Makoto Shimizu

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Food-derived peptides and intestinal functions
    Makoto Shimizu
    Department of Applied Biological Chemistry, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Biofactors 21:43-7. 2004
  2. ncbi request reprint Induction of nitric oxide synthase and subsequent production of nitric oxide not involved in interferon-gamma-induced hyperpermeability of Caco-2 intestinal epithelial monolayers
    M Satake
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Biosci Biotechnol Biochem 65:428-30. 2001
  3. ncbi request reprint Food-derived peptides and intestinal functions
    Makoto Shimizu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo, Japan
    Curr Pharm Des 13:885-95. 2007
  4. ncbi request reprint Interaction between food substances and the intestinal epithelium
    Makoto Shimizu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Biosci Biotechnol Biochem 74:232-41. 2010
  5. pmc In vitro System for Assessing Dioxin Absorption by Intestinal Epithelial Cells and for Preventing this Absorption by Food Substances
    Yayoi Natsume
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, 113 8657, Tokyo, Bunkyo ku, Japan
    Cytotechnology 47:79-88. 2005
  6. ncbi request reprint Dietary taurine attenuates dextran sulfate sodium (DSS)-induced experimental colitis in mice
    Makoto Shimizu
    Department of Applied Biological Chemistry, The University of Tokyo, Tokyo, Japan
    Adv Exp Med Biol 643:265-71. 2009
  7. ncbi request reprint A bitter melon extract inhibits the P-glycoprotein activity in intestinal Caco-2 cells: monoglyceride as an active compound
    Tomoko Konishi
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biofactors 22:71-4. 2004
  8. ncbi request reprint Induction by activated macrophage-like THP-1 cells of apoptotic and necrotic cell death in intestinal epithelial Caco-2 monolayers via tumor necrosis factor-alpha
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Exp Cell Res 312:3909-19. 2006
  9. ncbi request reprint Regulation of the human taurine transporter by TNF-alpha and an anti-inflammatory function of taurine in human intestinal Caco-2 cells
    Tetsunosuke Mochizuki
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 8657, Japan
    Biofactors 21:141-4. 2004
  10. ncbi request reprint The peroxisome proliferator-activated receptor gamma regulates expression of the perilipin gene in adipocytes
    Naoto Arimura
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Biol Chem 279:10070-6. 2004

Detail Information

Publications95

  1. ncbi request reprint Food-derived peptides and intestinal functions
    Makoto Shimizu
    Department of Applied Biological Chemistry, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Biofactors 21:43-7. 2004
    ..Understanding the behavior of dietary proteins and peptides in the intestines is important for designing functional foods with physiological functions...
  2. ncbi request reprint Induction of nitric oxide synthase and subsequent production of nitric oxide not involved in interferon-gamma-induced hyperpermeability of Caco-2 intestinal epithelial monolayers
    M Satake
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Biosci Biotechnol Biochem 65:428-30. 2001
    ..Therefore, IFN-gamma-induced hyperpermeability is not due to its induction of iNOS activity and resulting increases in NO levels...
  3. ncbi request reprint Food-derived peptides and intestinal functions
    Makoto Shimizu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo, Japan
    Curr Pharm Des 13:885-95. 2007
    ..These intestine-modulatory peptides would be useful as ingredients of future functional foods to prevent lifestyle-related diseases and promote gut health...
  4. ncbi request reprint Interaction between food substances and the intestinal epithelium
    Makoto Shimizu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Biosci Biotechnol Biochem 74:232-41. 2010
    ..Modulation of the intestinal functions by dietary substances is therefore essential to promote health...
  5. pmc In vitro System for Assessing Dioxin Absorption by Intestinal Epithelial Cells and for Preventing this Absorption by Food Substances
    Yayoi Natsume
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, 113 8657, Tokyo, Bunkyo ku, Japan
    Cytotechnology 47:79-88. 2005
    ..The system will therefore be useful to identify food substances having a preventive effect on the intestinal absorption of dioxins...
  6. ncbi request reprint Dietary taurine attenuates dextran sulfate sodium (DSS)-induced experimental colitis in mice
    Makoto Shimizu
    Department of Applied Biological Chemistry, The University of Tokyo, Tokyo, Japan
    Adv Exp Med Biol 643:265-71. 2009
    ..Inhibition of chemokine secretion from intestinal cells may be involved in the mechanisms underlying the cytoprotective function of taurine in the intestinal epithelium...
  7. ncbi request reprint A bitter melon extract inhibits the P-glycoprotein activity in intestinal Caco-2 cells: monoglyceride as an active compound
    Tomoko Konishi
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biofactors 22:71-4. 2004
    ..It is interesting that certain types of monoglyceride might be involved in the drug bioavailability by specifically inhibiting the efflux mediated by P-gp...
  8. ncbi request reprint Induction by activated macrophage-like THP-1 cells of apoptotic and necrotic cell death in intestinal epithelial Caco-2 monolayers via tumor necrosis factor-alpha
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Exp Cell Res 312:3909-19. 2006
    ....
