Katsue Suzuki-Inoue

Summary

Affiliation: University of Yamanashi
Country: Japan

Publications

  1. ncbi request reprint Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409 3898, Japan
    J Biol Chem 282:25993-6001. 2007
  2. pmc Involvement of Src kinases and PLCgamma2 in clot retraction
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, Yamanashi University, 1110 Shimokato, Chuo, Yamanashi, 409 3898, Japan
    Thromb Res 120:251-8. 2007
  3. ncbi request reprint The novel platelet activation receptor CLEC-2
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409 3898, Japan
    Platelets 22:380-4. 2011
  4. pmc Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites
    Katsue Suzuki-Inoue
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Biochem J 378:1023-9. 2004
  5. pmc Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    J Biol Chem 285:24494-507. 2010
  6. doi request reprint Essential in vivo roles of the platelet activation receptor CLEC-2 in tumour metastasis, lymphangiogenesis and thrombus formation
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    J Biochem 150:127-32. 2011
  7. ncbi request reprint [Identification of the novel platelet activation receptor CLEC-2 and Its pathological and physiological roles]
    Katsue Suzuki Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, Chuo 409 3898, Japan
    Rinsho Byori 58:1193-202. 2010
  8. pmc Integrin alpha2beta1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCgamma2
    Osamu Inoue
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK
    J Cell Biol 160:769-80. 2003
  9. ncbi request reprint Murine GPVI stimulates weak integrin activation in PLCgamma2-/- platelets: involvement of PLCgamma1 and PI3-kinase
    Katsue Suzuki-Inoue
    Department of Pharmacology, University of Oxford, United Kingdom
    Blood 102:1367-73. 2003
  10. ncbi request reprint A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, University of Yamanashi, Shimokato Tamaho Nakakoma, Yamanashi 409 3898, Japan
    Blood 107:542-9. 2006

