H Shimano

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. doi request reprint SREBPs: physiology and pathophysiology of the SREBP family
    Hitoshi Shimano
    Department of Internal Medicine Endocrinoglogy and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
    FEBS J 276:616-21. 2009
  2. pmc Abdominal Irradiation Ameliorates Obesity in ob/ob Mice
    Sumiyo Okada
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305 8575, Japan
    J Clin Biochem Nutr 40:123-30. 2007
  3. ncbi request reprint Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes
    H Shimano
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Prog Lipid Res 40:439-52. 2001
  4. ncbi request reprint [Oral hypoglycemic agents, present and future]
    Hitoshi Shimano
    Nihon Yakurigaku Zasshi 128:42-5. 2006
  5. ncbi request reprint SREBP-1c and TFE3, energy transcription factors that regulate hepatic insulin signaling
    Hitoshi Shimano
    Department of Internal Medicine, Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki, Japan
    J Mol Med (Berl) 85:437-44. 2007
  6. ncbi request reprint Proposed guidelines for hypertriglyceridemia in Japan with non-HDL cholesterol as the second target
    Hitoshi Shimano
    The Research Committee for Primary Hyperlipidemia, Research on Measures for Intractable Diseases by the Ministry for Health, Labor, and Welfare in Japan
    J Atheroscler Thromb 15:116-21. 2008
  7. ncbi request reprint Sterol regulatory element-binding protein-1 as a dominant transcription factor for gene regulation of lipogenic enzymes in the liver
    H Shimano
    Department of Internal Medicine, Institute of Clinical Medicine, 1 1 1 Tennodai, Tsukuba, Ibaraki, 305 8575 Japan
    Trends Cardiovasc Med 10:275-8. 2000
  8. ncbi request reprint Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes
    H Shimano
    Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 274:35832-9. 1999
  9. ncbi request reprint Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL
    Z Chen
    Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 21:372-7. 2001
  10. ncbi request reprint Sterol regulatory element-binding protein-1 is regulated by glucose at the transcriptional level
    A H Hasty
    Department of Metabolic Diseasese, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 275:31069-77. 2000

Collaborators

Detail Information

Publications110 found, 100 shown here

  1. doi request reprint SREBPs: physiology and pathophysiology of the SREBP family
    Hitoshi Shimano
    Department of Internal Medicine Endocrinoglogy and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
    FEBS J 276:616-21. 2009
    ....
  2. pmc Abdominal Irradiation Ameliorates Obesity in ob/ob Mice
    Sumiyo Okada
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305 8575, Japan
    J Clin Biochem Nutr 40:123-30. 2007
    ....
  3. ncbi request reprint Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes
    H Shimano
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Prog Lipid Res 40:439-52. 2001
    ..Future studies will be focused on understanding molecular mechanisms sensing cellular sterol and energy states where SREBPs are deeply involved...
  4. ncbi request reprint [Oral hypoglycemic agents, present and future]
    Hitoshi Shimano
    Nihon Yakurigaku Zasshi 128:42-5. 2006
  5. ncbi request reprint SREBP-1c and TFE3, energy transcription factors that regulate hepatic insulin signaling
    Hitoshi Shimano
    Department of Internal Medicine, Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki, Japan
    J Mol Med (Berl) 85:437-44. 2007
    ..In this review, I will discuss roles of SREBP-1c and TFE3 in homeostasis of energy metabolism and in metabolic disturbances, focusing on hepatic insulin sensitivity...
  6. ncbi request reprint Proposed guidelines for hypertriglyceridemia in Japan with non-HDL cholesterol as the second target
    Hitoshi Shimano
    The Research Committee for Primary Hyperlipidemia, Research on Measures for Intractable Diseases by the Ministry for Health, Labor, and Welfare in Japan
    J Atheroscler Thromb 15:116-21. 2008
    ....
  7. ncbi request reprint Sterol regulatory element-binding protein-1 as a dominant transcription factor for gene regulation of lipogenic enzymes in the liver
    H Shimano
    Department of Internal Medicine, Institute of Clinical Medicine, 1 1 1 Tennodai, Tsukuba, Ibaraki, 305 8575 Japan
    Trends Cardiovasc Med 10:275-8. 2000
    ..Promoter analysis of the SREBP-1 gene will be important to clarify the mechanism of nutritional regulation of lipogenic genes...
  8. ncbi request reprint Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes
    H Shimano
    Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 274:35832-9. 1999
    ..These data demonstrate that SREBP-1 plays a crucial role in the induction of lipogenesis but not cholesterol biosynthesis in liver when excess energy by carbohydrates is consumed...
  9. ncbi request reprint Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL
    Z Chen
    Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 21:372-7. 2001
    ..These results indicate that troglitazone potently inhibits fatty streak lesion formation by modulating both metabolic extracellular environments and arterial wall cell functions...