  9. ncbi request reprint Regulation of the human taurine transporter by TNF-alpha and an anti-inflammatory function of taurine in human intestinal Caco-2 cells
    Tetsunosuke Mochizuki
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 8657, Japan
    Biofactors 21:141-4. 2004
    ..The result shows that taurine significantly repressed the damage to Caco-2 cells caused by TNF-alpha secreted by THP-1 cells. Thus, taurine may be a useful substance against intestinal inflammation...
  10. ncbi request reprint The peroxisome proliferator-activated receptor gamma regulates expression of the perilipin gene in adipocytes
    Naoto Arimura
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Biol Chem 279:10070-6. 2004
    ....
  11. doi request reprint Inhibitory effect of carnosine on interleukin-8 production in intestinal epithelial cells through translational regulation
    Dong Ok Son
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Cytokine 42:265-76. 2008
    ..These results suggest that carnosine is a novel type of anti-inflammatory agent that down-regulates the inflammatory response in intestinal epithelial cells by a unique mechanism...
  12. ncbi request reprint Suppressive effect of an isoflavone fraction on tumor necrosis factor-alpha-induced interleukin-8 production in human intestinal epithelial Caco-2 cells
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Nutr Sci Vitaminol (Tokyo) 55:442-6. 2009
    ....
  13. ncbi request reprint Assessment system for dioxin absorption in the small intestine and prevention of its absorption by food factors
    Yayoi Natsume
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biofactors 21:375-7. 2004
    ..This assessment system would be useful to search for those food factors that could prevent dioxin absorption in the small intestine...
  14. doi request reprint Resveratrol increases the expression and activity of the low density lipoprotein receptor in hepatocytes by the proteolytic activation of the sterol regulatory element-binding proteins
    Takuya Yashiro
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo, Tokyo 113 8657, Japan
    Atherosclerosis 220:369-74. 2012
    ..The present study was conducted to investigate the effects of grape polyphenols on LDLR gene expression in human hepatocyte models...
  15. ncbi request reprint Development of the method for evaluating protective effect of food factors on THP-1-induced damage to human intestinal Caco-2 monolayers
    Fumiko Watanabe
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biofactors 21:145-7. 2004
    ..The disruption of the Caco-2 cell monolayers was significantly reduced by adding caffeine to the medium on the apical side. It is hoped that this coculture system will be a good model for the treatment of IBD...
  16. doi request reprint Activation of pregnane X receptor and induction of MDR1 by dietary phytochemicals
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Agric Food Chem 56:5366-73. 2008
    ..These findings strongly suggest that tangeretin and ginkgolides A and B activated PXR, thereby regulating detoxification enzymes and transporters in the intestines...
  17. ncbi request reprint Bile acid reduces the secretion of very low density lipoprotein by repressing microsomal triglyceride transfer protein gene expression mediated by hepatocyte nuclear factor-4
    Hisako Hirokane
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    J Biol Chem 279:45685-92. 2004
    ..These results indicate that two nuclear receptors, HNF-4 and FXR, are closely involved in MTP gene expression, and the results provide evidence for a novel interaction between bile acids and lipoprotein metabolism...
  18. ncbi request reprint Physiological significance of the taurine transporter and taurine biosynthetic enzymes in 3T3-L1 adipocytes
    Masakazu Takasaki
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biofactors 21:419-21. 2004
    ..These results suggest that murine TAUT and CDO were cooperatively regulated in response to hypertonicity and taurine-rich conditions...
  19. ncbi request reprint Disaccharide derived from chondroitin sulfate A suppressed CpG-induced IL-6 secretion in macrophage-like J774.1 cells
    Miao Jin
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Cytokine 51:53-9. 2010
    ..Oligosaccharides derived from chondroitin sulfates would be effective suppressing agents for the TLR9-mediated inflammation reaction...
  20. ncbi request reprint Cycloheximide treatment induces the uptake of neutral and dibasic amino acids via the activation of system b(0,+) in human intestinal Caco-2 cells
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Nutr Sci Vitaminol (Tokyo) 55:44-51. 2009
    ..These results strongly suggest that the CHX treatment increased the Leu and Lys uptake by activating system b(0,+) and inducing rBAT and b(0,+) AT mRNA expression in human intestinal epithelial Caco-2 cells...
  21. doi request reprint Metabolites of galangin by 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P450 1A1 in human intestinal epithelial Caco-2 cells and their antagonistic activity toward aryl hydrocarbon receptor
    Mika Hamada
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Agric Food Chem 58:8111-8. 2010
    ..Therefore, the oxidative metabolism of galangin to kaempferol in TCDD-pretreated Caco-2 cells implicated reduction in the inhibitory activity of galangin...
