H Satsu

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi Induction of NAD(P)H:quinone oxidoreductase 1 expression by cysteine via Nrf2 activation in human intestinal epithelial LS180 cells
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Amino Acids 43:1547-555. 2012
  2. ncbi Induction by activated macrophage-like THP-1 cells of apoptotic and necrotic cell death in intestinal epithelial Caco-2 monolayers via tumor necrosis factor-alpha
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Exp Cell Res 312:3909-19. 2006
  3. ncbi Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    FEBS Lett 569:123-8. 2004
  4. doi Activation of pregnane X receptor and induction of MDR1 by dietary phytochemicals
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Agric Food Chem 56:5366-73. 2008
  5. pmc Functional characterization and regulation of the taurine transporter and cysteine dioxygenase in human hepatoblastoma HepG2 cells
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biochem J 375:441-7. 2003
  6. ncbi Suppressive effect of an isoflavone fraction on tumor necrosis factor-alpha-induced interleukin-8 production in human intestinal epithelial Caco-2 cells
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Nutr Sci Vitaminol (Tokyo) 55:442-6. 2009
  7. ncbi Effect of neuronal PC12 cells on the functional properties of intestinal epithelial Caco-2 cells
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biosci Biotechnol Biochem 67:1312-8. 2003
  8. ncbi Effect of dietary sulfur amino acids on the taurine content of rat tissues
    H Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo, Japan
    Amino Acids 23:447-52. 2002
  9. ncbi Cycloheximide treatment induces the uptake of neutral and dibasic amino acids via the activation of system b(0,+) in human intestinal Caco-2 cells
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Nutr Sci Vitaminol (Tokyo) 55:44-51. 2009
  10. ncbi Regulation of interleukin-8 secretion in human intestinal epithelial Caco-2 cells by alpha-humulene
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biofactors 21:137-9. 2004

Collaborators

Detail Information

Publications46

  1. ncbi Induction of NAD(P)H:quinone oxidoreductase 1 expression by cysteine via Nrf2 activation in human intestinal epithelial LS180 cells
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Amino Acids 43:1547-555. 2012
    ..These findings show that cysteine induces NQO1 expression in both in vitro and in vivo systems and also suggest that Nrf2 activation is involved in this induction...
  2. ncbi Induction by activated macrophage-like THP-1 cells of apoptotic and necrotic cell death in intestinal epithelial Caco-2 monolayers via tumor necrosis factor-alpha
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Exp Cell Res 312:3909-19. 2006
    ....
  3. ncbi Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    FEBS Lett 569:123-8. 2004
    ..The activated form of Ca(2+)/CaM kinase II protein could only be detected in Caco-2 cells under hypertonic conditions...
  4. doi Activation of pregnane X receptor and induction of MDR1 by dietary phytochemicals
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Agric Food Chem 56:5366-73. 2008
    ..These findings strongly suggest that tangeretin and ginkgolides A and B activated PXR, thereby regulating detoxification enzymes and transporters in the intestines...
  5. pmc Functional characterization and regulation of the taurine transporter and cysteine dioxygenase in human hepatoblastoma HepG2 cells
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biochem J 375:441-7. 2003
    ..Generally, the TAUT and taurine biosynthetic enzymes have independent regulatory systems, but under certain conditions, they could be regulated in harmony with each other...
  6. ncbi Suppressive effect of an isoflavone fraction on tumor necrosis factor-alpha-induced interleukin-8 production in human intestinal epithelial Caco-2 cells
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Nutr Sci Vitaminol (Tokyo) 55:442-6. 2009
    ....
  7. ncbi Effect of neuronal PC12 cells on the functional properties of intestinal epithelial Caco-2 cells
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biosci Biotechnol Biochem 67:1312-8. 2003
    ..The TJ-modulating effect of PC12 was prevented by exposing PC12 to cycloheximide, suggesting that new protein synthesis in PC12 was necessary for this regulation...
  8. ncbi Effect of dietary sulfur amino acids on the taurine content of rat tissues
    H Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo, Japan
    Amino Acids 23:447-52. 2002
    ..The expression level of taurine transporter mRNA was altered only in the kidney under these dietary conditions: a higher expression level with LTD and lower expression level with HTD...
  9. ncbi Cycloheximide treatment induces the uptake of neutral and dibasic amino acids via the activation of system b(0,+) in human intestinal Caco-2 cells
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Nutr Sci Vitaminol (Tokyo) 55:44-51. 2009
    ..These results strongly suggest that the CHX treatment increased the Leu and Lys uptake by activating system b(0,+) and inducing rBAT and b(0,+) AT mRNA expression in human intestinal epithelial Caco-2 cells...
