Shuichiro Shiina

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc Percutaneous ethanol injection for hepatocellular carcinoma: 20-year outcome and prognostic factors
    Shuichiro Shiina
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Liver Int 32:1434-42. 2012
  2. pmc Radiofrequency ablation for hepatocellular carcinoma: 10-year outcome and prognostic factors
    Shuichiro Shiina
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Am J Gastroenterol 107:569-77; quiz 578. 2012
  3. ncbi request reprint Nonsurgical treatment of hepatocellular carcinoma: from percutaneous ethanol injection therapy and percutaneous microwave coagulation therapy to radiofrequency ablation
    Shuichiro Shiina
    Department of Gastroenterology, University of Tokyo, Japan
    Oncology 62:64-8. 2002
  4. ncbi request reprint Local ablation therapy for hepatocellular carcinoma. From ethanol injection to radiofrequency ablation
    Shuichiro Shiina
    Department of Gastroenterology, University of Tokyo 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Saudi Med J 28:831-7. 2007
  5. ncbi request reprint A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma
    Shuichiro Shiina
    Department of Gastroenterology, University of Tokyo, Japan
    Gastroenterology 129:122-30. 2005
  6. ncbi request reprint Evaluation of transcatheter arterial embolization prior to percutaneous tumor ablation in patients with hepatocellular carcinoma: a randomized controlled trial
    Masatoshi Akamatsu
    Department of Gastroenterology, The University of Tokyo Hospital, Tokyo, Japan
    Liver Int 24:625-9. 2004
  7. ncbi request reprint Percutaneous radiofrequency ablation for hepatocellular carcinoma. An analysis of 1000 cases
    Ryosuke Tateishi
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Cancer 103:1201-9. 2005
  8. doi request reprint Hepatocellular carcinoma with extrahepatic metastasis: clinical features and prognostic factors
    Koji Uchino
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Cancer 117:4475-83. 2011
  9. doi request reprint Evaluation of molecular targeted cancer drug by changes in tumor marker doubling times
    Kenichiro Enooku
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 47:71-8. 2012
  10. doi request reprint Obesity is an independent risk factor for hepatocellular carcinoma development in chronic hepatitis C patients
    Takamasa Ohki
    Department of Gastroenterology, University of Tokyo, Hongo, Tokyo, Japan
    Clin Gastroenterol Hepatol 6:459-64. 2008

Detail Information

Publications79

  1. pmc Percutaneous ethanol injection for hepatocellular carcinoma: 20-year outcome and prognostic factors
    Shuichiro Shiina
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Liver Int 32:1434-42. 2012
    ..Ethanol injection is the best-known image-guided percutaneous ablation for hepatocellular carcinoma (HCC) and a well-tolerated, inexpensive procedure with few adverse effects. However, there have been few reports on its long-term results...
  2. pmc Radiofrequency ablation for hepatocellular carcinoma: 10-year outcome and prognostic factors
    Shuichiro Shiina
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Am J Gastroenterol 107:569-77; quiz 578. 2012
    ..However, there has been no report on 10-year outcome of RFA. The objective of this study was to report a 10-year consecutive case series at a tertiary referral center...
  3. ncbi request reprint Nonsurgical treatment of hepatocellular carcinoma: from percutaneous ethanol injection therapy and percutaneous microwave coagulation therapy to radiofrequency ablation
    Shuichiro Shiina
    Department of Gastroenterology, University of Tokyo, Japan
    Oncology 62:64-8. 2002
    ..By virtue of their local curability, minimal effect on liver function, and easy repeatability for recurrence, image-guided percutaneous tumor ablations, especially RFA, will be increasingly important in the treatment of HCC...
  4. ncbi request reprint Local ablation therapy for hepatocellular carcinoma. From ethanol injection to radiofrequency ablation
    Shuichiro Shiina
    Department of Gastroenterology, University of Tokyo 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Saudi Med J 28:831-7. 2007
    ..Radiofrequency ablation will play more important roles in the treatment of HCC...