  22. ncbi request reprint Signaling pathways involved in tumor necrosis factor alpha-induced upregulation of the taurine transporter in Caco-2 cells
    Tetsunosuke Mochizuki
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    FEBS Lett 579:3069-74. 2005
    ..An electrophoretic mobility shift assay showed that NF-kappaB could bind to the NF-kappaB consensus-like sequence. The anti-TNF receptor 1 (TNFR1) antibody, but not the TNF receptor 2 (TNFR2) antibody, repressed this upregulation...
  23. ncbi request reprint Histidine inhibits oxidative stress- and TNF-alpha-induced interleukin-8 secretion in intestinal epithelial cells
    Dong Ok Son
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    FEBS Lett 579:4671-7. 2005
    ....
  24. ncbi request reprint Cadmium induces interleukin-8 production via NF-kappaB activation in the human intestinal epithelial cell, Caco-2
    Ja Shil Hyun
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, Japan
    Cytokine 37:26-34. 2007
    ..Our results suggest that CdCl2 induced IL-8 secretion, its transcription, and its transcriptional activation regulated by NF-kappaB via I-kappaB alpha degradation...
  25. doi request reprint 5-caffeoylquinic acid and caffeic acid down-regulate the oxidative stress- and TNF-alpha-induced secretion of interleukin-8 from Caco-2 cells
    Zhaohui Zhao
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Agric Food Chem 56:3863-8. 2008
    ..These results suggest that the habit of drinking coffee and/or eating fruits with a high CHA content may be beneficial to humans in preventing the genesis of inflammatory bowel diseases...
  26. pmc Functional characterization and regulation of the taurine transporter and cysteine dioxygenase in human hepatoblastoma HepG2 cells
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biochem J 375:441-7. 2003
    ..Generally, the TAUT and taurine biosynthetic enzymes have independent regulatory systems, but under certain conditions, they could be regulated in harmony with each other...
  27. ncbi request reprint Induction of NAD(P)H:quinone oxidoreductase 1 expression by cysteine via Nrf2 activation in human intestinal epithelial LS180 cells
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Amino Acids 43:1547-555. 2012
    ..These findings show that cysteine induces NQO1 expression in both in vitro and in vivo systems and also suggest that Nrf2 activation is involved in this induction...
  28. ncbi request reprint Permeation of disaccharides derived from chondroitin sulfate through human intestinal Caco-2 cell monolayers via the paracellular pathway
    Miao Jin
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Biosci Biotechnol Biochem 74:1243-9. 2010
    ....
  29. ncbi request reprint Effects of chondroitin sulfate and its oligosaccharides on toll-like receptor-mediated IL-6 secretion by macrophage-like J774.1 cells
    Miao Jin
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Biosci Biotechnol Biochem 75:1283-9. 2011
    ..The suppressing activity of oligo-CSs, particularly Di-CSs, against TLR-mediated inflammation was dependent on the CS structure, including the sulfation site...
  30. ncbi request reprint Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes
    Koichi Misawa
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    J Biol Chem 278:36176-82. 2003
    ..These data provide a novel pathway by which HNF-4 potentiates the SREBP functions and stimulates expression of SREBP-responsive genes in enterohepatic cells...
  31. ncbi request reprint Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    FEBS Lett 569:123-8. 2004
    ..The activated form of Ca(2+)/CaM kinase II protein could only be detected in Caco-2 cells under hypertonic conditions...
  32. doi request reprint Effect of taurine on mRNA expression of thioredoxin interacting protein in Caco-2 cells
    Yusuke Gondo
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 426:433-7. 2012
    ..Furthermore, taurine significantly increased TXNIP promoter activity. Our present study demonstrated the taurine-specific phenomenon of TXNIP up-regulation, which sheds light on the physiological function of taurine...
  33. ncbi request reprint Characterization of carnosine uptake and its physiological function in human intestinal epithelial Caco-2 cells
    Dong Ok Son
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biofactors 21:395-8. 2004
    ..These results suggest that carnosine had a protective effect against oxidative stress in intestinal epithelial cells...
  34. ncbi request reprint TCDD-induced CYP1A1 expression, an index of dioxin toxicity, is suppressed by flavonoids permeating the human intestinal Caco-2 cell monolayers
    Mika Hamada
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo ku, 113 8657, Japan
    J Agric Food Chem 54:8891-8. 2006
    ..It is proposed from these results that some flavonoids have the ability to suppress dioxin-induced AhR activity after permeating the human intestinal epithelial cell monolayer...
  35. doi request reprint Synergistic effect of tumor necrosis factor-alpha and hydrogen peroxide on the induction of IL-8 production in human intestinal Caco-2 cells
    Hee Soon Shin
    Department of Applied Biological Chemistry, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 8657, Japan
    Inflammation 34:440-7. 2011
    ..Oxidative stress and TNF-α may cooperatively enhance IL-8 production via NF-κB in Caco-2 cells...
