Akira Shibuya

Summary

Affiliation: University of Tsukuba
Country: Japan

Publications

  1. pmc Accelerated tumor growth in mice deficient in DNAM-1 receptor
    Akiko Iguchi-Manaka
    Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    J Exp Med 205:2959-64. 2008
  2. pmc The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses
    Takako Nakano-Yokomizo
    Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305 8575, Japan
    J Exp Med 208:1661-71. 2011
  3. pmc Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor
    Chigusa Nakahashi-Oda
    Department of Immunology, Division of Biomedical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    J Exp Med 209:1493-503. 2012
  4. pmc Regulation of Immune Responses by the Activating and Inhibitory Myeloid-Associate Immunoglobuline-Like Receptors (MAIR) (CD300)
    Akira Shibuya
    Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305 8575, Japan
    Immune Netw 9:41-5. 2009
  5. pmc Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation
    Katsumi Yotsumoto
    Laboratory for Immune Receptor, RIKEN Research Center for Allergy and Immunology, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    J Exp Med 198:223-33. 2003
  6. ncbi request reprint Molecular and functional characteristics of the Fcalpha/muR, a novel Fc receptor for IgM and IgA
    Akira Shibuya
    Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences and Center for TARA, University of Tsukuba, 1 1 1 Tennodai, Tsukuba Science City, Ibaraki, 305 8575, Japan
    Springer Semin Immunopathol 28:377-82. 2006
  7. ncbi request reprint Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes
    A Shibuya
    Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
    Nat Immunol 1:441-6. 2000
  8. ncbi request reprint Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)
    Satoko Tahara-Hanaoka
    Laboratory for Immune Receptor, RIKEN Research Center for Allergy and Immunology, Tsukuba, Ibaraki 305 0074, Japan
    Int Immunol 16:533-8. 2004
  9. pmc Critical role of DNAX accessory molecule-1 (DNAM-1) in the development of acute graft-versus-host disease in mice
    Tsukasa Nabekura
    Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Proc Natl Acad Sci U S A 107:18593-8. 2010
  10. ncbi request reprint LFA-1 decreases the antigen dose for T cell activation in vivo
    Yinan Wang
    Department of Immunology, Institute of Basic Medical Sciences and Center for TARA, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Ten nodai, Tsukuba, Ibaraki 305 8575, Japan
    Int Immunol 20:1119-27. 2008

Detail Information

Publications46

  1. pmc Accelerated tumor growth in mice deficient in DNAM-1 receptor
    Akiko Iguchi-Manaka
    Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    J Exp Med 205:2959-64. 2008
    ..These results indicate that DNAM-1 plays an important role in immune surveillance of tumor development...
  2. pmc The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses
    Takako Nakano-Yokomizo
    Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305 8575, Japan
    J Exp Med 208:1661-71. 2011
    ..Thus, DAP12-coupled MAIR-II negatively regulates B cell-mediated adaptive immune responses...
  3. pmc Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor
    Chigusa Nakahashi-Oda
    Department of Immunology, Division of Biomedical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    J Exp Med 209:1493-503. 2012
    ..These results indicated that CD300a is a nonphagocytic PS receptor that regulates mast cell inflammatory responses to microbial infections...
  4. pmc Regulation of Immune Responses by the Activating and Inhibitory Myeloid-Associate Immunoglobuline-Like Receptors (MAIR) (CD300)
    Akira Shibuya
    Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305 8575, Japan
    Immune Netw 9:41-5. 2009
    ..Thus, MAIR plays an important role in innate immunity mediated by myeloid cells...
  5. pmc Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation
    Katsumi Yotsumoto
    Laboratory for Immune Receptor, RIKEN Research Center for Allergy and Immunology, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    J Exp Med 198:223-33. 2003
    ..Thus, MAIR-I and MAIR-II play important regulatory roles in cell signaling and immune responses...
  6. ncbi request reprint Molecular and functional characteristics of the Fcalpha/muR, a novel Fc receptor for IgM and IgA
    Akira Shibuya
    Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences and Center for TARA, University of Tsukuba, 1 1 1 Tennodai, Tsukuba Science City, Ibaraki, 305 8575, Japan
    Springer Semin Immunopathol 28:377-82. 2006
    ..These results reveal a new mechanism in the primary stage of immune defense against microbes...
