Masahito Shimizu

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Mechanism of retarded liver regeneration in plasminogen activator-deficient mice: impaired activation of hepatocyte growth factor after Fas-mediated massive hepatic apoptosis
    M Shimizu
    Department of Pathology, Gifu University School of Medicine, Gifu, Japan
    Hepatology 33:569-76. 2001
  2. pmc Synergistic Effects of PPARgamma Ligands and Retinoids in Cancer Treatment
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    PPAR Res 2008:181047. 2008
  3. pmc Acyclic retinoid in chemoprevention of hepatocellular carcinoma: Targeting phosphorylated retinoid X receptor-α for prevention of liver carcinogenesis
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine 1 1 Yanagido, Gifu 501 1194, Japan
    J Carcinog 11:11. 2012
  4. pmc Targeting Receptor Tyrosine Kinases for Chemoprevention by Green Tea Catechin, EGCG
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Int J Mol Sci 9:1034-49. 2008
  5. pmc Synergistic growth inhibition by acyclic retinoid and phosphatidylinositol 3-kinase inhibitor in human hepatoma cells
    Atsushi Baba
    Department of Gastroenterology, Gifu University Graduate School of Medicine, Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    BMC Cancer 13:465. 2013
  6. doi request reprint Obesity and hepatocellular carcinoma: targeting obesity-related inflammation for chemoprevention of liver carcinogenesis
    Masahito Shimizu
    Department of Gastroenterology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Semin Immunopathol 35:191-202. 2013
  7. ncbi request reprint Role of acyclic retinoid in the chemoprevention of hepatocellular carcinoma: basic aspects, clinical applications, and future prospects
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, Japan
    Curr Cancer Drug Targets 12:1119-28. 2012
  8. doi request reprint EGCG inhibits activation of the insulin-like growth factor (IGF)/IGF-1 receptor axis in human hepatocellular carcinoma cells
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, Yanagido, Japan
    Cancer Lett 262:10-8. 2008
  9. doi request reprint (-)-Epigallocatechin gallate inhibits growth and activation of the VEGF/VEGFR axis in human colorectal cancer cells
    Masahito Shimizu
    Department of Internal Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Chem Biol Interact 185:247-52. 2010
  10. doi request reprint Acyclic retinoid inhibits diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BLKS/J- +(db)/+Lepr(db) mice
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Cancer Prev Res (Phila) 4:128-36. 2011

Collaborators

Detail Information

Publications80

  1. ncbi request reprint Mechanism of retarded liver regeneration in plasminogen activator-deficient mice: impaired activation of hepatocyte growth factor after Fas-mediated massive hepatic apoptosis
    M Shimizu
    Department of Pathology, Gifu University School of Medicine, Gifu, Japan
    Hepatology 33:569-76. 2001
    ..These results strongly suggest a physiologic role of uPA in the proteolytic maturation of HGF, and thereby in hepatic regeneration after Fas-mediated massive hepatocyte death...
  2. pmc Synergistic Effects of PPARgamma Ligands and Retinoids in Cancer Treatment
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    PPAR Res 2008:181047. 2008
    ....
  3. pmc Acyclic retinoid in chemoprevention of hepatocellular carcinoma: Targeting phosphorylated retinoid X receptor-α for prevention of liver carcinogenesis
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine 1 1 Yanagido, Gifu 501 1194, Japan
    J Carcinog 11:11. 2012
    ..Looking toward the future, we discuss "combination chemoprevention" using ACR as a key drug since it can generate a synergistic effect, and may thus be an effective new strategy for the prevention of HCC...
  4. pmc Targeting Receptor Tyrosine Kinases for Chemoprevention by Green Tea Catechin, EGCG
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Int J Mol Sci 9:1034-49. 2008
    ....
  5. pmc Synergistic growth inhibition by acyclic retinoid and phosphatidylinositol 3-kinase inhibitor in human hepatoma cells
    Atsushi Baba
    Department of Gastroenterology, Gifu University Graduate School of Medicine, Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    BMC Cancer 13:465. 2013
    ..Activation of PI3K/Akt signaling plays a critical role in the proliferation and survival of HCC cells. The present study examined the possible combined effects of ACR and LY294002, a PI3K inhibitor, on the growth of human HCC cells...