  36. ncbi request reprint Transient up-regulation of immunity- and apoptosis-related genes in Caco-2 cells cocultured with THP-1 cells evaluated by DNA microarray analysis
    Yoko Ishimoto
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Biosci Biotechnol Biochem 74:437-9. 2010
    ..Differentially expressed genes extracted with maSigPro indicated that an early defense response and cell death occured at the same time, causing an inflammatory condition...
  37. pmc Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells
    Tomoko Konishi
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Br J Pharmacol 143:379-87. 2004
    ..It was also suggested that the monoglyceride structure played an important role in the inhibition of P-gp activity. Monoglycerides could therefore alter the pharmacokinetics of drugs by inhibiting the P-gp-mediated efflux...
  38. ncbi request reprint Regulation of intestinal taurine transporter by cytokines
    Makoto Shimizu
    Department of Applied Biological Chemistry, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Adv Exp Med Biol 526:213-7. 2003
  39. ncbi request reprint Transepithelial transport of macromolecular substances in IL-4 treated human intestinal T84 cell monolayers
    Tetsunosuke Mochizuki
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Biosci Biotechnol Biochem 73:2422-6. 2009
    ..These results suggest that fairly large molecules are able to permeate intestinal epithelial monolayers via the energy-independent paracellular pathway when the monolayers are exposed to excessive IL-4...
  40. doi request reprint 5-Aminoimidazole-4-carboxamide ribonucleoside stabilizes low density lipoprotein receptor mRNA in hepatocytes via ERK-dependent HuR binding to an AU-rich element
    Takuya Yashiro
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo, Tokyo 113 8657, Japan
    Atherosclerosis 226:95-101. 2013
    ..5-Aminoimidazole-4-carboxamide ribonucleoside (AICAR) has pleiotropic and beneficial effects on metabolic disorders. However, the effects of AICAR on low density lipoprotein (LDL) metabolism are poorly understood...
  41. doi request reprint Dietary flavonoid naringenin induces regulatory T cells via an aryl hydrocarbon receptor mediated pathway
    Hsi Kai Wang
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Agric Food Chem 60:2171-8. 2012
    ..Indeed, naringenin induced CD4(+)Foxp3(+) Tregs, irrespective of the presence of the transforming growth factor-β (TGF-β), indicating that the conventional TGF-β-dependent signaling pathway might not be involved...
  42. doi request reprint IEX-1 suppresses apoptotic damage in human intestinal epithelial Caco-2 cells induced by co-culturing with macrophage-like THP-1 cells
    Yoko Ishimoto
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biosci Rep 31:345-51. 2011
    ....
  43. doi request reprint Protective effect of quercetin on ER stress caused by calcium dynamics dysregulation in intestinal epithelial cells
    Yayoi Natsume
    Department of Applied Biological Chemistry, The University of Tokyo, Tokyo, Japan
    Toxicology 258:164-75. 2009
    ..This study helps to clarify the mechanism for quercetin presenting its versatility...
  44. ncbi request reprint Characteristics of lysophosphatidylcholine in its inhibition of taurine uptake by human intestinal Caco-2 cells
    Koji Ishizuka
    Department of Applied Biological Chemistry, The University of Tokyo, Japan
    Biosci Biotechnol Biochem 66:730-6. 2002
    ..These results suggest that the interaction of LPC with the taurine transporter in the intestinal cell membrane was the cause of the reduced taurine uptake...
  45. ncbi request reprint Enhanced daunomycin accumulation in human intestinal Caco-2 cells from non-ionic food emulsifiers unrelated to the p-glycoprotein inhibitory mechanism
    Naoki Takaishi
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Biosci Biotechnol Biochem 70:2703-11. 2006
    ..The enhanced accumulation of daunomycin would therefore not have been due to P-gp inhibition, but instead to the increased daunomycin permeability of cell membranes caused by the emulsifiers...
  46. ncbi request reprint Taurine is involved in oxidation of IkappaB alpha at Met45: N-halogenated taurine and anti-inflammatory action
    Yusei Miyamoto
    Department of Integrated Biosciences, University of Tokyo, Tokyo, Japan
    Adv Exp Med Biol 526:373-80. 2003
  47. ncbi request reprint Effects of tributyltin on barrier functions in human intestinal Caco-2 cells
    Masashi Tsukazaki
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biochem Biophys Res Commun 315:991-7. 2004
    ..The activation of a multidrug resistance transporter P-glycoprotein by TBT would cause a disorder of the human intestines by changing the drug pharmacokinetics...
  48. doi request reprint Identification of MIG12 as a mediator for stimulation of lipogenesis by LXR activation
    Jun Inoue
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Mol Endocrinol 25:995-1005. 2011
    ..These results indicate that MIG12 is a mediator for stimulation of lipogenesis by LXR activation in the liver...
  49. ncbi request reprint Regulation of interleukin-8 secretion in human intestinal epithelial Caco-2 cells by alpha-humulene
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biofactors 21:137-9. 2004
    ..The expression level of IL-8 mRNA was significantly increased by treating with alpha-humulene. These results suggest that the secretion of IL-8 by alpha-humulene is regulated at the transcriptional level...
