Yasuo Suzuki

Summary

Affiliation: University of Shizuoka
Country: Japan

Publications

  1. ncbi request reprint Chemoenzymatic synthesis and application of a sialoglycopolymer with a chitosan backbone as a potent inhibitor of human influenza virus hemagglutination
    Yutaka Makimura
    Division of Life Science, Graduate School of Biostudies, Kyoto University, Sakyo ku, Japan
    Carbohydr Res 341:1803-8. 2006
  2. ncbi request reprint Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses
    Yasuo Suzuki
    Department of Biochemistry, University of Shizuoka School of Pharmaceutical Sciences, Shizuoka, Japan
    Biol Pharm Bull 28:399-408. 2005
  3. ncbi request reprint [Virus and glycan--an exhortation of glycovirology]
    Yasuo Suzuki
    University of Shizuoka, School of Pharmaceutical Sciences, 52 1 Yada, Shizuoka shi 422 8526
    Uirusu 53:127-31. 2003
  4. ncbi request reprint 2-Deoxy-2,3-didehydro-N-acetylneuraminic acid analogues structurally modified at the C-4 position: synthesis and biological evaluation as inhibitors of human parainfluenza virus type 1
    Kiyoshi Ikeda
    Department of Organic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Bioorg Med Chem 14:7893-7. 2006
  5. pmc Sialidase activity of influenza A virus in an endocytic pathway enhances viral replication
    Takashi Suzuki
    Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences and COE Program in the 21st Century, Shizuoka 422 8526, Japan
    J Virol 79:11705-15. 2005
  6. ncbi request reprint Human trachea primary epithelial cells express both sialyl(alpha2-3)Gal receptor for human parainfluenza virus type 1 and avian influenza viruses, and sialyl(alpha2-6)Gal receptor for human influenza viruses
    Toshihiro Kogure
    Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Glycoconj J 23:101-6. 2006
  7. ncbi request reprint Clarithromycin inhibits progeny virus production from human influenza virus-infected host cells
    Daisei Miyamoto
    Department of Biochemistry, University of Shizuoka School of Pharmaceutical Science, Shizuoka, Japan
    Biol Pharm Bull 31:217-22. 2008
  8. ncbi request reprint [Role of influenza virus sialidase]
    Tadanobu Takahashi
    Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, COE Program in the 21st Century, CREST, 52 1 Yada Shizuoka 422 8526, Japan
    Seikagaku 78:409-13. 2006
  9. pmc The low-pH stability discovered in neuraminidase of 1918 pandemic influenza A virus enhances virus replication
    Tadanobu Takahashi
    Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences and Global COE Program for Innovation in Human Health Sciences, Shizuoka, Japan
    PLoS ONE 5:e15556. 2010
  10. ncbi request reprint Edible bird's nest extract inhibits influenza virus infection
    Chao Tan Guo
    Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences and COE Program in the 21st Century, Suruga ku, Shizuoka 422 8526, Japan
    Antiviral Res 70:140-6. 2006

Detail Information

Publications69

  1. ncbi request reprint Chemoenzymatic synthesis and application of a sialoglycopolymer with a chitosan backbone as a potent inhibitor of human influenza virus hemagglutination
    Yutaka Makimura
    Division of Life Science, Graduate School of Biostudies, Kyoto University, Sakyo ku, Japan
    Carbohydr Res 341:1803-8. 2006
    ..These results indicate that a sialoglycopolymer having a multivalent sialo-oligosaccharide could potentially be used for the prevention of influenza virus infection...
  2. ncbi request reprint Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses
    Yasuo Suzuki
    Department of Biochemistry, University of Shizuoka School of Pharmaceutical Sciences, Shizuoka, Japan
    Biol Pharm Bull 28:399-408. 2005
    ....
  3. ncbi request reprint [Virus and glycan--an exhortation of glycovirology]
    Yasuo Suzuki
    University of Shizuoka, School of Pharmaceutical Sciences, 52 1 Yada, Shizuoka shi 422 8526
    Uirusu 53:127-31. 2003
  4. ncbi request reprint 2-Deoxy-2,3-didehydro-N-acetylneuraminic acid analogues structurally modified at the C-4 position: synthesis and biological evaluation as inhibitors of human parainfluenza virus type 1
    Kiyoshi Ikeda
    Department of Organic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Bioorg Med Chem 14:7893-7. 2006
    ..Among compounds 6a-e, the 4-O-ethyl-Neu5Ac2en derivative 6b showed the most potent inhibitory activity (IC50 6.3 microM) against hPIV-1 sialidase...
