Junji Shibahara

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc Interleukin-1beta expression in human gastric carcinoma with Epstein-Barr virus infection
    Ja Mun Chong
    Department of Pathology, Graduate School of Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    J Virol 76:6825-31. 2002
  2. doi request reprint Recently established entities of central nervous system tumors: review of radiological findings
    Shiori Amemiya
    Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Comput Assist Tomogr 32:279-85. 2008
  3. ncbi request reprint Podoplanin is expressed in subsets of tumors of the central nervous system
    Junji Shibahara
    Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Virchows Arch 448:493-9. 2006
  4. ncbi request reprint Primary pulmonary paraganglioma: report of a functioning case with immunohistochemical and ultrastructural study
    Junji Shibahara
    Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Am J Surg Pathol 28:825-9. 2004
  5. ncbi request reprint Papillary neuroepithelial tumor of the pineal region. A case report
    Junji Shibahara
    Department of Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 0033 Tokyo, Japan
    Acta Neuropathol 108:337-40. 2004
  6. ncbi request reprint Secondary glioblastoma with advanced neuronal immunophenotype
    Junji Shibahara
    Department of Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 0033 Tokyo, Japan
    Virchows Arch 447:665-8. 2005
  7. doi request reprint SALL4 represents fetal gut differentiation of gastric cancer, and is diagnostically useful in distinguishing hepatoid gastric carcinoma from hepatocellular carcinoma
    Tetsuo Ushiku
    Department of Pathology and Diagnostic Pathology, University of Tokyo, Japan
    Am J Surg Pathol 34:533-40. 2010
  8. doi request reprint Claudin-18 in biliary neoplasms. Its significance in the classification of intrahepatic cholangiocarcinoma
    Aya Shinozaki
    Department of Pathology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Virchows Arch 459:73-80. 2011
  9. doi request reprint Extended field stereotactic radiosurgery for recurrent glioblastoma
    Tomoyuki Koga
    Department of Neurosurgery, University of Tokyo Hospital, Tokyo, Japan
    Cancer 118:4193-200. 2012
  10. pmc Claudin-18 is an early-stage marker of pancreatic carcinogenesis
    Mariko Tanaka
    Department of Pathology, Graduate School of Medicine, The University of Tokyo, Japan
    J Histochem Cytochem 59:942-52. 2011

Detail Information

Publications47

  1. pmc Interleukin-1beta expression in human gastric carcinoma with Epstein-Barr virus infection
    Ja Mun Chong
    Department of Pathology, Graduate School of Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    J Virol 76:6825-31. 2002
    ..In vitro, IL-1beta increased the cell growth of a GC cell line, TMK1. Thus, IL-1beta may act as an autocrine growth factor in EBVaGC...
  2. doi request reprint Recently established entities of central nervous system tumors: review of radiological findings
    Shiori Amemiya
    Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Comput Assist Tomogr 32:279-85. 2008
    ....
  3. ncbi request reprint Podoplanin is expressed in subsets of tumors of the central nervous system
    Junji Shibahara
    Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Virchows Arch 448:493-9. 2006
    ..Given the widespread expression of podoplanin, the antibody D2-40 is of little use in diagnostic practice for CNS tumors...
  4. ncbi request reprint Primary pulmonary paraganglioma: report of a functioning case with immunohistochemical and ultrastructural study
    Junji Shibahara
    Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Am J Surg Pathol 28:825-9. 2004
    ..On the basis of our experience, our case is a bona fide primary pulmonary paraganglioma, a tumor heretofore subject to considerable skepticism...
  5. ncbi request reprint Papillary neuroepithelial tumor of the pineal region. A case report
    Junji Shibahara
    Department of Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 0033 Tokyo, Japan
    Acta Neuropathol 108:337-40. 2004
    ..Transthyretin expression of the present case further supports the likelihood of SCO origin, as transthyretin is one of the proteins presumed to be secreted by human SCO...
  6. ncbi request reprint Secondary glioblastoma with advanced neuronal immunophenotype
    Junji Shibahara
    Department of Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 0033 Tokyo, Japan
    Virchows Arch 447:665-8. 2005
    ..Although the secondary tumor was classified as glioblastoma according to World Health Organization (WHO) classification (2000), it might be categorized into new variants of malignant glioneuronal tumors proposed recently...