  50. ncbi request reprint ATF6α stimulates cholesterogenic gene expression and de novo cholesterol synthesis
    Ryuto Maruyama
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
    Biosci Biotechnol Biochem 77:1734-8. 2013
    ..Collectively, these results indicate that ATF6α can regulate de novo cholesterol synthesis through stimulation of cholesterogenic gene expression. ..
  51. doi request reprint Anti-obesity and anti-hyperglycemic effects of the dietary citrus limonoid nomilin in mice fed a high-fat diet
    Eri Ono
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Biochem Biophys Res Commun 410:677-81. 2011
    ..Our results suggest a novel biological function of nomilin as an agent having anti-obesity and anti-hyperglycemic effects that are likely to be mediated through the activation of TGR5...
  52. doi request reprint Glutamine stimulates the gene expression and processing of sterol regulatory element binding proteins, thereby increasing the expression of their target genes
    Jun Inoue
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan
    FEBS J 278:2739-50. 2011
    ....
  53. doi request reprint Chenodeoxycholic acid stabilization of LDL receptor mRNA depends on 3'-untranslated region and AU-rich element-binding protein
    Takuya Yashiro
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Biochem Biophys Res Commun 409:155-9. 2011
    ..The UV cross-linking assays showed that a protein of 80kDa increasingly binds to the region including the ARE1 in response to CDCA-mediated MAPK activation...
  54. ncbi request reprint Bile acids enhance low density lipoprotein receptor gene expression via a MAPK cascade-mediated stabilization of mRNA
    Mayuko Nakahara
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    J Biol Chem 277:37229-34. 2002
    ..This work opens up a new avenue for developing pharmaceutical interventions that lower plasma LDL by stabilizing LDL receptor mRNA...
  55. ncbi request reprint Oral exposure to cadmium chloride triggers an acute inflammatory response in the intestines of mice, initiated by the over-expression of tissue macrophage inflammatory protein-2 mRNA
    Zhaohui Zhao
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, Japan
    Toxicol Lett 164:144-54. 2006
    ....
  56. ncbi request reprint Effect of neuronal PC12 cells on the functional properties of intestinal epithelial Caco-2 cells
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biosci Biotechnol Biochem 67:1312-8. 2003
    ..The TJ-modulating effect of PC12 was prevented by exposing PC12 to cycloheximide, suggesting that new protein synthesis in PC12 was necessary for this regulation...
  57. ncbi request reprint Role of AMPK and PPARγ1 in exercise-induced lipoprotein lipase in skeletal muscle
    Takashi Sasaki
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan and
    Am J Physiol Endocrinol Metab 306:E1085-92. 2014
    ..Thus, we identified a novel critical role for PPARγ1 in response to AMPK activation for controlling the expression of a subset of genes associated with metabolic regulation in skeletal muscle...
  58. doi request reprint Antigen presentation by small intestinal epithelial cells uniquely enhances IFN-γ secretion from CD4+ intestinal intraepithelial lymphocytes
    Ryo Hatano
    Department of Applied Biological Chemistry, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biochem Biophys Res Commun 435:592-6. 2013
    ..Taken together, these results suggest that sIECs uniquely activate CD4(+) IELs and induce remarkable IFN-γ secretion upon antigenic stimulation in vivo...
  59. ncbi request reprint Transepithelial transport of alpha-lipoic acid across human intestinal Caco-2 cell monolayers
    Naoki Takaishi
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Agric Food Chem 55:5253-9. 2007
    ..The conversion of LA to the more antioxidative dihydrolipoic acid was also apparent during the transport process...
  60. ncbi request reprint Establishment of intestinal epithelial cell lines from adult mouse small and large intestinal crypts
    Taku Iwamoto
    Department of Applied Biological Chemistry, The University of Tokyo, Tokyo, Japan
    Biosci Biotechnol Biochem 75:925-9. 2011
    ..These results suggest that the aMoS7 and aMoC1 cell lines can serve as useful tools in analyzing the immunological functions of IECs, especially in studying the IEC response to microbial components and its antigen presenting ability...
  61. ncbi request reprint Low-molecular-weight hyaluronan permeates through human intestinal Caco-2 cell monolayers via the paracellular pathway
    Nozomi Hisada
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Biosci Biotechnol Biochem 72:1111-4. 2008
    ..The transport was observed to be energy-independent, and was correlated with the tight junction (TJ) permeability. These results suggest that LMW-HA permeated the Caco-2 cell monolayers via the paracellular pathway...
  62. ncbi request reprint Effect of a pore-forming protein derived from Flammulina velutipes on the Caco-2 intestinal epithelial cell monolayer
    Asako Narai
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Biosci Biotechnol Biochem 68:2230-8. 2004
    ..These results suggest that TEER reduction could sensitively detect small membrane pore formation by FTX in the intestinal epithelium which causes a morphological alteration and disruption of the paracellular barrier function...