  5. pmc Sialidase activity of influenza A virus in an endocytic pathway enhances viral replication
    Takashi Suzuki
    Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences and COE Program in the 21st Century, Shizuoka 422 8526, Japan
    J Virol 79:11705-15. 2005
    ..These results indicate that sialidase activity in late endosome/lysosome traffic enhances influenza A virus replication...
  6. ncbi request reprint Human trachea primary epithelial cells express both sialyl(alpha2-3)Gal receptor for human parainfluenza virus type 1 and avian influenza viruses, and sialyl(alpha2-6)Gal receptor for human influenza viruses
    Toshihiro Kogure
    Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Glycoconj J 23:101-6. 2006
    ..Thus, cultured NHBE cells showed both alpha2-3-linked Sias recognized by hPIV-1 and avian influenza virus receptors, and alpha2-6-linked Sias recognized by human influenza virus receptors...
  7. ncbi request reprint Clarithromycin inhibits progeny virus production from human influenza virus-infected host cells
    Daisei Miyamoto
    Department of Biochemistry, University of Shizuoka School of Pharmaceutical Science, Shizuoka, Japan
    Biol Pharm Bull 31:217-22. 2008
    ..These findings indicate that CAM acts on a middle to late stage of the viral replication cycle resulting in inhibition of progeny virus production from the infected cells...
  8. ncbi request reprint [Role of influenza virus sialidase]
    Tadanobu Takahashi
    Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, COE Program in the 21st Century, CREST, 52 1 Yada Shizuoka 422 8526, Japan
    Seikagaku 78:409-13. 2006
  9. pmc The low-pH stability discovered in neuraminidase of 1918 pandemic influenza A virus enhances virus replication
    Tadanobu Takahashi
    Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences and Global COE Program for Innovation in Human Health Sciences, Shizuoka, Japan
    PLoS ONE 5:e15556. 2010
    ..Our results suggest that the avian-like low-pH stability of sialidase activity in the 1918 pandemic virus NA contributes to the viral replication efficiency...
  10. ncbi request reprint Edible bird's nest extract inhibits influenza virus infection
    Chao Tan Guo
    Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences and COE Program in the 21st Century, Suruga ku, Shizuoka 422 8526, Japan
    Antiviral Res 70:140-6. 2006
    ..Fluorometric HPLC indicated that the major molecular species of sialic acid in EBN is N-acetylneuraminic acid. The results suggest that EBN is a safe and valid natural source for the prevention of influenza viruses...
  11. ncbi request reprint Sulfatide negatively regulates the fusion process of human parainfluenza virus type 3
    Tadanobu Takahashi
    Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka and Global COE Program, Shizuoka 422 8526, Japan
    J Biochem 152:373-80. 2012
    ..The results suggest that sulfatide negatively regulates the fusion process of hPIV3, possibly through interaction with HN or F glycoprotein on the cell surface...
  12. pmc Sulfatide is required for efficient replication of influenza A virus
    Tadanobu Takahashi
    Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, Shizuoka 422 8526, Japan
    J Virol 82:5940-50. 2008
    ..Our findings provide new insights into IAV replication and suggest new therapeutic strategies...
  13. doi request reprint Chemoenzymatic synthesis, characterization, and application of glycopolymers carrying lactosamine repeats as entry inhibitors against influenza virus infection
    Kazuya I P J Hidari
    Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, Shizuoka, Japan
    Glycobiology 18:779-88. 2008
    ..The core carbohydrate portion as well as sialyl linkages on the receptor glycoconjugate may affect host cell recognition of human and swine viruses...
  14. ncbi request reprint Evolutional analysis of human influenza A virus N2 neuraminidase genes based on the transition of the low-pH stability of sialidase activity
    Takashi Suzuki
    Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, CREST, JST, and COE Program in the 21st Century, Shizuoka 422 8526, Japan
    FEBS Lett 557:228-32. 2004
    ..These findings suggest that the prototype of the H3N2 epidemic influenza strains isolated after 1968 probably acquired the NA gene from the H2N2 low-pH-unstable sialidase strain by second genetic reassortment in humans...