  5. ncbi request reprint A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma
    Shuichiro Shiina
    Department of Gastroenterology, University of Tokyo, Japan
    Gastroenterology 129:122-30. 2005
    ..Percutaneous radiofrequency ablation is a recently introduced treatment for hepatocellular carcinoma, whereas ethanol injection is now a standard therapy. We compared their long-term outcomes...
  6. ncbi request reprint Evaluation of transcatheter arterial embolization prior to percutaneous tumor ablation in patients with hepatocellular carcinoma: a randomized controlled trial
    Masatoshi Akamatsu
    Department of Gastroenterology, The University of Tokyo Hospital, Tokyo, Japan
    Liver Int 24:625-9. 2004
    ..We continued the study after the introduction of RFA and compared TAE combined with RFA (TAE/RFA) with RFA only...
  7. ncbi request reprint Percutaneous radiofrequency ablation for hepatocellular carcinoma. An analysis of 1000 cases
    Ryosuke Tateishi
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Cancer 103:1201-9. 2005
    ..Previously reported treatment efficacy and complication rates have varied considerably...
  8. doi request reprint Hepatocellular carcinoma with extrahepatic metastasis: clinical features and prognostic factors
    Koji Uchino
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Cancer 117:4475-83. 2011
    ..The objective of this study was to further elucidate the clinical course and prognostic determinants of patients with this disease...
  9. doi request reprint Evaluation of molecular targeted cancer drug by changes in tumor marker doubling times
    Kenichiro Enooku
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 47:71-8. 2012
    ..We evaluated the usefulness of tumor marker doubling time (DT) as an efficacy indicator of a molecular targeted anticancer agent...
  10. doi request reprint Obesity is an independent risk factor for hepatocellular carcinoma development in chronic hepatitis C patients
    Takamasa Ohki
    Department of Gastroenterology, University of Tokyo, Hongo, Tokyo, Japan
    Clin Gastroenterol Hepatol 6:459-64. 2008
    ..The aim of this study was to investigate the relationship between body weight and risk of hepatocarcinogenesis in chronic hepatitis C patients...
  11. ncbi request reprint Prediction of recurrence of hepatocellular carcinoma after curative ablation using three tumor markers
    Ryosuke Tateishi
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Hepatology 44:1518-27. 2006
    ..In conclusion, tumor markers pre- and post-ablation were significant predictors for HCC recurrence and can complement imaging modalities in the evaluation of treatment efficacy...
  12. doi request reprint Systemic combination therapy of intravenous continuous 5-fluorouracil and subcutaneous pegylated interferon alfa-2a for advanced hepatocellular carcinoma
    Koji Uchino
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 47:1152-9. 2012
    ....
  13. ncbi request reprint Obesity did not diminish the efficacy of percutaneous ablation for hepatocellular carcinoma
    Takamasa Ohki
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Liver Int 27:360-7. 2007
    ..In addition, overweight may affect the treatment efficacy of ultrasound-guided percutaneous ablation. We evaluated the impact of overweight on the safety and efficacy of percutaneous ablation to hepatocellular carcinoma (HCC)...
  14. ncbi request reprint UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma in japanese patients with hepatitis C virus infection
    Yue Wang
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Clin Cancer Res 10:2441-6. 2004
    ..In this study, we evaluated the association of both genes with the risk of HCC in Japanese HCV-infected patients...
  15. doi request reprint Value of post-vascular phase (Kupffer imaging) by contrast-enhanced ultrasonography using Sonazoid in the detection of hepatocellular carcinoma
    Eriko Goto
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 47:477-85. 2012
    ....
  16. ncbi request reprint Factors affecting the prognosis of patients with hepatocellular carcinoma invading the portal vein--a retrospective analysis using 952 consecutive HCC patients
    Yukihiro Koike
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Hepatogastroenterology 50:2035-9. 2003
    ..Hepatocellular carcinoma with portal venous invasion has a very poor prognosis. The aim of this study is to clarify the factors contributing to the survival of hepatocellular carcinoma patients with portal venous invasion...