  7. ncbi request reprint Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes
    A Shibuya
    Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
    Nat Immunol 1:441-6. 2000
    ..Fc alpha/microR also mediated primary B lymphocyte endocytosis of IgM-coated Staphylococcus aureus. Thus, Fc alpha/microR is involved in the primary stages of the immune response to microbes...
  8. ncbi request reprint Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)
    Satoko Tahara-Hanaoka
    Laboratory for Immune Receptor, RIKEN Research Center for Allergy and Immunology, Tsukuba, Ibaraki 305 0074, Japan
    Int Immunol 16:533-8. 2004
    ..We also demonstrate that ligation of CD226 and LFA-1 with their respective ligands cooperates in triggering cytotoxicity and cytokine secretion by T and NK cells...
  9. pmc Critical role of DNAX accessory molecule-1 (DNAM-1) in the development of acute graft-versus-host disease in mice
    Tsukasa Nabekura
    Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Proc Natl Acad Sci U S A 107:18593-8. 2010
    ..These results indicate that DNAM-1 plays an important role in the development of GVHD and is an ideal molecular target for therapeutic approaches to GVHD...
  10. ncbi request reprint LFA-1 decreases the antigen dose for T cell activation in vivo
    Yinan Wang
    Department of Immunology, Institute of Basic Medical Sciences and Center for TARA, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Ten nodai, Tsukuba, Ibaraki 305 8575, Japan
    Int Immunol 20:1119-27. 2008
    ....
  11. ncbi request reprint A critical role of LFA-1 in the development of Th17 cells and induction of experimental autoimmune encephalomyelytis
    Yinan Wang
    Department of Immunology, Institute of Basic Medical Sciences and Center for TARA, University of Tsukuba, 1 1 1 Ten nodai, Tsukuba, Ibaraki 305 8575, Japan
    Biochem Biophys Res Commun 353:857-62. 2007
    ..These results suggest that LFA-1 may play an important role for the generation of MOG-specific Th17 cells in the dLN as well as the immigration of MOG-specific naïve CD4+ T cells to the dLN...
  12. ncbi request reprint Suppression of eosinophilic airway inflammation by treatment with alpha-galactosylceramide
    Yuko Morishima
    Department of Pulmonary Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
    Eur J Immunol 35:2803-14. 2005
    ..Hence, our data indicate that alpha-GalCer suppresses allergen-induced eosinophilic airway inflammation, possibly by inducing a Th1 bias that results in inhibition of eosinophil adhesion to the lung vessels...
  13. ncbi request reprint Requirement of the tyrosines at residues 258 and 270 of MAIR-I in inhibitory effect on degranulation from basophilic leukemia RBL-2H3
    Yasushi Okoshi
    Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba, Japan
    Int Immunol 17:65-72. 2005
    ....
  14. ncbi request reprint Activation of neutrophils by a novel triggering immunoglobulin-like receptor MAIR-IV
    Takako Nakano
    Department of Immunology, Institute of Basic Medical Sciences and Center for TARA, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305 8575, Japan
    Mol Immunol 45:289-94. 2008
    ..Thus, MAIR-IV may regulate activation of neutrophils and play an important role for innate immunity...
  15. ncbi request reprint Tumor rejection by the poliovirus receptor family ligands of the DNAM-1 (CD226) receptor
    Satoko Tahara-Hanaoka
    Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1, Ten nodai, Tsukuba, Ibaraki 305 8575, Japan
    Blood 107:1491-6. 2006
    ..Taken together, these results suggest that DNAM-1 ligands stimulate innate immunity by CD8alpha+ DCs as well as NK cells, which efficiently prime cell-mediated tumor-specific immunity...