  15. ncbi request reprint An O-glycoside of sialic acid derivative that inhibits both hemagglutinin and sialidase activities of influenza viruses
    Chao Tan Guo
    Department of Biochemistry, University of Shizuoka School of Pharmaceutical Sciences, 52 1 Yada, Shizuoka shi 422 8526, Japan
    Glycobiology 12:183-90. 2002
    ..The study suggested that the compound is a new class of bifunctional drug candidates for the future chemotherapy of influenza...
  16. doi request reprint Antiviral activity of chondroitin sulphate E targeting dengue virus envelope protein
    Daisuke Kato
    Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, and Global COE Program for Innovation in Human Health Sciences, 52 1 Yada, Suruga ku, Shizuoka shi, Shizuoka 422 8526, Japan
    Antiviral Res 88:236-43. 2010
    ..In conclusion, CSE showed antiviral activity as an entry inhibitor targeting E protein of dengue virus...
  17. ncbi request reprint Binding kinetics of influenza viruses to sialic acid-containing carbohydrates
    Kazuya I P J Hidari
    Department of Biochemistry, School of Pharmaceutical Sciences, Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Corporation, University of Shizuoka, Shizuoka shi, Shizuoka, Japan
    Glycoconj J 24:583-90. 2007
    ..Our findings demonstrated the remarkable distinction in the binding kinetics of sialic acid-containing carbohydrates between avian and human influenza viruses on the lipid bilayer...
  18. ncbi request reprint Purification and characterization of a soluble recombinant human ST6Gal I functionally expressed in Escherichia coli
    Kazuya I P J Hidari
    Department of Biochemistry, School of Pharmaceutical Sciences, Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Corporation, University of Shizuoka
    Glycoconj J 22:1-11. 2005
    ..In conclusion, soluble recombinant ST6Gal I obtained using our bacterial expression system is a valuable tool to investigate the molecular mechanisms of biological and pathological interactions mediated via carbohydrates...
  19. doi request reprint Identification of amino acid residues of influenza A virus H3 HA contributing to the recognition of molecular species of sialic acid
    Tadanobu Takahashi
    Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, Shizuoka 422 8526, Japan
    FEBS Lett 583:3171-4. 2009
    ..We evaluated the binding ability with four types of synthetic sialylglycolipids. The results indicate that the amino acid substitutions Thr155 to Tyr and Glu158 to Gly in H3 HA facilitate virus binding to N-glycolylneuraminic acid...
  20. pmc Sensitive and direct detection of receptor binding specificity of highly pathogenic avian influenza A virus in clinical samples
    Tadanobu Takahashi
    Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Shizuoka, Japan
    PLoS ONE 8:e78125. 2013
    ..The new assay enabled direct detection of receptor binding specificity of HPAIs in chicken clinical samples including trachea and cloaca swabs in only less than 4 h. ..
  21. ncbi request reprint Suppression of the biosynthesis of cellular sphingolipids results in the inhibition of the maturation of influenza virus particles in MDCK cells
    Kazuya I P J Hidari
    Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Corporation, Japan
    Biol Pharm Bull 29:1575-9. 2006
    ..Our findings strongly suggest that cellular sphingolipids play important roles in the events after viral adsorption to the host cells...
  22. pmc Restricted expression of shiga toxin binding sites on mucosal epithelium of mouse distal colon
    Yasuyuki Imai
    Department of Microbiology, University of Shizuoka School of Pharmaceutical Sciences, Japan
    Infect Immun 71:985-90. 2003
    ..The results indicate that Stx1B is stricter in the recognition of carbohydrate determinants than GS-I-B4 when examined with biological ligands...
  23. ncbi request reprint [Receptor binding specificity of influenza virus and its budding from the host cells]
    Yasuo Suzuki
    Tanpakushitsu Kakusan Koso 48:1141-6. 2003
  24. ncbi request reprint A molecular mechanism for the low-pH stability of sialidase activity of influenza A virus N2 neuraminidases
    Tadanobu Takahashi
    Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, CREST, JST, and COE Program in the 21st Century, 422 8526, Shizuoka, Japan
    FEBS Lett 543:71-5. 2003
    ....
  25. ncbi request reprint In vitro and in vivo inhibitory effects of disodium cromoglycate on influenza virus infection
    Kazuya I P J Hidari
    Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Yada, Shizuoka, Japan
    Biol Pharm Bull 27:825-30. 2004
    ..Our results indicate that treatment of patients including children with DSCG may take advantages for prevention from influenza virus infection...