  63. ncbi request reprint Transepithelial transport of the bioactive tripeptide, Val-Pro-Pro, in human intestinal Caco-2 cell monolayers
    Makoto Satake
    Department of Applied Biological Chemistry, The University of Tokyo, Japan
    Biosci Biotechnol Biochem 66:378-84. 2002
    ..Paracellular diffusion is suggested to have been the main mechanism for the transport of intact Val-Pro-Pro across the Caco-2 cell monolayer...
  64. doi request reprint 4'-Hydroxyflavanone suppresses activation of sterol regulatory element-binding proteins and de novo lipid synthesis
    Shingo Miyata
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    FEBS Lett 586:1778-82. 2012
    ..This study identifies 4'-HF as an inhibitor of SREBP maturation and lipid synthesis, and provides evidence that 4'-HF may have major potential as a pharmaceutical preparation against hepatic steatosis and dyslipidemia...
  65. ncbi request reprint Tumor necrosis factor alpha stimulates taurine uptake and transporter gene expression in human intestinal Caco-2 cells
    Tetsunosuke Mochizuki
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, Japan
    FEBS Lett 517:92-6. 2002
    ..TNF-alpha-treated cells showed a higher mRNA level of the TAUT than did the control cells...
  66. ncbi request reprint Effect of quercetin on the gene expression profile of the mouse intestine
    Yayoi Natsume
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Toky, Japan
    Biosci Biotechnol Biochem 73:722-5. 2009
    ..0 Array. A cluster analysis shows that only the "low dose group" had a significantly different gene expression profile from the negative control group...
  67. doi request reprint Vitamin D3 modulates the expression of bile acid regulatory genes and represses inflammation in bile duct-ligated mice
    Michitaka Ogura
    Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Tokyo, Japan
    J Pharmacol Exp Ther 328:564-70. 2009
    ..VDR ligands have the potential to prevent the cholestasis-induced inflammatory response...
  68. ncbi request reprint Sterol regulatory element-binding proteins are negatively regulated through SUMO-1 modification independent of the ubiquitin/26 S proteasome pathway
    Yuko Hirano
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    J Biol Chem 278:16809-19. 2003
    ..Considered together, our results indicate that SUMO-1 modification suppresses the transactivation capacity of nuclear SREBPs in a manner different from the negative regulatory mechanism mediated by proteolysis...
  69. pmc Lactobacillus gasseri OLL2809 and its RNA suppress proliferation of CD4(+) T cells through a MyD88-dependent signalling pathway
    Ayako Yoshida
    Department of Applied Biological Chemistry, The University of Tokyo, France
    Immunology 133:442-51. 2011
    ..Collectively, these results suggest that suppression of T-cell proliferation by RNA may be one of the mechanisms when a probiotic bacterial strain exerts suppressive effects on inflammatory responses...
  70. pmc New model for studying the migration of immune cells into intestinal epithelial cell monolayers
    Akira Mori
    Department of Applied Biological Chemistry, The University of Tokyo, 1 1 1, Yayoi, Bunkyo ku, Tokyo, 113 8657, Japan
    Cytotechnology 43:57-64. 2003
    ..This cell culture system will be useful for studying the behavior of macrophages in the intestinal epithelial cell monolayers at the initial stage of an intestinal immune reaction...
  71. ncbi request reprint Oxidation of Ikappa Balpha at methionine 45 is one cause of taurine chloramine-induced inhibition of NF-kappa B activation
    Atsuhiro Kanayama
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo, Tokyo 113 8657, Japan
    J Biol Chem 277:24049-56. 2002
    ..When rat neutrophils were incubated with bacteria, intracellular taurine decreased interleukin-8 production. Therefore, taurine may help suppress excessive inflammatory reaction in neutrophils...
  72. ncbi request reprint Matrix metalloproteinase production by COOH-terminal heparin-binding fibronectin fragment in rheumatoid synovial cells
    Tadashi Yasuda
    Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Shogoin, Sakyo ku, Japan
    Lab Invest 83:153-62. 2003
    ..Thus, the present results have clearly shown that COOH-HBFN-f and CS-1 stimulate MMP production in association with activation of MAPK pathways in RSF. Integrin alpha4beta1 may be partially involved in the MMP induction by COOH-HBFN-f...
  73. ncbi request reprint Transepithelial transport of fluorescein in Caco-2 cell monolayers and use of such transport in in vitro evaluation of phenolic acid availability
    Yutaka Konishi
    Applied Bioresearch Center, Research and Development Dept, Kirin Brewery Co, Ltd, 3 Miyaharacho, Takasaki shi, Gunma 370 1295, Japan
    Biosci Biotechnol Biochem 66:2449-57. 2002
    ..Measurement of the effects of phenolic acids on fluorescein transport across Caco-2 monolayers would be a useful way to evaluate the intestinal absorption or bioavailability of dietary phenolic acids...