  10. ncbi Regulation of interleukin-8 secretion in human intestinal epithelial Caco-2 cells by alpha-humulene
    Hideo Satsu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biofactors 21:137-9. 2004
    ..The expression level of IL-8 mRNA was significantly increased by treating with alpha-humulene. These results suggest that the secretion of IL-8 by alpha-humulene is regulated at the transcriptional level...
  11. ncbi Tumor necrosis factor alpha stimulates taurine uptake and transporter gene expression in human intestinal Caco-2 cells
    Tetsunosuke Mochizuki
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, Japan
    FEBS Lett 517:92-6. 2002
    ..TNF-alpha-treated cells showed a higher mRNA level of the TAUT than did the control cells...
  12. ncbi Physiological significance of taurine and the taurine transporter in intestinal epithelial cells
    M Shimizu
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Amino Acids 19:605-14. 2000
    ..Similar up-regulation of TAUT was observed in the small intestine of water-deprived rats...
  13. doi 5-caffeoylquinic acid and caffeic acid down-regulate the oxidative stress- and TNF-alpha-induced secretion of interleukin-8 from Caco-2 cells
    Zhaohui Zhao
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Agric Food Chem 56:3863-8. 2008
    ..These results suggest that the habit of drinking coffee and/or eating fruits with a high CHA content may be beneficial to humans in preventing the genesis of inflammatory bowel diseases...
  14. ncbi Development of the method for evaluating protective effect of food factors on THP-1-induced damage to human intestinal Caco-2 monolayers
    Fumiko Watanabe
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biofactors 21:145-7. 2004
    ..The disruption of the Caco-2 cell monolayers was significantly reduced by adding caffeine to the medium on the apical side. It is hoped that this coculture system will be a good model for the treatment of IBD...
  15. ncbi Characterization of carnosine uptake and its physiological function in human intestinal epithelial Caco-2 cells
    Dong Ok Son
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biofactors 21:395-8. 2004
    ..These results suggest that carnosine had a protective effect against oxidative stress in intestinal epithelial cells...
  16. ncbi Regulation of intestinal taurine transporter by cytokines
    Makoto Shimizu
    Department of Applied Biological Chemistry, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Adv Exp Med Biol 526:213-7. 2003
  17. ncbi Cadmium induces interleukin-8 production via NF-kappaB activation in the human intestinal epithelial cell, Caco-2
    Ja Shil Hyun
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, Japan
    Cytokine 37:26-34. 2007
    ..Our results suggest that CdCl2 induced IL-8 secretion, its transcription, and its transcriptional activation regulated by NF-kappaB via I-kappaB alpha degradation...
  18. pmc Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells
    Tomoko Konishi
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Br J Pharmacol 143:379-87. 2004
    ..It was also suggested that the monoglyceride structure played an important role in the inhibition of P-gp activity. Monoglycerides could therefore alter the pharmacokinetics of drugs by inhibiting the P-gp-mediated efflux...
  19. ncbi Physiological significance of the taurine transporter and taurine biosynthetic enzymes in 3T3-L1 adipocytes
    Masakazu Takasaki
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biofactors 21:419-21. 2004
    ..These results suggest that murine TAUT and CDO were cooperatively regulated in response to hypertonicity and taurine-rich conditions...
  20. doi Metabolites of galangin by 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P450 1A1 in human intestinal epithelial Caco-2 cells and their antagonistic activity toward aryl hydrocarbon receptor
    Mika Hamada
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Agric Food Chem 58:8111-8. 2010
    ..Therefore, the oxidative metabolism of galangin to kaempferol in TCDD-pretreated Caco-2 cells implicated reduction in the inhibitory activity of galangin...
  21. pmc In vitro System for Assessing Dioxin Absorption by Intestinal Epithelial Cells and for Preventing this Absorption by Food Substances
    Yayoi Natsume
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, 113 8657, Tokyo, Bunkyo ku, Japan
    Cytotechnology 47:79-88. 2005
    ..The system will therefore be useful to identify food substances having a preventive effect on the intestinal absorption of dioxins...
  22. ncbi Regulation of the human taurine transporter by TNF-alpha and an anti-inflammatory function of taurine in human intestinal Caco-2 cells
    Tetsunosuke Mochizuki
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 8657, Japan
    Biofactors 21:141-4. 2004
    ..The result shows that taurine significantly repressed the damage to Caco-2 cells caused by TNF-alpha secreted by THP-1 cells. Thus, taurine may be a useful substance against intestinal inflammation...