  6. doi request reprint Obesity and hepatocellular carcinoma: targeting obesity-related inflammation for chemoprevention of liver carcinogenesis
    Masahito Shimizu
    Department of Gastroenterology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Semin Immunopathol 35:191-202. 2013
    ....
  7. ncbi request reprint Role of acyclic retinoid in the chemoprevention of hepatocellular carcinoma: basic aspects, clinical applications, and future prospects
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, Japan
    Curr Cancer Drug Targets 12:1119-28. 2012
    ..Here, we review the detailed effects of ACR on preventing HCC development, especially based on the results of our basic and clinical research...
  8. doi request reprint EGCG inhibits activation of the insulin-like growth factor (IGF)/IGF-1 receptor axis in human hepatocellular carcinoma cells
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, Yanagido, Japan
    Cancer Lett 262:10-8. 2008
    ..These results provide further evidence that EGCG may be useful in the chemoprevention or treatment of liver cancer...
  9. doi request reprint (-)-Epigallocatechin gallate inhibits growth and activation of the VEGF/VEGFR axis in human colorectal cancer cells
    Masahito Shimizu
    Department of Internal Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Chem Biol Interact 185:247-52. 2010
    ..EGCG may therefore be useful in the chemoprevention and/or treatment of colorectal cancer...
  10. doi request reprint Acyclic retinoid inhibits diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BLKS/J- +(db)/+Lepr(db) mice
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Cancer Prev Res (Phila) 4:128-36. 2011
    ..ACR may be, therefore, useful in the chemoprevention of obesity-related HCC...
  11. ncbi request reprint Chemoprevention of hepatocellular carcinoma by acyclic retinoid
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Front Biosci (Landmark Ed) 16:759-69. 2011
    ..In summary, both basic and clinical research strongly suggest that ACR plays a critical role in preventing the development of HCC and that "clonal deletion" therapy is one of the most practical approaches for this purpose...
  12. doi request reprint Preventive effects of (-)-epigallocatechin gallate on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db Mice
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Cancer Prev Res (Phila) 4:396-403. 2011
    ..EGCG, therefore, may be useful in the chemoprevention of liver tumorigenesis in obese individuals. Cancer Prev Res; 4(3); 396-403. ©2011 AACR...
  13. ncbi request reprint Strategy and mechanism for the prevention of hepatocellular carcinoma: phosphorylated retinoid X receptor alpha is a critical target for hepatocellular carcinoma chemoprevention
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Cancer Sci 100:369-74. 2009
    ..Acyclic retinoid, which targets phosphorylated RXRalpha, may thus play a critical role in preventing the development of multicentric HCC...
  14. doi request reprint (-)-Epigallocatechin gallate suppresses azoxymethane-induced colonic premalignant lesions in male C57BL/KsJ-db/db mice
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Cancer Prev Res (Phila) 1:298-304. 2008
    ..EGCG may be, therefore, useful in the chemoprevention or treatment of obesity-related colorectal cancer...
  15. doi request reprint Supplementation with branched-chain amino acids inhibits azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice
    Masahito Shimizu
    Department of Medicine and Tumor Pathology, Gifu University Graduate School of Medicine, Japan
    Clin Cancer Res 15:3068-75. 2009
    ..The present study examined the effects of BCAA on the development of azoxymethane (AOM)-initiated colonic premalignant lesions in C57BL/KsJ-db/db (db/db) mice that were obese and had hyperinsulinemia...
  16. doi request reprint Cancer chemoprevention with green tea catechins by targeting receptor tyrosine kinases
    Masahito Shimizu
    Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, Japan
    Mol Nutr Food Res 55:832-43. 2011
    ....
  17. pmc Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    BMC Cancer 11:281. 2011
    ..In the present study, we examined the effects of pitavastatin - a drug used for the treatment of hyperlipidemia - on the development of diethylnitrosamine (DEN)-induced liver preneoplastic lesions in C57BL/KsJ-db/db (db/db) obese mice...
