T Sekine

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint [Molecular identification of the multispecific organic anion transporter family (the OAT family): the role in the pharmacokinetics and toxicokinetics]
    T Sekine
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    Nihon Yakurigaku Zasshi 117:177-86. 2001
  2. ncbi request reprint A familial case of multicystic dysplastic kidney
    Takashi Sekine
    Department of Pediatrics, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655 Tokyo, Japan
    Pediatr Nephrol 20:1245-8. 2005
  3. ncbi request reprint OCRL1 mutations in patients with Dent disease phenotype in Japan
    Takashi Sekine
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Pediatr Nephrol 22:975-80. 2007
  4. ncbi request reprint Children's toxicology from bench to bed--Drug-induced renal injury (1): The toxic effects of ARB/ACEI on fetal kidney development
    Takashi Sekine
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Japan
    J Toxicol Sci 34:SP245-50. 2009
  5. ncbi request reprint Children's toxicology from bench to bed--Drug-induced renal injury (3): Drug transporters and toxic nephropathy in childhood
    Takashi Sekine
    Department of Pediatrics, Gradate School of Medicine, The University of Tokyo, Japan
    J Toxicol Sci 34:SP259-65. 2009
  6. doi request reprint Patients with Epstein-Fechtner syndromes owing to MYH9 R702 mutations develop progressive proteinuric renal disease
    Takashi Sekine
    Faculty of Medicine, Department of Pediatrics, The University of Tokyo, Tokyo, Japan
    Kidney Int 78:207-14. 2010
  7. ncbi request reprint Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity
    M Takeda
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    Kidney Int 56:2128-36. 1999
  8. ncbi request reprint Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta
    S H Cha
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo, 181 8611, 113 0033, Japan
    J Biol Chem 275:4507-12. 2000
  9. ncbi request reprint The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1
    S Jariyawat
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    J Pharmacol Exp Ther 290:672-7. 1999
  10. ncbi request reprint Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain
    H Kusuhara
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 274:13675-80. 1999

Collaborators

Detail Information

Publications43

  1. ncbi request reprint [Molecular identification of the multispecific organic anion transporter family (the OAT family): the role in the pharmacokinetics and toxicokinetics]
    T Sekine
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    Nihon Yakurigaku Zasshi 117:177-86. 2001
    ..In addition, OAT members appear to be responsible for the distribution/elimination of water soluble anionic drugs into/from the liver, brain and fetus...
  2. ncbi request reprint A familial case of multicystic dysplastic kidney
    Takashi Sekine
    Department of Pediatrics, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655 Tokyo, Japan
    Pediatr Nephrol 20:1245-8. 2005
    ..Thus in this family MCDK occurs as an isolated phenomenon in three individuals within two generations, presumably as a result of autosomal dominant inheritance...
  3. ncbi request reprint OCRL1 mutations in patients with Dent disease phenotype in Japan
    Takashi Sekine
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Pediatr Nephrol 22:975-80. 2007
    ..The mutations identified in OCRL1 are one frame-shift mutation (I127stop) and two missense mutations (R301C and R476W). R301C and R476W mutations might be hot spots in OCRL1, which develop very similar phenotypes as Dent-2...
  4. ncbi request reprint Children's toxicology from bench to bed--Drug-induced renal injury (1): The toxic effects of ARB/ACEI on fetal kidney development
    Takashi Sekine
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Japan
    J Toxicol Sci 34:SP245-50. 2009
    ..In this paper, we overview the development of fetal kidney and address the effects of ACEIs/ARBs on fetal kidney...
  5. ncbi request reprint Children's toxicology from bench to bed--Drug-induced renal injury (3): Drug transporters and toxic nephropathy in childhood
    Takashi Sekine
    Department of Pediatrics, Gradate School of Medicine, The University of Tokyo, Japan
    J Toxicol Sci 34:SP259-65. 2009
    ..Regarding drug nephrotoxicity in children, development of the child and the kidney should also be taken into account. This review focuses on the mechanisms of toxic nephropathy in children with special attention to the OAT family...
  6. doi request reprint Patients with Epstein-Fechtner syndromes owing to MYH9 R702 mutations develop progressive proteinuric renal disease
    Takashi Sekine
    Faculty of Medicine, Department of Pediatrics, The University of Tokyo, Tokyo, Japan
    Kidney Int 78:207-14. 2010
    ..Thus, MYH9 R702 mutations display a strict genotype-phenotype correlation, and lead to the rapid deterioration of podocyte structure. Our results highlight the critical role of NMMHC-IIA in the development of FSGS...