  23. pmc New model for studying the migration of immune cells into intestinal epithelial cell monolayers
    Akira Mori
    Department of Applied Biological Chemistry, The University of Tokyo, 1 1 1, Yayoi, Bunkyo ku, Tokyo, 113 8657, Japan
    Cytotechnology 43:57-64. 2003
    ..This cell culture system will be useful for studying the behavior of macrophages in the intestinal epithelial cell monolayers at the initial stage of an intestinal immune reaction...
  24. ncbi Characteristics of lysophosphatidylcholine in its inhibition of taurine uptake by human intestinal Caco-2 cells
    Koji Ishizuka
    Department of Applied Biological Chemistry, The University of Tokyo, Japan
    Biosci Biotechnol Biochem 66:730-6. 2002
    ..These results suggest that the interaction of LPC with the taurine transporter in the intestinal cell membrane was the cause of the reduced taurine uptake...
  25. ncbi Transepithelial transport of macromolecular substances in IL-4 treated human intestinal T84 cell monolayers
    Tetsunosuke Mochizuki
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Biosci Biotechnol Biochem 73:2422-6. 2009
    ..These results suggest that fairly large molecules are able to permeate intestinal epithelial monolayers via the energy-independent paracellular pathway when the monolayers are exposed to excessive IL-4...
  26. ncbi Permeation of disaccharides derived from chondroitin sulfate through human intestinal Caco-2 cell monolayers via the paracellular pathway
    Miao Jin
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Biosci Biotechnol Biochem 74:1243-9. 2010
    ....
  27. doi Inhibitory effect of carnosine on interleukin-8 production in intestinal epithelial cells through translational regulation
    Dong Ok Son
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Cytokine 42:265-76. 2008
    ..These results suggest that carnosine is a novel type of anti-inflammatory agent that down-regulates the inflammatory response in intestinal epithelial cells by a unique mechanism...
  28. ncbi Dietary taurine attenuates dextran sulfate sodium (DSS)-induced experimental colitis in mice
    Makoto Shimizu
    Department of Applied Biological Chemistry, The University of Tokyo, Tokyo, Japan
    Adv Exp Med Biol 643:265-71. 2009
    ..Inhibition of chemokine secretion from intestinal cells may be involved in the mechanisms underlying the cytoprotective function of taurine in the intestinal epithelium...
  29. ncbi Signaling pathways involved in tumor necrosis factor alpha-induced upregulation of the taurine transporter in Caco-2 cells
    Tetsunosuke Mochizuki
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    FEBS Lett 579:3069-74. 2005
    ..An electrophoretic mobility shift assay showed that NF-kappaB could bind to the NF-kappaB consensus-like sequence. The anti-TNF receptor 1 (TNFR1) antibody, but not the TNF receptor 2 (TNFR2) antibody, repressed this upregulation...
  30. ncbi Histidine inhibits oxidative stress- and TNF-alpha-induced interleukin-8 secretion in intestinal epithelial cells
    Dong Ok Son
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    FEBS Lett 579:4671-7. 2005
    ....
  31. ncbi TCDD-induced CYP1A1 expression, an index of dioxin toxicity, is suppressed by flavonoids permeating the human intestinal Caco-2 cell monolayers
    Mika Hamada
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo ku, 113 8657, Japan
    J Agric Food Chem 54:8891-8. 2006
    ..It is proposed from these results that some flavonoids have the ability to suppress dioxin-induced AhR activity after permeating the human intestinal epithelial cell monolayer...
  32. ncbi Effects of tributyltin on barrier functions in human intestinal Caco-2 cells
    Masashi Tsukazaki
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biochem Biophys Res Commun 315:991-7. 2004
    ..The activation of a multidrug resistance transporter P-glycoprotein by TBT would cause a disorder of the human intestines by changing the drug pharmacokinetics...
  33. ncbi Attenuation by dietary taurine of dextran sulfate sodium-induced colitis in mice and of THP-1-induced damage to intestinal Caco-2 cell monolayers
    Z Zhao
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The University of Tokyo, Tokyo, Japan
    Amino Acids 35:217-24. 2008
    ....
  34. ncbi Enhanced daunomycin accumulation in human intestinal Caco-2 cells from non-ionic food emulsifiers unrelated to the p-glycoprotein inhibitory mechanism
    Naoki Takaishi
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Biosci Biotechnol Biochem 70:2703-11. 2006
    ..The enhanced accumulation of daunomycin would therefore not have been due to P-gp inhibition, but instead to the increased daunomycin permeability of cell membranes caused by the emulsifiers...