  18. doi request reprint Non-alcoholic steatohepatitis and preneoplastic lesions develop in the liver of obese and hypertensive rats: suppressing effects of EGCG on the development of liver lesions
    Takahiro Kochi
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Cancer Lett 342:60-9. 2014
    ..EGCG might also be able to prevent NASH-related liver fibrosis and tumorigenesis. ..
  19. ncbi request reprint Pitavastatin inhibits azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice
    Yoichi Yasuda
    Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Cancer Sci 101:1701-7. 2010
    ..Therefore, some types of statins, including pitavastatin, may be a useful chemoprevention modality for colon cancer in obese individuals...
  20. doi request reprint Serum level of soluble tumor necrosis factor receptor 2 is associated with the outcome of patients with diffuse large B-cell lymphoma treated with the R-CHOP regimen
    Nobuhiko Nakamura
    First Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Eur J Haematol 91:322-31. 2013
    ..However, after rituximab (R) was introduced in clinical practice, R-CHOP replaced CHOP as the standard therapy for DLBCL...
  21. doi request reprint Preventive effects of curcumin on the development of azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db obese mice
    Masaya Kubota
    Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Nutr Cancer 64:72-9. 2012
    ..Curcumin may be useful in the chemoprevention of colorectal carcinogenesis in obese individuals...
  22. doi request reprint (-)-Epigallocatechin gallate suppresses the growth of human hepatocellular carcinoma cells by inhibiting activation of the vascular endothelial growth factor-vascular endothelial growth factor receptor axis
    Yohei Shirakami
    Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Cancer Sci 100:1957-62. 2009
    ..These findings suggest that EGCG can exert, at least in part, its growth-inhibitive effect on HCC cells by inhibiting the VEGF-VEGFR axis. EGCG might therefore be useful in the treatment of HCC...
  23. doi request reprint Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice
    Junpei Iwasa
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Cancer Sci 101:460-7. 2010
    ..In conclusion, oral BCAA supplementation improves insulin resistance and prevents the development of liver tumorigenesis in obese and diabetic mice...
  24. doi request reprint Preventive effects of branched-chain amino acid supplementation on the spontaneous development of hepatic preneoplastic lesions in C57BL/KsJ-db/db obese mice
    Daishi Terakura
    Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Carcinogenesis 33:2499-506. 2012
    ..BCAA supplementation may be useful in the chemoprevention of liver tumorigenesis in obese individuals...
  25. pmc Enhanced development of azoxymethane-induced colonic preneoplastic lesions in hypertensive rats
    Takahiro Kochi
    Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Int J Mol Sci 14:14700-11. 2013
    ..Our findings suggest that hypertension plays a role in the early stage of colorectal carcinogenesis by inducing oxidative stress and chronic inflammation, which might be associated with activation of the renin-angiotensin system. ..
  26. doi request reprint Serum soluble interleukin-2 receptor (sIL-2R) level is associated with the outcome of patients with diffuse large B cell lymphoma treated with R-CHOP regimens
    Naoe Goto
    First Department of Internal Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Ann Hematol 91:705-14. 2012
    ..0316) were independent prognostic factors for progression-free survival in sIL-2R and every factor of the International Prognostic Index. Serum sIL-2R might be a useful prognostic factor for DLBCL patients in the rituximab era...
  27. doi request reprint A phase II study of rituximab combined with pirarubicin-cyclophosphamide, vincristine and prednisolone regimen as first-line therapy for patients with indolent B-cell lymphoma
    Hisashi Tsurumi
    First Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Leuk Lymphoma 53:247-53. 2012
    ..The present results indicate the need for randomized trials of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone) and R-THP-COP among patients with CD20-positive indolent lymphoma...
  28. doi request reprint Serum soluble CD27 level is associated with outcome in patients with diffuse large B-cell lymphoma treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone
    Naoe Goto
    First Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Leuk Lymphoma 53:1494-500. 2012
    ..6 U/mL and 109.9 U/mL, respectively (p =0.004). Thus, serum sCD27 level is associated with CD27 expression on lymphoma cells, and may be a powerful prognostic factor for DLBCL...
  29. ncbi request reprint Acyclic retinoid synergises with valproic acid to inhibit growth in human hepatocellular carcinoma cells
    Hideharu Tatebe
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Cancer Lett 285:210-7. 2009
    ..This combination might therefore be an effective regimen for the chemoprevention and chemotherapy of HCC...
