Research Topics
Genomes and GenesSpecies | Junji ShibaharaSummaryAffiliation: University of Tokyo Country: Japan Publications
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Detail Information
Publications
Interleukin-1beta expression in human gastric carcinoma with Epstein-Barr virus infectionJa Mun Chong
Department of Pathology, Graduate School of Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
J Virol 76:6825-31. 2002..In vitro, IL-1beta increased the cell growth of a GC cell line, TMK1. Thus, IL-1beta may act as an autocrine growth factor in EBVaGC...
Recently established entities of central nervous system tumors: review of radiological findingsShiori Amemiya
Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
J Comput Assist Tomogr 32:279-85. 2008....
Secondary glioblastoma with advanced neuronal immunophenotypeJunji Shibahara
Department of Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 0033 Tokyo, Japan
Virchows Arch 447:665-8. 2005..Although the secondary tumor was classified as glioblastoma according to World Health Organization (WHO) classification (2000), it might be categorized into new variants of malignant glioneuronal tumors proposed recently...- Primary pulmonary paraganglioma: report of a functioning case with immunohistochemical and ultrastructural studyJunji Shibahara
Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Am J Surg Pathol 28:825-9. 2004..On the basis of our experience, our case is a bona fide primary pulmonary paraganglioma, a tumor heretofore subject to considerable skepticism... - Papillary neuroepithelial tumor of the pineal region. A case reportJunji Shibahara
Department of Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 0033 Tokyo, Japan
Acta Neuropathol 108:337-40. 2004..Transthyretin expression of the present case further supports the likelihood of SCO origin, as transthyretin is one of the proteins presumed to be secreted by human SCO... - Podoplanin is expressed in subsets of tumors of the central nervous systemJunji Shibahara
Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Virchows Arch 448:493-9. 2006..Given the widespread expression of podoplanin, the antibody D2-40 is of little use in diagnostic practice for CNS tumors... - SALL4 represents fetal gut differentiation of gastric cancer, and is diagnostically useful in distinguishing hepatoid gastric carcinoma from hepatocellular carcinomaTetsuo Ushiku
Department of Pathology and Diagnostic Pathology, University of Tokyo, Japan
Am J Surg Pathol 34:533-40. 2010..SALL4 is a sensitive marker for AFP-producing gastric carcinoma and is especially useful to distinguish hepatoid gastric carcinoma from hepatocellular carcinoma... - Claudin-18 in biliary neoplasms. Its significance in the classification of intrahepatic cholangiocarcinomaAya Shinozaki
Department of Pathology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
Virchows Arch 459:73-80. 2011..These results suggest that CLDN18 may play an important role in biliary carcinogenesis, and especially in ICCs, it is associated with aggressive behavior and serves as a useful marker for the classification of ICC... - Claudin-18 is an early-stage marker of pancreatic carcinogenesisMariko Tanaka
Department of Pathology, Graduate School of Medicine, The University of Tokyo, Japan
J Histochem Cytochem 59:942-52. 2011..Activation of the PKC pathway might be involved in CLDN18 expression associated with pancreatic carcinogenesis... - Extended field stereotactic radiosurgery for recurrent glioblastomaTomoyuki Koga
Department of Neurosurgery, University of Tokyo Hospital, Tokyo, Japan
Cancer 118:4193-200. 2012..Stereotactic radiosurgery (SRS) is among the few therapeutic options for glioblastoma that recurs after standard radiation and chemotherapy, but its efficacy has been limited... - The glypican 3 oncofetal protein is a promising diagnostic marker for hepatocellular carcinomaNaoko Yamauchi
Department of Pathology, Graduate School of Medicine, University of Tokyo, Hongo, Tokyo, Japan
Mod Pathol 18:1591-8. 2005.... - Expression of α-taxilin in hepatocellular carcinoma correlates with growth activity and malignant potential of the tumorNatsuko Ohtomo
Department of Gastroenterology, University of Tokyo, Bunkyo ku, Tokyo, Japan
Int J Oncol 37:1417-23. 2010..taxilin may be involved in cell proliferation of HCC, and its expression can be a marker of malignant potential of HCC... - Severe hypokinesis caused by paraneoplastic anti-Ma2 encephalitis associated with bilateral intratubular germ-cell neoplasm of the testesLumine Matsumoto
Department of Neurology, The University of Tokyo, Tokyo, Japan
Mov Disord 22:728-31. 2007..Anti-Ma2 paraneoplastic encephalitis should be considered in patients with severe hypokinesis, and intensive investigation and aggressive approach to treatment is encouraged to prevent progression of the neurological deficits... - Significance of IDH mutations varies with tumor histology, grade, and genetics in Japanese glioma patientsAkitake Mukasa