  74. ncbi request reprint Antihyperglycemic effect of polyphenols from Acerola (Malpighia emarginata DC.) fruit
    Takayuki Hanamura
    Research and Development Division, Nichirei Foods Inc, Chiba, Japan
    Biosci Biotechnol Biochem 70:1813-20. 2006
    ..Despite such a preventive effect, the therapeutic effect of C-AP on hyperglycemia appeared to be low from the experiment with KKAy mice...
  75. ncbi request reprint Tea polyphenols inhibit the transport of dietary phenolic acids mediated by the monocarboxylic acid transporter (MCT) in intestinal Caco-2 cell monolayers
    Yutaka Konishi
    Applied Bioresearch Center, Research and Development Department, Kirin Brewery Company, Ltd, 3 Miyaharacho, Takasaki shi, Gunma 370 1295, Japan
    J Agric Food Chem 51:7296-302. 2003
    ..However, directional transport of ECg and EGCg from the basolateral to the apical side was observed, indicating that the behavior of tea polyphenols in the intestinal epithelium is complex...
  76. ncbi request reprint Suppression of the TNFalpha-induced increase in IL-1alpha expression by hypochlorite in human corneal epithelial cells
    Mayumi Mohri
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba, Japan
    Invest Ophthalmol Vis Sci 43:3190-5. 2002
    ..The current study was undertaken to examine in immortalized human corneal epithelial cells whether NaOCl alters TNFalpha-induced increases in expression of IL-1alpha gene and protein...
  77. ncbi request reprint Effects of carrageenans on the binding, phagocytotic, and killing abilities of macrophages to salmonella
    Yoshiko Sugita-Konishi
    Division of Microbiology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Biosci Biotechnol Biochem 67:1425-8. 2003
    ..1 cells, but it increased the killing activity of the cells. Kappa-CGN increased the binding activity, but reduced the killing ability. CGNs would affect the host defense mechanisms by modulating the macrophage functions...
  78. ncbi request reprint Transepithelial transport of p-coumaric acid and gallic acid in Caco-2 cell monolayers
    Yutaka Konishi
    Applied Bioresearch Center, Research and Development Department, Kirin Brewery Co, Ltd, Gunma, Japan
    Biosci Biotechnol Biochem 67:2317-24. 2003
    ..Dietary phenolic acids thus showed diversified characteristics in their intestinal absorption...
  79. ncbi request reprint Transepithelial transport of ferulic acid by monocarboxylic acid transporter in Caco-2 cell monolayers
    Yutaka Konishi
    Applied Bioresearch Center, Research and Development Dept, Kirin Brewery Co, Ltd, 3 Miyaharacho, Takasaki shi, Gunma 370 1295, Japan
    Biosci Biotechnol Biochem 67:856-62. 2003
    ..Antioxidative phenolic acid compounds from dietary sources like ferulic acid would be recognized and transported by MCT by intestinal absorption...
  80. doi request reprint Producibility and digestibility of antihypertensive beta-casein tripeptides, Val-Pro-Pro and Ile-Pro-Pro, in the gastrointestinal tract: analyses using an in vitro model of mammalian gastrointestinal digestion
    Kazuhito Ohsawa
    Research and Development Center, Calpis Company, Ltd, 11 10, 5 Chome, Fuchinobe, Sagamihara shi Kanagawa 229 0006, Japan
    J Agric Food Chem 56:854-8. 2008
    ..There may be a strong correlation between the resistance of peptides to gastrointestinal digestion and their real physiological effects after oral administration...
  81. doi request reprint Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells
    Yuri Kusano
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Biochemistry 47:6169-77. 2008
    ..The results of this study suggest the involvement of a novel Keap1-dependent signaling pathway for the induction of the constitutive GST A1 expression during epithelial cell differentiation...
  82. ncbi request reprint Involvement of CD44 in induction of matrix metalloproteinases by a COOH-terminal heparin-binding fragment of fibronectin in human articular cartilage in culture
    Tadashi Yasuda
    Kyoto University Graduate School of Medicine, Kyoto, Japan
    Arthritis Rheum 48:1271-80. 2003
    ..To investigate the mechanism of induction of matrix metalloproteinases (MMPs) by a 40-kd COOH-terminal heparin-binding fibronectin fragment (HBFN-f) containing III12-14 and IIICS domains in human articular cartilage in culture...
  83. pmc Tissue-selective, bidirectional regulation of PEX11 alpha and perilipin genes through a common peroxisome proliferator response element
    Makoto Shimizu
    Department of Life Science, Graduate School of Science, Himeji Institute of Technology, Kamigori, Hyogo 678 1297, Japan
    Mol Cell Biol 24:1313-23. 2004
    ..Hence, the expression of these genes is induced through the same PPRE in the liver and adipose tissue, where the two PPAR subtypes are specifically expressed...