  30. doi request reprint Serum interleukin-18 level is associated with the outcome of patients with diffuse large B-cell lymphoma treated with CHOP or R-CHOP regimens
    Naoe Goto
    First Department of Internal Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagi do, Gifu, Japan
    Eur J Haematol 87:217-27. 2011
    ..When rituximab (R) was added to this regimen, the prognosis of diffuse large B-cell lymphoma (DLBCL) was markedly improved...
  31. doi request reprint Synergistic growth inhibition in HL-60 cells by the combination of acyclic retinoid and vitamin K2
    Junichi Kitagawa
    First Department of Internal Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, 501 1194, Japan
    J Cancer Res Clin Oncol 137:779-87. 2011
    ..The aim of this study was to assess the effects of acyclic retinoid (ACR) and vitamin K(2) (VK(2)) in HL-60 cells...
  32. doi request reprint Synergistic growth inhibition by 9-cis-retinoic acid plus trastuzumab in human hepatocellular carcinoma cells
    Hideharu Tatebe
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Clin Cancer Res 14:2806-12. 2008
    ..In this study, the effects of phosphorylation of RXRalpha on the ability of RXRalpha ligand 9-cis-retinoic acid (9cRA) and trastuzumab to inhibit growth of HCC cells was examined...
  33. ncbi request reprint A phase II study of a THP-COP regimen for the treatment of elderly patients aged 70 years or older with diffuse large B-cell lymphoma
    Hisashi Tsurumi
    First Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    Hematol Oncol 25:107-14. 2007
    ..The present findings indicate the necessity of future studies investigating a combination therapy comprised of rituximab and THP-COP for the treatment of elderly patients with CD20-positive DLBCL...
  34. doi request reprint Suppression of azoxymethane-induced colonic preneoplastic lesions in rats by 1-methyltryptophan, an inhibitor of indoleamine 2,3-dioxygenase
    Kengo Ogawa
    First Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Cancer Sci 103:951-8. 2012
    ....
  35. pmc Cisplatin and ultra-violet-C synergistically down-regulate receptor tyrosine kinases in human colorectal cancer cells
    Junji Kawaguchi
    Departments of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Mol Cancer 11:45. 2012
    ....
  36. pmc Synergistic effects of RXR alpha and PPAR gamma ligands to inhibit growth in human colon cancer cells--phosphorylated RXR alpha is a critical target for colon cancer management
    Kenji Yamazaki
    Department of Medicine, Gifu University School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Gut 56:1557-63. 2007
    ..In this study the effects of p-RXR alpha on the ability of RXR alpha and PPAR gamma ligands to inhibit growth in colon cancer cells was examined...
  37. ncbi request reprint Expression of retinoid X receptor alpha is decreased in 3'-methyl-4-dimethylaminoazobenzene-induced hepatocellular carcinoma in rats
    Nobuhiro Ando
    Department of Medicine, Gifu University School of Medicine, Gifu 501 1194, Japan
    Oncol Rep 18:879-84. 2007
    ....
  38. doi request reprint Indoleamine 2,3-dioxygenase in tumor tissue indicates prognosis in patients with diffuse large B-cell lymphoma treated with R-CHOP
    Soranobu Ninomiya
    First Department of Internal Medicine, Gifu University Graduate School of Medicine, and Gifu Municipal Hospital, 1 1 Yanagido, Gifu, 501 1194, Japan
    Ann Hematol 90:409-16. 2011
    ..IDO might represent a candidate therapeutic target for DLBCL patients who show resistance to chemotherapy...
  39. doi request reprint Endoscopic ultrasound-guided fine needle aspiration biopsy for diagnosis of lymphoproliferative disorders: feasibility of immunohistological, flow cytometric, and cytogenetic assessments
    Ichiro Yasuda
    First Department of Internal Medicine, Gifu University Hospital, Gifu, Japan
    Am J Gastroenterol 107:397-404. 2012
    ....
