the neurons changed due to partial coagulation by GKT within both the coagulated and the surrounding thalamic lesions...
  37. ncbi request reprint Mouse myocilin (Myoc) gene expression in ocular tissues
    H Takahashi
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 248:104-9. 1998
    ..These findings suggest that myocilin mutation could affect the capacity of aqueous outflow and cause elevation of the intraocular pressure which is involved in the pathogenesis of glaucoma...
  38. ncbi request reprint Cloning of rat type I receptor cDNA for bone morphogenetic protein-2 and bone morphogenetic protein-4, and the localization compared with that of the ligands
    T Ikeda
    Department of Oral Pathology, School of Dentistry, Showa University, Tokyo, Japan
    Dev Dyn 206:318-29. 1996
    ....
  39. ncbi request reprint Molecular cloning and expression of the rat homologue of presenilin-1
    H Takahashi
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Neurosci Lett 206:113-6. 1996
    ..We found one transcript of the PS-1 gene in embryonic day 12 (E12)-E15 rat brain and two transcripts in E18-adult rat brain. Therefore, PS-1 may play a role in neurogenesis...
  40. pmc Stimulus phase locking of cortical oscillation for auditory stream segregation in rats
    Takahiro Noda
    Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan
    PLoS ONE 8:e83544. 2013
    ....
  41. pmc Cortical mapping of mismatch negativity with deviance detection property in rat
    Tomoyo Isoguchi Shiramatsu
    Department of Mechano Informatics, Graduate School of Information Science and Technology, The University of Tokyo, Tokyo, Japan Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan Research Fellow of Japan Society for the Promotion of Science, Tokyo, Japan
    PLoS ONE 8:e82663. 2013
    ..The present work will stimulate translational research into MMN, which may help bridge the gap between electroencephalography (EEG)/magnetoencephalography (MEG) studies in humans and electrophysiological studies in animals. ..
  42. ncbi request reprint Neural responses to human voice and hemisphere dominance for lexical-semantic processing--an fMRI study
    M Koeda
    Department of Bioinformatics, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo, 113 8510, Japan
    Methods Inf Med 46:247-50. 2007
    ..In the present study, we aimed to clarify the correlation between the degree of right-handedness and language dominance in the fronto-temporo-parietal cortices by examining cerebral activation for lexical-semantic processing...
  43. ncbi request reprint Characterization of Sri Lanka rabies virus isolates using nucleotide sequence analysis of nucleoprotein gene
    Y T Arai
    Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan
    Acta Virol 45:327-33. 2001
    ..These results suggest that one type of rabies virus is circulating among human, dog, cat, mongoose, jackal and water buffalo living near Colombo City and in other five remote regions in Sri Lanka...
  44. ncbi request reprint Amylase mRNA transcripts in normal tissues and neoplasms: the implication of different expressions of amylase isogenes
    K Seyama
    Department of Respiratory Medicine, Juntendo University, School of Medicine, Tokyo, Japan
    J Cancer Res Clin Oncol 120:213-20. 1994
    ....
  45. pmc Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G
    T Gotoh
    Division of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Mol Cell Biol 15:6746-53. 1995
    ..Furthermore, expression of C3G with a membrane localization signal in a v-Ki-ras transformant, DT, induced a reversion of the cells to the flat form, possibly through the activation of endogenous Rap1...
  46. ncbi request reprint Expression of VCAM-1 in lymphocytes during the process of apoptosis
    N Ishiyama
    Department of Pathology and Immunology, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Pathobiology 66:274-83. 1998
    ..Splenic lymphocytes and other lymphoid cell lines also expressed VCAM-1 during the process of apoptosis. VCAM-1 mRNA expression was also observed in RT-PCR performed on these cell lines...
  47. ncbi request reprint Cloning of oxetanocin A biosynthetic and resistance genes that reside on a plasmid of Bacillus megaterium strain NK84-0128
    M Morita
    Research and Development Division, Nippon Kayaku Co Ltd, Tokyo, Japan
    Biosci Biotechnol Biochem 63:563-6. 1999
    ..By a cloning experiment it was shown that a 6.8-kb BglI-D fragment of the pOXT1 plasmid was responsible for oxetanocin A productivity and resistance...
