Shin Sasaki

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi Isolation of a novel zinc finger repressor that regulates the kidney-specific CLC-K1 promoter
    S Uchida
    Homeostasis Medicine and Nephrology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Kidney Int 60:416-21. 2001
  2. ncbi DNA methylation and sensitivity to antimetabolites in cancer cell lines
    Shin Sasaki
    Department of Surgical Oncology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Oncol Rep 19:407-12. 2008
  3. ncbi Isolation and characterization of a novel gene, hRFI, preferentially expressed in esophageal cancer
    Shin Sasaki
    Department of Surgical Oncology, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Oncogene 21:5024-30. 2002
  4. ncbi Effect of cystathionine beta-synthase variant 844ins68bp and methylenetetrahydrofolate reductase A1298C polymorphisms in xenografts on 5-FU efficacy and doubling time
    Shin Sasaki
    Department of Surgical Oncology, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Cancer Lett 241:256-62. 2006
  5. ncbi Diffuse expression of hRFI is correlated with blood vessel invasion in gastric carcinoma
    Shin Sasaki
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Jpn J Clin Oncol 34:584-7. 2004
  6. ncbi High hRFI expression correlates with resistance to fluoropyrimidines in human colon cancer cell lines and in xenografts
    S Sasaki
    Dept of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    J Exp Clin Cancer Res 24:397-403. 2005
  7. ncbi Effects of expression of hRFI on adenoma formation and tumor progression in colorectal adenoma-carcinoma sequence
    S Sasaki
    Dept of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    J Exp Clin Cancer Res 23:507-12. 2004
  8. ncbi Overexpression of hRFI (human ring finger homologous to inhibitor of apoptosis protein type) inhibits death receptor-mediated apoptosis in colorectal cancer cells
    Tsuyoshi Konishi
    Department of Surgical Oncology, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Mol Cancer Ther 4:743-50. 2005
  9. ncbi hRFI overexpressed in HCT116 cells modulates Bcl-2 family proteins when treated with 5-fluorouracil
    Shin Sasaki
    Department of Surgical Oncology, The University of Tokyo, Hongo, Tokyo 113 8655, Japan
    Oncol Rep 15:1293-8. 2006
  10. ncbi Exogenous expression of hRFI induces multidrug resistance through escape from apoptosis in colorectal cancer cells
    Tsuyoshi Konishi
    Department of Surgical Oncology, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    Anticancer Res 25:2737-41. 2005

Collaborators

Detail Information

Publications67

  1. ncbi Isolation of a novel zinc finger repressor that regulates the kidney-specific CLC-K1 promoter
    S Uchida
    Homeostasis Medicine and Nephrology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Kidney Int 60:416-21. 2001
    ..These results suggest that a novel set of zinc finger proteins may help regulate the strict tissue and nephron segment-specific expression of CLC-K1 and CLC-K2 channel genes through their GA cis element...
  2. ncbi DNA methylation and sensitivity to antimetabolites in cancer cell lines
    Shin Sasaki
    Department of Surgical Oncology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Oncol Rep 19:407-12. 2008
    ..These genes could be useful biological markers for predicting the efficacy of antimetabolites...
  3. ncbi Isolation and characterization of a novel gene, hRFI, preferentially expressed in esophageal cancer
    Shin Sasaki
    Department of Surgical Oncology, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Oncogene 21:5024-30. 2002
    ..Finally, hRFI protein was shown to be cleaved within the DEDD sequence spanning residues 230-233 by caspase-3 during the apoptotic induction...
  4. ncbi Effect of cystathionine beta-synthase variant 844ins68bp and methylenetetrahydrofolate reductase A1298C polymorphisms in xenografts on 5-FU efficacy and doubling time
    Shin Sasaki
    Department of Surgical Oncology, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Cancer Lett 241:256-62. 2006
    ..0008). Twenty-nine cellular proliferation-related genes were associated with MTHFR-A1298C genotyping and with the doubling time...