  17. ncbi request reprint Hepatocellular carcinoma in elderly patients: beneficial therapeutic efficacy using percutaneous ethanol injection therapy
    Takuma Teratani
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Japan
    Cancer 95:816-23. 2002
    ..The age of patients with hepatocellular carcinoma (HCC) has been increasing worldwide. The objective of this study was to assess the efficacy and safety of percutaneous ethanol injection therapy (PEIT) in elderly patients with HCC...
  18. ncbi request reprint Recurrent hepatocellular carcinoma has an increased risk of subsequent recurrence after curative treatment
    Noriyo Yamashiki
    Department of Gastroenterology, University of Tokyo, Graduate School of Medicine, Tokyo, Japan
    J Gastroenterol Hepatol 22:2155-60. 2007
    ..The aim of this study was to evaluate the difference in the risk for subsequent recurrence, if any, between primary and recurrent cases...
  19. ncbi request reprint Age-related comparison of the profiles of patients with hepatocellular carcinoma
    Tomonori Fujishima
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Japan
    Hepatogastroenterology 53:913-8. 2006
    ..Therefore this study aims to evaluate whether the clinicopathological features in young patients with HCC significantly differ from those of elderly patients...
  20. doi request reprint Treatment strategy for hepatocellular carcinoma: expanding the indications for radiofrequency ablation
    Ryosuke Tateishi
    Department of Gastroenterology, The University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Gastroenterol 44:142-6. 2009
    ..This study investigated whether an apparent threshold exists in the diameter and number of nodules in terms of the prognosis of patients with HCC...
  21. doi request reprint Extrahepatic metastasis of hepatocellular carcinoma: incidence and risk factors
    Miho Kanda
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Liver Int 28:1256-63. 2008
    ..Extrahepatic metastasis of hepatocellular carcinoma (HCC) is of growing importance as the survival of patients has been improved owing to advances in treatments to intrahepatic lesions...
  22. ncbi request reprint Analysis of factors influencing hepatocellular carcinoma detection: efficient use of computed tomography during arterial portography and during hepatic arteriography
    Tomonori Fujishima
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Gastroenterol 40:266-73. 2005
    ..This study was performed to investigate the situations in which computed tomography (CT) combined with arterial portography and hepatic arteriography surpassed dynamic CT in the detection of hepatocellular carcinoma...
  23. ncbi request reprint Hepatic gene expression profiles associated with fibrosis progression and hepatocarcinogenesis in hepatitis C patients
    Run Xuan Shao
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1, Hongo, Tokyo 113 8655, Japan
    World J Gastroenterol 11:1995-9. 2005
    ..To determine fibrosis progression and hepatocellular carcinoma (HCC), using simultaneous gene expression analysis...
  24. doi request reprint Hepatocellular carcinoma in viral hepatitis: improving standard therapy
    Ryota Masuzaki
    Department of Gastroenterology, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Best Pract Res Clin Gastroenterol 22:1137-51. 2008
    ..Prevention of HCC recurrence, or tertiary prevention, is one of the most challenging tasks in current hepatology...
  25. ncbi request reprint Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma
    Ryosuke Muroyama
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Hepatol 45:805-12. 2006
    ..In this study, we investigated whether nucleotide changes in the X gene of genotype C are associated with the development of HCC...
  26. ncbi request reprint Sustained viral response prolonged survival of patients with C-viral hepatocellular carcinoma
    Masatoshi Akamatsu
    Department of Gastroenterology, The University of Tokyo Hospital, Tokyo, Japan
    Liver Int 26:536-42. 2006
    ..We conducted this retrospective study to evaluate the position of interferon therapy in the curative treatment of hepatitis C virus-associated hepatocellular carcinoma (HCC)...
  27. ncbi request reprint Neither hepatitis C virus genotype nor virus load affects survival of patients with hepatocellular carcinoma
    Masatoshi Akamatsu
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Eur J Gastroenterol Hepatol 16:459-66. 2004
    ..This study was conducted to elucidate whether these two factors are capable of predicting the prognosis of patients with HCC...
