Takayuki Sumida

Summary

Affiliation: University of Tsukuba
Country: Japan

Publications

  1. ncbi request reprint The role of M3 muscarinic acetylcholine receptor reactive T cells in Sjögren's syndrome: a critical review
    Takayuki Sumida
    Department of Internal Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305 8575, Japan Electronic address
    J Autoimmun 51:44-50. 2014
  2. pmc Activation of Invariant NKT cells with glycolipid ligand α-galactosylceramide ameliorates glucose-6-phosphate isomerase peptide-induced arthritis
    Masanobu Horikoshi
    Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
    PLoS ONE 7:e51215. 2012
  3. ncbi request reprint Anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren's syndrome
    Takayuki Sumida
    Department of Internal Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki, 305 8575, Japan
    Mod Rheumatol 23:841-5. 2013
  4. pmc Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model
    Misato Hashizume
    Product Research Department, Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co, Ltd, 1 135 Komakado, Gotemba, Shizuoka, 412 8513, Japan
    Arthritis Res Ther 14:R96. 2012
  5. ncbi request reprint Pathogenic role of anti-M3 muscarinic acetylcholine receptor immune response in Sjögren's syndrome
    Takayuki Sumida
    University of Tsukuba, Department of Internal Medicine, Ibaraki, Japan
    Presse Med 41:e461-6. 2012
  6. ncbi request reprint Reiter's syndrome following intravesical bacille biliE de Calmette-GuErin treatment for superficial bladder carcinoma: report of six cases
    Hideyuki Murata
    Division of Rheumatology, Department of Internal Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, 305 8575, Japan
    Mod Rheumatol 14:82-6. 2004
  7. doi request reprint Functional role of M3 muscarinic acetylcholine receptor (M3R) reactive T cells and anti-M3R autoantibodies in patients with Sjögren's syndrome
    Takayuki Sumida
    Division of Clinical Immunology, Doctoral Program in Clinical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    Autoimmun Rev 9:615-7. 2010
  8. ncbi request reprint Effects of infliximab therapy on gene expression levels of tumor necrosis factor alpha, tristetraprolin, T cell intracellular antigen 1, and Hu antigen R in patients with rheumatoid arthritis
    Makoto Sugihara
    University of Tsukuba, Tsukuba, Ibaraki, Japan
    Arthritis Rheum 56:2160-9. 2007
  9. pmc Altered peptide ligands inhibit arthritis induced by glucose-6-phosphate isomerase peptide
    Keiichi Iwanami
    Department of Clinical Immunology, Doctoral Program in Clinical Science, Graduate School of Comprehensive Human Science, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8575, Japan
    Arthritis Res Ther 11:R167. 2009
  10. pmc Tumor necrosis factor alpha-induced adipose-related protein expression in experimental arthritis and in rheumatoid arthritis
    Asuka Inoue
    Division of Clinical Immunology, Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Japan
    Arthritis Res Ther 11:R118. 2009

Detail Information

Publications89

  1. ncbi request reprint The role of M3 muscarinic acetylcholine receptor reactive T cells in Sjögren's syndrome: a critical review
    Takayuki Sumida
    Department of Internal Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305 8575, Japan Electronic address
    J Autoimmun 51:44-50. 2014
    ..These findings indicate the crucial roles of M3R-reactive Th1 and Th17 cells in autoimmune sialadenitis, and suggest that these cells, in addition to anti-M3R antibodies, are potential targets in new treatments for SS. ..
  2. pmc Activation of Invariant NKT cells with glycolipid ligand α-galactosylceramide ameliorates glucose-6-phosphate isomerase peptide-induced arthritis
    Masanobu Horikoshi
    Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
    PLoS ONE 7:e51215. 2012
    ..Dominant T cell epitope peptide of GPI (GPI325-339) can induce arthritis similar to GPI-induced arthritis. In this study, we investigated the roles of activation of iNKT cells by α-GalCer in GPI peptide-induced arthritis...
  3. ncbi request reprint Anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren's syndrome
    Takayuki Sumida
    Department of Internal Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki, 305 8575, Japan
    Mod Rheumatol 23:841-5. 2013
    ..In this review, we summarize the current state of knowledge of anti-M3R autoantibodies in patients with SS and the correlation between B cell epitopes and the function of anti-M3R antibodies. ..
  4. pmc Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model
    Misato Hashizume
    Product Research Department, Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co, Ltd, 1 135 Komakado, Gotemba, Shizuoka, 412 8513, Japan
    Arthritis Res Ther 14:R96. 2012
    ..We found that interleukin-6 (IL-6) regulated the expression of SLC19A1, so we studied the effect of a combination of MTX and anti-mouse IL-6 receptor antibody (MR16-1)...
  5. ncbi request reprint Pathogenic role of anti-M3 muscarinic acetylcholine receptor immune response in Sjögren's syndrome
    Takayuki Sumida
    University of Tsukuba, Department of Internal Medicine, Ibaraki, Japan
    Presse Med 41:e461-6. 2012
    ..These results indicate that the M3R immune reaction plays a key pathogenic role in AIS, suggesting that M3R molecule acts as an autoantigen in the pathogenesis of SS...