  5. ncbi Diffuse expression of hRFI is correlated with blood vessel invasion in gastric carcinoma
    Shin Sasaki
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Jpn J Clin Oncol 34:584-7. 2004
    ..Furthermore, its diffuse expression is associated with colorectal carcinogenesis. However, hRFI expression in gastric carcinomas has not been evaluated so far...
  6. ncbi High hRFI expression correlates with resistance to fluoropyrimidines in human colon cancer cell lines and in xenografts
    S Sasaki
    Dept of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    J Exp Clin Cancer Res 24:397-403. 2005
    ..This evidence suggests that hRFI may be a marker predicting the response to fluorouracil derived chemotherapeutic agents and that the reduction of the expression level of hRFI might improve the outcome of chemotherapy...
  7. ncbi Effects of expression of hRFI on adenoma formation and tumor progression in colorectal adenoma-carcinoma sequence
    S Sasaki
    Dept of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    J Exp Clin Cancer Res 23:507-12. 2004
    ..This evidence suggests that hRFI may act as an oncogenic molecule affecting the apoptotic pathway...
  8. ncbi Overexpression of hRFI (human ring finger homologous to inhibitor of apoptosis protein type) inhibits death receptor-mediated apoptosis in colorectal cancer cells
    Tsuyoshi Konishi
    Department of Surgical Oncology, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Mol Cancer Ther 4:743-50. 2005
    ..Considering the progressive increase of hRFI expression in the advance of the colorectal adenoma-carcinoma sequence, hRFI is one of the important players in colorectal carcinogenesis through its effect on apoptosis regulation...
  9. ncbi hRFI overexpressed in HCT116 cells modulates Bcl-2 family proteins when treated with 5-fluorouracil
    Shin Sasaki
    Department of Surgical Oncology, The University of Tokyo, Hongo, Tokyo 113 8655, Japan
    Oncol Rep 15:1293-8. 2006
    ..Such evidence suggests that the modulation of Bcl-2 family proteins seen in 5-FU treatment plays an important role in the anti-apoptotic function of HCT116/hRFI cells...
  10. ncbi Exogenous expression of hRFI induces multidrug resistance through escape from apoptosis in colorectal cancer cells
    Tsuyoshi Konishi
    Department of Surgical Oncology, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    Anticancer Res 25:2737-41. 2005
    ..Growth in the normal medium was not altered. CONCLUSION: hRFI plays an important role in the resistance to chemotherapeutic agent-induced apoptosis in colorectal cancer cells...
  11. ncbi Changes to the dihydropyrimidine dehydrogenase gene copy number influence the susceptibility of cancers to 5-FU-based drugs: Data mining of the NCI-DTP data sets and validation with human tumour xenografts
    Takashi Kobunai
    Department of Systematic Clinical Oncology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Eur J Cancer 43:791-8. 2007
    ..002). Moreover, DPD mRNA expression levels were significantly correlated with DPD copy numbers (P<0.046). An assessment of copy number may be a more precise method of predicting the sensitivity of cancer patients to 5-FU related drugs...
  12. ncbi Aberrant expression of lysophosphatidic acid (LPA) receptors in human colorectal cancer
    Dai Shida
    Department of Surgical Oncology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Lab Invest 84:1352-62. 2004
    ..These results suggested that alteration of LPA receptor expression might be an important event in the development of colorectal cancer, and therefore, LPA and its receptors could be a chemopreventive target against colorectal cancer...
  13. ncbi Apoptosis induction by p38 MAPK inhibitor in human colon cancer cells
    Takeshi Tsuchiya
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Hepatogastroenterology 55:930-5. 2008
    ..However, the role of p38s is cell type- and stimulus-dependent. The present study aimed to evaluate the effects of p38 MAPK inhibitor on human colon cancer cells...