  16. ncbi request reprint Caspase-independent cell death by CD300LF (MAIR-V), an inhibitory immunoglobulin-like receptor on myeloid cells
    Ismail Can
    Department of Immunology, Institute of Basic Medical Sciences and Center for Tsukuba Advanced Research Alliance, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    J Immunol 180:207-13. 2008
    ..Together, these results indicate that CD300LF mediates caspase and endoplasmic reticulum stress-independent cell death by a novel mechanism...
  17. pmc Critical role of M. tuberculosis for dendritic cell maturation to induce collagen-induced arthritis in H-2b background of C57BL/6 mice
    Hirayasu Kai
    Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsubuka, Ibaraki, Japan
    Immunology 118:233-9. 2006
    ..tuberculosis. These results suggested that high dose of M. tuberculosis were required for maturation of DC enough to prime CD4+ helper T cells specific to CII antigen in DLN of H-2b background of C57BL/6 mice...
  18. ncbi request reprint LFA-1-dependent lipid raft recruitment of DNAM-1 (CD226) in CD4+ T cell
    Jun Shirakawa
    Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences and Center for TARA, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Int Immunol 18:951-7. 2006
    ..These results suggest that the serine phosphorylation of DNAM-1 primarily induces physical association of DNAM-1 with LFA-1, which then takes DNAM-1 into lipid raft compartment...
  19. ncbi request reprint Identification and characterization of murine DNAM-1 (CD226) and its poliovirus receptor family ligands
    Satoko Tahara-Hanaoka
    Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, Center for TARA, University of Tsukuba, Ibaraki 305 8575, Japan
    Biochem Biophys Res Commun 329:996-1000. 2005
    ..We demonstrated that ligand binding of murine DNAM-1 induced a costimulatory signal in antigen-specific CD8+ T cells. These results should provide a useful animal model to explore a role of DNAM-1 in immune responses in vivo...
  20. ncbi request reprint An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions
    Kaori Hitomi
    Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Nat Immunol 11:601-7. 2010
    ..Moreover, mice deficient in Allergin-1 developed enhanced passive systemic and cutaneous anaphylaxis. Thus, Allergin-1 suppresses IgE-mediated, mast cell-dependent anaphylaxis in mice...
  21. doi request reprint Identification of phosphatidylserine as a ligand for the CD300a immunoreceptor
    Chigusa Nakahashi-Oda
    Department of Immunology, Division of Biomedical Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 417:646-50. 2012
    ..PS binding to CD300a induced SHP-1 recruitment by CD300a in mast cells in response to LPS. These results indicated that CD300a is a new PS receptor...
  22. ncbi request reprint Dual assemblies of an activating immune receptor, MAIR-II, with ITAM-bearing adapters DAP12 and FcRgamma chain on peritoneal macrophages
    Chigusa Nakahashi
    Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    J Immunol 178:765-70. 2007
    ..The FcRgamma chain may provide cooperation with and/or compensation for DAP12 in MAIR-II-mediated inflammatory responses by peritoneal macrophages...
  23. doi request reprint Identification of the Fcalpha/muR isoform specifically expressed in the kidney tubules
    Naoki Kurita
    Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, and Center for TARA, University of Tsukuba, 1 1 1 Ten nodai, Tsukuba, Ibaraki 305 8575, Japan
    Mol Immunol 46:749-53. 2009
    ..These results suggest that Fcalpha/muR may not be involved in IgA deposition in glomerular mesangium cells in IgA nephropathy. Rather, it may play an important role in immunity in the renal tubular regions...
  24. ncbi request reprint The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors
    Hiromitsu Hara
    Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
    Nat Immunol 8:619-29. 2007
    ..Thus, the activation of lymphoid and myeloid cells through ITAM-associated receptors or Toll-like receptors is regulated by CARMA1-Bcl-10 and CARD9-Bcl-10, respectively...
  25. ncbi request reprint Th1 and type 1 cytotoxic T cells dominate responses in T-bet overexpression transgenic mice that develop contact dermatitis
    Kazusa Ishizaki
    Department of Anatomy and Embryology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    J Immunol 178:605-12. 2007
    ..These results suggest that the level of expression of T-bet might play an important role in the development of contact dermatitis and that these Tg mice should be a useful model for contact dermatitis...