  28. pmc Comparison of liver biopsy and transient elastography based on clinical relevance
    Ryota Masuzaki
    Department of Gastroenterology, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Can J Gastroenterol 22:753-7. 2008
    ..Liver stiffness measurement (LSM) by transient elastography has recently been validated for the evaluation of liver fibrosis in chronic liver diseases. The present study focused on cases in which liver biopsy and LSM were discordant...
  29. doi request reprint Prospective risk assessment for hepatocellular carcinoma development in patients with chronic hepatitis C by transient elastography
    Ryota Masuzaki
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Hepatology 49:1954-61. 2009
    ..71-75.2; P < 0.001) when LSM 10.1-15 kPa, 20.9 (95% CI, 4.43-98.8; P < 0.001) when LSM 15.1-20 kPa, 25.6 (95%CI, 5.21-126.1; P < 0.001) when LSM 20.1-25 kPa, and 45.5 (95% CI, 9.75-212.3; P < 0.001) when LSM >25 kPa...
  30. ncbi request reprint Interferon therapy after tumor ablation improves prognosis in patients with hepatocellular carcinoma associated with hepatitis C virus
    Yasushi Shiratori
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113, Japan
    Ann Intern Med 138:299-306. 2003
    ..Even after the surgical or medical treatment of hepatocellular carcinoma, tumors frequently develop at new foci, leading to a poor prognosis...
  31. doi request reprint Serum level of adiponectin and the risk of liver cancer development in chronic hepatitis C patients
    Toru Arano
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655
    Int J Cancer 129:2226-35. 2011
    ..In conclusion, Patients who had CHC with high serum adiponectin levels had a higher risk of liver cancer development. Adiponectin may thus be tumorigenic or indicate a liver disease state independently of other clinical parameters...
  32. doi request reprint Serum IL-6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients: an analysis based on gender differences
    Hayato Nakagawa
    Department of Gastroenterology, University of Tokyo, Tokyo 113 8655, Japan
    Int J Cancer 125:2264-9. 2009
    ..Measurement of serum IL-6 levels may provide useful information for predicting future HCC development in female chronic hepatitis C patients...
  33. doi request reprint Three-dimensional conformal radiotherapy for hepatocellular carcinoma with inferior vena cava invasion
    Hiroshi Igaki
    Department of Radiology, The University of Tokyo Hospital, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Jpn J Clin Oncol 38:438-44. 2008
    ..The aim of this study was to analyze the results of treatment for hepatocellular carcinoma with inferior vena cava invasion by three-dimensional conformal radiation therapy...
  34. ncbi request reprint Risk assessment of hepatocellular carcinoma in chronic hepatitis C patients by transient elastography
    Ryota Masuzaki
    Department of Gastroenterology, The University of Tokyo Hospital, Tokyo, Japan
    J Clin Gastroenterol 42:839-43. 2008
    ..In this cross-sectional study, we investigated the relationship between liver stiffness and HCC presence...
  35. doi request reprint Utility of contrast-enhanced ultrasonography with Sonazoid in radiofrequency ablation for hepatocellular carcinoma
    Ryota Masuzaki
    Graduate School of Medicine, Department of Gastroenterology, The University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 26:759-64. 2011
    ..The utility of Sonazoid in radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) was investigated in this study...
  36. ncbi request reprint Factors predisposing to poorly differentiated hepatocellular carcinoma and its recurrence
    Masatoshi Akamatsu
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Hepatogastroenterology 52:391-7. 2005
    ....
  37. doi request reprint Computed tomography follow-up for the detection of hepatocellular carcinoma recurrence after initial radiofrequency ablation: a single-center experience
    Shintaro Mikami
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Vasc Interv Radiol 23:1269-75. 2012
    ..This retrospective study compared the radiologic features of recurrent HCC seen by computed tomography (CT) to evaluate our empirical protocol of CT surveillance using 4-month intervals...