Department of Neurosurgery, University of Tokyo, Tokyo, Japan
Cancer Sci 103:587-92. 2012..Therefore, IDH mutation would be most useful when assessing prognosis of patients with grade 3 glioma with intact 1p/19q; anaplastic astrocytomas account for most of these grade 3 gliomas... - Lymphomatoid granulomatosis involving central nervous system successfully treated with rituximab aloneHiroyuki Ishiura
Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Arch Neurol 65:662-5. 2008..Because central nervous system (CNS) involvement of LYG has been known to show poor prognosis, the establishment of an effective treatment for CNS LYG with mild adverse effects is desired... - Long-term control of disseminated pleomorphic xanthoastrocytoma with anaplastic features by means of stereotactic irradiationTomoyuki Koga
Department of Neurosurgery, University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Neuro Oncol 11:446-51. 2009..Autopsy showed that the nodules remained well demarcated from the surrounding nervous system tissue. STI may be an effective therapeutic tool for controlling nodular dissemination of PXA with anaplastic features... - Intraductal oncocytic papillary neoplasm of the bile duct: clinicopathologic and immunohistochemical characteristics of 6 casesMariko Tanaka
Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
Hum Pathol 40:1543-52. 2009..Our results also suggest that oncocytic changes occur in epithelial cells of biliary tracts that show a predominant gastric phenotype... - Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers' non-small cell lung carcinomasShin-ichi Fukumoto
Genome Science Division and Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, Graduate School of Medicine, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan
Clin Cancer Res 11:1776-85. 2005..These results suggest that AKR1B10 is a potential diagnostic marker specific to smokers' NSCLCs and might be involved in tobacco-related carcinogenesis... - Multifocal pilocytic astrocytomas with ependymal differentiation in the bilateral medial temporal lobes: case reportKeisuke Maruyama
Department of Neurosurgery, The University of Tokyo Hospital, Japan
Neurol Med Chir (Tokyo) 45:411-4. 2005..Ependymal differentiation with extremely high proliferative activity might be related to this unusual clinical presentation. Intensive treatment is recommended for patients with such specific neuroimaging and histological features... - Global and non-random CpG-island methylation in gastric carcinoma associated with Epstein-Barr virusJa Mun Chong
Department of Pathology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033
Cancer Sci 94:76-80. 2003..The DNA methylation of specific genes, independently of DNMTs expression, may be important in the development of EBVaGC... - Real-time identification of liver cancers by using indocyanine green fluorescent imagingTakeaki Ishizawa
Hepato Biliary Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
Cancer 115:2491-504. 2009..Fluorescent imaging using indocyanine green (ICG) has the potential to detect liver cancers through the visualization of the disordered biliary excretion of ICG in cancer tissues and noncancerous liver tissues compressed by the tumor... - Lymphoplasmacyte-rich meningioma with atypical invasive natureHidenori Nohara
Department of Neurosurgery, University of Tokyo Hospital, Tokyo, Japan
Neurol Med Chir (Tokyo) 47:32-5. 2007..The Ki-67 staining index using MIB-1 monoclonal antibody was relatively high. (18)F-2-fluoro-2-deoxy-D-glucose positron emission tomography revealed high uptake in the tumor. These findings indicate the atypical nature of LPR meningioma... - Sarcomatous transformation of clival chordoma after charged-particle radiotherapy. Report of two casesTakayuki Hara
Department of Neurosurgery, Faculty of Medicine, University of Tokyo, Japan
J Neurosurg 105:136-41. 2006..Although these sarcomatous transformations are rare in conventional chordomas, a careful histological examination and thorough follow-up imaging studies are crucial when treating patients with such lesions... - High-density methylation of p14ARF and p16INK4A in Epstein-Barr virus-associated gastric carcinomaKazuya Sakuma
Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Int J Cancer 112:273-8. 2004..These findings suggest the presence of mechanisms of de novo and maintenance methylation specific to EBVaGC that might be associated with EBV infection... - Reduced expression and promoter methylation of p16 gene in Epstein-Barr virus-associated gastric carcinomaToshiya Osawa
Department of Pathology, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan
Jpn J Cancer Res 93:1195-200. 2002..9+/-21.6) than the unmethylated ones (55.2+/-22.7) (P=0.0014). Thus, a marked decrease of p16 expression, caused by the aberrant methylation of the p16 gene promoter, is closely associated with the development of EBVaGC... - β-catenin (CTNNB1) S33C mutation in ovarian microcystic stromal tumorsDaichi Maeda
Department of Pathology, Graduate School of Medicine, The University of Tokyo, Japan