  48. ncbi request reprint Murine antibodies against E2 and hypervariable region 1 cross-reactively capture hepatitis C virus
    M Esumi
    First Department of Pathology, Nihon University School of Medicine, 30 1, Ooyaguchikami machi, Itabashi ku, Tokyo, 173 0032, Japan
    Virology 251:158-64. 1998
    ....
  49. ncbi request reprint Mutation analysis of the p51 gene and correlation between p53, p73, and p51 expressions in prostatic carcinoma
    H Takahashi
    Department of Pathology, Jikei University School of Medicine, Tokyo, Japan
    Prostate 47:85-90. 2001
    ..8%). CONCLUSIONS: Somatic mutations in p73 and p51 are not important in prostatic carcinogenesis. These genes may be associated with tumors by expression levels and may have roles in addition to tumor suppression...
  50. ncbi request reprint Imaginary motor movement EEG classification by Accumulative-Autocorrelation-Pulse
    I V Mayer
    Department of Information and Communication Engineering, The University of Electro-Communications, Tokyo, Japan
    Electromyogr Clin Neurophysiol 41:159-69. 2001
    ..Robust generalization results indicate that the autocorrelation nature of the human EEG signal contains typical patterns for classification in imaginary left and right motor events...
  51. ncbi request reprint An Arabidopsis sigma factor (SIG2)-dependent expression of plastid-encoded tRNAs in chloroplasts
    K Kanamaru
    Laboratory of Molecular Genetics, Department of Molecular Biology, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, 113 0032 Japan
    Plant Cell Physiol 42:1034-43. 2001
    ..These results indicate that progress of chloroplast development requires SIG2-dependent expression of plastid genes, particularly some of the tRNA genes...
  52. ncbi request reprint Localization of neurovirulence determinant for rats on the S1 subunit of murine coronavirus JHMV
    F Taguchi
    National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    Virology 208:67-74. 1995
    ..Furthermore, it is suggested that the neurovirulence of cl-2 for mice is controlled by a different viral factor...
  53. ncbi request reprint A case of pleomorphic xanthoastrocytoma presenting with massive tumoral hemorrhage
    D Yoshida
    Department of Neurosurgery, Nippon Medical School, Tokyo, Japan
    J Neurooncol 71:169-71. 2005
    ..The unusual hemorrhagic presentation of this typically benign entity is extremely rare and is thought to be intra-tumoral bleeding in this case, since subarachnoid hemorrhage was absent...
  54. ncbi request reprint Isolates of Cryptococcus neoformans serotype A and D developed on canavanine-glycine-bromthymol blue medium
    Y Nakamura
    Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan
    Mycoses 41:35-40. 1998
    ..1 mmol l-1 of canavanine and 133 mmol l-1 of glycine. Three isolates of Cr. neoformans developed on CGB medium were also confirmed to be serotype A or D by the molecular analysis...
  55. ncbi request reprint Antinociceptive effects of (+)-matrine in mice
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Eur J Pharmacol 337:223-6. 1997
    ..In conclusion, (+)-matrine produced an antinociceptive effect mainly through the activation of kappa-opioid receptors and partially through mu-opioid receptors...
  56. doi request reprint Nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy in 2007: general view of the pathogens' antibacterial susceptibility
    Y Niki
    The JSC Surveillance Committee, Japanese Society of Chemotherapy, Nichinai Kaikan B1, 3 28 8 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    J Infect Chemother 15:156-67. 2009
    ..Continued surveillance is required to prevent the further spread of these antimicrobial resistances...
  57. ncbi request reprint Immunoreactive core peptides of hepatitis C virus produced in Escherichia coli and in vitro DNA amplification-restricted transcription-translation system
    M Esumi
    First Department of Pathology, Nihon University School of Medicine, Tokyo, Japan
    J Virol Methods 59:91-8. 1996
    ..These results indicate that the C-terminus of the mature core protein p22 may be generated at around aa 174 by cleavage with the signal peptidase...
  58. doi request reprint Effects of STN stimulation on the initiation and inhibition of saccade in Parkinson disease
    A Yugeta
    Department of Neurology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurology 74:743-8. 2010
    ..Nevertheless, the effects of STN DBS on saccade performance are not fully clarified in a systematic manner. In this study, we examined the effects of bilateral STN DBS on both the initiation and inhibition of saccades in PD...
  59. ncbi request reprint Effect of alpha-ketobutyrate on microvascular thickness in the diabetic rat kidney
    R Hirota
    Department of Biochemistry, Nihon University School of Medicine, Itabashi, Tokyo, Japan
    Exp Clin Endocrinol Diabetes 111:499-504. 2003
    ..01). These results suggest that alpha-KB may have a role in the renal microvascular complications of diabetes...