  38. doi request reprint Intrahepatic bile duct dilatation after percutaneous radiofrequency ablation for hepatocellular carcinoma: impact on patient's prognosis
    Yuji Kondo
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Liver Int 31:197-205. 2011
    ..The intrahepatic bile duct may be injured and result in chronic bile duct dilatation upstream of the injured site. However, the impact of such an injury on the overall prognosis has been unclear...
  39. ncbi request reprint Ablation therapy in containing extension of hepatocellular carcinoma: a simulative analysis of dropout from the waiting list for liver transplantation
    Noriyo Yamashiki
    Department of Gastroenterology, University of Tokyo, Graduate School of Medicine, Tokyo, Japan
    Liver Transpl 11:508-14. 2005
    ..In conclusion, local ablation therapy for HCC was effective in containing the tumor progression within the Milan criteria in selected patients...
  40. pmc Assessment of disease progression in patients with transfusion-associated chronic hepatitis C using transient elastography
    Ryota Masuzaki
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 1138655 Tokyo, Japan
    World J Gastroenterol 18:1385-90. 2012
    ..To evaluate the relationship between liver stiffness and duration of infection in blood transfusion-associated hepatitis C virus (HCV) patients with or without hepatocellular carcinoma (HCC)...
  41. ncbi request reprint External beam radiotherapy to treat intra- and extra-hepatic dissemination of hepatocellular carcinoma after radiofrequency thermal ablation
    Hideomi Yamashita
    Department of Radiology, University of Tokyo Hospital, Tokyo, Japan
    J Gastroenterol Hepatol 21:1555-60. 2006
    ..Radiofrequency ablation (RFA) is an alternative to percutaneous ethanol injection therapy (PEIT) for single non-surgical hepatocellular carcinoma. However, the risk of seeding along the needle track has been reported...
  42. doi request reprint Prediction of hepatocellular carcinoma development by plasma ADAMTS13 in chronic hepatitis B and C
    Hitoshi Ikeda
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 20:2204-11. 2011
    ....
  43. ncbi request reprint Clinical features of patients with HCC who are negative for both HBV and HCV markers
    Hirotsugu Watabe
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Hepatogastroenterology 50:2157-60. 2003
    ..The aim of this study is to clarify the clinical features of hepatocellular carcinoma that are negative for both hepatitis B surface antigen and anti-hepatitis C antibody...
  44. doi request reprint Neoplastic seeding after radiofrequency ablation for hepatocellular carcinoma
    Jun Imamura
    Department of Gastroenterology, The University of Tokyo Hospital, Tokyo, Japan
    Am J Gastroenterol 103:3057-62. 2008
    ..The aim of this study is to assess the incidence, risk factors, and prognosis of neoplastic seeding after RFA among a large number of patients with a long-term follow-up...
  45. ncbi request reprint Large-scale search of single nucleotide polymorphisms for hepatocellular carcinoma susceptibility genes in patients with hepatitis C
    Naoya Kato
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Hepatology 42:846-53. 2005
    ..In conclusion, these SNPs and haplotypes located in the SCBY14, CRHR2, and GFRA1 genes will be used as markers to identify a subgroup of Japanese patients with chronic HCV infection who are at high risk of developing HCC...
  46. ncbi request reprint Radiofrequency ablation for hepatocellular carcinoma in so-called high-risk locations
    Takuma Teratani
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Japan
    Hepatology 43:1101-8. 2006
    ..However, even though without significant difference, some complications occurred at risky locations and need to be carefully considered...
  47. doi request reprint Gain of GRHL2 is associated with early recurrence of hepatocellular carcinoma
    Yasuo Tanaka
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    J Hepatol 49:746-57. 2008
    ..The aim of this study is to identify genomic changes that might be implicated in hepatocellular carcinoma (HCC) progression, and evaluate the associations with clinico-pathological features...