  35. ncbi A bitter melon extract inhibits the P-glycoprotein activity in intestinal Caco-2 cells: monoglyceride as an active compound
    Tomoko Konishi
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biofactors 22:71-4. 2004
    ..It is interesting that certain types of monoglyceride might be involved in the drug bioavailability by specifically inhibiting the efflux mediated by P-gp...
  36. ncbi Assessment system for dioxin absorption in the small intestine and prevention of its absorption by food factors
    Yayoi Natsume
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biofactors 21:375-7. 2004
    ..This assessment system would be useful to search for those food factors that could prevent dioxin absorption in the small intestine...
  37. ncbi Transient up-regulation of immunity- and apoptosis-related genes in Caco-2 cells cocultured with THP-1 cells evaluated by DNA microarray analysis
    Yoko Ishimoto
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Biosci Biotechnol Biochem 74:437-9. 2010
    ..Differentially expressed genes extracted with maSigPro indicated that an early defense response and cell death occured at the same time, causing an inflammatory condition...
  38. ncbi Oral exposure to cadmium chloride triggers an acute inflammatory response in the intestines of mice, initiated by the over-expression of tissue macrophage inflammatory protein-2 mRNA
    Zhaohui Zhao
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, Japan
    Toxicol Lett 164:144-54. 2006
    ....
  39. ncbi Transepithelial transport of alpha-lipoic acid across human intestinal Caco-2 cell monolayers
    Naoki Takaishi
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Agric Food Chem 55:5253-9. 2007
    ..The conversion of LA to the more antioxidative dihydrolipoic acid was also apparent during the transport process...
  40. doi Protective effect of quercetin on ER stress caused by calcium dynamics dysregulation in intestinal epithelial cells
    Yayoi Natsume
    Department of Applied Biological Chemistry, The University of Tokyo, Tokyo, Japan
    Toxicology 258:164-75. 2009
    ..This study helps to clarify the mechanism for quercetin presenting its versatility...
  41. ncbi Low-molecular-weight hyaluronan permeates through human intestinal Caco-2 cell monolayers via the paracellular pathway
    Nozomi Hisada
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Biosci Biotechnol Biochem 72:1111-4. 2008
    ..The transport was observed to be energy-independent, and was correlated with the tight junction (TJ) permeability. These results suggest that LMW-HA permeated the Caco-2 cell monolayers via the paracellular pathway...
  42. doi Disaccharide derived from chondroitin sulfate A suppressed CpG-induced IL-6 secretion in macrophage-like J774.1 cells
    Miao Jin
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Cytokine 51:53-9. 2010
    ..Oligosaccharides derived from chondroitin sulfates would be effective suppressing agents for the TLR9-mediated inflammation reaction...
  43. ncbi Effect of quercetin on the gene expression profile of the mouse intestine
    Yayoi Natsume
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Toky, Japan
    Biosci Biotechnol Biochem 73:722-5. 2009
    ..0 Array. A cluster analysis shows that only the "low dose group" had a significantly different gene expression profile from the negative control group...
  44. doi Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells
    Yuri Kusano
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Biochemistry 47:6169-77. 2008
    ..The results of this study suggest the involvement of a novel Keap1-dependent signaling pathway for the induction of the constitutive GST A1 expression during epithelial cell differentiation...
  45. ncbi Expression profiling of translation-associated genes in sporulating Bacillus subtilis and consequence of sporulation by gene inactivation
    Yoshiaki Ohashi
    National Food Research Institute, Tsukuba, Ibaraki, Japan
    Biosci Biotechnol Biochem 67:2245-53. 2003
    ..Thus, we successfully demonstrated the significance of several translation-associated genes in sporulation by using the results of the gene expression profiling...
  46. doi Producibility and digestibility of antihypertensive beta-casein tripeptides, Val-Pro-Pro and Ile-Pro-Pro, in the gastrointestinal tract: analyses using an in vitro model of mammalian gastrointestinal digestion
    Kazuhito Ohsawa
    Research and Development Center, Calpis Company, Ltd, 11 10, 5 Chome, Fuchinobe, Sagamihara shi Kanagawa 229 0006, Japan
    J Agric Food Chem 56:854-8. 2008
    ..There may be a strong correlation between the resistance of peptides to gastrointestinal digestion and their real physiological effects after oral administration...