  14. ncbi [Expression of hRFI in digestive system cancer]
    Shin Sasaki
    Department of Surgical Oncology, University of Tokyo
    Nippon Rinsho 61:242-6. 2003
  15. ncbi Involvement of APC and K-ras mutation in non-polypoid colorectal tumorigenesis
    N Umetani
    Department of Surgical Oncology, School of Medicine, The University of Tokyo, Japan
    Br J Cancer 82:9-15. 2000
    ..In this non-polypoid pathway, APC mutation seems to be requisite but K-ras mutation not. It is possible that new APC mutations are acquired after the development of superficial depressed adenomas...
  16. ncbi Cloning, characterization and chromosomal assignment of the human genes homologous to yeast PMS1, a member of mismatch repair genes
    A Horii
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Biochem Biophys Res Commun 204:1257-64. 1994
    ..DNA sequencing analyses indicated that human PMS genes constituted a multiple gene family and that some of the family members have been mapped to chromosomal bands 7q11.23 and 7q22 by fluorescent in situ hybridization...
  17. ncbi Mutational analysis of the hMLH1 gene using an automated two-dimensional DNA typing system
    S Sasaki
    Laboratory of Molecular Medicine, University of Tokyo, Japan
    Hum Mutat 9:164-71. 1997
    ..This new diagnostic method is applicable to mutational analysis of any disease-causing gene, and it offers a major improvement over current approaches...
  18. ncbi Epigallocatechin gallate induces apoptosis of monocytes
    Kazushige Kawai
    Department of Surgical Oncology, Faculty of Medicine, University of Tokyo, Japan
    J Allergy Clin Immunol 115:186-91. 2005
    ..Green tea polyphenol catechin has been reported to have antiallergic and anti-inflammatory activities, but its effect on monocytes has not yet been explored...
  19. ncbi Detection of cancer cells in mesenteric vein and peripheral vessels by measuring telomerase activity in patients with colorectal cancer
    Hiroaki Nozawa
    Department of Surgical Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Surgery 134:791-8. 2003
    ..CONCLUSIONS: Our assay was proven to be a feasible method for detecting cancer cells in tumor-drainage veins. High telomerase activity of mesenteric blood samples reflected the existence of liver metastasis of colorectal cancer...
  20. ncbi [Introduction to genome assembler]
    Shinichi Morishita
    Tanpakushitsu Kakusan Koso 50:2255-62. 2005
  21. ncbi Microsatellite instability of cancers and concomitant adenomas in synchronous multiple colorectal cancer patients
    E Ueda
    Dept of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Japan
    J Exp Clin Cancer Res 21:149-54. 2002
    ....
  22. ncbi Characteristics in primary signet-ring cell carcinoma of the colorectum, from clinicopathological observations
    S Sasaki
    First Department of Surgery, University of Tokyo, Japan
    Jpn J Clin Oncol 28:202-6. 1998
    ..However, in previous studies, clinicopathological features of this disease have been somewhat ill-defined because various histological criteria of this disease were adopted...
  23. ncbi Microsatellite instability is associated with the macroscopic configuration of neoplasms in patients with multiple colorectal adenomas
    S Sasaki
    Department of Surgery, University of Tokyo, Japan
    Jpn J Clin Oncol 28:427-30. 1998
    ..The management of patients with multiple colorectal adenomas, 10-100 in number, is often troublesome clinically. To establish the reasonable management of such cases, genetic backgrounds should be made clear...
  24. ncbi 5-Fluorouracil induces apoptosis in human colon cancer cell lines with modulation of Bcl-2 family proteins
    M E Nita
    Department of Surgical Oncology, Graduate School of Medical Sciences, Faculty of Medicine, The University of Tokyo, Japan
    Br J Cancer 78:986-92. 1998
    ..In conclusion, these results suggest that some members of the Bcl-2 family of proteins, in human colon cancer cell lines, are modulated by 5-FU and that the ratio of Bcl-X(L) to Bax may be related to chemosensitivity to 5-FU...