  6. ncbi request reprint Reiter's syndrome following intravesical bacille biliE de Calmette-GuErin treatment for superficial bladder carcinoma: report of six cases
    Hideyuki Murata
    Division of Rheumatology, Department of Internal Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, 305 8575, Japan
    Mod Rheumatol 14:82-6. 2004
    ..Further analysis of the relationship between HLA-B and -DR alleles and arthritis should shed light on the mechanism of BCG-induced Reiter's syndrome...
  7. doi request reprint Functional role of M3 muscarinic acetylcholine receptor (M3R) reactive T cells and anti-M3R autoantibodies in patients with Sjögren's syndrome
    Takayuki Sumida
    Division of Clinical Immunology, Doctoral Program in Clinical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    Autoimmun Rev 9:615-7. 2010
    ..The functional role of M3R reactive T cells in the generation of SS was also discussed...
  8. ncbi request reprint Effects of infliximab therapy on gene expression levels of tumor necrosis factor alpha, tristetraprolin, T cell intracellular antigen 1, and Hu antigen R in patients with rheumatoid arthritis
    Makoto Sugihara
    University of Tsukuba, Tsukuba, Ibaraki, Japan
    Arthritis Rheum 56:2160-9. 2007
    ..The aims of this study were to understand the posttranscriptional control of TNFalpha production in patients with rheumatoid arthritis (RA), and to identify parameters that may predict the efficacy of anti-TNFalpha therapy...
  9. pmc Altered peptide ligands inhibit arthritis induced by glucose-6-phosphate isomerase peptide
    Keiichi Iwanami
    Department of Clinical Immunology, Doctoral Program in Clinical Science, Graduate School of Comprehensive Human Science, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8575, Japan
    Arthritis Res Ther 11:R167. 2009
    ..The present study was designed to examine the effects and immunological change of action of altered peptide ligands (APLs) on glucose-6-phosphate isomerase (GPI) peptide-induced arthritis...
  10. pmc Tumor necrosis factor alpha-induced adipose-related protein expression in experimental arthritis and in rheumatoid arthritis
    Asuka Inoue
    Division of Clinical Immunology, Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Japan
    Arthritis Res Ther 11:R118. 2009
    ..This arthritis can be controlled by TNFalpha antagonists, suggesting similar etiology to RA. In this study, we explored TNFalpha-related mechanisms of arthritis...
  11. doi request reprint Importance of serine727 phosphorylated STAT1 in IFNγ-induced signaling and apoptosis of human salivary gland cells
    Hiroto Tsuboi
    Division of Clinical Immunology, Doctoral Programs in Clinical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Int J Rheum Dis 14:86-91. 2011
    ..The aim of this study is to clarify which phosphorylation of STAT1, serine727 (Ser(727)) or tyrosine701 (Tyr(701)) of STAT1, is important for IFNγ signaling and IFNγ-induced apoptosis in salivary gland cells...
  12. doi request reprint Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase
    Keiichi Iwanami
    University of Tsukuba, Tsukuba, Japan
    Arthritis Rheum 58:754-63. 2008
    ..To clarify the glucose-6-phosphate isomerase (GPI)-specific CD4+ T cell lineage involved in GPI-induced arthritis and to investigate their pathologic and regulatory roles in the induction of the disease...
  13. doi request reprint Six-transmembrane epithelial antigen of prostate4 (STEAP4) is a tumor necrosis factor alpha-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis
    Yoko Tanaka
    Division of Clinical Immunology, Doctoral Program in Clinical Science, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8575, Japan
    Mod Rheumatol 22:128-36. 2012
    ....
  14. pmc A new low-field extremity magnetic resonance imaging and proposed compact MRI score: evaluation of anti-tumor necrosis factor biologics on rheumatoid arthritis
    Takeshi Suzuki
    Division of Clinical Immunology, Doctoral Program in Clinical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Mod Rheumatol 19:358-65. 2009
    ..055, P < 0.05). We conclude that cMRI and cMRIS are useful for assessing total disease activity and as a method linking MRI image evaluation to clinical evaluation...
  15. pmc A functional variant of Fcgamma receptor IIIA is associated with rheumatoid arthritis in individuals who are positive for anti-glucose-6-phosphate isomerase antibodies
    Isao Matsumoto
    Clinical Immunology, University of Tsukuba, Ibaraki, Japan
    Arthritis Res Ther 7:R1183-8. 2005
    ..0027 and P = 0.0015, respectively). Our findings provide a molecular model of the genetic regulation of autoantibody-induced arthritis by allele-specific affinity of the FcgammaRs...
  16. pmc Therapeutic effects of antibodies to tumor necrosis factor-alpha, interleukin-6 and cytotoxic T-lymphocyte antigen 4 immunoglobulin in mice with glucose-6-phosphate isomerase induced arthritis
    Isao Matsumoto
    Division of Clinical Immunology, Major of Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tennodai, Tsukuba 305 8575, Japan
    Arthritis Res Ther 10:R66. 2008
    ..Immunization with glucose-6-phosphate isomerase (GPI) induces severe arthritis in DBA/1 mice. The present study was designed to identify the cytokines and co-stimulatory molecules involved in the development of GPI-induced arthritis...