  7. ncbi request reprint Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity
    M Takeda
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    Kidney Int 56:2128-36. 1999
    ..Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity...
  8. ncbi request reprint Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta
    S H Cha
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo, 181 8611, 113 0033, Japan
    J Biol Chem 275:4507-12. 2000
    ..OAT4 is the first member of the multispecific organic anion transporter family, which is expressed abundantly in the placenta. OAT4 might be responsible for the elimination and detoxification of harmful anionic substances from the fetus...
  9. ncbi request reprint The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1
    S Jariyawat
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    J Pharmacol Exp Ther 290:672-7. 1999
    ..Furthermore, the culture cell system expressing OAT1 was revealed to be useful for the prediction of the nephrotoxicity of beta-lactam antibiotics...
  10. ncbi request reprint Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain
    H Kusuhara
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 274:13675-80. 1999
    ..These results suggest an important role of OAT3 in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain...
  11. ncbi request reprint Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney
    S H Cha
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Shinkawa, Mitaka, Tokyo, Japan
    Mol Pharmacol 59:1277-86. 2001
    ..3 by fluorescent in situ hybridization analysis. These results suggest an important role of hOAT3 in the excretion/detoxification of endogenous and exogenous organic anions in the kidney...
  12. ncbi request reprint Functional characterization of rat organic anion transporter 2 in LLC-PK1 cells
    N Morita
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    J Pharmacol Exp Ther 298:1179-84. 2001
    ..The present study shows that rOat2 is a multispecific transporter and suggests that it may be involved at least partly, in the hepatic uptake of IDM, salicylate and nucleoside derivatives...
  13. ncbi request reprint Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney
    M Hosoyamada
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo 181 8611, Japan
    Am J Physiol 276:F122-8. 1999
    ..1 by fluorescent in situ hybridization analysis. These results indicate that hOAT1 is a multispecific organic anion transporter on the basolateral membrane of the proximal tubule in human kidney...
  14. ncbi request reprint Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier
    D Sugiyama
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    J Pharmacol Exp Ther 298:316-22. 2001
    ..Taking the selectivity of these inhibitors into consideration, the maximum contribution made by the Oatp2 and Oat family to the total efflux of E(2)17betaG from the brain appears to be about 40 and 20%, respectively...
  15. ncbi request reprint Novel nonsense mutation in the Na+/HCO3- cotransporter gene (SLC4A4) in a patient with permanent isolated proximal renal tubular acidosis and bilateral glaucoma
    T Igarashi
    Department of Pediatrics, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Am Soc Nephrol 12:713-8. 2001
    ..These results have implications for understanding the role of kNBC1 in the pathophysiologic processes of pRTA associated with ocular abnormalities and mental retardation...
  16. ncbi request reprint Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters
    M Takeda
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Eur J Pharmacol 419:113-20. 2001
    ..In contrast, KW-3902 did not exert the effects of significance, whereas KW-3902 was the most potent...
  17. ncbi request reprint Characterization of ochratoxin A transport by human organic anion transporters
    K Y Jung
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    Life Sci 69:2123-35. 2001
    ..These pharmacological characteristics of hOAT1 and hOAT3 may be significantly related with the events in the development of OTA-induced nephrotoxicity in the human kidney...
  18. ncbi request reprint Molecular cloning and characterization of high-affinity carnitine transporter from rat intestine
    T Sekine
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Mitaka, Japan
    Biochem Biophys Res Commun 251:586-91. 1998
    ..No CT1 expression was detected in the heart, spleen, or lung. The present study provides the molecular basis of carnitine transport in the body...
  19. doi request reprint Molecular analysis of digenic inheritance in Bartter syndrome with sensorineural deafness
    K Nozu
    Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
    J Med Genet 45:182-6. 2008
    ..Our case provides clear evidence of digenic inheritance outside the scope of Mendelian inheritance disorders...
  20. ncbi request reprint Identification of multispecific organic anion transporter 2 expressed predominantly in the liver
    T Sekine
    Kyorin University School of Medicine, Department of Pharmacology and Toxicology, Mitaka, Tokyo, Japan
    FEBS Lett 429:179-82. 1998
    ..14C]Salicylate uptake via NLT was saturable (Km = 88.8 +/- 23.4 microM) and sodium-independent. Expression of the mRNA of NLT was detected in the liver and kidney (liver >> kidney). We propose that NLT be renamed OAT2...