  7. doi request reprint SALL4 represents fetal gut differentiation of gastric cancer, and is diagnostically useful in distinguishing hepatoid gastric carcinoma from hepatocellular carcinoma
    Tetsuo Ushiku
    Department of Pathology and Diagnostic Pathology, University of Tokyo, Japan
    Am J Surg Pathol 34:533-40. 2010
    ..SALL4 is a sensitive marker for AFP-producing gastric carcinoma and is especially useful to distinguish hepatoid gastric carcinoma from hepatocellular carcinoma...
  8. doi request reprint Claudin-18 in biliary neoplasms. Its significance in the classification of intrahepatic cholangiocarcinoma
    Aya Shinozaki
    Department of Pathology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Virchows Arch 459:73-80. 2011
    ..These results suggest that CLDN18 may play an important role in biliary carcinogenesis, and especially in ICCs, it is associated with aggressive behavior and serves as a useful marker for the classification of ICC...
  9. doi request reprint Extended field stereotactic radiosurgery for recurrent glioblastoma
    Tomoyuki Koga
    Department of Neurosurgery, University of Tokyo Hospital, Tokyo, Japan
    Cancer 118:4193-200. 2012
    ..Stereotactic radiosurgery (SRS) is among the few therapeutic options for glioblastoma that recurs after standard radiation and chemotherapy, but its efficacy has been limited...
  10. pmc Claudin-18 is an early-stage marker of pancreatic carcinogenesis
    Mariko Tanaka
    Department of Pathology, Graduate School of Medicine, The University of Tokyo, Japan
    J Histochem Cytochem 59:942-52. 2011
    ..Activation of the PKC pathway might be involved in CLDN18 expression associated with pancreatic carcinogenesis...
  11. ncbi request reprint The glypican 3 oncofetal protein is a promising diagnostic marker for hepatocellular carcinoma
    Naoko Yamauchi
    Department of Pathology, Graduate School of Medicine, University of Tokyo, Hongo, Tokyo, Japan
    Mod Pathol 18:1591-8. 2005
    ....
  12. doi request reprint Uninodular combined hepatocellular and cholangiocarcinoma with multiple non-neoplastic hypervascular lesions appearing in the liver of a patient with HIV and HCV coinfection
    Koji Uchino
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Clin Virol 57:173-7. 2013
    ..The patient underwent partial hepatic resection and is currently alive without recurrence for 15 months. Multiple ring-enhanced lesions have been undetectable in postoperative follow-up CT examinations...
  13. ncbi request reprint Overexpression of MUC13 is associated with intestinal-type gastric cancer
    Takahiro Shimamura
    Genome Science Division, University of Tokyo, Meguro ku, Tokyo 153 8904, Japan
    Cancer Sci 96:265-73. 2005
    ..These results suggest that MUC13 is a good differentiation marker for gastrointestinal mucosa and that it may have a causal role that correlates with two distinct gastric tumorigenesis pathways...
  14. ncbi request reprint Expression of α-taxilin in hepatocellular carcinoma correlates with growth activity and malignant potential of the tumor
    Natsuko Ohtomo
    Department of Gastroenterology, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Int J Oncol 37:1417-23. 2010
    ..taxilin may be involved in cell proliferation of HCC, and its expression can be a marker of malignant potential of HCC...
  15. pmc Severe hypokinesis caused by paraneoplastic anti-Ma2 encephalitis associated with bilateral intratubular germ-cell neoplasm of the testes
    Lumine Matsumoto
    Department of Neurology, The University of Tokyo, Tokyo, Japan
    Mov Disord 22:728-31. 2007
    ..Anti-Ma2 paraneoplastic encephalitis should be considered in patients with severe hypokinesis, and intensive investigation and aggressive approach to treatment is encouraged to prevent progression of the neurological deficits...
  16. doi request reprint Mechanistic background and clinical applications of indocyanine green fluorescence imaging of hepatocellular carcinoma
    Takeaki Ishizawa
    Hepato Biliary Pancreatic Surgery Division, Department of Surgery, University of Tokyo, Tokyo, Japan
    Ann Surg Oncol 21:440-8. 2014
    ..Although clinical applications of intraoperative fluorescence imaging of liver cancer using indocyanine green (ICG) have begun, the mechanistic background of ICG accumulation in the cancerous tissues remains unclear...