  48. doi request reprint Hemorrhagic complications of percutaneous radiofrequency ablation for liver tumors
    Eriko Goto
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    J Clin Gastroenterol 44:374-80. 2010
    ..1% to 0.5% mortality. This study analyzed the risk factors and management of hemorrhagic complications, such as hemoperitoneum, hemothorax, and hemobilia...
  49. ncbi request reprint Proteomic analysis of sera from hepatocellular carcinoma patients after radiofrequency ablation treatment
    Takayuki Kawakami
    Department of Gastroenterology, Graduate School of Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Proteomics 5:4287-95. 2005
    ..These data facilitate the identification of differentially expressed proteins that are involved in HCC carcinogenesis and provide candidate biomarkers for the development of diagnostic and therapeutic tools...
  50. ncbi request reprint Health-related quality of life of chronic liver disease patients with and without hepatocellular carcinoma
    Yuji Kondo
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 22:197-203. 2007
    ..Impaired health-related quality of life has been reported in patients with cirrhosis and chronic hepatitis. However, only limited data are available concerning the influence of hepatocellular carcinoma...
  51. doi request reprint Increased activity of serum mitochondrial isoenzyme of creatine kinase in hepatocellular carcinoma patients predominantly with recurrence
    Yoko Soroida
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Hepatol 57:330-6. 2012
    ..Mitochondrial isoenzyme of creatine kinase (MtCK) is reportedly highly expressed in hepatocellular carcinoma (HCC). Clinical relevance of serum MtCK activity in patients with HCC was assessed using a novel immuno-inhibition method...
  52. ncbi request reprint Early liver cancer: concepts, diagnosis, and management
    Hideo Yoshida
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Clin Oncol 10:384-90. 2005
    ..Here, we give an overview of the present management of hepatocellular carcinoma. Further studies in diagnosis, treatment, and prevention are required to achieve the best clinical management of this disease...
  53. ncbi request reprint Combination therapy of intraarterial 5-fluorouracil and systemic interferon-alpha for advanced hepatocellular carcinoma with portal venous invasion
    Shuntaro Obi
    Department of Hepatology, Kyoundo Hospital, Tokyo, Japan
    Cancer 106:1990-7. 2006
    ..The combination of intraarterial 5-fluorouracil (FU) and systemic interferon-alpha (IFNalpha) was recently reported to be effective against HCC with PVI, but these were small pilot studies...
  54. ncbi request reprint Congenital absence of portal vein with multiple hyperplastic nodular lesions in the liver
    Yasuo Tanaka
    Department of Gastroenterology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 38:288-94. 2003
    ..In addition to this case report, the clinical features of 25 reported cases of congenital absence of the portal vein are reviewed...
  55. doi request reprint A phase I/II trial of the oral antiangiogenic agent TSU-68 in patients with advanced hepatocellular carcinoma
    Fumihiko Kanai
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Cancer Chemother Pharmacol 67:315-24. 2011
    ....
  56. pmc CT With Hepatic Arterioportography as a Pretreatment Examination for Hepatocellular Carcinoma Patients: A Randomized Controlled Trial
    Takamasa Ohki
    1 Department of gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan 2 Department of Gastroenterology, Mitsui Memorial Hospital, Tokyo, Japan 3 The first two authors contributed equally to this work
    Am J Gastroenterol 108:1305-13. 2013
    ..The combination of computed tomography with hepatic arteriography and arterial portography (CTHA/CTAP) can detect additional hepatocellular carcinoma (HCC) nodules undetected by conventional dynamic CT...
  57. ncbi request reprint Influence of serum HBV DNA load on recurrence of hepatocellular carcinoma after treatment with percutaneous radiofrequency ablation
    Tadashi Goto
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Hepatol Int 5:767-73. 2011
    ..We evaluated whether serum HBV DNA load is associated with the risk of recurrence of HBV-related HCC treated with radiofrequency ablation (RFA)...
  58. ncbi request reprint Three-dimensional power Doppler ultrasonography for hepatocellular carcinoma: a comparison with angiography?