  25. ncbi Diagnostic primer sets for microsatellite instability optimized for a minimal amount of damaged DNA from colorectal tissue samples
    N Umetani
    Department of Surgical Oncology, School of Medicine, University of Tokyo, Japan
    Ann Surg Oncol 7:276-80. 2000
    ..Therefore, optimized primer sets were newly designed for substitution of documented ones...
  26. ncbi Genetic alterations in ulcerative colitis-associated neoplasia focusing on APC, K-ras gene and microsatellite instability
    N Umetani
    Department of Surgical Oncology, School of Medicine, The University of Tokyo
    Jpn J Cancer Res 90:1081-7. 1999
    ..MSI may be one of the mechanisms of the increased neoplastic risk in UC, and UCAN may develop through a different carcinogenic pathway from sporadic carcinomas...
  27. ncbi Overexpression of hRFI inhibits 5-fluorouracil-induced apoptosis in colorectal cancer cells via activation of NF-kappaB and upregulation of BCL-2 and BCL-XL
    T Konishi
    Department of Surgical Oncology, The University of Tokyo, Hongo, Tokyo, Japan
    Oncogene 25:3160-9. 2006
    ..hRFI might be a novel therapeutic target for gene therapy in colorectal cancer...
  28. ncbi Ulcerative colitis patients with a family history of colorectal cancer should be subjected to close and careful surveillance
    K Matsuda
    Department of Surgical Oncology, Graduate School of Medicine, University of Tokyo, Japan
    Jpn J Clin Oncol 29:448-51. 1999
    ..These findings suggest that UC patients with a family history of colon cancer should be put under close surveillance. It should also be emphasized that IAA is the procedure of choice for UC patients with this particular condition...
  29. ncbi Molecular cloning of CLC chloride channels in Oreochromis mossambicus and their functional complementation of yeast CLC gene mutant
    H Miyazaki
    Second Department of Internal Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo, Bunkyo, 113 8519, Japan
    Biochem Biophys Res Commun 255:175-81. 1999
    ..These results clearly indicated that CLC channels closely related to the mammalian CLC-3, -4, and -5 subfamily exist also in tilapia and that OmCLC-3 and OmCLC-5 function as intracellular chloride channels...
  30. ncbi Microsatellite instability of colorectal cancer and adenoma in synchronous multiple colorectal cancer patients with associated extracolonic malignancies
    E Ueda
    Department of Surgical Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    Surg Today 31:405-9. 2001
    ..On the other hand, there was a significant correlation between MSI-positivity and the existence of extracolonic malignancies...
  31. ncbi UTGB toolkit for personalized genome browsers
    Taro L Saito
    Department of Computational Biology, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa City, Chiba 277 0882, Japan
    Bioinformatics 25:1856-61. 2009
    ..The UTGB Toolkit is licensed under an open source license. AVAILABILITY: The software is freely available at http://utgenome.org/...
  32. ncbi Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Krüppel-like factor, a novel zinc finger repressor
    S Uchida
    Second Department of Internal Medicine, School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Mol Cell Biol 20:7319-31. 2000
    ..These results suggest that a novel set of zinc finger proteins may help regulate the strict tissue- and nephron segment-specific expression of the CLC-K1 and CLC-K2 channel genes through their GA cis element...
  33. ncbi [Genetics of colon carcinogenesis]
    Shin Sasaki
    Department of Surgical Oncology, University of Tokyo
    Nippon Rinsho 61:72-4. 2003
  34. ncbi Identification of a new outwardly rectifying Cl- channel that belongs to a subfamily of the ClC Cl- channels
    H Sakamoto
    Second Department of Internal Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113, Japan
    J Biol Chem 271:10210-6. 1996
    ..The molecular structure and functional properties of ClC-5 will provide an important insight into ORCCs and the pathogenesis of Dent's disease...