  17. doi request reprint Significance of IDH mutations varies with tumor histology, grade, and genetics in Japanese glioma patients
    Akitake Mukasa
    Department of Neurosurgery, University of Tokyo, Tokyo, Japan
    Cancer Sci 103:587-92. 2012
    ..Therefore, IDH mutation would be most useful when assessing prognosis of patients with grade 3 glioma with intact 1p/19q; anaplastic astrocytomas account for most of these grade 3 gliomas...
  18. doi request reprint Lymphomatoid granulomatosis involving central nervous system successfully treated with rituximab alone
    Hiroyuki Ishiura
    Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Arch Neurol 65:662-5. 2008
    ..Because central nervous system (CNS) involvement of LYG has been known to show poor prognosis, the establishment of an effective treatment for CNS LYG with mild adverse effects is desired...
  19. pmc Long-term control of disseminated pleomorphic xanthoastrocytoma with anaplastic features by means of stereotactic irradiation
    Tomoyuki Koga
    Department of Neurosurgery, University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neuro Oncol 11:446-51. 2009
    ..Autopsy showed that the nodules remained well demarcated from the surrounding nervous system tissue. STI may be an effective therapeutic tool for controlling nodular dissemination of PXA with anaplastic features...
  20. ncbi request reprint Intraductal oncocytic papillary neoplasm of the bile duct: clinicopathologic and immunohistochemical characteristics of 6 cases
    Mariko Tanaka
    Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
    Hum Pathol 40:1543-52. 2009
    ..Our results also suggest that oncocytic changes occur in epithelial cells of biliary tracts that show a predominant gastric phenotype...
  21. ncbi request reprint Global and non-random CpG-island methylation in gastric carcinoma associated with Epstein-Barr virus
    Ja Mun Chong
    Department of Pathology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033
    Cancer Sci 94:76-80. 2003
    ..The DNA methylation of specific genes, independently of DNMTs expression, may be important in the development of EBVaGC...
  22. ncbi request reprint Multifocal pilocytic astrocytomas with ependymal differentiation in the bilateral medial temporal lobes: case report
    Keisuke Maruyama
    Department of Neurosurgery, The University of Tokyo Hospital, Japan
    Neurol Med Chir (Tokyo) 45:411-4. 2005
    ..Ependymal differentiation with extremely high proliferative activity might be related to this unusual clinical presentation. Intensive treatment is recommended for patients with such specific neuroimaging and histological features...
  23. pmc Concurrent activation of acetylation and tri-methylation of H3K27 in a subset of hepatocellular carcinoma with aggressive behavior
    Akimasa Hayashi
    Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan Genome Science Division, Research Center for Advanced Science and Technology RCAST, The University of Tokyo, Tokyo, Japan
    PLoS ONE 9:e91330. 2014
    ..These findings demonstrate that image analyzer-assisted H-scores of H3K27ac and H3K27me3 identified an aggressive subgroup of HCC, and could serve as a prognostic marker for HCC. ..
  24. ncbi request reprint Erdheim-Chester disease with an 18F-fluorodeoxyglucose-avid breast mass and BRAF V600E mutation
    Toshihiro Furuta
    Department of Radiology, Research Hospital, The Institute of Medical Science, The University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
    Jpn J Radiol 32:282-7. 2014
    ..Both specimens revealed involvement by histiocytic infiltrates with features suggestive of ECD. The BRAF V600E mutation was detected by DNA sequencing and immunohistochemistry. ..
  25. doi request reprint The niche component periostin is produced by cancer-associated fibroblasts, supporting growth of gastric cancer through ERK activation
    Yoshinao Kikuchi
    Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Am J Pathol 184:859-70. 2014
    ..Ki-67 and p-ERK positive rates were both lower in Postn(-/-) mice. These findings suggest that POSTN produced by cancer-associated fibroblasts constitutes a growth-supportive microenvironment for gastric cancer...
  26. ncbi request reprint Hepatocellular carcinoma with steatohepatitic features: a clinicopathological study of Japanese patients
    Junji Shibahara
    Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Histopathology 64:951-62. 2014
    ..The aim of this study was to investigate the clinicopathological significance of steatohepatitic features in hepatocellular carcinomas (HCCs) using a large-scale analysis...
  27. doi request reprint β-catenin (CTNNB1) S33C mutation in ovarian microcystic stromal tumors
    Daichi Maeda
    Department of Pathology, Graduate School of Medicine, The University of Tokyo, Japan
    Am J Surg Pathol 35:1429-40. 2011
    ..Finally, by comparing the immunophenotype of MCST with its histologic mimics and other ovarian sex cord-stromal tumors, we were able to identify unique features of MCST and a panel of markers useful in differential diagnosis...