  40. doi request reprint (-)-Epigallocatechin gallate downregulates EGF receptor via phosphorylation at Ser1046/1047 by p38 MAPK in colon cancer cells
    Seiji Adachi
    Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Carcinogenesis 30:1544-52. 2009
    ..Taken together, our results strongly suggest that phosphorylation of EGFR at serine 1046/1047 via activation of p38 MAPK plays a pivotal role in EGCG-induced downregulation of EGFR in colon cancer cells...
  41. doi request reprint Renin-angiotensin system inhibitors suppress azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice
    Masaya Kubota
    Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Biochem Biophys Res Commun 410:108-13. 2011
    ..Therefore, targeting dysregulation of the RAS might be an effective strategy for chemoprevention of colorectal carcinogenesis in obese individuals...
  42. doi request reprint (-)-Epigallocatechin gallate prevents carbon tetrachloride-induced rat hepatic fibrosis by inhibiting the expression of the PDGFRbeta and IGF-1R
    Yoichi Yasuda
    Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Chem Biol Interact 182:159-64. 2009
    ..These findings suggest that EGCG can exert, at least in part, an anti-fibrotic effect on the liver by targeting PDGFRbeta and IGF-1R. EGCG might therefore be useful in both the prevention and treatment of hepatic fibrosis...
  43. pmc Effects of indoleamine 2,3-dioxygenase deficiency on high-fat diet-induced hepatic inflammation
    Junji Nagano
    Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    PLoS ONE 8:e73404. 2013
    ..Therefore, IDO may have a protective effect against hepatic fibrosis, at least in this HFD-induced liver injury model. ..
  44. doi request reprint Serum-soluble interleukin-2 receptor (sIL-2R) is an extremely strong prognostic factor for patients with peripheral T-cell lymphoma, unspecified (PTCL-U)
    Jun Ichi Kitagawa
    First Department of Internal Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, 501 1194, Japan
    J Cancer Res Clin Oncol 135:53-9. 2009
    ..The aim of this study was to assess the prognostic factors of peripheral T-cell lymphoma, unspecified (PTCL-U)...
  45. ncbi request reprint Fas and Fas ligand expression on germinal center type-diffuse large B-cell lymphoma is associated with the clinical outcome
    Yasushi Kojima
    First Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Eur J Haematol 76:465-72. 2006
    ..In the GC type, Fas and FasL expressions were significantly associated with a favorable overall survival (Fas: P < 0.005; FasL: P < 0.05). Hence, Fas or FasL expression might contribute to a better prognosis of this type of DLBCL...
  46. doi request reprint Possible role of visfatin in hepatoma progression and the effects of branched-chain amino acids on visfatin-induced proliferation in human hepatoma cells
    Soranobu Ninomiya
    Department of Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Cancer Prev Res (Phila) 4:2092-100. 2011
    ..In addition, BCAA might inhibit obesity-related liver carcinogenesis by targeting and, possibly, by overcoming the stimulatory effects of visfatin...
  47. pmc Ultraviolet irradiation can induce evasion of colon cancer cells from stimulation of epidermal growth factor
    Seiji Adachi
    Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    J Biol Chem 286:26178-87. 2011
    ..Hence, UV-C might be applied for clinical strategy against human colon cancers...
  48. doi request reprint Monosodium glutamate-induced diabetic mice are susceptible to azoxymethane-induced colon tumorigenesis
    Kazuya Hata
    Department of Tumor Pathology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Carcinogenesis 33:702-7. 2012
    ....
  49. ncbi request reprint Phosphorylated retinoid X receptor alpha loses its heterodimeric activity with retinoic acid receptor beta
    Kotaro Yoshimura
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu, 501 1194, Japan
    Cancer Sci 98:1868-74. 2007
    ..In conclusion, the inhibition of RXRalpha phosphorylation and the restoration of its original function as a master regulator of nuclear receptors might therefore be an effective strategy for controlling cancer cell growth...
  50. doi request reprint Efficacy and safety of micafungin for treating febrile neutropenia in hematological malignancies
    Naoe Goto
    First Department of Internal Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, Japan
    Am J Hematol 85:872-6. 2010
    ..Plasma levels of micafungin and the degree of hepatic or renal dysfunction did not correlate. Micafungin is safe and effective for the empirical antifungal therapy of febrile neutropenia in patients with hematological malignancies...