  17. pmc Association of TNFAIP3 polymorphism with susceptibility to systemic lupus erythematosus in a Japanese population
    Aya Kawasaki
    Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305 8575, Japan
    J Biomed Biotechnol 2010:207578. 2010
    ..013). These results indicated that TNFAIP3 is a susceptibility gene to SLE both in the Caucasian and Asian populations...
  18. doi request reprint Therapeutic efficacy of tocilizumab in patients with rheumatoid arthritis refractory to anti-tumor-necrosis-factor inhibitors: 1 year follow-up with low-field extremity MRI
    Takeshi Suzuki
    Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Mod Rheumatol 23:782-7. 2013
    ..The aim of our study was to test the usefulness of magnetic resonance imaging (MRI)-based markers of response to TCZ treatment...
  19. doi request reprint Comparative suppressive effects of tyrosine kinase inhibitors imatinib and nilotinib in models of autoimmune arthritis
    Naotsugu Akashi
    Clinical Immunology, Advanced Biochemical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8575, Japan
    Mod Rheumatol 21:267-75. 2011
    ..Imatinib and nilotinib could have therapeutic potential for rheumatoid arthritis (RA) and other inflammatory diseases...
  20. ncbi request reprint The exploration of joint-specific immunoreactions on immunoglobulins G of anti-glucose-6-phosphate isomerase antibody-positive patients with rheumatoid arthritis
    Isao Matsumoto
    Division of Rheumatology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba 305 8575, Japan
    Int J Mol Med 16:793-800. 2005
    ..Our results suggest that IgG fraction from RA patients, including that of anti-GPI Abs, may play a role in the synovitis of RA, although the pathogenesis of human anti-GPI Abs is still uncertain...
  21. doi request reprint Association of a functional polymorphism in the 3'-untranslated region of SPI1 with systemic lupus erythematosus
    Koki Hikami
    University of Tsukuba, Tsukuba, Japan
    Arthritis Rheum 63:755-63. 2011
    ..In view of the significance of the type I interferon pathway in systemic lupus erythematosus (SLE), this study was undertaken to investigate a possible association between SPI1 polymorphisms and SLE...
  22. ncbi request reprint Altered peptide ligands regulate type II collagen-induced arthritis in mice
    Ei Wakamatsu
    Division of Clinical Immunology, Doctoral Programs in Medical Sciences, Major of Advanced Biomedical Applications, Graduate School Comprehensive Human Science, University of Tsukuba, 1 1 1 Tenodai, Tsukuba, Ibaraki 305 8575, Japan
    Mod Rheumatol 19:366-71. 2009
    ..Compared with the control, APL-5 suppressed interleukin (IL)-17 production by T cells from CII-induced arthritis mice. These results suggest that CII APL is a potentially suitable therapeutic strategy for the control of RA...
  23. pmc Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region
    Aya Kawasaki
    Molecular and Genetic Epidemiology Laboratory, Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8575, Japan
    Arthritis Res Ther 10:R113. 2008
    ..To accomplish these aims, we carried out a comprehensive association analysis of 52 tag single nucleotide polymorphisms (SNPs) encompassing the STAT1-STAT4 region...
  24. ncbi request reprint Interleukin-17 gene expression in patients with rheumatoid arthritis
    Mika Kohno
    Division of Clinical Immunology, Major of Advanced Biomedical Applications, Graduate School Comprehensive Human Science, University of Tsukuba, Tsukuba, Japan
    Mod Rheumatol 18:15-22. 2008
    ..Expression of IL-17 gene in PBMC may be associated with the inflammatory process of RA. IL-17/TNF-alpha expression ratio is a potentially suitable marker of response to anti-TNF-alpha therapy...
  25. doi request reprint Overexpression of T-bet gene regulates murine autoimmune arthritis
    Yuya Kondo
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba City, Ibaraki, Japan
    Arthritis Rheum 64:162-72. 2012
    ..To clarify the role of T-bet in the pathogenesis of collagen-induced arthritis (CIA)...
  26. doi request reprint Pathogenic role of immune response to M3 muscarinic acetylcholine receptor in Sjögren's syndrome-like sialoadenitis
    Mana Iizuka
    Division of Clinical Immunology, Doctoral Programs in Clinical Sciences, Graduate School Comprehensive Human Science, University of Tsukuba, 1 1 1 Tenodai, Tsukuba City, Ibaraki 305 8575, Japan
    J Autoimmun 35:383-9. 2010
    ..Our findings support the notion that the immune response to M3R plays a crucial role in the pathogenesis of SS-like autoimmune sialoadenitis...
  27. ncbi request reprint Six-transmembrane epithelial antigen of prostate 4 (STEAP4) is expressed on monocytes/neutrophils, and is regulated by TNF antagonist in patients with rheumatoid arthritis
    Y Tanaka
    Division of Clinical Immunology, Doctoral Programme in Clinical Science, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Japan
    Clin Exp Rheumatol 30:99-102. 2012
    ..The aim of the present study was to assess the expression, localisation and function of STEAP4 in peripheral blood of patients with rheumatoid arthritis (RA)...
  28. ncbi request reprint Expression of TNF-alpha, tristetraprolin, T-cell intracellular antigen-1 and Hu antigen R genes in synovium of patients with rheumatoid arthritis
    Eiji Suzuki
    Department of Clinical Immunology, University of Tsukuba, Ibaraki 305 8575, Japan
    Int J Mol Med 18:273-8. 2006
    ....