  26. ncbi request reprint 2beta,3beta-Difluorosialic acid derivatives structurally modified at the C-4 position: synthesis and biological evaluation as inhibitors of human parainfluenza virus type 1
    Kiyoshi Ikeda
    Department of Organic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Carbohydr Res 339:1367-72. 2004
    ..OEt(2). Among compounds 3a-d, the 4-O-thiocarbamoylmethyl derivative 3c showed the most potent inhibitory activity against sialidase of human parainfluenza virus type 1. [structure: see text]...
  27. ncbi request reprint [Sugar recognition process in viral infection]
    Yasuo Suzuki
    Department of Biochemistry, University of Shizuoka School of Pharmaceutical Sciences, 52 1 Yada, Shizuoka 422 8526, Japan
    Seikagaku 76:227-33. 2004
  28. ncbi request reprint The highly pathogenic avian influenza H5N1 - initial molecular signals for the next influenza pandemic
    Yasuo Suzuki
    Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Aichi, Japan Global COE Program for Innovation in Human Health Sciences, University of Shizuoka School of Pharmaceutical Sciences, Shizuoka, Japan
    Chang Gung Med J 32:258-63. 2009
    ..This paper describes recent advances in the mechanism of transmission of highly pathogenic avian influenza to humans and measures for control of a new pandemic...
  29. ncbi request reprint Virus infection and lipid rafts
    Takashi Suzuki
    COE Program in the 21st Century, Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Biol Pharm Bull 29:1538-41. 2006
    ..In this review, we describe the involvement of membrane lipid rafts in the virus replication cycle with our current findings for understanding the role of membrane lipid rafts in virus infection...
  30. ncbi request reprint Identification and characterization of carbohydrate molecules in mammalian cells recognized by dengue virus type 2
    Chie Aoki
    Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Corporation, and COE Program in the 21st Century
    J Biochem 139:607-14. 2006
    ..These findings strongly suggested that multivalent nLc4 oligosaccharide could act as a competitive inhibitor against the binding of DEN2 to the host cells...
  31. ncbi request reprint Inhibition of influenza A virus sialidase activity by sulfatide
    Takashi Suzuki
    Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, 422 8526 Shizuoka, Japan
    FEBS Lett 553:355-9. 2003
    ..The kinetic parameters of the effect of sulfatide on the sialidase activities of human influenza A viruses using fluorometric assay indicated that sulfatide was a powerful and non-competitive type inhibitor in low-pH conditions...
  32. ncbi request reprint Novel linear polymers bearing thiosialosides as pendant-type epitopes for influenza neuraminidase inhibitors
    Koji Matsuoka
    Area for Molecular Function, Division of Material Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama 338 8570, Japan
    Bioorg Med Chem Lett 17:3826-30. 2007
    ....
  33. ncbi request reprint Thiosialoside clusters using carbosilane dendrimer core scaffolds as a new class of influenza neuraminidase inhibitors
    Jun Ichi Sakamoto
    Division of Materials Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama 338 8570, Japan
    Bioorg Med Chem Lett 17:717-21. 2007
    ..The results of a preliminary study on biological responses against influenza virus sialidases using thiosialoside clusters showed that some of the glycodendrimers have inhibitory potencies against the sialidases...
  34. ncbi request reprint Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors
    Shinya Yamada
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Nature 444:378-82. 2006
    ..The amino acid changes that we identify might serve as molecular markers for assessing the pandemic potential of H5N1 field isolates...
  35. ncbi request reprint Synthesis and evaluation of 4-O-alkylated 2-deoxy-2,3-didehydro-N-acetylneuraminic acid derivatives as inhibitors of human parainfluenza virus type-3 sialidase activity
    David J Tindal
    Institute for Glycomics, Griffith University Gold Coast Campus, PMB 50 Gold Coast Mail Centre, Queensland 9726, Australia
    Bioorg Med Chem Lett 17:1655-8. 2007
    ..This is comparable or improved activity compared to the parent 4-hydroxy compound...