  10. ncbi request reprint Sterol regulatory element-binding protein-1 is regulated by glucose at the transcriptional level
    A H Hasty
    Department of Metabolic Diseasese, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 275:31069-77. 2000
    ..These data provide strong evidence for the induction of SREBP-1c mRNA by glucose leading to increased mature protein in the nucleus, thus providing a potential mechanism for the up-regulation of lipogenic genes by glucose in vivo...
  11. ncbi request reprint A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids
    N Yahagi
    Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 274:35840-4. 1999
    ....
  12. doi request reprint Development of a new scoring system for predicting the 5 year incidence of type 2 diabetes in Japan: the Toranomon Hospital Health Management Center Study 6 (TOPICS 6)
    Y Heianza
    Department of Internal Medicine, Niigata University Faculty of Medicine, Niigata, Japan
    Diabetologia 55:3213-23. 2012
    ..The aims of this study were to assess the clinical significance of introducing HbA(1c) into a risk score for diabetes and to develop a scoring system to predict the 5 year incidence of diabetes in Japanese individuals...
  13. doi request reprint High normal HbA(1c) levels were associated with impaired insulin secretion without escalating insulin resistance in Japanese individuals: the Toranomon Hospital Health Management Center Study 8 (TOPICS 8)
    Y Heianza
    Department of Internal Medicine, University of Tsukuba Institute of Clinical Medicine, Ibaraki, Japan
    Diabet Med 29:1285-90. 2012
    ..We aimed to characterize the association of insulin resistance, impaired insulin secretion and β-cell dysfunction in relation to HbA(1c) levels in a non-diabetic range in Japanese individuals without clinically diagnosed diabetes...
  14. pmc Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter
    T Yoshikawa
    Department of Metabolic Diseases, University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan
    Mol Cell Biol 21:2991-3000. 2001
    ..These data demonstrate that LXR-RXR can modify the expression of genes for lipogenic enzymes by regulating SREBP-1c expression, providing a novel link between fatty acid and cholesterol metabolism...
  15. ncbi request reprint Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor
    A H Hasty
    Department of Metabolic Diseases, University of Tokyo, Tokyo, 113 8655, Japan
    J Biol Chem 276:37402-8. 2001
    ..This model will be an excellent tool for future studies on the relationship between impaired fuel metabolism, increased plasma remnant lipoproteins, diabetes, and atherosclerosis...
  16. ncbi request reprint Asialoglycoprotein receptor deficiency in mice lacking the major receptor subunit. Its obligate requirement for the stable expression of oligomeric receptor
    R Tozawa
    Department of Metabolic Diseases, Cardiovascular Medicine, and Infectious Diseases, Faculty of Medicine, University of Tokyo, Japan
    J Biol Chem 276:12624-8. 2001
    ..Although these mice are almost unable to clear asialo-orosomucoid, a high affinity ligand for asialoglycoprotein receptor, they do not accumulate desialylated glycoproteins or lipoproteins in the plasma...
  17. pmc Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E
    J Osuga
    The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Clin Invest 102:386-94. 1998
    ..These results imply that stimulation of hepatic production of apo E may be used as a promising adjunctive therapy for homozygous familial hypercholesterolemia...
  18. ncbi request reprint Neutralization of vascular endothelial growth factor prevents collagen-induced arthritis and ameliorates established disease in mice
    H Sone
    Department of Internal Medicine, University of Tsukuba, Tsukuba 305, Japan
    Biochem Biophys Res Commun 281:562-8. 2001
    ..Anti-VEGF antibody also significantly ameliorated clinical and histological parameters even when administered after disease onset. These results indicate a possible therapeutical potential for anti-VEGF treatment in human arthritis...
  19. ncbi request reprint Sterol regulatory element-binding proteins induce an entire pathway of cholesterol synthesis
    Y Sakakura
    Division of Metabolism and Endocrinology, Department of Internal Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukubashi, Ibaraki 305, Japan
    Biochem Biophys Res Commun 286:176-83. 2001
    ..These results demonstrate that SREBPs activate every step of cholesterol synthetic pathway, contributing to an efficient cholesterol synthesis...
  20. ncbi request reprint Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia
    H Yagyu
    Departments of Metabolic Diseases, Ophthalmology, Pathology, Faculty of Medicine, University of Tokyo, Hongo, Tokyo 113 8655, Japan
    J Biol Chem 275:21324-30. 2000
    ..These results indicate that the local inhibition of ACAT activity in tissue macrophages is protective against cholesteryl ester accumulation but causes cutaneous xanthomatosis in mice that lack apo E or LDLR...
