Toshihiko Suzuki

Summary

Affiliation: University of the Ryukyus
Country: Japan

Publications

  1. ncbi request reprint A role for Nod-like receptors in autophagy induced by Shigella infection
    Toshihiko Suzuki
    Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    Autophagy 4:73-5. 2008
  2. pmc Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages
    Toshihiko Suzuki
    Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    PLoS Pathog 3:e111. 2007
  3. doi request reprint Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling
    Claudia Toma
    Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Okinawa
    J Immunol 184:5287-97. 2010
  4. doi request reprint Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages
    Andrea J McCoy
    Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Nishiharacho, Okinawa, Japan
    Eur J Immunol 40:2797-803. 2010
  5. pmc Vibrio parahaemolyticus effector proteins suppress inflammasome activation by interfering with host autophagy signaling
    Naomi Higa
    Department of Molecular Bacteriology and Immunology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    PLoS Pathog 9:e1003142. 2013
  6. doi request reprint Inflammasome activation via intracellular NLRs triggered by bacterial infection
    Yukiko Koizumi
    Department of Molecular Bacteriology and Immunology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903 0125, Japan
    Cell Microbiol 14:149-54. 2012
  7. doi request reprint Lose the battle to win the war: bacterial strategies for evading host inflammasome activation
    Naomi Higa
    Department of Molecular Bacteriology and Immunology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903 0125, Japan
    Trends Microbiol 21:342-9. 2013
  8. doi request reprint Differential adherence of Shiga toxin-producing Escherichia coli harboring saa to epithelial cells
    Claudia Toma
    Division of Bacterial Pathogenesis, Department of Microbiology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Uehara 207, Okinawa, 903 0125, Japan
    Int J Med Microbiol 298:571-8. 2008
  9. doi request reprint Detergents enhance EspB secretion from Escherichia coli strains harboring the locus for the enterocyte effacement (LEE) gene
    Noboru Nakasone
    Department of Molecular Bacteriology and Immunology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    FEMS Microbiol Lett 315:109-14. 2011
  10. doi request reprint Characteristic features of intracellular pathogenic Leptospira in infected murine macrophages
    Claudia Toma
    Department of Molecular Bacteriology and Immunology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903 0125, Japan
    Cell Microbiol 13:1783-92. 2011