  51. ncbi request reprint Retinoid X receptor alpha is highly phosphorylated in retinoic acid-resistant HL-60R cells and the combination of 9-cis retinoic acid plus MEK inhibitor induces apoptosis in the cells
    Nobuhiro Kanemura
    First Department of Internal Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Leuk Res 32:884-92. 2008
    ..Moreover, the combination of those agents induced apoptosis in HL-60R cells. Phosphorylation of RXR alpha might be associated with RA-resistance in HL-60R cells...
  52. ncbi request reprint Serum-soluble tumor necrosis factor receptor 2 (sTNF-R2) level determines clinical outcome in patients with aggressive non-Hodgkin's lymphoma
    Naoe Goto
    First Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    Eur J Haematol 77:217-25. 2006
    ..The aim of the present study was to assess the prognostic significance of serum soluble tumor necrosis factor receptor (sTNF-R) 2 in aggressive NHL...
  53. ncbi request reprint Cell cycle-dependent priming action of granulocyte colony-stimulating factor (G-CSF) enhances in vitro apoptosis induction by cytarabine and etoposide in leukemia cell lines
    Junichi Kitagawa
    First Department of Internal Medicine, Gifu University Graduate School of Medicine, Japan
    J Clin Exp Hematop 50:99-105. 2010
    ..It was thought that this difference was a result of different responses to G-CSF. G-CSF potentiates Ara-C- and VP-16-induced cytotoxicities through apoptosis induction by mobilizing resting G0-G1-phase cells into S phase...
  54. doi request reprint Synergistic effects of acyclic retinoid and gemcitabine on growth inhibition in pancreatic cancer cells
    Takayuki Nakagawa
    Department of Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Cancer Lett 273:250-6. 2009
    ..These results suggest that the combination of ACR plus gemcitabine may therefore be an effective regimen for the chemotherapy of pancreatic cancer...
  55. ncbi request reprint Synergistic growth inhibition by acyclic retinoid and vitamin K2 in human hepatocellular carcinoma cells
    Toh Kanamori
    Department of Medicine, Gifu University School of Medicine, Gifu, Japan
    Cancer Sci 98:431-7. 2007
    ..This combination might therefore be effective for the chemoprevention and chemotherapy of HCC...
  56. ncbi request reprint Impact of serum chemerin levels on liver functional reserves and platelet counts in patients with hepatocellular carcinoma
    Kenji Imai
    Department of Gastroenterology Internal Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Int J Mol Sci 15:11294-306. 2014
    ..3691) or overall survival (p = 0.7916). In HCC patients, serum chemerin concentrations were correlated with liver functional reserves and platelet counts, but not with recurrence or prognosis. ..
  57. ncbi request reprint Continuous drip infusion of low dose cytarabine and etoposide with granulocyte colony-stimulating factor for elderly patients with acute myeloid leukaemia ineligible for intensive chemotherapy
    Nobuhiro Kanemura
    First Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    Hematol Oncol 26:33-8. 2008
    ..We initiated the present feasibility study to improve the efficacy by using glanulocyte-colony stimulating factor (G-CSF) with AV therapy (AVG therapy)...
  58. doi request reprint Comparison of long-term outcomes after endoscopic sphincterotomy versus endoscopic papillary balloon dilation: a propensity score-based cohort analysis
    Shinpei Doi
    First Department of Internal Medicine, Gifu University Hospital, 1 1 Yanagido, Gifu, 501 1194, Japan
    J Gastroenterol 48:1090-6. 2013
    ..This study aimed to compare the long-term outcomes of patients with CBDS treated with ES to those treated with EPBD in a large cohort. In addition, a subgroup analysis was performed, according to gallbladder (GB) status...
  59. doi request reprint Clinical significance of jejunoileal involvement of non-Hodgkin's lymphoma detected by double-balloon enteroscopy
    Takashi Ibuka
    First Department of Internal Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, 501 1194, Japan
    Int J Hematol 97:369-81. 2013
    ..92 %, p < 0.005). Four participants developed aspiration pneumonia, but recovered after treatment with antibiotics...