  21. ncbi request reprint Molecular and clinical studies of Dent's disease in Japan: biochemical examination and renal ultrasonography do not predict carrier state
    T Matsuyama
    Department of Pediatrics, Fussa Hospital, Fussa City, Tokyo, Japan
    Clin Nephrol 61:231-7. 2004
    ....
  22. pmc Patency of the left subclavian artery following implantation of stent graft to rectify a stenosis, as demonstrated by multislice computed tomography
    N Funabashi
    Heart 90:362. 2004
  23. ncbi request reprint The W258X mutation in SLC22A12 is the predominant cause of Japanese renal hypouricemia
    Fusako Komoda
    Department of Pediatrics, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Pediatr Nephrol 19:728-33. 2004
    ..The present study demonstrates that homozygous W258X mutation is the predominant genetic cause of idiopathic renal hypouricemia in Japanese patients...
  24. ncbi request reprint Expression cloning and characterization of a novel multispecific organic anion transporter
    T Sekine
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181, Japan
    J Biol Chem 272:18526-9. 1997
    ..Isolation of OAT1 will facilitate elucidation of the molecular basis of drug kinetics and the development of new drugs lacking unwanted side effects...
  25. ncbi request reprint Detection of tumor cells in blood using CD45 magnetic cell separation followed by nested mutant allele-specific amplification of p53 and K-ras genes in patients with colorectal cancer
    H Iinuma
    Second Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Int J Cancer 89:337-44. 2000
    ..Our results suggest that the method may be useful for reliable detection of tumor cells circulating in the blood and may help to identify patients at high risk for relapse...
  26. ncbi request reprint Four cases of postrenal renal failure induced by renal stone associated with rotavirus infection
    T Morita
    Department of Pediatrics, Kochi Medical School, Kochi University, Kochi, Japan
    Clin Nephrol 73:398-402. 2010
    ..Uric acid stone formation was considered to have originated from the low pH caused by dehydration and the increase of urinary uric acid excretion from damaged cells...
  27. ncbi request reprint The multispecific organic anion transporter family: properties and pharmacological significance
    Hiroki Miyazaki
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2, Shinkawa, Mitaka shi, Tokyo 181 8611, Japan
    Trends Pharmacol Sci 25:654-62. 2004
    ..The molecular characterization of the OAT family encoded by SLC22A will be discussed...
  28. doi request reprint ABO-incompatible renal transplantation in Epstein syndrome
    Masao Ogura
    Department of Pediatric Nephrology, National Center for Child Health and Development, 2 10 1 Okura, Setagaya Ku, Tokyo, 157 8535, Japan
    Clin Transplant 24:31-4. 2010
    ..5 mg/dL with a recovery in RI to 0.6. Although his platelet count was maintained at a minimum of 50 x 10(3)/microL, he had several severe bleeding episodes, concluding that sufficient platelets are necessary after transplantation in ES...
  29. ncbi request reprint Functional analysis of a novel missense NBC1 mutation and of other mutations causing proximal renal tubular acidosis
    Masashi Suzuki
    Department of Internal Medicine, Faculty of Medicine, Tokyo University, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Pflugers Arch 455:583-93. 2008
    ..Multiple experimental approaches would be required to elucidate potential disease mechanism by NBC1 mutations...
  30. pmc Real time visualization of 13N-translocation in rice under different environmental conditions using positron emitting Ttacer imaging system
    S Kiyomiya
    Department of Applied Biological Chemistry, The University of Tokyo, 1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
    Plant Physiol 125:1743-53. 2001
    ..These results suggest that ammonium assimilation (from the roots to the discrimination center) depends passively on water flow, but actively on NH4+-transporter(s) or glutamine synthetase(s)...
  31. doi request reprint Salt-losing nephrogenic diabetes insipidus caused by fetal exposure to angiotensin receptor blocker
    Kenichiro Miura
    Department of Pediatrics, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, Japan
    Pediatr Nephrol 24:1235-8. 2009
    ..ACEIs/ARBs must not be administered to pregnant women...
  32. ncbi request reprint Human organic anion transporters and human organic cation transporters mediate renal antiviral transport
    Michio Takeda
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    J Pharmacol Exp Ther 300:918-24. 2002
    ..In addition, L-valyl ester appears to be important in differential substrate recognition between hOAT1 and hOAT3. hOAT1 may not be the molecule responsible for the drug interaction between ACV and probenecid...