  29. doi request reprint Involvement of NK 1.1-positive γδT cells in interleukin-18 plus interleukin-2-induced interstitial lung disease
    Seiji Segawa
    Division of Clinical Immunology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8575, Japan
    Am J Respir Cell Mol Biol 45:659-66. 2011
    ..1(+) γδT cells could induce the expansion of NK cells and IFN-γ mRNA in the lung by IL-18/IL-2. Our results suggest that NK1.1(+) γδT cells function as inflammatory mediators in the early phase of IL-18/IL-2-induced ILD...
  30. doi request reprint New low-field extremity MRI, compacTscan: comparison with whole-body 1.5 T conventional MRI
    Takeshi Suzuki
    Division of Clinical Immunology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Mod Rheumatol 20:331-6. 2010
    ..5 T MRI with regard to diagnosis and the scoring of bone erosion, edema, and synovitis. We conclude that compacTscan is useful for diagnosis and estimation of disease activity in patients with RA...
  31. pmc TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study
    Aya Kawasaki
    Molecular and Genetic Epidemiology Laboratory, Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8575, Japan
    Arthritis Res Ther 13:R41. 2011
    ..To test whether additional polymorphisms contribute to SLE in Japanese, we systematically analyzed the association of TLR7 with SLE in a Japanese female population...
  32. pmc Arthritogenic T cell epitope in glucose-6-phosphate isomerase-induced arthritis
    Keiichi Iwanami
    Department of Clinical Immunology, Doctoral Program in Clinical Sciences, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Japan
    Arthritis Res Ther 10:R130. 2008
    ..We undertook this study to identify GPI-specific T cell epitopes in DBA/1 mice (H-2q) and investigate the mechanisms of arthritis generation...
  33. doi request reprint Use of laser microdissection in the analysis of renal-infiltrating T cells in MRL/lpr mice
    Yingge Wang
    Division of Clinical Immunology, Major of Advanced Biomedical Applications, Graduate School of Comprehensive Human Science, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Mod Rheumatol 18:385-93. 2008
    ..These findings also support the concept of different molecular mechanisms for glomerulonephritis and vasculitis in these mice...
  34. doi request reprint Tristetraprolin (TTP) gene polymorphisms in patients with rheumatoid arthritis and healthy individuals
    Takeshi Suzuki
    Division of Clinical Immunology, Major of Advanced Biomedical Applications, Graduate School of Comprehensive Human Science, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, 305 8575, Ibaraki, Japan
    Mod Rheumatol 18:472-9. 2008
    ..We conclude that this SNP in the promoter region of the TTP gene mildly affects promoter activity, and thus, may influence the disease activity of inflammatory disorders including RA...
  35. ncbi request reprint Altered peptide ligands control type II collagen-reactive T cells from rheumatoid arthritis patients
    Yasuyuki Ohnishi
    Division of Rheumatology, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tenodai, Tsukuba, 305 8575, Japan
    Mod Rheumatol 16:226-8. 2006
    ..Results showed that 262 (G-->A) APL of CII 256-271 exhibited antagonistic activity in all T-cell lines and it was suggested that the application of CII APL might be a new therapeutic strategy in the regulation of RA...
  36. pmc Efficacy of mizoribine pulse therapy in patients with rheumatoid arthritis who show a reduced or insufficient response to infliximab
    Masanobu Horikoshi
    Division of Clinical Immunology, Doctoral Program in Clinical Sciences, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Japan
    Mod Rheumatol 19:229-34. 2009
    ..Based on these results, we propose that MZR pulse therapy should be attempted before the patient is switched to other biologics...
  37. ncbi request reprint Glucose-6-phosphate isomerase variants play a key role in the generation of anti-GPI antibodies: possible mechanism of autoantibody production
    Yoshifumi Muraki
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tenodai, Ibaraki 305 8575, Japan
    Biochem Biophys Res Commun 323:518-22. 2004
    ..6%) was more significantly higher than in anti-GPI Ab-negative patients (1/63, 1.6%, p < 0.0001). Our results suggest that GPI variants may play a crucial role in the production of autoantibodies against ubiquitous GPI autoantigens...
  38. ncbi request reprint Biased usage of synovial immunoglobulin heavy chain variable region 4 by the anti-glucose-6-phosphate isomerase antibody in patients with rheumatoid arthritis
    Taichi Hayashi
    Division of Clinical Immunology, Major of Advanced Biomedical Applications, Graduate School of Comprehensive Human Science, University of Tsukuba, Ibaraki 305 8575, Japan
    Int J Mol Med 20:247-53. 2007
    ..Our results support the notion that Ig-VH4 B cells in RA synovium with anti-GPI Ab are affinity-matured and that anti-GPI Ab might be associated with the skewed IgH-CDR3...
  39. ncbi request reprint Low levels of soluble CD1d protein alters NKT cell function in patients with rheumatoid arthritis
    Seiji Segawa
    Division of Clinical Immunology, Doctoral Program in Clinical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
    Int J Mol Med 24:481-6. 2009
    ..It is therefore hypothesized that sCD1d stimulates NKT cells and low plasma sCD1d levels in RA reflect a pathogenic mechanism associated with a decrease in NKT cells...
