Kazunari Sugita

Summary

Affiliation: University of Occupational and Environmental Health
Country: Japan

Publications

  1. pmc FTY720 regulates bone marrow egress of eosinophils and modulates late-phase skin reaction in mice
    Kazunari Sugita
    Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan
    Am J Pathol 177:1881-7. 2010
  2. doi request reprint Drug-induced papuloerythroderma: analysis of T-cell populations and a literature review
    Kazunari Sugita
    Department of Dermatology, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Japan
    Acta Derm Venereol 89:618-22. 2009
  3. ncbi request reprint Oral allergy syndrome caused by raw fish in a Japanese sushi bar worker
    Kazunari Sugita
    Department of Dermatology, University of Occupational and Environmental Health, Japan, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Contact Dermatitis 56:369-70. 2007
  4. pmc Innate immunity mediated by epidermal keratinocytes promotes acquired immunity involving Langerhans cells and T cells in the skin
    K Sugita
    Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan
    Clin Exp Immunol 147:176-83. 2007
  5. doi request reprint Inducible nitric oxide synthase downmodulates contact hypersensitivity by suppressing dendritic cell migration and survival
    Kazunari Sugita
    Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Invest Dermatol 130:464-71. 2010
  6. ncbi request reprint Vitiligo with inflammatory raised borders, associated with atopic dermatitis
    K Sugita
    Department of Dermatology, School of Medicine, University of Occupational and Environmental Health, Japan
    Clin Exp Dermatol 31:80-2. 2006
  7. ncbi request reprint D-penicillamine-induced pemphigus successfully treated with combination therapy of mizoribine and prednisolone
    K Sugita
    Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    J Dermatolog Treat 15:214-7. 2004
  8. ncbi request reprint Chronic actinic dermatitis associated with adult T-cell leukemia
    Kazunari Sugita
    Department of Dermatology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Am Acad Dermatol 52:38-40. 2005
  9. pmc CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells
    Kenji Kabashima
    Department of Dermatology, University of Environmental and Occupational Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Am J Pathol 171:1249-57. 2007
  10. ncbi request reprint Cutaneous hypersensitivities to hapten are controlled by IFN-gamma-upregulated keratinocyte Th1 chemokines and IFN-gamma-downregulated langerhans cell Th2 chemokines
    Tomoko Mori
    Department of Dermatology, University of Occupational and Environmental Health, Yahatanishi, Kitakyushu, Japan
    J Invest Dermatol 128:1719-27. 2008