  28. doi request reprint Osteomalacia caused by skull base tumors: report of 2 cases
    Takeshi Uno
    Department of Neurosurgery, The University of Tokyo Hospital, Tokyo, Japan
    Neurosurgery 69:E239-44; discussion E244. 2011
    ..Although the diagnosis of TIO is difficult to make and often is delayed because of the insidious nature of the symptoms, mostly systemic pain and weakness, it is curable once it is diagnosed and properly treated...
  29. ncbi request reprint Successful treatment of an unresectable inflammatory myofibroblastic tumor of the frontal bone using a cyclooxygenase-2 inhibitor and methotrexate
    Fumiko Kusunoki-Nakamoto
    Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan
    Intern Med 52:623-8. 2013
    ..Performing total excision seemed difficult. Celecoxib and methotrexate were effective treatments. Our experience suggests the efficacy of celecoxib and methotrexate as alternatives for treating unresectable IMT...
  30. ncbi request reprint Lymphoplasmacyte-rich meningioma with atypical invasive nature
    Hidenori Nohara
    Department of Neurosurgery, University of Tokyo Hospital, Tokyo, Japan
    Neurol Med Chir (Tokyo) 47:32-5. 2007
    ..The Ki-67 staining index using MIB-1 monoclonal antibody was relatively high. (18)F-2-fluoro-2-deoxy-D-glucose positron emission tomography revealed high uptake in the tumor. These findings indicate the atypical nature of LPR meningioma...
  31. ncbi request reprint Sarcomatous transformation of clival chordoma after charged-particle radiotherapy. Report of two cases
    Takayuki Hara
    Department of Neurosurgery, Faculty of Medicine, University of Tokyo, Japan
    J Neurosurg 105:136-41. 2006
    ..Although these sarcomatous transformations are rare in conventional chordomas, a careful histological examination and thorough follow-up imaging studies are crucial when treating patients with such lesions...
  32. doi request reprint Real-time identification of liver cancers by using indocyanine green fluorescent imaging
    Takeaki Ishizawa
    Hepato Biliary Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Cancer 115:2491-504. 2009
    ..Fluorescent imaging using indocyanine green (ICG) has the potential to detect liver cancers through the visualization of the disordered biliary excretion of ICG in cancer tissues and noncancerous liver tissues compressed by the tumor...
  33. ncbi request reprint Reduced expression and promoter methylation of p16 gene in Epstein-Barr virus-associated gastric carcinoma
    Toshiya Osawa
    Department of Pathology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Jpn J Cancer Res 93:1195-200. 2002
    ..9+/-21.6) than the unmethylated ones (55.2+/-22.7) (P=0.0014). Thus, a marked decrease of p16 expression, caused by the aberrant methylation of the p16 gene promoter, is closely associated with the development of EBVaGC...
  34. ncbi request reprint High-density methylation of p14ARF and p16INK4A in Epstein-Barr virus-associated gastric carcinoma
    Kazuya Sakuma
    Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Int J Cancer 112:273-8. 2004
    ..These findings suggest the presence of mechanisms of de novo and maintenance methylation specific to EBVaGC that might be associated with EBV infection...
  35. doi request reprint MALT lymphoma of the small bowel with protein-losing enteropathy
    Ayato Tsukamoto
    Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Int J Hematol 99:198-201. 2014
    ..Gastrointestinal reconstruction may be responsible for underlying chronic inflammation via small intestinal bacterial overgrowth. ..
  36. ncbi request reprint Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers' non-small cell lung carcinomas
    Shin ichi Fukumoto
    Genome Science Division and Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, Graduate School of Medicine, University of Tokyo, 4 6 1 Komaba, Meguro ku, Tokyo 153 8904, Japan
    Clin Cancer Res 11:1776-85. 2005
    ..The aim of this study is to identify a molecular target with diagnostic and therapeutic values for SCC...
  37. ncbi request reprint Aspergillus thyroiditis in a living donor liver transplant recipient
    Yuichi Matsui
    Department of Surgery, Artificial Organ and Transplantation Division, Graduate School of Medicine, University of Tokyo, Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Infect 53:e231-3. 2006
    ..01 mg/dl. The patient died of liver sepsis due to Pseudomonas aeruginosa. (1-3)-beta-d Glucan monitoring and systematic radionuclide images are useful modalities for early diagnosis of Aspergillosis...