  40. doi request reprint Murine tumor necrosis factor α-induced adipose-related protein (tumor necrosis factor α-induced protein 9) deficiency leads to arthritis via interleukin-6 overproduction with enhanced NF-κB, STAT-3 signaling, and dysregulated apoptosis of macrophages
    Asuka Inoue
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Arthritis Rheum 64:3877-85. 2012
    ..To elucidate the role of tumor necrosis factor α-induced adipose-related protein (TIARP; or tumor necrosis factor α-induced protein 9 [TNFAIP-9]) in the development and pathogenesis of arthritis...
  41. ncbi request reprint Successful treatment of refractory thrombotic thrombocytopenic purpura with cyclosporine and corticosteroids in a patient with systemic lupus erythematosus and antibodies to ADAMTS13
    Terukazu Enami
    Clinical Immunology, Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba
    Intern Med 46:1033-7. 2007
    ..We propose that cyclosporine may be an effective treatment for cases of refractory TTP...
  42. doi request reprint Cumulative association of eight susceptibility genes with systemic lupus erythematosus in a Japanese female population
    Minori Koga
    Molecular and Genetic Epidemiology Laboratory, Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    J Hum Genet 56:503-7. 2011
    ..30, CI 1.09-4.83, P=0.025). This study suggested that the cumulative number of risk alleles may efficiently distinguish groups with high and low genetic predisposition to SLE and its severe manifestation...
  43. pmc Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study
    Aya Kawasaki
    Molecular and Genetic Epidemiology Laboratory, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Arthritis Res Ther 12:R174. 2010
    ..In this study, we investigated whether the association of TNIP1 with SLE was replicated in a Japanese population. In addition, association of TNIP1 with RA was also examined...
  44. ncbi request reprint A patient with rheumatoid arthritis who had a normal delivery under etanercept treatment
    Naoto Umeda
    Division of Clinical Immunology, Doctoral Program in Clinical Sciences, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba
    Intern Med 49:187-9. 2010
    ..This suggests that etanercept may be selected to treat RA patients with active arthritis who desire pregnancy with lower risks...
  45. ncbi request reprint Mannose binding lectin gene polymorphism and the severity of chronic periodontitis
    Akito Tsutsumi
    Division of Clinical Immunology, Advanced Biomedical Applications, Graduate School of Comprehensive Human Science, University of Tsukuba
    Nihon Rinsho Meneki Gakkai Kaishi 32:48-52. 2009
    ..We aimed to determine whether there is a relationship between occurrence or severity of chronic periodontitis (CP) and polymorphism of the MBL gene...
  46. ncbi request reprint Expression of tristetraprolin (G0S24) mRNA, a regulator of tumor necrosis factor-alpha production, in synovial tissues of patients with rheumatoid arthritis
    Akito Tsutsumi
    Division of Rheumatology, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
    J Rheumatol 31:1044-9. 2004
    ..To determine the significance of tristetraprolin (TTP) gene expression in synovial tissues of patients with rheumatoid arthritis (RA)...
  47. ncbi request reprint Primary and secondary surveys on epidemiology of Sjögren's syndrome in Japan
    Hiroto Tsuboi
    Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Mod Rheumatol 24:464-70. 2014
    ..To characterize the epidemiology of Sjögren's syndrome (SS), including prevalence, disease type, extra-glandular involvement, satisfaction of diagnostic criteria sets, and treatment used in Japan...
  48. ncbi request reprint Immunoglobulin G from anti-glucose-6-phosphate isomerase antibodies positive patient with rheumatoid arthritis induces synovitis in cynomolgus monkeys
    Takeshi Suzuki
    Clinical Immunology, Major of Advanced Biomedical Applications, Graduate of Comprehensive Human Sciences, University of Tsukuba, University of Tsukuba, 1 1 1 Tenodai, Ibaraki 305 8575, Japan
    Autoimmun Rev 4:475-8. 2005
    ..Our results suggest that IgG fraction from RA patients including anti-GPI Abs may play a crucial role in the generation of synovitis in monkeys, although the pathogenesis of anti-GPI Abs in RA patients is still uncertain...
  49. ncbi request reprint Overexpression of phosphorylated STAT-1alpha in the labial salivary glands of patients with Sjögren's syndrome
    Ei Wakamatsu
    University of Tsukuba, Tsukuba City, Ibaraki 305 8575, Japan
    Arthritis Rheum 54:3476-84. 2006
    ..To clarify the molecular mechanisms of Sjögren's syndrome (SS), we analyzed the functional role of the STAT-1 gene, one of the interferon-gamma (IFNgamma)-inducible genes, in labial salivary glands (LSGs) from SS patients...
  50. doi request reprint Intravascular large B-cell lymphoma with acute abdomen as a presenting symptom in a patient with systemic lupus erythematosus
    Wataru Ishii
    Division of Clinical Immunology, Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    J Clin Oncol 26:1553-5. 2008
  51. doi request reprint Generation and functional analysis of monoclonal antibodies against the second extracellular loop of human M3 muscarinic acetylcholine receptor
    Hiroto Tsuboi
    Division of Clinical Immunology, Doctoral Programs in Clinical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Mod Rheumatol 22:264-71. 2012
    ....