  21. ncbi request reprint Association of living alone with the presence of undiagnosed diabetes in Japanese men: the role of modifiable risk factors for diabetes: Toranomon Hospital Health Management Center Study 13 (TOPICS 13)
    Y Heianza
    Department of Internal Medicine, Niigata University Faculty of Medicine, Niigata Health Management Center, Toranomon Hospital, Tokyo Department of Internal Medicine, University of Tsukuba Institute of Clinical Medicine, Ibaraki
    Diabet Med 30:1355-9. 2013
    ..To investigate whether living alone was associated with the presence of undiagnosed diabetes and whether this association could be attenuated by modifiable lifestyle habits...
  22. pmc Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall
    H Shimano
    Third Department of Internal Medicine, Faculty of Medicine, Tokyo University, Japan
    J Clin Invest 95:469-76. 1995
    ..Thus, apoE has anti-atherogenic action which is mediated via enhancing reverse cholesterol transport from arterial wall...
  23. ncbi request reprint Sterol regulatory element-binding protein-1c and pancreatic beta-cell dysfunction
    H Shimano
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Diabetes Obes Metab 9:133-9. 2007
    ..These data implicate a therapeutic potential of EPA against insulin secretion defects caused by lipotoxicity...
  24. doi request reprint Impact of psychological stress caused by the Great East Japan Earthquake on glycemic control in patients with diabetes
    K Fujihara
    Department of Endocrinology and Metabolism, University of Tsukuba Institute of Clinical Medicine, Ibaraki, Japan
    Exp Clin Endocrinol Diabetes 120:560-3. 2012
    ..26 [1.08-1.46]; p<0.01) were independently associated with glycemic control. These results suggest that psychological stress during a disaster has independent effects on worsening of glycemic control...
  25. ncbi request reprint Effects of probucol on atherosclerosis of apoE-deficient or LDL receptor-deficient mice
    T Yoshikawa
    Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Horm Metab Res 33:472-9. 2001
    ..The varying effects of probucol on atherogenesis depend upon the portion of aorta and which animal model is evaluated, implicating that complex cellular events are involved in the effect of probucol...
  26. ncbi request reprint Apolipoprotein E metabolism in sciatic nerves of diabetic rats. Implication for diabetic neuropathy
    S Ishibashi
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Horm Metab Res 25:82-7. 1993
    ..These abnormalities might contribute to the development of diabetic neuropathy...
  27. ncbi request reprint Elevated levels of vascular endothelial growth factor in the sera of patients with rheumatoid arthritis correlation with disease activity
    H Sone
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Life Sci 69:1861-9. 2001
    ..Serum VEGF levels may therefore be valuable as a marker of disease activity in patients with early RA, and this cytokine may play a significant role in the pathophysiology of RA...
  28. ncbi request reprint Effect of macrophage colony stimulating factor on the advanced atherosclerosis in Watanabe heritable hyperlipidemic rabbits
    Y Watanabe
    3rd Department of Internal Medicine, University of Tokyo, Japan
    Horm Metab Res 29:507-9. 1997
    ..08 vs 1.7, p < 0.01). Thus, M-CSF may influence vascular smooth muscle cell function and modify the process of atherosclerosis in advance lesions...
  29. ncbi request reprint Cholesterol-free diet with a high ratio of polyunsaturated to saturated fatty acids in heterozygous familial hypercholesterolemia: significant lowering effect on plasma cholesterol
    H Mokuno
    Third Department of Internal Medicine, University of Tokyo, Japan
    Horm Metab Res 22:246-51. 1990
    ..These results indicate that diet therapy with free-cholesterol and a high ratio of P/S is highly effective in controlling plasma cholesterol levels in heterozygous familial hypercholesterolemia...
  30. doi request reprint Screening for pre-diabetes to predict future diabetes using various cut-off points for HbA(1c) and impaired fasting glucose: the Toranomon Hospital Health Management Center Study 4 (TOPICS 4)
    Y Heianza
    Department of Internal Medicine, University of Tsukuba Institute of Clinical Medicine, Ibaraki, Japan
    Diabet Med 29:e279-85. 2012
    ..To evaluate various screening criteria for pre-diabetes to identify which combination of impaired fasting glucose and elevated HbA(1c) values performs most effectively in predicting future diabetes in a large cohort of Japanese individuals...
  31. doi request reprint HbA(1c) variability and the development of microalbuminuria in type 2 diabetes: Tsukuba Kawai Diabetes Registry 2
    A Sugawara
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, 3 2 7 Miya machi, Mito, Ibaraki, Japan, 310 0015
    Diabetologia 55:2128-31. 2012
    ..4 mg/mmol (≥ 30 mg/g) in at least two of three consecutive urine samples in Japanese patients with type 2 diabetes...