    Shinpei Sato
    Department of Gastroenterology University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Hepatogastroenterology 52:72-5. 2005
    ..To assess clinical usefulness of three-dimensional power Doppler ultrasonography for the diagnosis of hepatocellular carcinoma...
  59. ncbi request reprint Radiation therapy for portal venous invasion by hepatocellular carcinoma
    Keiichi Nakagawa
    Department of Radiology, Faculty of Medicine, University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113, Japan
    World J Gastroenterol 11:7237-41. 2005
    ..To clarify the efficacy and safety of three-dimensional conformal radiotherapy (3-D CRT) for this disease and to specify patient subgroups suitable for this treatment...
  60. pmc Ultrasound surveillance for early detection of hepatocellular carcinoma among patients with chronic hepatitis C
    Takahisa Sato
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Hepatol Int 3:544-50. 2009
    ..However, the optimal surveillance interval is still controversial and the usefulness of supplementary tumor marker determination has not been confirmed...
  61. doi request reprint Endoscopic management of biliocutaneous fistula after percutaneous radiofrequency ablation therapy for hepatocellular carcinoma
    Takeshi Tsujino
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Dig Endosc 22:53-5. 2010
    ..Biliocutaneous fistula is an extremely rare complication after percutaneous RFA, and the present case report suggests that endoscopic drainage is the first-line therapy for bile leaks after RFA...
  62. ncbi request reprint Complications of percutaneous radiofrequency ablation for hepato-cellular carcinoma: imaging spectrum and management
    Masaaki Akahane
    Departments of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Radiographics 25:S57-68. 2005
    ..Because an early and accurate diagnosis is necessary for proper management, radiologists should be familiar with the imaging features of each type of complication...
  63. doi request reprint Image-guided percutaneous ablation therapies for hepatocellular carcinoma
    Shuichiro Shiina
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Gastroenterol 44:122-31. 2009
    ..The better cure rate of resection can be canceled, however, by deterioration of liver function...
  64. pmc Changes in hepatic functional reserve after percutaneous tumor ablation for hepatocellular carcinoma: long-term follow up for 227 consecutive patients with a single lesion
    Yukihiro Koike
    Department of Gastroenterology, Faculty of Medicine, Kanto Central Hospital, 6 25 1 Kamiyoga, Setagaya Ku, Tokyo, 158 8531, Japan
    Hepatol Int 1:295-301. 2007
    ..Percutaneous tumor ablation is presumed to be relatively non-invasive, but there are few studies on long-term follow-up of liver function after tumor ablation...
  65. pmc Assessing liver tumor stiffness by transient elastography
    Ryota Masuzaki
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Hepatol Int 1:394-7. 2007
    ..Transient elastography is a novel noninvasive method to assess liver fibrosis by measuring liver stiffness. This study is a first step toward the provision of a noninvasive measurement of hepatic tumor stiffness by transient elastography...
  66. ncbi request reprint Treatment of hepatocellular carcinoma by percutaneous tumor ablation methods: Ethanol injection therapy and radiofrequency ablation
    Masao Omata
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Gastroenterology 127:S159-66. 2004
    ..We initiated a prospective controlled study to evaluate treatment with PTA and interferon. Results suggest that if the virus is eradicated, a 5-year survival rate as high as 80% can be expected...
  67. pmc Safety and efficacy of lamivudine after radiofrequency ablation in patients with hepatitis B virus-related hepatocellular carcinoma
    Hideo Yoshida
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo, Japan, 113 8655
    Hepatol Int 2:89-94. 2008
    ..Antiviral treatments for hepatitis B virus (HBV) are not established in patients with HBV-related hepatocellular carcinoma (HCC)...
  68. ncbi request reprint Interleukin-1beta gene polymorphisms associated with hepatocellular carcinoma in hepatitis C virus infection
    Yue Wang
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Japan
    Hepatology 37:65-71. 2003
    ..73 (T/T vs. C/C), 4.12, 4.03, 3.89, and 3.27, respectively. In conclusion, the IL-1beta-31 genotype T/T or the IL-1beta-511/-31 haplotype C-T is associated with the presence of HCC in Japanese patients with chronic HCV infection...