  60. ncbi request reprint The effect of antenatal administration of solcoseryl on hepatic glycogen synthesis in rat fetuses with intrauterine growth retardation
    H Takahashi
    Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
    Asia Oceania J Obstet Gynaecol 19:205-12. 1993
    ..These findings suggest that antenatal solcoseryl administration stimulates hepatic glycogen synthesis and storage in IUGR rat fetuses, and thus might favorably influence the development of neonatal hypoglycemia...
  61. ncbi request reprint Growth factor gene expression in kidney of murine polycystic kidney disease
    T Nakamura
    Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan
    J Am Soc Nephrol 3:1378-86. 1993
    ....
  62. ncbi request reprint Molecular cloning and expression of rat and mouse B61 gene: implications on organogenesis
    H Takahashi
    Laboratory of Histochemistry, Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Oncogene 11:879-83. 1995
    ..Our data suggest that B61 plays pivotal roles in organogenesis, especially vasculogenesis/angiogenesis and epithelial cell proliferation/differentiation...
  63. pmc Human immunodeficiency virus type 1 reverse transcriptase: enhancement of activity by interaction with cellular topoisomerase I
    H Takahashi
    Department of Pathology, National Institute of Health, Tokyo, Japan
    Proc Natl Acad Sci U S A 92:5694-8. 1995
    ..The findings suggest that cellular topo I plays an important role in the reverse transcription of HIV-1 RNA and that the recruitment of this enzyme may be an important step in virus replication...
  64. ncbi request reprint Altered extracellular matrix component gene expression in murine polycystic kidney
    I Ebihara
    Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Ren Physiol Biochem 18:73-80. 1995
    ..These data suggest that changes in the expression of basement membrane components and interstitial collagens are associated with the development of polycystic kidney disease...
  65. ncbi request reprint Artifacts from dental casting alloys in magnetic resonance imaging
    F Shafiei
    Advanced Biomaterials, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8549, Japan
    J Dent Res 82:602-6. 2003
    ..We concluded that selection of specific dental casting alloys according to their elemental compositions could minimize the metal artifacts in MRI; however, titanium alloys currently pose a problem with respect to causing MRI artifacts...
  66. ncbi request reprint Metabolic studies of the edematous cerebral cortex of the pyrithiamine-treated thiamine-deficient rat
    H Takahashi
    Department of Neurosurgery, Nippon Medical School, Tokyo, Japan
    Brain Res 441:202-8. 1988
    ..The fact that oxygen consumption was hardly diminished, however, strongly suggested that amino acids were selectively supplied to the tricarboxylic acid cycle from the free amino acid pool...
  67. ncbi request reprint The influences of insulin and food intake on intestinal ornithine transcarbamylase activity in diabetic rats
    R Hirota
    Department of Biochemistry, Nihon University School of Medicine, Tokyo, Japan
    Exp Clin Endocrinol Diabetes 106:117-22. 1998
    ..These observations suggest that altered regulation of intestinal epithelial over-growth and immoderate food-intake were normalized by insulin treatment, leading to the restoration of normal OTC activity in the small intestine...
  68. pmc Increased levels of epsilon and gamma isoforms of 14-3-3 proteins in cerebrospinal fluid in patients with Creutzfeldt-Jakob disease
    H Takahashi
    Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
    Clin Diagn Lab Immunol 6:983-5. 1999
    ..Furthermore, dot immunoblot analysis showed that MAbs were more specific for native antigen than polyclonal antibodies were...
  69. ncbi request reprint Monoclonal antibodies against topoisomerase I suppressed DNA relaxation and HIV-1 cDNA synthesis
    H Takahashi
    Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
    Hybridoma 19:331-4. 2000
    ..Thus, the results suggest that topoisomerase I plays an important role in RNA-directed DNA polymerization...
  70. ncbi request reprint Discrepant distribution of big endothelin (ET)-1 and ET receptors in the pulmonary artery
    H Takahashi
    Department of Respiratory Medicine, Juntendo University, School of Medicine, Tokyo, Japan
    Eur Respir J 18:5-14. 2001
    ..This heterogeneity may play an important role in the regulation of pulmonary vascular tone...