  38. ncbi request reprint Intracranial extracerebral glioneuronal heterotopia. Case report and review of the literature
    Soichi Oya
    Department of Neurosurgery, Faculty of Medicine, University of Tokyo, Japan
    J Neurosurg 102:105-12. 2005
    ..More detailed case reports are necessary to understand fully the pathogenesis of IEGHs...
  39. doi request reprint Soft-tissue hemangioblastoma of the retroperitoneum: a case study and review of the literature
    Akihiko Yoshida
    Clinical Laboratory Division, National Cancer Center Hospital, University of Tokyo, Tokyo, Japan
    Appl Immunohistochem Mol Morphol 18:479-82. 2010
    ..The patient is well 4 years after the surgery without any recurrence. A review of the literature revealed that soft-tissue hemangioblastoma is typically a solid tumor found in older females and often involves the retroperitoneum/pelvis...
  40. pmc Selective loss of Purkinje cells in a patient with anti-glutamic acid decarboxylase antibody-associated cerebellar ataxia
    Kazuyuki Ishida
    Department of Neurology, Tamagawa Hospital, Setagaya Ku, Tokyo, Japan
    J Neurol Neurosurg Psychiatry 78:190-2. 2007
    ..Therefore, the main cause of cerebellar ataxia observed in this case may be attributed to the near-complete depletion of the Purkinje cells. In this paper, the pathomechanisms underlying Purkinje cell damage are discussed...
  41. ncbi request reprint Radiation-induced spinal cord cavernous malformation. Case report
    Masanori Yoshino
    Department of Neurosurgery, Faculty of Medicine, University of Tokyo, Japan
    J Neurosurg 102:101-4. 2005
    ..This is believed to be the third case of de novo formation of an intramedullary cavernous malformation following spinal radiation therapy...
  42. ncbi request reprint Papillary glioneuronal tumor with minigemistocytic components and increased proliferative activity
    Takashi Ishizawa
    Department of Pathology, Saitama Medical School, Moroyama, Iruma gun, Saitama 350 0495, Japan
    Hum Pathol 37:627-30. 2006
    ..Although PGNT is defined as an indolent glioneuronal tumor, the presence of minigemistocytic components with the high Ki-67 labeling index may indicate more aggressive nature...
  43. ncbi request reprint Pathology of the sympathetic nervous system corresponding to the decreased cardiac uptake in 123I-metaiodobenzylguanidine (MIBG) scintigraphy in a patient with Parkinson disease
    Jun Mitsui
    Department of Neurology, Division of Neuroscience, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Neurol Sci 243:101-4. 2006
    ..Our study may provide further evidence that the markedly decreased cardiac uptake of MIBG observed in PD cases represents preferential involvement of the cardiac sympathetic nerve plexus in this disorder...
  44. ncbi request reprint Endoscopic and histopathologic findings after formalin application for hemorrhage caused by chronic radiation-induced proctitis
    Tsuyoshi Konishi
    Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Japan
    Gastrointest Endosc 61:161-4. 2005
  45. ncbi request reprint A distinct pattern of Olig2-positive cellular distribution in papillary glioneuronal tumors: a manifestation of the oligodendroglial phenotype?
    Yuko Tanaka
    Department of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Acta Neuropathol 110:39-47. 2005
    ....
  46. ncbi request reprint Identification of ROBO1 as a novel hepatocellular carcinoma antigen and a potential therapeutic and diagnostic target
    Hirotaka Ito
    Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Japan
    Clin Cancer Res 12:3257-64. 2006
    ..The present study was done to identify new transmembrane molecules for antibody therapy in hepatocellular carcinoma...
  47. ncbi request reprint Loss of FHIT expression in squamous cell carcinoma and premalignant lesions of the larynx
    Tadashi Yuge
    Department of Otolaryngology, International Medical Center of Japan, Toyama 1 21 1, Shinjuku, Tokyo 162 8655, Japan
    Ann Otol Rhinol Laryngol 114:127-31. 2005
    ..These findings of loss of FHIT protein expression, not only in squamous cell carcinoma, but also in premalignant lesions, indicate that FHIT alterations play an important role in the early events of carcinogenesis...