  35. ncbi Adenomyoma of the small intestine in an adult: report of a case
    Atsushi Tomibayashi
    Department of Surgery, Omori Red Cross Hospital, 4 30 11 Chuo, Ota ku, Tokyo, 143 8527, Japan
    Surg Today 41:1101-5. 2011
    ..To our knowledge, this is only the second report of an adenomyoma of small intestine causing intestinal obstruction in an adult...
  36. ncbi The medaka draft genome and insights into vertebrate genome evolution
    Masahiro Kasahara
    Department of Computational Biology, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa 277 0882, Japan
    Nature 447:714-9. 2007
    ....
  37. ncbi Isolation and characterization of the human CLC-5 chloride channel gene promoter
    A Hayama
    Second Department of Internal Medicine, Tokyo Medical and Dental University, School of Medicine, 1 5 45 Yushima Bunkyo ku, 113 8519, Tokyo, Japan
    Gene 261:355-64. 2000
    ..This study clarified the key element of the human CLCN5 promoter, and the mutation in this region could be the cause of Dent's disease...
  38. ncbi Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene
    N Koyama
    Second Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, 1 5 45 Yushima, Bunkyo ku, 113 8519, Japan
    Genomics 54:169-72. 1998
    ..AQP8 was not permeable to urea nor to glycerol. The AQP8 gene has five introns, and the locations of exon-intron boundaries were different from those of the other mammalian aquaporins, suggesting its separate phylogenetic origin...
  39. ncbi Developmental expression of CLC-K1 in the postnatal rat kidney
    K Kobayashi
    Department of Pediatrics, Tokyo Medical and Dental University, School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Histochem Cell Biol 116:49-56. 2001
    ..These results suggest that CLC-K1 expression is one of the major determinants of the urine-concentrating capacity of the developing rat kidney...
  40. ncbi Carcinoembryonic antigen mRNA in abdominal cavity as a useful predictor of peritoneal recurrence of gastric cancer with serosal exposure
    S Fujii
    Dept. of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Exp Clin Cancer Res 21:547-53. 2002
    ....
  41. ncbi Two sporadic cases of Liddle's syndrome caused by De novo ENaC mutations
    Y Yamashita
    Homeostasis Medicine and Nephrology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Am J Kidney Dis 37:499-504. 2001
    ..These data indicate that Liddle's syndrome should be considered even in patients without a family history of hypertension...
  42. ncbi Chromatin-associated periodicity in genetic variation downstream of transcriptional start sites
    Shin Sasaki
    Department of Computational Biology, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, 277 0882, Japan
    Science 323:401-4. 2009
    ..These data exemplify the potential for genetic activity (transcription) and chromatin structure to contribute to molding the DNA sequence on an evolutionary time scale...
  43. ncbi UTGB/medaka: genomic resource database for medaka biology
    Budrul Ahsan
    Department of Computational Biology, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa 277 0882, Japan
    Nucleic Acids Res 36:D747-52. 2008
    ..UTGB/medaka is available at: http://medaka.utgenome.org/...
  44. ncbi Phosphorylation of serine 256 is required for cAMP-dependent regulatory exocytosis of the aquaporin-2 water channel
    K Fushimi
    Second Department of Internal Medicine, School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113, Japan
    J Biol Chem 272:14800-4. 1997
    ..Our results indicated that serine 256 of AQP2 is necessary for regulatory exocytosis and that cAMP-responsive redistribution of AQP2 may be regulated by phosphorylation of AQP2...
  45. ncbi Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury
    T Kobayashi
    Department of Nephrology and Blood Purification, Tokyo Medical and Dental University, Tokyo, Japan
    Kidney Int 73:1240-50. 2008
    ..Recombinant Delta-1 significantly stimulated NRK-52E cell proliferation. Our study suggests that the Delta-1/Notch-2/Hes-1 signaling pathway may regulate the regeneration and proliferation of renal tubules during acute kidney injury...