  84. ncbi request reprint Structural effects of phenolic acids on the transepithelial transport of fluorescein in caco-2 cell monolayers
    Yutaka Konishi
    Applied Bioresearch Center, Research and Development Department, Kirin Brewery Co, Ltd, Gunma, Japan
    Biosci Biotechnol Biochem 67:2014-7. 2003
    ..The methoxylated derivatives were more inhibitory than the hydroxylated ones in all the meta-substituted derivatives, suggesting that meta-hydroxylation of the substrate would decrease the affinity for MCT...
  85. ncbi request reprint Hyaluronan inhibits matrix metalloproteinase-1 production by rheumatoid synovial fibroblasts stimulated by proinflammatory cytokines
    Makoto Shimizu
    Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Japan
    J Rheumatol 30:1164-72. 2003
    ....
  86. ncbi request reprint Recent trends in functional food science and the industry in Japan
    Soichi Arai
    Faculty of Applied Biological Sciences, Tokyo University of Agriculture, Setagaya Ku, Tokyo 156 8502, Japan
    Biosci Biotechnol Biochem 66:2017-29. 2002
    ..Emphasis has been placed on the study of antioxidant and anticarcinogenic food factors as well as pre- and probiotics. This review pinpoints recent trends in the science and industry in this field...
  87. ncbi request reprint LOX-1 expressed in cultured rat chondrocytes mediates oxidized LDL-induced cell death-possible role of dephosphorylation of Akt
    Takefumi Nakagawa
    Department of Orthopaedic Surgery, Kyoto University Graduates School of Medicine, Kyoto, Japan
    Biochem Biophys Res Commun 299:91-7. 2002
    ..LOX-1 might be involved in the pathogenesis of osteoarthritis, inducing chondrocyte death through PI3 kinase/Akt pathway...
  88. ncbi request reprint Modulation of the intestinal Ca2+ uptake by a cheese whey protein digest
    Yoshihiko Takano
    Product Research and Development Department, Nippon Milk Community Co, Ltd, Japan
    Biosci Biotechnol Biochem 71:1487-93. 2007
    ..Although enteral feeding decreased the portal calcium concentration, CWP-D partially suppressed the decrease, suggesting that CWP-D could be used for food to enhance calcium absorption...
  89. ncbi request reprint Soluble Fas and Fas ligand provide new information on metastasis and response to chemotherapy in SCLC patients
    Makoto Shimizu
    Department of Respiratory Medicine, Nagoya University School of Medicine 65, Tsurumai cho, Showa Ku, Nagoya, Aichi 466 8560, Japan
    Cancer Detect Prev 29:175-80. 2005
    ..Soluble Fas and FasL concentrations are reportedly elevated in the peripheral blood of patients with lung cancer, but the roles of circulating soluble Fas and FasL in that disease have not been clarified...
  90. ncbi request reprint Phenolic acids are absorbed from the rat stomach with different absorption rates
    Yutaka Konishi
    Central Laboratories for Frontier Technology, Kirin Brewery Co, Ltd, Yokohama shi, Kanagawa 236 0004, Japan
    J Agric Food Chem 54:7539-43. 2006
    ..These results indicated that MCT might be involved in the gastric absorption of PAs, similar to the intestinal absorption...
  91. ncbi request reprint Pyridylazulenes: synthesis, color changes, and structure of the colored product
    Shigeharu Wakabayashi
    Department of Clinical Nutrition, Faculty of Health Science, Suzuka University of Medical Science, Suzuka, Mie 510 0293, Japan
    J Org Chem 72:744-9. 2007
    ..The transition intervals of several pyridylazulenes for use as pH indicators were also determined...
  92. ncbi request reprint Transplacental transport of alpha 2-macroglobulin (alpha 2M) and induction of alpha 2M in maternal and neonatal rats with acute inflammation
    Makoto Shimizu
    Laboratory of Immunology, College of Environmental and Health Sciences, Azabu University, 1 17 71 Fuchinobe, Sagamihara, Kanagawa 229 8501, Japan
    Exp Anim 51:361-5. 2002
    ..It was demonstrated that induction of alpha 2M in neonatal rats was lower than in maternal rats when inoculated with turpentine oil. These results suggest that alpha 2M is transplacentally transported from maternal rats to fetal ones...
  93. ncbi request reprint 3-(Dimethylboryl)pyridine: synthesis, structure, and remarkable steric effects in scrambling reactions
    Shigeharu Wakabayashi
    Department of Clinical Nutrition, Faculty of Health Science, Suzuka University of Medical Science, Suzuka, Mie 510 0293, Japan
    J Org Chem 73:81-7. 2008
    ....
  94. ncbi request reprint Efficient pyrrole synthesis using double nucleophilic addition to alpha,beta-unsaturated imines with plural nucleophiles
    Makoto Shimizu
    Department of Chemistry for Materials, Graduate School of Engineering, Mie University, Tsu, Mie 514 8507, Japan
    Org Lett 8:3585-7. 2006
    ..Using this methodology an imidazole glycerol phosphate dehydratase inhibitor (IGPDI) possessing a monopyrrole aldehyde moiety was synthesized...