Collaborators

Detail Information

Publications23

  1. ncbi request reprint A role for Nod-like receptors in autophagy induced by Shigella infection
    Toshihiko Suzuki
    Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    Autophagy 4:73-5. 2008
    ..These results indicate that autophagy in macrophages is regulated by the Ipaf inflammasome, providing a novel function for NLR proteins in bacterial-host interactions...
  2. pmc Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages
    Toshihiko Suzuki
    Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    PLoS Pathog 3:e111. 2007
    ..Furthermore, the absence of Ipaf or caspase-1, but not ASC, regulates pyroptosis and the induction of autophagy in Shigella-infected macrophages, providing a novel function for NLR proteins in bacterial-host interactions...
  3. doi request reprint Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling
    Claudia Toma
    Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Okinawa
    J Immunol 184:5287-97. 2010
    ..Our results identify the NLRP3 inflammasome as a sensor of Vibrio infections through the action of bacterial cytotoxins and differential activation of innate signaling pathways acting upstream of NF-kappaB...
  4. doi request reprint Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages
    Andrea J McCoy
    Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Nishiharacho, Okinawa, Japan
    Eur J Immunol 40:2797-803. 2010
    ..hydrophila. Our results indicated that the NLRP3 inflammasome senses A. hydrophila infection through the action of bacterial cytotoxins...
  5. pmc Vibrio parahaemolyticus effector proteins suppress inflammasome activation by interfering with host autophagy signaling
    Naomi Higa
    Department of Molecular Bacteriology and Immunology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    PLoS Pathog 9:e1003142. 2013
    ..VopQ and VopS interfere with the assembly of specks in infected macrophages. These data suggest that bacterial effectors interfere with inflammasome activation and contribute to bacterial evasion from the host inflammatory responses...
  6. doi request reprint Inflammasome activation via intracellular NLRs triggered by bacterial infection
    Yukiko Koizumi
    Department of Molecular Bacteriology and Immunology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903 0125, Japan
    Cell Microbiol 14:149-54. 2012
    ..Further understanding of NLR function should provide new insights into the mechanisms of host pro-inflammatory responses and the pathogenesis of bacterial infections...
  7. doi request reprint Lose the battle to win the war: bacterial strategies for evading host inflammasome activation
    Naomi Higa
    Department of Molecular Bacteriology and Immunology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903 0125, Japan
    Trends Microbiol 21:342-9. 2013
    ..In this review, we focus on NLR-mediated inflammasome activation and bacterial evasion of the inflammasome as part of the battle between the host defenses and pathogens. ..
  8. doi request reprint Differential adherence of Shiga toxin-producing Escherichia coli harboring saa to epithelial cells
    Claudia Toma
    Division of Bacterial Pathogenesis, Department of Microbiology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Uehara 207, Okinawa, 903 0125, Japan
    Int J Med Microbiol 298:571-8. 2008
    ..Our results suggest that multiple adherence mechanisms are present in saa-harboring STEC, implying a high degree of diversity in this group of STEC...
  9. doi request reprint Detergents enhance EspB secretion from Escherichia coli strains harboring the locus for the enterocyte effacement (LEE) gene
    Noboru Nakasone
    Department of Molecular Bacteriology and Immunology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    FEMS Microbiol Lett 315:109-14. 2011
    ..The results obtained in this study can be applied to immunological diagnostic methods for detecting EspB and also to the production of EspB for research purposes...
  10. doi request reprint Characteristic features of intracellular pathogenic Leptospira in infected murine macrophages
    Claudia Toma
    Department of Molecular Bacteriology and Immunology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903 0125, Japan
    Cell Microbiol 13:1783-92. 2011
    ..interrogans but not L. biflexa, were released to the extracellular milieu. These results suggest that pathogenic leptospires are able to survive, replicate and exit from mouse macrophages, enabling their eventual spread to target organs...
  11. doi request reprint Differential regulation of caspase-1 activation via NLRP3/NLRC4 inflammasomes mediated by aerolysin and type III secretion system during Aeromonas veronii infection
    Andrea J McCoy
    Department of Molecular Bacteriology and Immunology, Graduate School of Medicine, University of the Ryukyus, Nishiharacho, Okinawa, Japan
    J Immunol 185:7077-84. 2010
    ..veronii infection in mice. Our results indicated that multiple factors from both the bacteria and the host play a role in eliciting caspase-1 activation during A. veronii infection...
  12. ncbi request reprint Microtubule-severing activity of Shigella is pivotal for intercellular spreading
    Sei Yoshida
    Department of Microbiology and Immunology, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Science 314:985-9. 2006
    ..Degradation of microtubules by VirA was dependent on its alpha-tubulin-specific cysteine protease-like activity. virA mutants did not move within the host cytoplasm and failed to move into adjacent cells...
  13. pmc Intestinal villous M cells: an antigen entry site in the mucosal epithelium
    Myoung Ho Jang
    Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 101:6110-5. 2004
    ..Thus, the identified villous M cells could be an alternative and PP-independent gateway for the induction of antigen-specific immune responses by means of the mucosal compartment...
  14. ncbi request reprint A novel caspase-1/toll-like receptor 4-independent pathway of cell death induced by cytosolic Shigella in infected macrophages
    Toshihiko Suzuki
    Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 280:14042-50. 2005
    ..These results identify a novel cell death pathway induced by intracellular Gram-negative bacteria that may play a role in microbial-host interactions and inflammatory responses...
  15. ncbi request reprint High vaccine efficacy against shigellosis of recombinant noninvasive Shigella mutant that expresses Yersinia invasin
    Toshihiko Suzuki
    Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Immunol 177:4709-17. 2006
    ....
  16. ncbi request reprint [Studies on the actin-based spreading of Shigella]
    Toshihiko Suzuki
    Division of Bacterial Infection, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639
    Nihon Saikingaku Zasshi 57:443-52. 2002
  17. ncbi request reprint Muscularis inflammation and the loss of interstitial cells of Cajal in the endothelin ETB receptor null rat
    Toshihiko Suzuki
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Am J Physiol Gastrointest Liver Physiol 287:G638-46. 2004
    ..Increased numbers and activation of macrophages may result in damage to ICC networks leading to disordered intestinal rhythmicity in regions of the gut in which myenteric ganglia are intact...
  18. ncbi request reprint Escape of intracellular Shigella from autophagy
    Michinaga Ogawa
    Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Science 307:727-31. 2005
    ..Rather, Shigella VirG, a protein required for intracellular actin-based motility, induced autophagy by binding to the autophagy protein, Atg5. In nonmutant Shigella, this binding is competitively inhibited by IcsB binding to VirG...
  19. ncbi request reprint Helicobacter pylori dampens gut epithelial self-renewal by inhibiting apoptosis, a bacterial strategy to enhance colonization of the stomach
    Hitomi Mimuro
    Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Cell Host Microbe 2:250-63. 2007
    ..Thus, CagA activates host cell survival and antiapoptotic pathways to overcome self-renewal of the gastric epithelium and help sustain Hp infection...
  20. pmc Interaction of CagA with Crk plays an important role in Helicobacter pylori-induced loss of gastric epithelial cell adhesion
    Masato Suzuki
    Department of Microbiology and Immunology, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Minato ku, Japan
    J Exp Med 202:1235-47. 2005
    ..Thus, CagA targeting of Crk plays a central role in inducing the pleiotropic cell responses to H. pylori infection that cause several gastric diseases, including gastric cancer...
  21. pmc Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis
    Shigenori Nagai
    Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Proc Natl Acad Sci U S A 104:8971-6. 2007
    ..We also observed that the coccoid form of H. pylori is phagocytosed by dendritic cells in PPs. We propose that H. pylori converts to the coccoid form in the anaerobic small intestine and stimulates the host immune system through PPs...
  22. ncbi request reprint New animal model of shigellosis in the Guinea pig: its usefulness for protective efficacy studies
    Doo Hee Shim
    Mucosal Immunology Section, International Vaccine Institute, Seoul, Korea
    J Immunol 178:2476-82. 2007
    ..In the guinea pig, administration of Shigella by i.r. route induces acute inflammation, making this animal model useful for assessing the protective efficacy of Shigella vaccine candidates...
  23. ncbi request reprint Neural Wiskott-Aldrich syndrome protein (N-WASP) is the specific ligand for Shigella VirG among the WASP family and determines the host cell type allowing actin-based spreading
    Toshihiko Suzuki
    PRESTO, Japan Science and Technology Corporation JST, Japan
    Cell Microbiol 4:223-33. 2002
    ..Thus, our findings demonstrate that N-WASP is a specific ligand of VirG, which determines the host cell type allowing actin-based spreading of Shigella...