  32. ncbi request reprint Overexpression of apolipoprotein E prevents development of diabetic hyperlipidemia in transgenic mice
    K Yamamoto
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Diabetes 44:580-5. 1995
    ..In these studies, we demonstrated the usefulness of STZ-induced diabetes in mice as an animal model for diabetic hyperlipidemia and demonstrated that endogenous induction of apoE in transgenic mice improved diabetic hyperlipidemia...
  33. ncbi request reprint Insulin up-regulates tumor necrosis factor-alpha production in macrophages through an extracellular-regulated kinase-dependent pathway
    K T Iida
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305, Japan
    J Biol Chem 276:32531-7. 2001
    ....
  34. ncbi request reprint SREBPs suppress IRS-2-mediated insulin signalling in the liver
    Tomohiro Ide
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tennodai, Tsukuba, Ibaraki, 305 8575, Japan
    Nat Cell Biol 6:351-7. 2004
    ..These data suggest a molecular mechanism for the physiological switching from glycogen synthesis to lipogenesis and hepatic insulin resistance that is associated with hepatosteatosis...
  35. ncbi request reprint Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance
    Takashi Matsuzaka
    Department of Internal Medicine Endocrinology and Metabolism Graduate School of Comprehensive Human Sciences, 1 1 1 Tennodai, Tsukuba Ibaraki 305 8575, Japan
    Nat Med 13:1193-202. 2007
    ..Inhibition of this elongase could be a new therapeutic approach for ameliorating insulin resistance, diabetes and cardiovascular risks, even in the presence of a continuing state of obesity...
  36. ncbi request reprint Plasma chloride concentration as a new diagnostic indicator of insulin insufficiency
    Hiroko Kikuchi
    Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba City, Ibaraki 305 8575, Japan
    Diabetes Res Clin Pract 67:137-43. 2005
    ..Our results suggest that plasma chloride concentration is a possible new indicator of insulin insufficiency...
  37. ncbi request reprint Effects of atorvastatin on glucose metabolism and insulin resistance in KK/Ay mice
    Masatsune Suzuki
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    J Atheroscler Thromb 12:77-84. 2005
    ....
  38. ncbi request reprint Sterol regulatory element-binding protein family as global regulators of lipid synthetic genes in energy metabolism
    Hitoshi Shimano
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Vitam Horm 65:167-94. 2002
    ..Future studies in this field will certainly focus on understanding the molecular mechanisms sensing cellular sterol and energy states leading to the activation of SREBP-mediated gene transcription...
  39. doi request reprint Effect of Web-based lifestyle modification on weight control: a meta-analysis
    S Kodama
    Department of Internal Medicine, University of Tsukuba Institute of Clinical Medicine, Mito, Ibaraki, Japan
    Int J Obes (Lond) 36:675-85. 2012
    ..Our aim of this meta-analysis is to systematically review the weight loss or maintenance effect of the Internet component in obesity treatment programs...
  40. ncbi request reprint Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status
    Hirohito Sone
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba 305 8575, Japan
    Am J Physiol Endocrinol Metab 282:E222-30. 2002
    ..However, its high conservation among different species and the wide range of its tissue distribution suggest that this enzyme might also play an important role in basic cellular energy metabolism...
  41. ncbi request reprint Effect of thiazolidinediones and metformin on LDL oxidation and aortic endothelium relaxation in diabetic GK rats
    Kaoruko Tada Iida
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki 305 8575, Japan
    Am J Physiol Endocrinol Metab 284:E1125-30. 2003
    ..It is also suggested that the thiazolidinediones and metformin improve vascular function in diabetes. These effects may play a role in the prevention of atherosclerosis in diabetic patients...
  42. ncbi request reprint TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes
    Yoshimi Nakagawa
    Department of Internal Medicine, Metabolism and Endocrinology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki, Japan, 305 8575
    Nat Med 12:107-13. 2006
    ..Promoter analyses showed that IRS2, HK2 and INSIG1 are direct targets of TFE3. Activation of insulin signals in both insulin depletion and resistance suggests that TFE3 could be a therapeutic target for diabetes...
  43. ncbi request reprint Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver
    Hiroaki Okazaki
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Lipid Res 47:1950-8. 2006
    ....
  44. ncbi request reprint Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression
    Motohiro Sekiya
    Department of Internal Medicine, Tokyo University Graduate School of Medicine, Tokyo, Japan
    Hepatology 38:1529-39. 2003
    ..In conclusion, PUFAs ameliorate obesity-associated symptoms, such as hepatic steatosis and insulin resistance, presumably through both down-regulation of SREBP-1 and activation of PPARalpha...