  46. ncbi Plasma folate and risk of colorectal cancer in a nested case-control study: the Japan Public Health Center-based prospective study
    Tetsuya Otani
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo, Japan
    Cancer Causes Control 19:67-74. 2008
    ..We investigated the association between plasma folate and the risk of colorectal cancer in a nested case-control study...
  47. ncbi Daily total physical activity level and total cancer risk in men and women: results from a large-scale population-based cohort study in Japan
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Am J Epidemiol 168:391-403. 2008
    ..By site, decreased risks were observed for cancers of the colon, liver, and pancreas in men and for cancer of the stomach in women. Increased daily physical activity may be beneficial in preventing cancer in a relatively lean population...
  48. ncbi Assignment of the genes encoding the human chloride channels, CLCNKA and CLCNKB, to 1p36 and of CLCN3 to 4q32-q33 by in situ hybridization
    F Saito-Ohara
    Department of Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113, Japan
    Genomics 36:372-4. 1996
  49. ncbi Reproductive factors, exogenous female hormone use and colorectal cancer risk: the Japan Public Health Center-based Prospective Study
    Munira Akhter
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Eur J Cancer Prev 17:515-24. 2008
    ..59). In contrast, no statistically significant association was found for rectal cancer. These findings suggest that late age at first birth is associated with a reduced risk of colon cancer in postmenopausal Japanese women...
  50. ncbi Significance of pre-storage leucoreduction for autologous blood
    T Tasaki
    Blood Transfusion Service, Tokyo Jikei University Hospital, 3 19 18 Nishi Shimbashi, Minato ku, Tokyo, Japan
    Vox Sang 96:226-33. 2009
    ....
  51. ncbi Characterization of the human p57KIP2 gene: alternative splicing, insertion/deletion polymorphisms in VNTR sequences in the coding region, and mutational analysis
    T Tokino
    Laboratory of Molecular Medicine, The Institute of Medical Science, The University of Tokyo, Japan
    Hum Genet 97:625-31. 1996
    ..5'-CCGGCC-3', are tandemly repeated...
  52. ncbi High dietary intake of magnesium may decrease risk of colorectal cancer in Japanese men
    Enbo Ma
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    J Nutr 140:779-85. 2010
    ..There were no significant associations between magnesium intake and cancer risk in women. Higher dietary intake of magnesium may decrease the risk of CRC in Japanese men...
  53. ncbi Female reproductive factors and the risk of gastric cancer in a large-scale population-based cohort study in Japan (JPHC study)
    Christina Persson
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Eur J Cancer Prev 17:345-53. 2008
    ..Although early estrogen exposure may have some protective effect, female reproductive factors may have no substantial influence on gastric cancer development...
  54. ncbi Localization of mouse CLC-6 and CLC-7 mRNA and their functional complementation of yeast CLC gene mutant
    Y Kida
    Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan
    Histochem Cell Biol 115:189-94. 2001
    ..This study identified the cell types that express mCLC-6 and mCLC-7 in the mouse tissues, and the complementation assay suggested that mCLC-6 functions as an intracellular chloride channel...
  55. ncbi Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta
    Y Takei
    Laboratory of Molecular Medicine, University of Tokyo, Japan
    Cytogenet Cell Genet 78:295-300. 1997
    ..We mapped CD33L by fluorescence in situ hybridization (FISH) to human chromosome 19q13.3, where the CD33 gene is also located...
  56. ncbi Glucocorticoids stimulate p21(CIP1) in mesangial cells and in anti-GBM glomerulonephritis
    Y Terada
    Second Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Kidney Int 59:1706-16. 2001
    ..Glucocorticoids are widely used for the treatment of glomerulonephritis, but the mechanism of cell cycle inhibition by glucocorticoids is poorly understood at a molecular level...