  60. doi request reprint Elevated serum tumor necrosis factor-alpha and soluble tumor necrosis factor receptors correlate with aberrant energy metabolism in liver cirrhosis
    Makoto Shiraki
    Department of Internal Medicine, Gifu University School of Medicine, Yanagido, Gifu, Japan
    Nutrition 26:269-75. 2010
    ..Tumor necrosis factor-alpha (TNF-alpha) is elevated in those patients and may contribute to the alterations of energy metabolism. Our aim was to characterize the aberrant energy metabolism in cirrhotic patients with regard to TNF-alpha...
  61. doi request reprint Hepatocellular carcinoma patients with increased oxidative stress levels are prone to recurrence after curative treatment: a prospective case series study using the d-ROM test
    Yusuke Suzuki
    Department of Gastroenterology, Gifu Municipal Hospital, Gifu, Japan
    J Cancer Res Clin Oncol 139:845-52. 2013
    ..To determine the impact of oxidative stress on the recurrence of stage I/II hepatocellular carcinoma (HCC) after curative treatment, we conducted a prospective case series analysis...
  62. doi request reprint Pharmaceutical and nutraceutical approaches for preventing liver carcinogenesis: chemoprevention of hepatocellular carcinoma using acyclic retinoid and branched-chain amino acids
    Masahito Shimizu
    Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, Japan
    Mol Nutr Food Res 58:124-35. 2014
    ..These findings suggest that pharmaceutical and nutraceutical approaches using ACR and BCAA may be promising strategies for preventing HCC and improving the prognosis of this malignancy. ..
  63. ncbi request reprint [A case of acute autoimmune hepatitis associated with autoimmune hemolytic anemia]
    Tatsunori Hanai
    Department of Gastroenterology, Gifu University School of Medicine
    Nihon Shokakibyo Gakkai Zasshi 110:1814-22. 2013
    ..Although AIH occurs in association with various immunological disorders, an association with AIHA is rarely reported. We report a rare case of severe AIH associated with AIHA. ..
  64. ncbi request reprint Cancer chemoprevention with green tea catechins: from bench to bed
    Yohei Shirakami
    Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, Japan
    Curr Drug Targets 13:1842-57. 2012
    ..This review article analyzes the results of these studies to explicate the effects of consumption or administration of green tea and its constituents on malignancies observed to date and discuss future directions in this research field...
  65. pmc Diagnosis of the jejunoileal lymphoma by double-balloon endoscopy
    Takashi Ibuka
    Takashi Ibuka, Hiroshi Araki, Tomohiko Sugiyama, Takayuki Nakanishi, Fumito Onogi, Masahito Shimizu, Takeshi Hara, Hisashi Tsurumi, Hisataka Moriwaki, First Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    World J Gastrointest Endosc 5:111-6. 2013
    ..To investigate the feasibility of double-balloon endoscopy (DBE) to detect jejunoileal lymphoma, compared with fluorodeoxyglucose positron emission tomography (FDG-PET)...
  66. doi request reprint Combination of acyclic retinoid with branched-chain amino acids inhibits xenograft growth of human hepatoma cells in nude mice
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Hepatol Res 42:1241-7. 2012
    ..Therefore, this combination might be an effective regimen for the treatment and, probably, chemoprevention of HCC...
  67. doi request reprint Endoscopic ultrasound-guided fine-needle aspiration of lesions near the aortoiliac bifurcation via an upper gastrointestinal approach
    Shinpei Doi
    First Department of Internal Medicine, Gifu University Hospital, Gifu, Japan
    J Gastroenterol Hepatol 26:1717-20. 2011
    ..This study aimed to determine the feasibility of using EUS-guided FNA to study lesions near the aortoiliac bifurcation via the upper gastrointestinal approach...
  68. ncbi request reprint [Chemoprevention of hepatocellular carcinoma by acyclic retinoid]
    Masahito Nagaki
    Department of Gastroenterology, Gifu University Graduate School of Medicine
    Nihon Shokakibyo Gakkai Zasshi 105:802-7. 2008
  69. pmc C57BL/KsJ-db/db-Apc mice exhibit an increased incidence of intestinal neoplasms
    Kazuya Hata
    Department of Tumor Pathology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan E Mails T K A H Y H
    Int J Mol Sci 12:8133-45. 2011
    ..Our results thus suggested that the db/db-Min/+ mice should be invaluable for studies on the pathogenesis of CRC in obese and diabetes patients and the therapy and prevention of CRC in these patients...