  45. doi request reprint Elovl6: a new player in fatty acid metabolism and insulin sensitivity
    Takashi Matsuzaka
    Department of Internal Medicine, University of Tsukuba, Tennodai, Ibaraki, Japan
    J Mol Med (Berl) 87:379-84. 2009
    ..We suggest that inhibition of this elongase could be a new therapeutic approach for the treatment of insulin resistance, diabetes, cardiovascular disease, and other metabolic diseases...
  46. pmc Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets
    Toyonori Kato
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Diabetes 57:2382-92. 2008
    ..Chronic exposure to fatty acids causes beta-cell failure, often referred to as lipotoxicity. We investigated its mechanisms, focusing on contribution of SREBP-1c, a key transcription factor for lipogenesis...
  47. ncbi request reprint Transgenic mice overexpressing SREBP-1a under the control of the PEPCK promoter exhibit insulin resistance, but not diabetes
    Akimitsu Takahashi
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Biochim Biophys Acta 1740:427-33. 2005
    ..These data demonstrate that SREBP-1a activation in the liver has a strong impact on plasma insulin levels, implicating the potential role of SREBPs in hepatic insulin metabolism relating to insulin resistance...
  48. ncbi request reprint MafK overexpression in pancreatic beta-cells caused impairment of glucose-stimulated insulin secretion
    Homare Shimohata
    Department of Anatomy and Embryology, Biomolecular and Integrated Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 346:671-80. 2006
    ..These results indicated that MafA may have relevance to compensatory response...
  49. ncbi request reprint Even low-intensity and low-volume exercise training may improve insulin resistance in the elderly
    Satoru Kodama
    Department of Internal Medicine, University of Tsukuba
    Intern Med 46:1071-7. 2007
    ..Therefore, we investigated the effects of low-intensity and low-volume exercise training on blood lipid values and insulin resistance in the elderly...
  50. doi request reprint The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha
    Hirosuke Danno
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba Ibaraki 305 8575, Japan
    Biochem Biophys Res Commun 391:1222-7. 2010
    ..Activation of CREBH at fasting through fatty acids and PPARalpha suggest that CREBH is involved in nutritional regulation...
  51. pmc Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin
    Takashi Yamamoto
    Department of Internal Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Lipid Res 51:1859-70. 2010
    ..This new understanding of PKCbeta involvement in nutritional regulation of SREBP-1c activation provides a new aspect of PKCbeta inhibition as a potential therapeutic target for diabetic complications...
  52. doi request reprint Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity
    Mayumi Ishikawa
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki, Japan, 305 8575
    J Lipid Res 49:2524-34. 2008
    ....
  53. doi request reprint Nuclear SREBP-1a causes loss of pancreatic beta-cells and impaired insulin secretion
    Yuko Iwasaki
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Biochem Biophys Res Commun 378:545-50. 2009
    ..The transgenic mice on a high fat/high sucrose diet still exhibited impaired insulin secretion and continuous beta-cell growth defect. Therefore, nuclear SREBP-1a, even at a low level, strongly disrupts beta-cell mass and function...
  54. ncbi request reprint Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice
    Naoya Yahagi
    Department of Internal Medicine, University of Tokyo Graduate School of Medicine, Tokyo 113 8655, Japan
    J Biol Chem 277:19353-7. 2002
    ..In conclusion, SREBP-1 regulation of lipogenesis is highly involved in the development of fatty livers but does not seem to be a determinant of obesity in Lep(ob)/Lep(ob) mice...
  55. ncbi request reprint Receptor-type protein tyrosine phosphatase epsilon (PTPepsilonM) is a negative regulator of insulin signaling in primary hepatocytes and liver
    Yoshimi Nakagawa
    Gene Research Center, University of Tsukuba, Japan
    Zoolog Sci 22:169-75. 2005
    ..These results suggest that PTPepsilonM is a negative regulator of IR signaling and involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver...
  56. ncbi request reprint Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells
    Akimitsu Takahashi
    Department of Internal Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Diabetes 54:492-9. 2005
    ..Taken together with enhanced insulin secretion from SREBP-1-null islets, these data suggest that SREBP-1c and endogenous lipogenesis could be involved in beta-cell dysfunction and diabetes...
  57. ncbi request reprint Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis
    Norihito Shibata
    Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    FASEB J 20:2642-4. 2006
    ..These findings suggest that co-administration of fibrates and an SPF inhibitor may reduce not only plasma triglyceride but also cholesterol levels, indicating that SPF is a promising hypocholesterolemic drug target...
  58. ncbi request reprint Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene
    Ken Ohashi
    Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 278:42936-41. 2003
    ....
  59. ncbi request reprint Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling
    Tomohiro Ide
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki 305 8575, Japan
    Mol Endocrinol 17:1255-67. 2003
    ....