Collaborators

Detail Information

Publications35

  1. pmc FTY720 regulates bone marrow egress of eosinophils and modulates late-phase skin reaction in mice
    Kazunari Sugita
    Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan
    Am J Pathol 177:1881-7. 2010
    ..These findings suggest that FTY720 affects the number of eosinophils in both the blood and skin by inhibiting the egress of eosinophils from the bone marrow and thus downmodulating the late-phase reaction...
  2. doi request reprint Drug-induced papuloerythroderma: analysis of T-cell populations and a literature review
    Kazunari Sugita
    Department of Dermatology, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Japan
    Acta Derm Venereol 89:618-22. 2009
    ..The patients had higher percentages of circulating CCR4+CD4+ T helper (Th) 2 cells than CXCR3+CD4+ Th1 cells. Drug-induced papuloerythroderma seems to be mediated by Th2 cells reacting with the causative drug...
  3. ncbi request reprint Oral allergy syndrome caused by raw fish in a Japanese sushi bar worker
    Kazunari Sugita
    Department of Dermatology, University of Occupational and Environmental Health, Japan, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Contact Dermatitis 56:369-70. 2007
    ..She had worked in a sushi bar since 2003. Clinical symptoms and positive prick-by-prick test to raw fish confirmed the diagnosis of OAS. It is likely that, our patient was sensitized by direct hand contact with raw fish...
  4. pmc Innate immunity mediated by epidermal keratinocytes promotes acquired immunity involving Langerhans cells and T cells in the skin
    K Sugita
    Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan
    Clin Exp Immunol 147:176-83. 2007
    ..This also implies that innate immunity evoked by TLR ligation of keratinocytes enhances acquired immunity comprising LCs and T cells...
  5. doi request reprint Inducible nitric oxide synthase downmodulates contact hypersensitivity by suppressing dendritic cell migration and survival
    Kazunari Sugita
    Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Invest Dermatol 130:464-71. 2010
    ..Finally, we showed that iNOS inhibitor enhanced LC survival in vitro. We concluded that NO suppresses migration and survival of cutaneous DCs, resulting in a downmodulation of CHS...
  6. ncbi request reprint Vitiligo with inflammatory raised borders, associated with atopic dermatitis
    K Sugita
    Department of Dermatology, School of Medicine, University of Occupational and Environmental Health, Japan
    Clin Exp Dermatol 31:80-2. 2006
    ..This case suggests that vitiligo with inflammatory raised borders can occur even in patients with atopic dermatitis when Th1 cells are activated and overcome the Th2-dominant state...
  7. ncbi request reprint D-penicillamine-induced pemphigus successfully treated with combination therapy of mizoribine and prednisolone
    K Sugita
    Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    J Dermatolog Treat 15:214-7. 2004
    ..The skin eruption was improved by this combination with a declined value of circulating anti-desmoglein 1 antibody. Currently, a remission of 2 months has been achieved, and prednisolone could be tapered...
  8. ncbi request reprint Chronic actinic dermatitis associated with adult T-cell leukemia
    Kazunari Sugita
    Department of Dermatology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Am Acad Dermatol 52:38-40. 2005
    ..Our patient suggests that chronic actinic dermatitis may occur in association with the advanced human T-lymphotrophic virus-I infectious disorder...
  9. pmc CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells
    Kenji Kabashima
    Department of Dermatology, University of Environmental and Occupational Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Am J Pathol 171:1249-57. 2007
    ..These findings demonstrated that CXCL12-CXCR4 engagement on cutaneous DCs plays a crucial role in the initiation of skin immune response by enhancing cutaneous DC migration...
  10. ncbi request reprint Cutaneous hypersensitivities to hapten are controlled by IFN-gamma-upregulated keratinocyte Th1 chemokines and IFN-gamma-downregulated langerhans cell Th2 chemokines
    Tomoko Mori
    Department of Dermatology, University of Occupational and Environmental Health, Yahatanishi, Kitakyushu, Japan
    J Invest Dermatol 128:1719-27. 2008
    ..Our study suggests that one of the crucial actions of IFN-gamma is upregulation of keratinocyte production of Th1 chemokines and downregulation of LC production of Th2 chemokines...
  11. doi request reprint A group of atopic dermatitis without IgE elevation or barrier impairment shows a high Th1 frequency: possible immunological state of the intrinsic type
    Rieko Kabashima-Kubo
    Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Dermatol Sci 67:37-43. 2012
    ..Atopic dermatitis (AD) can be classified into the major extrinsic type with high serum IgE levels and impaired barrier, and the minor intrinsic type with normal IgE levels and unimpaired barrier...
  12. doi request reprint The mandatory role of IL-10-producing and OX40 ligand-expressing mature Langerhans cells in local UVB-induced immunosuppression
    Ryutaro Yoshiki
    Department of Dermatology, University of Occupational and Environmental Health, Fukuoka, Japan
    J Immunol 184:5670-7. 2010
    ..These results suggest that IL-10-producing and OX40L-expressing LCs in the UVB-exposed skin are mandatory for the induction of Ag-specific regulatory T cells...
  13. doi request reprint Impaired initiation of contact hypersensitivity by FTY720
    Daiki Nakashima
    Department of Dermatology, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Japan
    J Invest Dermatol 128:2833-41. 2008
    ..FTY720 seems to decrease the incidence of interactions between antigen-loaded dendritic cells and circulating naive T-cell clones in the lymph nodes, thereby depressing the sensitization of naive T cells in CHS...
  14. doi request reprint IL-10-producing Langerhans cells and regulatory T cells are responsible for depressed contact hypersensitivity in grafted skin
    Ryutaro Yoshiki
    Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Invest Dermatol 129:705-13. 2009
    ..These findings suggest that the hyposensitization of CHS through the grafted skin is not attributable merely to the reduction of LC number but that IL-10-producing LCs exert a downmodulatory effect by inducing regulatory T cells...
  15. doi request reprint Combination of skin-directed therapy and oral etoposide for smoldering adult T-cell leukemia/lymphoma with skin involvement
    Yu Sawada
    Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan
    Leuk Lymphoma 54:520-7. 2013
    ..1, p = 0.001; HR 0.2, p = 0.002, respectively). These results suggest that the combination of skin-directed therapy and oral EP improves the clinical outcome of patients with smoldering, skin lesion-bearing ATLL...
  16. ncbi request reprint CXCR4 engagement promotes dendritic cell survival and maturation
    Kenji Kabashima
    Department of Dermatology, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Biochem Biophys Res Commun 361:1012-6. 2007
    ..These findings suggest that CXCL12-CXCR4 engagement enhances DC maturation and survival to initiate acquired immune response...
  17. doi request reprint Alterations of serum Th1 and Th2 chemokines by combination therapy of interferon-gamma and narrowband UVB in patients with mycosis fungoides
    Takatoshi Shimauchi
    Department of Dermatology, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyusyu 807 8555, Japan
    J Dermatol Sci 50:217-25. 2008
    ..Although interferon-gamma (IFN-gamma) administration and narrowband-UVB (NB-UVB) phototherapy are used for the treatment of MF, a combination therapy of these two modalities is not fully established...
  18. ncbi request reprint Nadifloxacin downmodulates antigen-presenting functions of epidermal Langerhans cells and keratinocytes
    Koji Murata
    Department of Dermatology, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J Dermatol Sci 42:91-9. 2006
    ..This drug has been suggested to have not only anti-bacterial but also anti-inflammatory actions, which may have a beneficial effect on some aspects of inflammatory acne...
  19. ncbi request reprint IL-23 from Langerhans Cells Is Required for the Development of Imiquimod-Induced Psoriasis-Like Dermatitis by Induction of IL-17A-Producing γδ T Cells
    Ryutaro Yoshiki
    Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Invest Dermatol 134:1912-21. 2014
    ..Moreover, the IMQ-treated skin of LC-depleted mice showed a decreased number of IL-17A-producing CCR6(+) γδ T cells. These results suggest that LCs are required for the development of psoriasis-like lesions induced by IMQ in mice. ..
  20. ncbi request reprint Augmented expression of programmed death-1 in both neoplastic and non-neoplastic CD4+ T-cells in adult T-cell leukemia/lymphoma
    Takatoshi Shimauchi
    Department of Dermatology, University of Occupational and Environmental Health, Japan, Kitakyusyu, Fukuoka, Japan
    Int J Cancer 121:2585-90. 2007
    ....
  21. doi request reprint Leukaemic cutaneous T-cell lymphoma-manifesting papuloerythroderma with CD3(-) CD4(+) phenotype
    Takatoshi Shimauchi
    Department of Dermatology, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu, 807 8555, Japan
    Acta Derm Venereol 90:68-72. 2010
    ..The unresponsiveness of T cells to the T-cell mitogen may be associated with the non-epidermotropic behaviour of the tumour cells and the initially non-erythrodermic eruption...