  70. doi request reprint Green tea extracts for the prevention of metachronous colorectal adenomas: a pilot study
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Cancer Epidemiol Biomarkers Prev 17:3020-5. 2008
    ..5 g GTE) daily to > or = 10 cups equivalent (2.5 g GTE) by supplemental GTE tablets...
  71. ncbi request reprint Long-term outcome of branched-chain amino acid treatment in patients with liver cirrhosis
    Hisataka Moriwaki
    Department of Internal Medicine, Gifu University School of Medicine
    Hepatol Res 38:S102-6. 2008
    ....
  72. doi request reprint Genetic ablation of Tnfalpha demonstrates no detectable suppressive effect on inflammation-related mouse colon tumorigenesis
    Hiroyasu Sakai
    Department of Tumor Pathology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Chem Biol Interact 184:423-30. 2010
    ..Our observations suggest that intricate inflammatory responses promote the inflammation-related mouse colon tumorigenesis...
  73. pmc Increased levels of serum leptin are a risk factor for the recurrence of stage I/II hepatocellular carcinoma after curative treatment
    Naoki Watanabe
    Department of Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    J Clin Biochem Nutr 49:153-8. 2011
    ..0221). These results suggest that the serum leptin level is a useful biomarker for predicting the early recurrence of hepatocellular carcinoma...
  74. ncbi request reprint EGCG and Polyphenon E attenuate inflammation-related mouse colon carcinogenesis induced by AOM plus DDS
    Yohei Shirakami
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Mol Med Report 1:355-61. 2008
    ..Our findings provide evidence that tea catechins are beneficial to the suppression of cancer development in the inflamed colon...
  75. pmc Nutraceutical approach for preventing obesity-related colorectal and liver carcinogenesis
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan E Mails M K H M
    Int J Mol Sci 13:579-95. 2012
    ....
  76. ncbi request reprint No involvement of beta-catenin gene mutation in gastric carcinomas induced by N-methyl-N-nitrosourea in male F344 rats
    Masahito Shimizu
    Department of Pathology, Gifu University School of Medicine, 40 Tsukasa Machi, Japan
    Cancer Lett 195:147-52. 2003
    ..This animal model may provide a system for evaluating the mechanism of human gastric carcinogenesis that is not associated with beta-catenin gene mutations...
  77. ncbi request reprint Chemoprevention of liver carcinogenesis with retinoids: Basic and clinical aspects
    Hisataka Moriwaki
    Department of Gastroenterology, Gifu University School of Medicine, Gifu, Japan
    Hepatol Res 37:S299-302. 2007
    ..In this article, clinical trials of retinoid analog to inhibit second primary hepatoma, supposed molecular mechanism of the action of the compound, and aberrant metabolism of RXR and its role in liver carcinogenesis are briefly reviewed...
  78. ncbi request reprint A prospective study of P-IMVP-16/CBDCA: a novel salvage chemotherapy for patients with aggressive non-Hodgkin's lymphoma who had previously received CHOP therapy as first-line chemotherapy
    Michio Sawada
    First Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    Eur J Haematol 68:354-61. 2002
    ..Salvage chemotherapy with P-IMVP-16/CBDCA is not sufficient to cure relapsed or refractory aggressive NHL. Aggressive NHL should be cured by first-line chemotherapy with or without hematopoietic stem cell transplantation...
  79. ncbi request reprint Chemopreventive effect of N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide (NS-398), a selective cyclooxygenase-2 inhibitor, in rat colon carcinogenesis induced by azoxymethane
    N Yoshimi
    Department of Pathology, Gifu University School of Medicine
    Jpn J Cancer Res 90:406-12. 1999
    ..03+/-0.82) (P<0.001 by Welch's method). The results suggest that NS-398, a selective COX inhibitor, has a chemopreventive activity against colon carcinogenesis without side-effects such as gastric ulceration...
  80. ncbi request reprint Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary zerumbone isolated from Zingiber zerumbet
    T Tanaka
    Department of Pathology, Kanazawa Medical University, Ishikawa, Japan
    Life Sci 69:1935-45. 2001
    ....