  60. ncbi request reprint Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter
    Miwako Kajihara
    Department of Internal Medicine, University of Tsukuba, 1 1 1, Tennodai, Tsukuba 305 8575, Japan
    Biochem Biophys Res Commun 312:831-42. 2003
    ..These results indicate that MafA is the homologue of zebrafish SMaf1 and acts as a transcriptional activator of the insulin gene promoter through the RIPE3b element...
  61. ncbi request reprint Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR sig
    Tomohiro Yoshikawa
    Department of Metabolic Diseases, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo ku, Japan
    Mol Endocrinol 17:1240-54. 2003
    ..These data suggest that PPARalpha activation can suppress LXR-SREBP-1c pathway through reduction of LXR/RXR formation, proposing a novel transcription factor cross-talk between LXR and PPARalpha in hepatic lipid homeostasis...
  62. ncbi request reprint HMG-CoA reductase inhibitor decreases small dense low-density lipoprotein and remnant-like particle cholesterol in patients with type-2 diabetes
    Hirohito Sone
    Department of Internal Medicine Endocrinology Metabolism, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, 305 8575, Ibaraki, Japan
    Life Sci 71:2403-12. 2002
    ....
  63. ncbi request reprint Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice
    Takashi Matsuzaka
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Diabetes 53:560-9. 2004
    ..These data clearly demonstrate that nutritional regulation of SREBP-1c and lipogenic genes may be completely independent of insulin as long as sufficient carbohydrates are available...
  64. ncbi request reprint Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes
    Michiyo Amemiya-Kudo
    Department of Metabolic Diseases, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan
    J Lipid Res 43:1220-35. 2002
    ....
  65. ncbi request reprint SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes
    Takashi Yamamoto
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    J Biol Chem 279:12027-35. 2004
    ..Our data indicate that SREBP-1 has a novel role as negative regulator of gluconeogenic genes through a cross-talk with HNF-4alpha interference with PGC-1 recruitment...
  66. ncbi request reprint Differential phenotypic expression by three mutant alleles in familial lecithin:cholesterol acyltransferase deficiency
    T Gotoda
    Third Department of Internal Medicine, University of Tokyo, Japan
    Lancet 338:778-81. 1991
    ..These results show that distinct mutations cause differences in plasma LCAT activity and LCAT mass, ultimately leading to differential phenotypic expression of familial LCAT deficiency...
  67. ncbi request reprint Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPARalpha
    Takashi Matsuzaka
    Department of Metabolic Diseases, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Lipid Res 43:107-14. 2002
    ..The data suggested that D5D and D6D expression is dually regulated by SREBP-1c and PPARalpha, two reciprocal transcription factors for fatty acid metabolism, and could be involved in lipogenic gene regulation by producing PUFA...
  68. ncbi request reprint Insulin inhibits apoptosis of macrophage cell line, THP-1 cells, via phosphatidylinositol-3-kinase-dependent pathway
    Kaoruko Tada Iida
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Arterioscler Thromb Vasc Biol 22:380-6. 2002
    ..These mechanisms could be involved in the possible role of insulin in the development of atherosclerosis...
  69. ncbi request reprint Elimination of cholesterol ester from macrophage foam cells by adenovirus-mediated gene transfer of hormone-sensitive lipase
    Hiroaki Okazaki
    Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Biol Chem 277:31893-9. 2002
    ..In conclusion, increased hydrolysis of CE by the overexpression of HSL leads to complete elimination of CE from THP-1 foam cells not only by increasing efflux but also by decreasing influx of cholesterol...
  70. ncbi request reprint Physiological changes in circulating mannose levels in normal, glucose-intolerant, and diabetic subjects
    Hirohito Sone
    Department of Endocrinology and Metabolism, Laboratory of Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Metabolism 52:1019-27. 2003
    ....
  71. pmc Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance
    Noriyuki Inoue
    Department of Internal Medicine Metabolism and Endocrinology and Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki, Japan
    J Biol Chem 283:21220-9. 2008
    ..Via both of these mechanisms, p21 promotes adipose tissue expansion during high fat diet feeding, leading to increased downstream pathophysiological consequences such as insulin resistance...
  72. doi request reprint Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis
    Motohiro Sekiya
    Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Lipid Res 49:1829-38. 2008
    ..Incubation with LDL further augmented the accumulation of CE in the HSL-deficient hepatocytes. From these results, we conclude that HSL is involved in the hydrolysis of CE in hepatocyes...
  73. doi request reprint Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lep ob/ob mice
    Motohiro Sekiya
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 387:511-5. 2009
    ..The deficiency of HSL also diminished the islet mass in Lep(ob/ob) mice due to decreased cell proliferation. In conclusion, HSL affects insulin secretary capacity especially in the setting of obesity...