  22. ncbi request reprint Primary cutaneous anaplastic large cell lymphoma with fatal leukemic outcome in association with CLA and CCR4-negative conversion
    Yoshiki Tokura
    Department of Dermatology at the University of Occupational and Environmental Health, Kitakyushu, Japan
    J Am Acad Dermatol 57:S92-6. 2007
    ..The altered expression of skin-homing receptors might change its clinical behavior...
  23. doi request reprint Therapeutic effectiveness of various treatments for eosinophilic pustular folliculitis
    Shoko Fukamachi
    Department of Dermatology, University of Environmental and Occupational Health, Kitakyushu, Japan
    Acta Derm Venereol 89:155-9. 2009
    ..In addition to indomethacin or other oral non-steroidal anti-inflammatory drugs, oral cyclosporine and topical tacrolimus may be beneficial choices when patients have been resistant to previous treatments...
  24. pmc Prostaglandin E₂ is critical for the development of niacin-deficiency-induced photosensitivity via ROS production
    Kazunari Sugita
    1 Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan 2 Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Sci Rep 3:2973. 2013
    ..Niacin deficiency-induced photosensitivity was mediated through EP4 signaling in response to increased PGE2 production via induction of ROS formation...
  25. ncbi request reprint Spinal cord compression presumably due to metastasized cutaneous squamous cell carcinoma to the thoracic spine
    Sanehito Haruyama
    Department of Dermatology, School of Medicine, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J UOEH 32:155-9. 2010
    ..Spinal metastasis is one of the items to be kept in mind during the follow-up of patients with cutaneous SCC...
  26. ncbi request reprint [A case of dyshidrosiform pemphigoid]
    Yoko Yamada
    Department of Dermatology, School of Medicine, University of Occupational and Environmental Health, Japan, Yahatanishi ku, Kitakyushu, 807 8555, Japan
    J UOEH 33:183-7. 2011
    ..Although he got better by orally taking steroids, the eruptions recurred just after tapering off. Thereafter, he died due to worsened general condition partly complicated by pancreatitis...
  27. ncbi request reprint Erythema annulare centrifugum associated with herpes zoster
    Shun Ohmori
    Department of Dermatology, School of Medicine, University of Occupational and Environmental Health, Japan
    J UOEH 34:225-9. 2012
    ..An etiologic relationship between EAC and herpes zoster is strongly suggested by the present case and by our review...
  28. ncbi request reprint Alopecia universalis associated with impaired interleukin-4 production and low serum IgE level
    Yoshiki Tokura
    Department of Dermatology at the University of Occupational and Environmental Health, Kitakyushu, Japan
    J Am Acad Dermatol 57:S22-5. 2007
    ..The autoimmune hair loss might occur via activation of cytotoxic T cells and Th(1) cells as a result of a relief from IL-4 control...
  29. doi request reprint Type of skin eruption is an independent prognostic indicator for adult T-cell leukemia/lymphoma
    Yu Sawada
    Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
    Blood 117:3961-7. 2011
    ..The overall survival was worse as the T stage became more advanced: the multipapular type and T2 were comparable, and the purpuric type had a significantly poorer prognosis than T1...
  30. ncbi request reprint The effects of a walking intervention on depressive feelings and social adaptation in healthy workers
    Atsuko Ikenouchi-Sugita
    Department of Psychiatry, University of Occupational and Environmental Health, Japan
    J UOEH 35:1-8. 2013
    ..The walking program improved depressive feelings and social adaptation in the non-exercising group...
  31. doi request reprint Little impact of donor/recipient major mismatch for neutrophil-specific antigen NA2 on neutrophil recovery after allogeneic SCT
    T Inukai
    Department of Paediatrics, School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
    Bone Marrow Transplant 43:229-35. 2009
    ....
  32. ncbi request reprint Fexofenadine downmodulates antigen-presenting ability of murine epidermal Langerhans cells
    Kazunari Sugita
    J Dermatol Sci 49:88-91. 2008
  33. doi request reprint Agaricus blazei Murill augments keratinocyte production of bioactive cytokines capable of promoting antigen-presenting capacity
    Kazunari Sugita
    J Dermatol 35:373-6. 2008
  34. ncbi request reprint A Japanese case of typical epstein-barr virus non-associated subcutaneous panniculitis-like T-cell lymphoma
    Kazunari Sugita
    J Dermatol 31:253-4. 2004
  35. doi request reprint Drug-induced papuloerythroderma of Ofuji: comment
    Kazunari Sugita
    J Dermatol 35:377. 2008