  71. ncbi request reprint Adeno-associated virus vector-mediated anti-angiogenic gene therapy for collagen-induced arthritis in mice
    H Takahashi
    Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan
    Clin Exp Rheumatol 23:455-61. 2005
    ..The goal of this study was to determine the utility of adeno-associated virus (AAV) vectors for anti-angiogenic gene therapy in a mouse model of collagen-induced arthritis (CIA)...
  72. ncbi request reprint Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains
    S Taniguchi
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Science, The University of Tokyo, Japan
    FEBS Lett 489:46-50. 2001
    ..These observations suggest that the conversion of p35 to p25 is a postmortem degradation event and may not be upregulated in AD brains...
  73. ncbi request reprint A functional MRI study: cerebral laterality for lexical-semantic processing and human voice perception
    M Koeda
    Department of Bioinformatics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    AJNR Am J Neuroradiol 27:1472-9. 2006
    ..We aimed to accurately clarify language dominance for lexical-semantic processing in the temporal cortices by focusing on human voice perception...
  74. ncbi request reprint Studies on 8-methoxyquinolones: synthesis and antibacterial activity of 7-(3-amino-4-substituted)pyrrolidinyl derivatives
    K Kawakami
    New Product Research Laboratories I, Daiichi Pharmaceutical Co, Ltd, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 48:1667-72. 2000
    ..These results suggested that the introduction of a fluorine atom into the 3-aminopyrrolidinyl substituent resulted in favorable influence on genetic toxicity as well as into the N-1 cyclopropyl substituent...
  75. ncbi request reprint Compound heterozygosity for a point mutation and a deletion located at splice acceptor sites in the LAMB3 gene leads to generalized atrophic benign epidermolysis bullosa
    Y Takizawa
    Departments of Dermatology and Anatomy, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 115:312-6. 2000
    ....
  76. ncbi request reprint Purification and characterization of a thrombin-like enzyme, elegaxobin, from the venom of Trimeresurus elegans (Sakishima-habu)
    E Oyama
    Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo, Japan
    Toxicon 38:1087-100. 2000
    ..The N-terminal sequences (Val-Ile-Gly-Gly) of this enzyme was identical to typical sequence of serine proteinases...
  77. ncbi request reprint Experimental treatment of malignant gliomas with human monoclonal antibody-drug conjugates
    H Takahashi
    Department of Neurosurgery, Nippon Medical School, Tokyo, Japan
    Anticancer Res 19:4151-5. 1999
    ..Thus, the human monoclonal antibody-drug conjugates constitute a potential new approach for the treatment of malignant gliomas...
  78. pmc Salmonella Enteritidis outbreak associated with a school-lunch dessert: cross-contamination and a long incubation period, Japan, 2001
    T Matsui
    Field Epidemiology Training Program, National Institute of Infectious Diseases, Tokyo, Japan
    Epidemiol Infect 132:873-9. 2004
    ..The investigation was complicated by concurrent illnesses from other SE phage types. It was successful, in part, because adequate food samples were available for microbiological testing...
  79. ncbi request reprint Impaired proteolytic processing of presenilin-1 in chromosome 14-linked familial Alzheimer's disease patient lymphocytes
    H Takahashi
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Neurosci Lett 260:121-4. 1999
    ..This result suggests that impaired proteolysis of PS1 may be associated with the pathogenesis of FAD. Moreover, our simple test using lymphocytes from FAD patients might be useful from a diagnostic point of view...
  80. ncbi request reprint Possible involvement of c-myc but not ras genes in hepatocellular carcinomas developing after spontaneous hepatitis in LEC rats
    Y Fujimoto
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Mol Carcinog 4:269-74. 1991
    ....
  81. ncbi request reprint Effects of poly-L-arginine on the permeation of hydrophilic compounds through surface ocular tissues
    Eiichi Nemoto
    Biol Pharm Bull 29:155-60. 2006
    ..Our findings suggest that PLA may be useful in promoting the ocular delivery of hydrophilic drugs without producing significant epithelial damage...
  82. ncbi request reprint Anorexigenic effects of pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide in the chick brain are mediated by corticotrophin-releasing factor
    Tetsuya Tachibana
    Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Science, Kyushu University, Fukuoka 812 8581, Japan
    Regul Pept 120:99-105. 2004
    ..Overall, the present study suggests that the anorexigenic effects of PACAP and VIP are mediated by the activation of CRF neurons...