  74. ncbi request reprint Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs
    Takashi Matsuzaka
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki 305 8575, Japan
    J Lipid Res 43:911-20. 2002
    ....
  75. ncbi request reprint PPAR gamma ligands, troglitazone and pioglitazone, up-regulate expression of HMG-CoA synthase and HMG-CoA reductase gene in THP-1 macrophages
    Kaoruko Tada Iida
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba shi, Ibaraki 305 8575, Japan
    FEBS Lett 520:177-81. 2002
    ..These findings suggest that PPAR gamma may play a role in cholesterol metabolism in macrophages...
  76. ncbi request reprint [Quality aspects of lipid accumulation in insulin resistance--a lesson from long fatty acid elongase, Elovl-6]
    Hitoshi Shimano
    Dept of Internal Medicine Endocrinology and Metabolism, Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba City, Ibaraki 305 8575, Japan
    Seikagaku 80:762-7. 2008
  77. doi request reprint Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis
    Satoru Kodama
    Department of Internal Medicine, University of Tsukuba Institute of Clinical Medicine, 3 2 7 Miya machi, Mito, Ibaraki 310 0015, Japan
    JAMA 301:2024-35. 2009
    ..Epidemiological studies have indicated an inverse association between cardiorespiratory fitness (CRF) and coronary heart disease (CHD) or all-cause mortality in healthy participants...
  78. ncbi request reprint The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice
    Noriko Nakanishi
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Biochem Biophys Res Commun 385:492-6. 2009
    ..These findings provide the first evidence that the up-regulated expressions of miR-335 in liver and WAT of obese mice might contribute to the pathophysiology of obesity...
  79. ncbi request reprint In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression
    Yoshinori Takeuchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 363:329-35. 2007
    ..These mice are the first models to provide the mechanistic insight into the transcriptional regulation of SREBP-1c gene in vivo...
  80. ncbi request reprint [Dysfunction of transcription factors in energy metabolism]
    Hitoshi Shimano
    Department of Internal Medicine Endocrinology and Metabolism, Institute of Clinical Medicine, University of Tsukuba
    Nihon Rinsho 65:111-4. 2007
  81. ncbi request reprint Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice
    Toyonori Kato
    Department of Internal Medicine, Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba Ibaraki 305 8575, Japan
    Cell Metab 4:143-54. 2006
    ..Collectively, our data provide evidence that activation of the SREBP-1c/granuphilin pathway is a potential mechanism for impaired insulin secretion in diabetes, contributing to beta cell lipotoxicity...
  82. ncbi request reprint Distinct effects of pravastatin, atorvastatin, and simvastatin on insulin secretion from a beta-cell line, MIN6 cells
    Mayumi Ishikawa
    Department of Internal Medicine Endocrinology and Metabolism Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    J Atheroscler Thromb 13:329-35. 2006
    ....
  83. ncbi request reprint Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver
    Takashi Yamamoto
    Department of Internal Medicine, Metabolism and Endocrinology, Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    J Biol Chem 282:11687-95. 2007
    ....
  84. ncbi request reprint Statins downregulate ATP-binding-cassette transporter A1 gene expression in macrophages
    Hirohito Sone
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba 305 8575, Japan
    Biochem Biophys Res Commun 316:790-4. 2004
    ..These findings imply that there is a possible modulation of the well-known beneficial effects of the statins on the reverse cholesterol transport pathway...
  85. pmc Lipid synthetic transcription factor SREBP-1a activates p21WAF1/CIP1, a universal cyclin-dependent kinase inhibitor
    Noriyuki Inoue
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Mol Cell Biol 25:8938-47. 2005
    ..These data suggest a physiological role of SREBP-1a in p21 regulation. Identification of p21 as a new SREBP target might implicate a new paradigm in the link between lipid synthesis and cell growth...
  86. ncbi request reprint High mobility group protein-B1 interacts with sterol regulatory element-binding proteins to enhance their DNA binding
    Yuho Najima
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 280:27523-32. 2005
    ..These findings raise the intriguing possibility that HMGB1 is potentially involved in the regulation of lipogenic and cholesterogenic gene transcription...
  87. ncbi request reprint [Pathophysiology of metabolic syndrome]
    Hitoshi Shimano
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba
    Nihon Rinsho 62:1029-35. 2004
    ..Proinflammatory agents should also be involved and adipocytokines could play an important role in peripheral insulin resistance...
  88. ncbi request reprint WGEF is a novel RhoGEF expressed in intestine, liver, heart, and kidney
    Yuhui Wang
    Department of Metabolism and Endocrinology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences and University Hospital, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Biochem Biophys Res Commun 324:1053-8. 2004
    ..The expression pattern may also suggest the possible importance of WGEF in the understanding of diseases based on metabolic disorder...