  26. pmc Enhanced humoral immune responses against T-independent antigens in Fc alpha/muR-deficient mice
    Shin ichiro Honda
    Department of Immunology and Anatomy, Graduate School of Comprehensive Human Sciences, and Center for TARA, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Proc Natl Acad Sci U S A 106:11230-5. 2009
    ..Taken together, these results suggest that Fc alpha/muR negatively regulates TI antigen retention by MZB cells and FDCs, leading to suppression of humoral immune responses against T-independent antigens...
  27. ncbi request reprint Molecular characteristics of IgA and IgM Fc binding to the Fcalpha/muR
    Yukiko Cho
    Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences and Center for TARA, University of Tsukuba, 1 1 1 Tennodai, Tsukuba Science City, Ibaraki 305 8575, Japan
    Biochem Biophys Res Commun 345:474-8. 2006
    ..These results suggest that IgA and IgM bind to an epitope in the conserved amino acids in the Ig-like domain of Fcalpha/muR as well as poly-IgR...
  28. pmc CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation
    Kazuko Shibuya
    Laboratory for Immune Receptor, RIKEN Research Center for Allergy and Immunology, 3 1 1 Koyadai, Ibaraki 305 0074, Japan
    J Exp Med 198:1829-39. 2003
    ..Moreover, proliferation initiated by LFA-1 costimulatory signal is suppressed by lipid raft disruption in CD4+, but not CD8+, T cells, suggesting that the LFA-1 costimulatory signal is independent of lipid rafts in CD8+ T cells...
  29. doi request reprint Overexpression of RORγt under control of the CD2 promoter induces polyclonal plasmacytosis and autoantibody production in transgenic mice
    Keigyou Yoh
    Department of Nephrology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan
    Eur J Immunol 42:1999-2009. 2012
    ..These results suggest that RORγt plays important roles in the development of plasmacytosis and autoantibody production...
  30. doi request reprint Involvement of Fcα/μR (CD351) in autoantibody production
    Yuichi Yoshizawa
    Department of Immunology, Institute of Basic Medical Sciences, Faculty of Medicine, Tsukuba, Japan
    Mol Immunol 57:216-9. 2014
    ..These results suggest that Fcα/μR enhances, rather than suppresses, autoantibody production. ..
  31. doi request reprint Requirement of the cytoplasmic portion for dimer formation of Fcalpha/micro receptor expressed on cell surface
    Yukiko Cho
    Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Ten nohdai, Tsukuba, Ibaraki 305 8575, Japan
    Mol Immunol 47:878-82. 2010
    ..These results suggest that the cytoplasmic portion is required for the dimer formation and thus for efficient cell surface expression of Fcalpha/microR...
  32. pmc Expression and function of Allergin-1 on human primary mast cells
    Kei Nagai
    Department of Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan Department of Nephrology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan Japan Science and Technology Agency JST, Core Research for Evolutional Science and Technology CREST, Tokyo, Japan
    PLoS ONE 8:e76160. 2013
    ..These results indicate that Allergin-1 on human primary MC exhibits similar characteristics as mouse Allergin-1 in the expression profile and function. ..
  33. doi request reprint Expression of a splicing isoform of MAIR-V (CD300LF), an inhibitory immunoglobulin-like receptor on myeloid cells
    Ismail Can
    Department of Immunology, Institute of Basic Medical Sciences and Center for TARA, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Hybridoma (Larchmt) 27:59-61. 2008
    ..Thus, these MAbs are useful for analyses of molecular and functional characteristics of MAIR-Va and MAIR-Vb...
  34. ncbi request reprint Treatment with alpha-galactosylceramide attenuates the development of bleomycin-induced pulmonary fibrosis
    Toru Kimura
    Department of Respiratory Medicine, University of Tsukuba, Tennoudai, Tsukuba, Japan
    J Immunol 172:5782-9. 2004
    ..These results suggest that alpha-GalCer suppresses bleomycin-induced acute pulmonary inflammation and thus attenuates the development of pulmonary fibrosis possibly by regulating several cytokine levels...