  36. ncbi request reprint Influenza viral hemagglutinin complicated shape is advantageous to its binding affinity for sialosaccharide receptor
    Toshihiko Sawada
    Department of Applied Bioorganic Chemistry, The United Graduate School of Agricultural Science, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    Biochem Biophys Res Commun 355:6-9. 2007
    ..3kcal/mol higher than that of the smallest domain-receptor complex. These data provide the consideration of the backyard bulkiness beyond the binding site of protein to the protein-ligand stability...
  37. ncbi request reprint The quail and chicken intestine have sialyl-galactose sugar chains responsible for the binding of influenza A viruses to human type receptors
    Chao Tan Guo
    Institute of Bioengineering, Zhejiang Academy of Medical Sciences, 182 Tianmushan Road, Hangzhou 310016, China
    Glycobiology 17:713-24. 2007
    ....
  38. doi request reprint Sialyl alpha(2-->3) lactose clusters using carbosilane dendrimer core scaffolds as influenza hemagglutinin blockers
    Hiroyuki Oka
    Division of Material Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama 338 8570, Japan
    Bioorg Med Chem Lett 18:4405-8. 2008
    ....
  39. pmc An avian influenza H5N1 virus that binds to a human-type receptor
    Prasert Auewarakul
    Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    J Virol 81:9950-5. 2007
    ..Our data confirm the presence of H5N1 virus with the ability to bind to a human-type receptor in this patient and suggest the selection and expansion of the mutant with human-type receptor specificity in the human host environment...
  40. doi request reprint A simple screening assay for receptor switching of avian influenza viruses
    Ornpreya Suptawiwat
    Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Clin Virol 42:186-9. 2008
    ..The currently available assays for receptor-binding preference are complex and not widely available...
  41. ncbi request reprint In vitro inhibition of human influenza A virus infection by fruit-juice concentrate of Japanese plum (Prunus mume SIEB. et ZUCC)
    Sangchai Yingsakmongkon
    Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto, Kasugai, Aichi 487 8501, Japan
    Biol Pharm Bull 31:511-5. 2008
    ....
  42. ncbi request reprint Design of N-acetyl-6-sulfo-beta-d-glucosaminide-based inhibitors of influenza virus sialidase
    Kenji Sasaki
    Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa ku, Nagoya 464 8603, Japan
    Bioorg Med Chem 12:1367-75. 2004
    ..The activity was enhanced nearly 100-fold when the pNP group of 1a was converted to p-acetamidophenyl one 5 (IC(50)=30 microM) or replaced with 1-naphthyl 6 (IC(50)=10 microM) or n-propyl one 8 (IC(50)=11 microM)...
  43. ncbi request reprint Antigenic alteration of influenza B virus associated with loss of a glycosylation site due to host-cell adaptation
    Takehiko Saito
    Department of Virology III, National Institute of Infectious Diseases, Tokyo, Japan
    J Med Virol 74:336-43. 2004
    ....
  44. ncbi request reprint Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus
    Darwyn Kobasa
    Department of Pathobiological Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Nature 431:703-7. 2004
    ....
  45. ncbi request reprint Glycotentacles: synthesis of cyclic glycopeptides, toward a tailored blocker of influenza virus hemagglutinin
    Takashi Ohta
    Division of Biological Sciences, Graduate School of Science, Frontier Research Center for Post Genomic Science and Technology, Hokkaido University, Kita 21 Nishi 11, Sapporo 001 0021, Japan
    Angew Chem Int Ed Engl 42:5186-9. 2003
  46. pmc Characterization of a human H5N1 influenza A virus isolated in 2003
    Kyoko Shinya
    Department of Virology, Institute of Medical Science, University of Tokyo, Japan
    J Virol 79:9926-32. 2005
    ..This case challenges the view that adaptation to land-based poultry is a prerequisite for the replication of aquatic avian influenza A viruses in humans...
  47. ncbi request reprint Identification of glycosphingolipid receptors for pierisin-1, a guanine-specific ADP-ribosylating toxin from the cabbage butterfly
    Yuko Matsushima-Hibiya
    Cancer Prevention Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Biol Chem 278:9972-8. 2003
    ..Thus, our results suggest that pierisin-1 binds to Gb3 and Gb4 receptors at the C-terminal region, in a manner similar to ricin, and then exhibits cytotoxicity after incorporation into the cell...