Am J Surg Pathol 35:1429-40. 2011..Finally, by comparing the immunophenotype of MCST with its histologic mimics and other ovarian sex cord-stromal tumors, we were able to identify unique features of MCST and a panel of markers useful in differential diagnosis... - Soft-tissue hemangioblastoma of the retroperitoneum: a case study and review of the literatureAkihiko Yoshida
Clinical Laboratory Division, National Cancer Center Hospital, University of Tokyo, Tokyo, Japan
Appl Immunohistochem Mol Morphol 18:479-82. 2010..The patient is well 4 years after the surgery without any recurrence. A review of the literature revealed that soft-tissue hemangioblastoma is typically a solid tumor found in older females and often involves the retroperitoneum/pelvis... - Papillary glioneuronal tumor with minigemistocytic components and increased proliferative activityTakashi Ishizawa
Department of Pathology, Saitama Medical School, Moroyama, Iruma gun, Saitama 350 0495, Japan
Hum Pathol 37:627-30. 2006..Although PGNT is defined as an indolent glioneuronal tumor, the presence of minigemistocytic components with the high Ki-67 labeling index may indicate more aggressive nature... - Intracranial extracerebral glioneuronal heterotopia. Case report and review of the literatureSoichi Oya
Department of Neurosurgery, Faculty of Medicine, University of Tokyo, Japan
J Neurosurg 102:105-12. 2005..More detailed case reports are necessary to understand fully the pathogenesis of IEGHs... - Selective loss of Purkinje cells in a patient with anti-glutamic acid decarboxylase antibody-associated cerebellar ataxiaKazuyuki Ishida
Department of Neurology, Tamagawa Hospital, Setagaya Ku, Tokyo, Japan
J Neurol Neurosurg Psychiatry 78:190-2. 2007..Therefore, the main cause of cerebellar ataxia observed in this case may be attributed to the near-complete depletion of the Purkinje cells. In this paper, the pathomechanisms underlying Purkinje cell damage are discussed... - Radiation-induced spinal cord cavernous malformation. Case reportMasanori Yoshino
Department of Neurosurgery, Faculty of Medicine, University of Tokyo, Japan
J Neurosurg 102:101-4. 2005..This is believed to be the third case of de novo formation of an intramedullary cavernous malformation following spinal radiation therapy... - Pathology of the sympathetic nervous system corresponding to the decreased cardiac uptake in 123I-metaiodobenzylguanidine (MIBG) scintigraphy in a patient with Parkinson diseaseJun Mitsui
Department of Neurology, Division of Neuroscience, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
J Neurol Sci 243:101-4. 2006..Our study may provide further evidence that the markedly decreased cardiac uptake of MIBG observed in PD cases represents preferential involvement of the cardiac sympathetic nerve plexus in this disorder... - Aspergillus thyroiditis in a living donor liver transplant recipientYuichi Matsui
Department of Surgery, Artificial Organ and Transplantation Division, Graduate School of Medicine, University of Tokyo, Tokyo 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
J Infect 53:e231-3. 2006..01 mg/dl. The patient died of liver sepsis due to Pseudomonas aeruginosa. (1-3)-beta-d Glucan monitoring and systematic radionuclide images are useful modalities for early diagnosis of Aspergillosis... - Overexpression of MUC13 is associated with intestinal-type gastric cancerTakahiro Shimamura
Genome Science Division, University of Tokyo, Meguro ku, Tokyo 153 8904, Japan
Cancer Sci 96:265-73. 2005..These results suggest that MUC13 is a good differentiation marker for gastrointestinal mucosa and that it may have a causal role that correlates with two distinct gastric tumorigenesis pathways... - Endoscopic and histopathologic findings after formalin application for hemorrhage caused by chronic radiation-induced proctitisTsuyoshi Konishi
Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Japan
Gastrointest Endosc 61:161-4. 2005 - Identification of ROBO1 as a novel hepatocellular carcinoma antigen and a potential therapeutic and diagnostic targetHirotaka Ito
Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Japan
Clin Cancer Res 12:3257-64. 2006..The present study was done to identify new transmembrane molecules for antibody therapy in hepatocellular carcinoma... - A distinct pattern of Olig2-positive cellular distribution in papillary glioneuronal tumors: a manifestation of the oligodendroglial phenotype?Yuko Tanaka
Department of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
Acta Neuropathol 110:39-47. 2005.... - Loss of FHIT expression in squamous cell carcinoma and premalignant lesions of the larynxTadashi Yuge
Department of Otolaryngology, International Medical Center of Japan, Toyama 1-21-1, Shinjuku, Tokyo 162-8655, Japan
Ann Otol Rhinol Laryngol 114:127-31. 2005..These findings of loss of FHIT protein expression, not only in squamous cell carcinoma, but also in premalignant lesions, indicate that FHIT alterations play an important role in the early events of carcinogenesis...