  52. ncbi request reprint Anti-interleukin-6 receptor antibody (tocilizumab) treatment of multicentric Castleman's disease
    Masashi Matsuyama
    Clinical Immunology, Major of Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba
    Intern Med 46:771-4. 2007
    ..These results indicate that tocilizumab is effective for the treatment of MCD. This is the first report on tocilizumab efficacy for Castleman's disease after approval for use for Castleman's disease...
  53. doi request reprint Replication of the association between the C8orf13-BLK region and systemic lupus erythematosus in a Japanese population
    Ikue Ito
    University of Tsukuba, Tsukuba, Japan
    Arthritis Rheum 60:553-8. 2009
    ..The purpose of this study was to evaluate the significance of this region in the genetic background of Japanese patients with SLE...
  54. ncbi request reprint [Targeted therapies including monoclonal antibodies for connective tissue diseases]
    Taichi Hayashi
    Field of Clinical Immunology, Doctoral Program in Clinical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba
    Nihon Rinsho 67:588-92. 2009
    ..Recent year, some of novel small molecules, which inhibit the signal transduction of various surface receptors of immune cells, are in clinical trials. These drugs will be a breakthrough for the treatment of some autoimmune disorders...
  55. ncbi request reprint [Anti-cytokine therapy for connective tissue disease]
    Taichi Hayashi
    Division of Clinical Immunology, Major of Advanced Biomedical Applications, Graduate School of Comprehensive Human Science, University of Tsukuba
    Nihon Rinsho 63:233-9. 2005
  56. ncbi request reprint Polymorphisms of IL-1 beta gene in Japanese patients with Sjögren's syndrome and systemic lupus erythematosus
    Yoshifumi Muraki
    Division of Rheumatology, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
    J Rheumatol 31:720-5. 2004
    ..Evidence suggests that IL-1 beta may be involved in the destruction of salivary and lacrimal glands in Sjögren's syndrome (SS). We evaluated the significance of IL-1 beta gene polymorphisms in SS...
  57. ncbi request reprint Role of immune response to M3 muscarinic acethylcholine receptor in the pathogenesis of Sjögren's syndrome
    Mana Iizuka
    Division of Clinical Immunology, Doctoral Programs in Clinical Sciences, Graduate School Comprehensive Human Science, University of Tsukuba
    Nihon Rinsho Meneki Gakkai Kaishi 33:87-91. 2010
    ..In their salivary glands, mononuclear infiltration was also detected. These findings suggest that the immune response to M3R plays a crucial role in the generation of SS like sialoadenitis...
  58. ncbi request reprint [The role of TNFalpha-induced adipose-related protein (TIARP) in TNFalpha dependent arthritic model--GPI-induced arthritis]
    Asuka Inoue
    Division of Clinical Immunology, Doctoral Program in Clinical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba
    Nihon Rinsho Meneki Gakkai Kaishi 32:15-9. 2009
    ..In this study, to understand the mechanisms of arthritis that was regulated by TNFalpha, we focused on TNFalpha-induced adipose-related protein (TIARP) in the generation of GPI-induced arthritis...
  59. ncbi request reprint Sarcoid myositis with muscle weakness as a presenting symptom
    Hideyasu Yamada
    Clinical Immunology, Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8575, Japan
    Mod Rheumatol 17:243-6. 2007
    ..Sarcoidosis should be considered in the differential diagnosis of polymyositis...
  60. doi request reprint Early diagnosis and treatment of steroid-induced diabetes mellitus in patients with rheumatoid arthritis and other connective tissue diseases
    Satoshi Ito
    Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Mod Rheumatol 24:52-9. 2014
    ....
  61. doi request reprint Analysis of subclinical synovitis detected by ultrasonography and low-field magnetic resonance imaging in patients with rheumatoid arthritis
    Hiroshi Ogishima
    Department of Internal Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Mod Rheumatol 24:60-8. 2014
    ..To assess the utilities of ultrasonography (US) and low-field magnetic resonance imaging (compacTscan, cMRI) in the diagnosis of subclinical synovitis of hand joints of patients with rheumatoid arthritis (RA)...
  62. ncbi request reprint A case of disseminated sporotrichosis treated with prednisolone, immunosuppressants, and tocilizumab under the diagnosis of rheumatoid arthritis
    Tetsuto Yamaguchi
    Department of Internal Medicine, University of Tsukuba, Japan
    Intern Med 51:2035-9. 2012
    ..Any case of intractable arthritis or skin ulcers, which does not improve, despite adequate immunosuppressive therapy, is likely to be suspicious of sporotrichosis...
  63. doi request reprint High-dose unfractionated heparin therapy in a pregnant patient with antiphospolipid syndrome: a case report
    Hiroshi Ogishima
    Division of Clinical Immunology, Doctoral Program in Clinical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Int J Rheum Dis 13:e32-5. 2010
    ..A healthy baby weighing 1818 g at birth was delivered by Cesarean section at the 34th week of pregnancy. High-dose UFH infusion may be considered to be one of the preferable options to manage pregnant patients with refractory APS...