  48. ncbi request reprint Chemoenzymatic synthesis and application of glycopolymers containing multivalent sialyloligosaccharides with a poly(L-glutamic acid) backbone for inhibition of infection by influenza viruses
    Kazuhide Totani
    Department of Applied Biological Chemistry, Shizuoka University, Ohya 836, Shizuoka 422 8529, Japan
    Glycobiology 13:315-26. 2003
    ..Inhibition of infection by viruses was remarkably enhanced by increasing the molecular weight and sialic acid content of glycopolymers...
  49. pmc Enhanced expression of an alpha2,6-linked sialic acid on MDCK cells improves isolation of human influenza viruses and evaluation of their sensitivity to a neuraminidase inhibitor
    Shuji Hatakeyama
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Clin Microbiol 43:4139-46. 2005
    ..We conclude that the human ST6Gal I-expressing MDCK cell line is useful not only for evaluating their sensitivity to NA inhibitors, but also for isolation of influenza viruses from clinical samples...
  50. ncbi request reprint Avian flu: isolation of drug-resistant H5N1 virus
    Q Mai Le
    National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
    Nature 437:1108. 2005
    ..Further investigation is necessary to determine the prevalence of oseltamivir-resistant H5N1 viruses among patients treated with this drug...
  51. doi request reprint The expression of sialylated high-antennary N-glycans in edible bird's nest
    Hirokazu Yagi
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Carbohydr Res 343:1373-7. 2008
    ..We suggest that the sialylated high-antennary N-glycans of EBN contribute to the inhibition of influenza viral infection...
  52. pmc Oligosaccharides as receptors for JC virus
    Rika Komagome
    Laboratory of Molecular and Cellular Pathology, School of Medicine, Hokkaido University, CREST, JST, N15 W7, Kita ku, Sapporo 060 8638, Japan
    J Virol 76:12992-3000. 2002
    ..These results suggest that the oligosaccharides of glycoproteins and glycolipids work as JCV receptors and may be feasible as anti-JCV agents...
  53. ncbi request reprint Cerebroside sulfotransferase deficiency ameliorates L-selectin-dependent monocyte infiltration in the kidney after ureteral obstruction
    Daisuke Ogawa
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Biol Chem 279:2085-90. 2004
    ..Our results suggest that sulfatide is a major L-selectin-binding molecule in the kidney and that the interaction between L-selectin and sulfatide plays a critical role in monocyte infiltration into the kidney interstitium...
  54. ncbi request reprint Therapeutic effect of sulphated hyaluronic acid, a potential selectin-blocking agent, on experimental progressive mesangial proliferative glomerulonephritis
    Mitsuhiro Matsuda
    Department of Medicine III, Okayama University Medical School, Japan
    J Pathol 198:407-14. 2002
    ..Sulphated oligosaccharides may be beneficial for the therapy of mesangial proliferative glomerulonephritis...
  55. ncbi request reprint Mesenchymal expression of Foxl1, a winged helix transcriptional factor, regulates generation and maintenance of gut-associated lymphoid organs
    Katsuyuki Fukuda
    Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Dev Biol 255:278-89. 2003
    ..Together, the data suggest that Foxl1 might be involved in cellular responses of gut-associated lymphoid tissues dependent upon the Lymphotoxins/Lymphotoxin beta-receptor axis...
  56. ncbi request reprint Asialo-GM1 and asialo-GM2 are putative adhesion molecules for Moraxella catarrhalis
    Kamruddin Ahmed
    Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey
    Med Microbiol Immunol 191:5-10. 2002
    ..Our results indicate that Gg4Cer on human pharyngeal epithelial cells, and Gg3Cer,possibly on other cells, could serve as molecules for attachment of M. catarrhalis...
  57. ncbi request reprint Reduction of Smad3 accelerates re-epithelialization in a murine model of colitis
    Atsuko Tokumasa
    Clinical Cell Biology F5, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ward, Chiba City 260 8670, Japan
    Biochem Biophys Res Commun 317:377-83. 2004
    ..Suppression of TGF-beta1 induction in the colonic mucosa of the heterozygotes may lead to a higher level of proliferation of intestinal epithelial cells...
  58. ncbi request reprint Functional analysis of mouse 3-phosphoglycerate dehydrogenase (Phgdh) gene promoter in developing brain
    Motohiro Shimizu
    Neuronal Circuit Mechanism Research Group, RIKEN Brain Science Institute, Wako, Saitama, Japan
    J Neurosci Res 76:623-32. 2004
    ..These observations suggest the presence of cis-acting elements that confer the cell type specificity of Phgdh transcription in the distal promoter region...