  69. doi request reprint Percutaneous radiofrequency ablation of hepatocellular carcinoma in 14 patients undergoing regular hemodialysis for end-stage renal disease
    Yuji Kondo
    Department of Gastroenterology, Mitsui Memorial Hospital, 1 Kanda Izumi cho, Chiyoda ku, Tokyo, Japan
    AJR Am J Roentgenol 193:964-9. 2009
    ....
  70. ncbi request reprint Hepatic volumetry to predict adverse events in percutaneous ablation of hepatocellular carcinoma
    Yujin Hoshida
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Japan
    Hepatogastroenterology 49:451-5. 2002
    ..This study aimed to clarify the relation of hepatic volumetry to adverse events after percutaneous transhepatic ablation for hepatocellular carcinoma...
  71. ncbi request reprint Risk factors for esophageal variceal bleeding in patients with hepatocellular carcinoma
    Masao Akanuma
    Division of Gastroenterology, Department of Internal Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Hepatogastroenterology 49:1039-44. 2002
    ..To evaluate the risk factors for esophageal variceal bleeding in patients with hepatocellular carcinoma...
  72. ncbi request reprint Re-appearance of power Doppler signals in the tumor nodules of hepatocellular carcinoma after transarterial embolization reflects residual viable tumor cells: histological confirmation
    Shin pei Sato
    Department of Gastroenterology, University of Tokyo, Japan
    Hepatogastroenterology 51:56-61. 2004
    ..The present study was prospectively performed to elucidate the relationship between the power Doppler signals of hepatocellular carcinoma after transarterial embolization and histological confirmation of viable tumor cells...
  73. doi request reprint Effect of vitamin K2 on the recurrence of hepatocellular carcinoma
    Haruhiko Yoshida
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, and Department of Gastroenterology and Hepatology, Kanto Central Hospital, Tokyo, Japan
    Hepatology 54:532-40. 2011
    ..150 (95% confidence interval: 0.843-1.570, one-sided; P=0.811) between the placebo and combined active-drug groups, and the study was discontinued in March 2007...
  74. ncbi request reprint [Radiofrequency ablation of liposarcoma liver metastasis]
    Munenori Takata
    Department of Gastroenterology, University of Tokyo
    Nihon Naika Gakkai Zasshi 96:144-6. 2007
  75. pmc Weak association between SEN virus viremia and liver disease
    Hideo Yoshida
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Microbiol 40:3140-5. 2002
    ..SEN-V was detected at almost the same frequency in patients with and without liver disease. SEN-V does not seem to contribute either to the pathogenesis of liver disease or to the development of HCC from chronic liver disease...
  76. ncbi request reprint 18F-FDG PET for hepatocellular carcinoma presenting with portal vein tumor thrombus
    Kazuyuki Hanajiri
    J Gastroenterol 40:1005-6. 2005
  77. ncbi request reprint Contrast harmonic sonographically guided radio frequency ablation for spontaneous ruptured hepatocellular carcinoma
    Hideyuki Tamai
    Second Department of Internal Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama 640 0012, Japan
    J Ultrasound Med 24:1021-6. 2005
  78. ncbi request reprint Progression from chronic hepatitis to hepatocellular carcinoma: natural course and treatments
    Masao Omata
    Department of Medicine II, Tokyo University Hospital, Tokyo, Japan
    J Gastroenterol Hepatol 17:S434-6. 2002
  79. ncbi request reprint A novel display of reconstruction computed tomography for the detection of small hepatocellular carcinoma
    Takuma Teratani
    University of Tokyo Graduate School of Medicine, Gastroenterology, Tokyo, Japan
    Liver Int 24:619-24. 2004
    ..To evaluate the usefulness of the alternate display of arterial and equilibrium phase images (ADAEI) of 2 mm-pitch reconstruction computed tomography (CT) in the detection of hepatocellular carcinoma (HCC)...