  64. ncbi request reprint Two cases of systemic lupus erythematosus complicated with colonic ulcers
    Shoko Miyahara
    Department of Internal Medicine, University of Tsukuba, Ibaraki, Japan
    Intern Med 44:1298-306. 2005
    ..Further analysis of its outcomes, and establishment of the regular guideline for its treatment are expected...
  65. doi request reprint Elevated level of serum cystatin-C concentration is a useful predictor for myelosuppression induced by methotrexate for treatment of rheumatoid arthritis
    Taichi Hayashi
    Doctoral Program in Clinical Sciences, Division of Clinical Immunology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki, 305 8575, Japan
    Mod Rheumatol 20:548-55. 2010
    ..The elevated level of serum Cys-C is a more sensitive indicator to predict MTX-induced myelotoxicity than that of serum creatinine...
  66. ncbi request reprint Gene transduction of tristetraprolin or its active domain reduces TNF-alpha production by Jurkat T cells
    Eiji Suzuki
    Department of Clinical Immunology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba shi, Ibaraki 305 8575, Japan
    Int J Mol Med 17:801-9. 2006
    ..These results suggest that TTP may be a potential target for new therapies against RA...
  67. ncbi request reprint T cell receptor BV gene repertoire of lymphocytes in bronchoalveolar lavage fluid of polymyositis/dermatomyositis patients with interstitial pneumonitis
    Yusuke Chino
    Division of Rheumatology, Department of Internal Medicine, University of Tsukuba, Tsukuba City, Japan
    Int J Mol Med 17:101-9. 2006
    ..Our findings suggest that T cells in BALF may recognize the restricted antigen and accumulate via antigen-driven stimulation, suggesting that T cells may play a crucial role in the development of IP in patients with PM/DM...
  68. ncbi request reprint [Autoimmunity to glycolytic enzyme in rheumatoid arthritis]
    Isao Matsumoto
    Division of Clinical Immunology, Graduate School of Comprehensive Human Science, University of Tsukuba, Japan
    Nihon Rinsho Meneki Gakkai Kaishi 34:456-63. 2011
    ..Here we focus on glycolytic enzyme such as glucose-6-phospate isomerase, that is confirmed as arthritogenic in two different mouse models, and discuss about pathogenic relevance to RA...
  69. pmc Significance of antiprothrombin antibodies in patients with systemic lupus erythematosus: clinical evaluation of the antiprothrombin assay and the antiphosphatidylserine/prothrombin assay, and comparison with other antiphospholipid antibody assays
    Akito Tsutsumi
    Division of Clinical Immunology, Major of Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, 305 8575, Japan
    Mod Rheumatol 16:158-64. 2006
    ....
  70. ncbi request reprint Analysis of abnormally expressed genes in synovium from patients with rheumatoid arthritis using a column gel electrophoresis-coupled subtractive hybridization technique
    Takashi Tomoo
    Division of Rheumatology, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba City, Ibaraki 305 8575, Japan
    Int J Mol Med 15:453-7. 2005
    ..Our results imply that the CGESH technique is a useful tool to detect genes involved in the pathogenesis of RA. Further investigation of the functional roles of candidate genes should shed light on the pathogenesis of RA...
  71. doi request reprint [Evaluation of joint inflammation by MRI in patients with RA]
    Takayuki Sumida
    Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
    Clin Calcium 22:193-8. 2012
    ..US imaging is also useful for estimation of therapy and a criteria for complete remission, and cheep machine. We hope that both imaging technologies will be a standard for diagnosis and therapy evaluation in RA patients...
  72. ncbi request reprint [Crucial role of TNFα-induced adipose-related protein (TIARP) in the pathogenesis of autoimmune arthritis]
    Asuka Inoue
    Department of Internal Medicine, Faculty of Medicine, University of Tsukuba
    Nihon Rinsho Meneki Gakkai Kaishi 35:51-5. 2012
    ..In this study, we discuss the role of TIARP in the generation of experimental autoimmune arthritis and the possible clinical application of for the treatment of RA...
  73. ncbi request reprint [Adalimumab]
    Daisuke Goto
    Department of Internal Medicine, University of Tsukuba
    Nihon Rinsho 60:2384-9. 2002
    ..For patients with RA, the treatment of adalimumab will set a new standard for symptom control and joint protection...
  74. ncbi request reprint [Ovarian cancer with swelling of the right upper arm, amyopathic dermatomyositis, and elevated serum KL-6]
    Atsushi Uchida
    Division of Rheumatology, Tsukuba University Hospital, Tsukuba
    Nihon Naika Gakkai Zasshi 95:742-4. 2006
  75. doi request reprint Comparison of low-field dedicated extremity magnetic resonance imaging with articular ultrasonography in patients with rheumatoid arthritis
    Masanobu Horikoshi
    Doctoral Program in Clinical Sciences, Division of Clinical Immunology, Graduate School of Comprehensive Human Science, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki, 305 8575, Japan
    Mod Rheumatol 20:556-60. 2010
    ..807 for PD-US, suggesting specificity of PD-US in detecting joint inflammation. Our results show that findings of PD-US correlated with those of MRI. Low-field MRI and PD-US are useful tools for assessment of patients with RA...