  33. ncbi request reprint Children's toxicology from bench to bed--Drug-induced renal injury (2): Nephrotoxicity induced by cisplatin and ifosfamide in children
    Mikiya Fujieda
    Department of Pediatrics, Kochi Medical School, Kochi University, Japan
    J Toxicol Sci 34:SP251-7. 2009
    ....
  34. ncbi request reprint Molecular identification of a renal urate anion exchanger that regulates blood urate levels
    Atsushi Enomoto
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo 181 8611, Japan
    Nature 417:447-52. 2002
    ..Identification of URAT1 should provide insights into the nature of urate homeostasis, as well as lead to the development of better agents against hyperuricaemia, a disadvantage concomitant with human evolution...
  35. ncbi request reprint Molecular physiology of renal organic anion transporters
    Takashi Sekine
    Kyorin University School of Medicine, Department of Pharmacology and Toxicology, 6 20 2 Shinkawa, Mitaka shi, Tokyo 181 8611, Japan
    Am J Physiol Renal Physiol 290:F251-61. 2006
    ..We will also discuss the physiological roles of each organic anion transporter in the light of the transepithelial transport of organic anions in the kidneys...
  36. ncbi request reprint Role of human organic anion transporter 4 in the transport of ochratoxin A
    Ellappan Babu
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    Biochim Biophys Acta 1590:64-75. 2002
    ..These results indicate that hOAT4 mediates the high-affinity transport of OTA on the apical side of the proximal tubule, whereas the transport characteristics of OTA are distinct from those by basolateral OATs...
  37. ncbi request reprint Functional characterization of LMX1B mutations associated with nail-patella syndrome
    Utako Sato
    Department of Pediatrics, University of Tokyo, Tokyo 113 8655, Japan
    Pediatr Res 57:783-8. 2005
    ..These results suggested that NPS is caused by loss-of-function mutations of LMX1B, and haploinsufficiency of LMX1B should be the predominant pathogenesis of NPS in humans...
  38. ncbi request reprint Functional analysis of NBC1 mutants associated with proximal renal tubular acidosis and ocular abnormalities
    Shoko Horita
    Department of Internal Medicine, Faculty of Medicine, Tokyo University, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Am Soc Nephrol 16:2270-8. 2005
    ..These results, together with the presence of nonfunctional mutants (Q29X and DeltaA) in other patients, suggest that at least approximately 50% reduction of NBC1 activity would be required to cause severe pRTA...
  39. ncbi request reprint [Rickets/osteomalacia due to tubular dysfunction]
    Takashi Sekine
    The University of Tokyo, Graduate School of Medicine, Department of Pediatrics
    Clin Calcium 17:1529-33. 2007
    ..As clinical manifestations, Fanconi syndrome is most common. Rickets in Dent disease is also described...
  40. pmc Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2
    Yutaka Harita
    Division of Cellular Proteomics BML, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    J Biol Chem 283:9177-86. 2008
    ..Thus, SFK orchestrates a wide spectrum of protein-protein interactions and intracellular signaling networks at SD through tyrosine phosphorylation...
  41. ncbi request reprint Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1
    Kyu Yong Jung
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka shi, Tokyo, Japan
    Life Sci 70:1861-74. 2002
    ..48 to 1.32 mM, respectively. These results suggest that rOAT3, at least in part, mediates CER uptake and CER-induced nephrotoxicity as rOAT1. There was some difference of affinity between rOAT3 and rOAT1 for cephalosporin antibiotics...
  42. doi request reprint Reevaluation of glomerular charge selective protein-sieving function
    Hiroshi Saito
    Department of Pediatrics, Nihon University School of Medicine, 1 8 13 Surugadai, Kanda, Chiyoda ku, Tokyo, 101 8309, Japan
    Pediatr Nephrol 24:609-12. 2009
    ....
  43. pmc Defective membrane expression of the Na(+)-HCO(3)(-) cotransporter NBCe1 is associated with familial migraine
    Masashi Suzuki
    Department of Internal Medicine, University of Tokyo, Bunkyo ku, Japan
    Proc Natl Acad Sci U S A 107:15963-8. 2010
    ..The immunohistological and functional analyses of these mutants demonstrate that the near total loss of NBCe1 activity in astrocytes can cause migraine potentially through dysregulation of synaptic pH...