  89. ncbi request reprint Antioxidants and an inhibitor of advanced glycation ameliorate death of retinal microvascular cells in diabetic retinopathy
    Shigeru Yatoh
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Diabetes Metab Res Rev 22:38-45. 2006
    ..Therefore, we investigated apoptosis of RMCs in Goto-Kakizaki (GK) rats, a type 2 diabetic model, and involvement with antioxidants (a combination of vitamins C and E) or a novel inhibitor of advanced glycation, OPB-9195...
  90. ncbi request reprint A transcription factor of lipid synthesis, sterol regulatory element-binding protein (SREBP)-1a causes G(1) cell-cycle arrest after accumulation of cyclin-dependent kinase (cdk) inhibitors
    Masanori Nakakuki
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
    FEBS J 274:4440-52. 2007
    ..SREBP-1-null mouse embryonic fibroblasts had a higher cell proliferation rate than wild-type cells. The unexpected cell growth-inhibitory role of SREBP-1a provides a new paradigm to link lipid synthesis and cell growth...
  91. ncbi request reprint p53 Activation in adipocytes of obese mice
    Naoya Yahagi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 278:25395-400. 2003
    ..Thus, the activation of p53 might constitute a negative feedback loop against excess fat accumulation in adipocytes. In conclusion, we discovered a novel role of p53 in the pathophysiology of obesity...
  92. ncbi request reprint Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma
    Naoya Yahagi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyoku, Tokyo 113 8655, Japan
    Eur J Cancer 41:1316-22. 2005
    ..Thus, lipogenic enzymes are markedly induced in hepatocellular carcinomas, and in some cases SREBP-1c is involved in this activation...
  93. ncbi request reprint p53 involvement in the pathogenesis of fatty liver disease
    Naoya Yahagi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 279:20571-5. 2004
    ..In conclusion, we revealed that p53 plays an important role in the pathogenesis of fatty liver disease...
  94. ncbi request reprint Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements
    Tomohiro Yoshikawa
    Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Biol Chem 277:1705-11. 2002
    ..These data suggest that PUFAs could be deeply involved in nutritional regulation of cellular fatty acid levels by inhibiting an LXR-SREBP-1c system crucial for lipogenesis...
  95. ncbi request reprint Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules
    Haiyan Song
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113, Tokyo, Japan
    Biochem Biophys Res Commun 299:291-8. 2002
    ..These findings indicate that resistin expression is regulated by C/EBPalpha and PPARgamma, partly via modulation of signal transduction in the PI3-kinase and MAP kinase pathways...
  96. doi request reprint SREBP1 is required for the induction by glucose of pancreatic beta-cell genes involved in glucose sensing
    Frederique Diraison
    Department of Cell Biology, Division of Medicine, Faculty of Medicine, Imperial College, London SW72A2, UK
    J Lipid Res 49:814-22. 2008
    ..We conclude that enhanced lipid synthesis mediated by SREBP1c-dependent genes is required for the adaptive changes in islet gene expression and insulin secretion at high glucose concentrations...
  97. ncbi request reprint Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement
    Hiraku Ono
    Institute for Adult Diseases, Asahi Life Foundation, Shinjuku ku, Tokyo, Japan
    Diabetes 52:2905-13. 2003
    ..In contrast, myr-Akt-induced hypertriglyceridemia and hepatic triglyceride accumulation are mediated by both Akt-induced SREBP-1 expression and a mechanism involving fatty acid synthesis independent of SREBP-1...
  98. ncbi request reprint SREBP-1c expression in Schwann cells is affected by diabetes and nutritional status
    Anne Sophie de Preux
    Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland
    Mol Cell Neurosci 35:525-34. 2007
    ..This suggests that disturbed SREBP-1c regulated lipid metabolism may contribute to the pathophysiology of diabetic peripheral neuropathy...
  99. ncbi request reprint [Roles of energy metabolism transcription factors]
    Hitoshi Shimano
    Department of Internal Medicine Metabolism and Endocrinology, Doctoral Program in Advanced Biomedical Applications, Graduate School of Comprehensive Human Science, University of Tsukuba
    Nihon Rinsho 64:98-102. 2006
  100. ncbi request reprint Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes
    Koichi Misawa
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    J Biol Chem 278:36176-82. 2003
    ..These data provide a novel pathway by which HNF-4 potentiates the SREBP functions and stimulates expression of SREBP-responsive genes in enterohepatic cells...
  101. ncbi request reprint [Diverse physiological and pharmacological functions of fatty acids]
    Harumi Okuyama
    Nihon Yakurigaku Zasshi 131:259-67. 2008