  76. ncbi request reprint [Anakinra for therapy of rheumatoid arthritis]
    Takashi Tomoo
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba
    Nihon Rinsho 63:534-7. 2005
  77. ncbi request reprint Mannose binding lectin gene polymorphism in patients with type I diabetes
    Akito Tsutsumi
    Division of Rheumatology, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
    Hum Immunol 64:621-4. 2003
    ..Possession of the minority allele of the MBL gene may be a minor risk factor for having type I diabetes...
  78. ncbi request reprint [Analysis of epitopes and function of anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren's syndrome]
    Hiroto Tsuboi
    Division of Clinical Immunology, Doctoral Program in Clinical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba
    Nihon Rinsho Meneki Gakkai Kaishi 33:222-8. 2010
    ..These findings indicated the presence of several B cell epitopes on M3R in SS and effect of anti-M3R antibodies on the salivary secretion might differ with these epitopes...
  79. ncbi request reprint Atypical Cogan's syndrome with aortitis
    Yuya Kondo
    Division of Clinical Immunology, Doctoral Program of Clinical Sciences, Graduate School of Comprehensive Human Science, University of Tsukuba
    Intern Med 48:1093-7. 2009
    ....
  80. ncbi request reprint Mannose binding lectin: genetics and autoimmune disease
    Akito Tsutsumi
    Division of Clinical Immunology, Graduate School of Comprehensive Human Sciences, University of Tsukuba 1 1 1, Tennodai, Tsukuba 305 8575, Ibaraki, Japan
    Autoimmun Rev 4:364-72. 2005
    ..Recently, presence of anti-MBL autoantibodies in sera of SLE patients has been reported. The significance of this autoantibody remains to be elucidated...
  81. ncbi request reprint B cells and immunoglobulins dependent mechanisms in rheumatoid arthritis: a possible rationale of the extracorporeal immunomodulation for rheumatoid arthritis
    Isao Matsumoto
    Division of Rheumatology, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Ther Apher 6:317-9. 2002
    ..We also propose several efficacious treatments for treating these patients as made-to-order therapies...
  82. ncbi request reprint T cell receptor repertoire of T cells in the kidneys of patients with lupus nephritis
    Hideyuki Murata
    University of Tsukuba, Ibaraki, Japan
    Arthritis Rheum 46:2141-7. 2002
    ..To determine the role of T cells in the pathogenesis of lupus nephritis (LN)...
  83. ncbi request reprint A multicenter phase I/II trial of rituximab for refractory systemic lupus erythematosus
    Yoshiya Tanaka
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1 1 Iseigaoka, Yahata Nishi, Kitakyushu 807 8555, Japan
    Mod Rheumatol 17:191-7. 2007
    ..Rituximab therapy appears to be safe for the treatment of active SLE patients and holds significant therapeutic promise, at least for the majority of patients experiencing profound B-cell depletion...
  84. ncbi request reprint Low expression levels of soluble CD1d gene in patients with rheumatoid arthritis
    Satoshi Kojo
    Division of Rheumatology, Department of Internal Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    J Rheumatol 30:2524-8. 2003
    ..V1 lacking exon 4 (CD1d without beta2 microglobulin, beta2m) and V2 lacking exons 4 and 5 (soluble CD1d) may be functional molecules, because the antigen binding sites (exons 2 and 3) are intact...
  85. pmc Critical role of M. tuberculosis for dendritic cell maturation to induce collagen-induced arthritis in H-2b background of C57BL/6 mice
    Hirayasu Kai
    Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsubuka, Ibaraki, Japan
    Immunology 118:233-9. 2006
    ..tuberculosis. These results suggested that high dose of M. tuberculosis were required for maturation of DC enough to prime CD4+ helper T cells specific to CII antigen in DLN of H-2b background of C57BL/6 mice...
  86. ncbi request reprint [Sjögren's syndrome]
    Takayuki Sumida
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba
    Nihon Rinsho 60:376-80. 2002
  87. doi request reprint Femoral nerve palsy caused by a huge iliopectineal synovitis extending to the iliac fossa in a rheumatoid arthritis case
    Masaki Tatsumura
    Department of Orthopaedic Surgery, Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Mod Rheumatol 18:81-5. 2008
    ..The patient fully recovered from femoral nerve palsy after surgery. It was considered that synovitis of the hip joint had developed following huge iliopectineal bursitis...
  88. ncbi request reprint T cell epitopes of type II collagen in HLA-DRB1*0101 or DRB1*0405-positive Japanese patients with rheumatoid arthritis
    Yasuyuki Ohnishi
    Division of Rheumatology, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba City, Ibaraki 305 8575, Japan
    Int J Mol Med 11:331-5. 2003
    ..In DRB1*0405-positive RA patients, CII reactive T cells might play a crucial role in the development of RA through IFN-gamma production...
  89. ncbi request reprint [MRI is coming up as a new diagnostic imaging andan appraisal method for rheumatoid arthritis (RA)]
    Takeshi Suzuki
    University of Tsukuba, Graduate School of Comprehensive Human Science, Division of Clinical Immunology, Major of Advanced Biomedical Applications
    Clin Calcium 17:535-40. 2007
    ..MRI, which shows the active lesions in about 90% of patients diagnosed with clinical remission, is an extremely valuable tool aiding in treatment leading to true remission...