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409 3898, Japan
    J Biol Chem 282:25993-6001. 2007
    ..These findings suggest that CLEC-2 is a physiological target protein of podoplanin and imply that it is involved in podoplanin-induced platelet aggregation, tumor metastasis, and other cellular responses related to podoplanin...
  2. pmc Involvement of Src kinases and PLCgamma2 in clot retraction
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, Yamanashi University, 1110 Shimokato, Chuo, Yamanashi, 409 3898, Japan
    Thromb Res 120:251-8. 2007
    ..These results demonstrate a partial role for Src kinase-dependent activation of PLCgamma2 and MLC phosphorylation in mediating clot retraction downstream of integrin alpha(IIb)beta(3)...
  3. ncbi request reprint The novel platelet activation receptor CLEC-2
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409 3898, Japan
    Platelets 22:380-4. 2011
    ..In this article and its accompanying poster, we outline the structure, distribution, signal transduction mechanism and functions of CLEC-2...
  4. pmc Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites
    Katsue Suzuki-Inoue
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Biochem J 378:1023-9. 2004
    ..Our results demonstrate fundamental differences between GPVI and GPIb-IX-V in the regulation of tyrosine phosphorylation of Syk and PLCg2 consistent with the functional impairment of phospholipase in signalling by GPIb-IX-V...
  5. pmc Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    J Biol Chem 285:24494-507. 2010
    ..We propose that CLEC-2 could be an ideal novel target protein for an anti-platelet drug, which inhibits pathological thrombus formation but not physiological hemostasis...
  6. doi request reprint Essential in vivo roles of the platelet activation receptor CLEC-2 in tumour metastasis, lymphangiogenesis and thrombus formation
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    J Biochem 150:127-32. 2011
    ..The absence of CLEC-2 does not significantly increase bleeding tendency, implying that CLEC-2 may be a good target protein for anti-platelet drugs in addition to anti-metastatic drugs...
  7. ncbi request reprint [Identification of the novel platelet activation receptor CLEC-2 and Its pathological and physiological roles]
    Katsue Suzuki Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, Chuo 409 3898, Japan
    Rinsho Byori 58:1193-202. 2010
    ..We propose that CLEC-2 could be an ideal novel target protein for an anti-platelet drug, which inhibits pathological thrombus formation but not physiological hemostasis, as well as a novel target protein for an anti-metastatic drug...
  8. pmc Integrin alpha2beta1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCgamma2
    Osamu Inoue
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK
    J Cell Biol 160:769-80. 2003
    ....
  9. ncbi request reprint Murine GPVI stimulates weak integrin activation in PLCgamma2-/- platelets: involvement of PLCgamma1 and PI3-kinase
    Katsue Suzuki-Inoue
    Department of Pharmacology, University of Oxford, United Kingdom
    Blood 102:1367-73. 2003
    ..These results provide strong evidence that engagement of GPVI stimulates limited integrin activation in PLCgamma2-/- platelets via PLCgamma1 and PI3-kinase...
  10. ncbi request reprint A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, University of Yamanashi, Shimokato Tamaho Nakakoma, Yamanashi 409 3898, Japan
    Blood 107:542-9. 2006
    ..CLEC-2 is the first C-type lectin receptor to be found on platelets which signals through this novel pathway...
  11. pmc Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells
    Makoto Osada
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    J Biol Chem 287:22241-52. 2012
    ..We propose that platelets regulate blood/lymphatic vessel separation by inhibiting the proliferation, migration, and tube formation of LECs, mainly because of the release of BMP-9 upon activation by CLEC-2/podoplanin interaction...
  12. ncbi request reprint Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling
    Katsue Suzuki-Inoue
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom
    J Biol Chem 277:21561-6. 2002
    ..These findings demonstrate that the proline-rich domain of GPVI mediates the association with Fyn/Lyn via their SH3 domain and that this interaction initiates activation signals through GPVI...
  13. ncbi request reprint Docking protein Gab2 positively regulates glycoprotein VI-mediated platelet activation
    Qun Yi
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho, Nakakoma, Japan
    Biochem Biophys Res Commun 337:446-51. 2005
    ..These findings provide evidence for a functional role of Gab2 in supporting platelet activation by GPVI...
  14. pmc Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI
    Osamu Inoue
    Department of Clinical and Laboratory Medicine, Yamanashi Medical University, 1110 Shimokato Tamaho Nakakoma, Yamanashi 409 3898, Japan
    Blood 107:1405-12. 2006
    ..We speculate that laminin contributes to platelet spreading in vivo through a direct interaction with GPVI...
  15. ncbi request reprint Mechanisms of platelet retention in the collagen-coated-bead column
    Makoto Kaneko
    Department of Clinical and Laboratory Medicine, Yamanashi Medical University, Nakakoma, Yamanashi, Japan
    J Lab Clin Med 142:258-67. 2003
    ..Our findings suggest that GPVI and GPIIb/IIIa but not the GPIb-von Willebrand factor interaction are mainly involved in platelet retention in this column...
  16. doi request reprint Redundant mechanism of platelet adhesion to laminin and collagen under flow: involvement of von Willebrand factor and glycoprotein Ib-IX-V
    Osamu Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409 3898 Japan
    J Biol Chem 283:16279-82. 2008
    ..This mechanism is similar to that of collagen. We propose that integrins, GPVI, GPIb-IX-V, and VWF represent a general paradigm for the interaction between platelets and subendothelial matrices...
  17. doi request reprint Novel synthetic collagen fibers, poly(PHG), stimulate platelet aggregation through glycoprotein VI
    Osamu Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
    FEBS Lett 583:81-7. 2009
    ..Poly(PHG) is an useful research tool to investigate GPVI-mediated signals and a substitute for collagen in platelet functional assays...
  18. ncbi request reprint [A role of the platelet receptor CLEC-2 in lymphangiogenesis and its clinical application]
    Makoto Osada
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, Chuo 409 3898, Japan
    Rinsho Byori 61:318-27. 2013
    ..We are now investigating the potential of soluble CLEC-2 as a useful marker for in vivo platelet activation...
  19. doi request reprint Regulation of adaptor protein GIT1 in platelets, leading to the interaction between GIT1 and integrin alpha(IIb)beta3
    Hitomi Sato
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    Biochem Biophys Res Commun 368:157-61. 2008
    ..These results suggest that tyrosine phosphorylation of GIT1 by Src kinases may regulate cytoskeletal reorganization downstream of alpha(IIb)beta(3) by bringing the Rac GEF betaPIX to the vicinity of the integrin...
  20. doi request reprint Causes of thrombocytopenia in chronic hepatitis C viral infection
    Makoto Osada
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, Chuo, Japan
    Clin Appl Thromb Hemost 18:272-80. 2012
    ..It is positively correlated with vWF and inversely with the platelet count. Our present results imply that vascular endothelial dysfunction is also involved in thrombocytopenia during chronic HCV infection...
  21. ncbi request reprint Grape seed extracts inhibit platelet aggregation by inhibiting protein tyrosine phosphatase
    Joseph Wuxun Jin
    1Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan
    Clin Appl Thromb Hemost 20:278-84. 2014
    ..Moreover, we showed that GSE ingestion inhibited platelet aggregation in mice without enhancing tail bleeding, implying that GSE supplementation might be beneficial to prevention of thrombotic diseases. ..
  22. pmc DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets
    Chawaree Chaipan
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Gl├╝ckstrasse 6, 91054 Erlangen, Germany
    J Virol 80:8951-60. 2006
    ..Our results identify CLEC-2 as a novel HIV-1 attachment factor and provide evidence that platelets capture and transfer infectious HIV-1 via DC-SIGN and CLEC-2, thereby possibly facilitating HIV-1 dissemination in infected patients...
  23. ncbi request reprint Molecular analysis of the pathophysiological binding of the platelet aggregation-inducing factor podoplanin to the C-type lectin-like receptor CLEC-2
    Yukinari Kato
    Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, Open Space Laboratory C 2, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    Cancer Sci 99:54-61. 2008
    ..Podoplanin and CLEC-2 might represent promising therapeutic targets in cancer metastasis...
  24. ncbi request reprint Interaction of calmodulin with the cytoplasmic domain of platelet glycoprotein VI
    Robert K Andrews
    Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Melbourne, Australia
    Blood 99:4219-21. 2002
    ..His269-Pro287 is analogous to the calmodulin-binding sequence in GPIbbeta. The novel interaction of GPVI and calmodulin may regulate aspects of GPVI function...
  25. pmc The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade
    Gemma L J Fuller
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Biol Chem 282:12397-409. 2007
    ..These results demonstrate that CLEC-2 and Dectin-1 signal through a single YXXL motif that requires the tandem SH2 domains of Syk but is only partially dependent on the SLP-76/BLNK family of adapters...