  59. ncbi request reprint Connexin 26-mediated gap junctional intercellular communication suppresses paracellular permeability of human intestinal epithelial cell monolayers
    Hidekazu Morita
    Clinical Cell Biology F5, Graduate School of Medicine, Chiba University, 260 8670, Chuo Ward, Japan
    Exp Cell Res 298:1-8. 2004
    ..These results suggest that Cx26-mediated GJIC may play a crucial role in enhancing the barrier function of Caco-2 cell monolayers...
  60. ncbi request reprint Glycobiological study of adult Opisthorchis viverrini: characterization of N-linked oligosaccharides
    Krajang Talabnin
    Graduate School, Khon Kaen University, 40002 Khon Kaen, Thailand
    Mol Biochem Parasitol 147:230-3. 2006
  61. ncbi request reprint Comprehensive analysis of monoclonal antibodies against detergent-insoluble membrane/lipid rafts of HL60 cells
    Yasuhiro Yamazaki
    Laboratory for Neural Architecture, Advanced Technology Development Group, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Immunol Methods 311:106-16. 2006
    ..Interestingly, MAbs belonging to the former group had the potential to induce cell proliferation/differentiation in vitro. Our MAbs against the DIM fraction of HL60 cells can be valuable tools for the study of membrane microdomains...
  62. ncbi request reprint Regulation of self-incompatibility by acetylcholine and cAMP in Lilium longiflorum
    Takafumi Tezuka
    Division of Life Sciences, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya, 464 8601, Japan
    J Plant Physiol 164:878-85. 2007
    ....
  63. ncbi request reprint Chemoenzymatic synthesis of artificial glycopolypeptides containing multivalent sialyloligosaccharides with a gamma-polyglutamic acid backbone and their effect on inhibition of infection by influenza viruses
    Makoto Ogata
    Science of Biological Resource, The United Graduate School of Agricultural Science, Gifu University, Yanagido 1 1, Gifu 501 1193, Japan
    Bioorg Med Chem 15:1383-93. 2007
    ..Taken together, these results indicate that the binding of viruses to terminal sialic acids is markedly affected by the structure of the asialo portion, in this case either LacNAc or lactose, in the sugar chain of glycopolypeptides...
  64. ncbi request reprint Sulfatide and its synthetic analogues recognition by Moraxella catarrhalis
    Pinar Ozcelik
    Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey
    Microbiol Immunol 50:967-70. 2006
    ..catarrhalis significantly at an optimum concentration of 10 microg/ml. Synthetic sulfatides may have the potential to be used as a therapy to prevent M. catarrhalis infections...
  65. pmc Influence of glycosylation on the efficacy of an Env-based vaccine against simian immunodeficiency virus SIVmac239 in a macaque AIDS model
    Kazuyasu Mori
    AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    J Virol 79:10386-96. 2005
    ..This study demonstrated that the prime-boost Env vaccine was effective against homologous SIVmac239 challenge. Changes in glycosylation affected both cell-mediated and humoral immune responses and vaccine efficacy...
  66. ncbi request reprint The synthetic peptide derived from the NH2-terminal extracellular region of an orphan G protein-coupled receptor, GPR1, preferentially inhibits infection of X4 HIV-1
    Atsushi Jinno-Oue
    Department of Virology and Preventive Medicine, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    J Biol Chem 280:30924-34. 2005
    ....
  67. ncbi request reprint Mouse 3-phosphoglycerate dehydrogenase gene: genomic organization, chromosomal localization, and promoter analysis
    Junya Mitoma
    Glycobiology Program, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Gene 334:15-22. 2004
    ....
  68. ncbi request reprint [Hypolipidemia in malabsorption syndrome]
    Atsuhito Saiki
    Center of Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center
    Nihon Rinsho 65:621-6. 2007
  69. ncbi request reprint Butyrate reduces colonic paracellular permeability by enhancing PPARgamma activation
    Mako Kinoshita
    The Second Department of Internal Medicine, School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 0856, Japan
    Biochem Biophys Res Commun 293:827-31. 2002
    ..01). These findings suggest that the effect of butyrate on paracellular permeability has apparently taken place through PPARgamma activation and this effect attributes to preventing inflammation of the colon...