  35. doi request reprint Isolation and characterization of naïve follicular dendritic cells
    Kenta Usui
    Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Ten nodai, Tsukuba, Ibaraki 305 8575, Japan
    Mol Immunol 50:172-6. 2012
    ....
  36. ncbi request reprint Requirement of the serine at residue 329 for lipid raft recruitment of DNAM-1 (CD226)
    Jun Shirakawa
    Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences and Center for TARA, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Int Immunol 17:217-23. 2005
    ....
  37. doi request reprint Molecular characterization of the dimer formation of Fcα/μ receptor (CD351)
    Kana Takagaki
    Department of Immunology, Institute of Basic Medical Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Mol Immunol 56:23-7. 2013
    ..Instead, our data suggest that Fcα/μR forms heterodimers with an as-yet-unknown molecule with a molecular weight of 60-70 kDa...
  38. doi request reprint Establishment and characterization of a novel anti-DNAM-1 monoclonal antibody
    Yumi Yamashita
    Department of Immunology, Division of Biomedical Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Monoclon Antib Immunodiagn Immunother 32:60-4. 2013
    ..Thus, TX92 is a unique MAb that is characterized not only by inhibitory function of DNAM-1 binding to the ligands but also by function of partial depletion of PB CD8(+) T cells...
  39. pmc Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE₂
    Yun Gi Kim
    Department of Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan Japan Science and Technology Agency, Core Research for Evolutional Science and Technology CREST, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cell Host Microbe 15:95-102. 2014
    ..Thus, Abx treatment can cause overgrowth of particular fungal species in the gut and promote M2 macrophage activation at distant sites to influence systemic responses including allergic inflammation...
  40. ncbi request reprint CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells
    Hiroshi Kojima
    Division of Hematology, Institute of Clinical Medicine and Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    J Biol Chem 278:36748-53. 2003
    ..Anti-CD226 monoclonal antibody inhibited binding of megakaryocytic cell lines to HUVEC. Taken together, these results reveal a novel mechanism for adhesion of platelets and megakaryocytic cells to vascular endothelial cells...
  41. ncbi request reprint Transgenic overexpression of GATA-3 in T lymphocytes improves autoimmune glomerulonephritis in mice with a BXSB/MpJ-Yaa genetic background
    Keigyou Yoh
    Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    J Am Soc Nephrol 14:2494-502. 2003
    ..These data suggest that transcriptional regulation therapy may have potential as an effective strategy for treating autoimmune glomerulonephritis...
  42. ncbi request reprint Development and functions of natural killer cells
    Akira Shibuya
    Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
    Int J Hematol 78:1-6. 2003
    ....
  43. pmc A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory
    Akiko Murayama
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba Science City, Ibaraki, Japan
    EMBO J 25:1081-92. 2006
    ..Our observations indicate that Oct-1-binding followed by CpG demethylation are key events in the epigenetic regulation of IL2 expression and may act as a memory of the regulatory event...
  44. pmc Reciprocal roles for CCAAT/enhancer binding protein (C/EBP) and PU.1 transcription factors in Langerhans cell commitment
    Atsushi Iwama
    Department of Immunology, Institute of Basic Medical Sciences, Core Research for Evolutional Science and Technology CREST Program of Japan Science and Technology JST
    J Exp Med 195:547-58. 2002
    ..Our findings establish reciprocal roles for C/EBP and PU.1 in LC development, and provide new insight into the molecular mechanism of LC development, which has not yet been well characterized...
  45. ncbi request reprint Successful multilineage engraftment of human cord blood cells in pigs after in utero transplantation
    Yutaka Fujiki
    Department of Immunology, Institute of Basic Medical Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Japan
    Transplantation 75:916-22. 2003
    ..The aim of this study was to accomplish xenotransplantation of human HSPCs into pig...
  46. ncbi request reprint Positional identification of an asthma susceptibility gene on human chromosome 5q33
    Emiko Noguchi
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki Ken, 305 8577, Japan
    Am J Respir Crit Care Med 172:183-8. 2005
    ..This area of linkage includes a region homologous to a mouse area that contains a locus involved in regulation of airway hyperreactivity...