  57. ncbi Intrarenal and cellular localization of CLC-K2 protein in the mouse kidney
    K Kobayashi
    Department of Pediatrics, Tokyo Medical and Dental University, School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113, Japan
    J Am Soc Nephrol 12:1327-34. 2001
    ..These aspects of CLC-K2 localization suggest that CLC-K2 is important in Cl(-) transport in the distal nephron segments...
  58. ncbi Gene expression signature and the prediction of ulcerative colitis-associated colorectal cancer by DNA microarray
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo 173 8605, Japan
    Clin Cancer Res 13:415-20. 2007
    ..Ulcerative colitis (UC) is associated with a high risk of colorectal cancer. To identify genes that could predict the development of cancer in UC, we conducted a DNA microarray analysis using nonneoplastic rectal mucosa of UC patients...
  59. ncbi Distal colorectal cancers with microsatellite instability (MSI) display distinct gene expression profiles that are different from proximal MSI cancers
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Tokyo 173 8605, Japan
    Cancer Res 66:9804-8. 2006
    ..The inactivation form of hMLH, per se, differed between proximal and distal MSI cancers. These results suggested that distal MSI cancers constitute a distinct subgroup of sporadic MSI cancers...
  60. ncbi Transcriptional regulation of the human TLR9 gene
    Fumihiko Takeshita
    Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Immunol 173:2552-61. 2004
    ..These findings will help to elucidate the mechanism of TLR9 gene regulation and to provide insight into the process by which TLR9 evolved in the mammalian immune system...
  61. ncbi Genetic tagging shows increased frequency and longevity of antigen-presenting, skin-derived dendritic cells in vivo
    Sanjay Garg
    Department of Microbiology and Immunology, Vaccine Research Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, Georgia 30322, USA
    Nat Immunol 4:907-12. 2003
    ..The substantial frequency and longevity of DCs in situ ensures ample antigen presentation and stimulation for the rare antigen-specific T cells in draining lymph nodes...
  62. ncbi Mental state as a possible independent prognostic variable for survival in patients with advanced lung carcinoma
    Yasuharu Nakahara
    Department of Respiratory Medicine, Himeji National Hospital, Himeji City, Japan
    Cancer 94:3006-15. 2002
    ..A prospective study of patients with advanced lung carcinoma was performed to explore the influence of the patient's mental state on survival...
  63. ncbi TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF
    Fumihiko Takeshita
    Department of Molecular Biodefense Research, Yokohama City University School of Medicine, Yokohama, Japan
    Eur J Immunol 35:2477-85. 2005
    ..These results suggest that TRAF4 participates in the molecular mechanism underlying silencing of TLR-mediated signaling through the interaction with molecules harboring phagosome/endosome membrane...
  64. ncbi Blocking of the TLR5 activation domain hampers protective potential of flagellin DNA vaccine
    Sukumar Saha
    Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Japan
    J Immunol 179:1147-54. 2007
    ....
  65. ncbi Regulation of DNA-raised immune responses by cotransfected interferon regulatory factors
    Shin Sasaki
    Division of Microbiology and Immunology, Yerkes National Primate Research Center and Vaccine Research Center, Emory University School of Medicine, 954 Gatewood Road, Atlanta, GA 30329, USA
    J Virol 76:6652-9. 2002
    ..These biases were enhanced by the codelivered IRFs. Overall, under the conditions of our experiments, IRF-3 had good activity for T cells, IRF-7 had good activity for both antibody and T cells, and IRF-1 had good activity for antibody...
  66. ncbi Toll-like receptor adaptor molecules enhance DNA-raised adaptive immune responses against influenza and tumors through activation of innate immunity
    Fumihiko Takeshita
    Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawaku, Yokohama 236 0004, Japan
    J Virol 80:6218-24. 2006
    ..These results indicate that TLR adaptor molecules can bridge innate and adaptive immunity and potentiate the effects of DNA vaccines against virus infection and tumors...
  67. ncbi The genome sequence of silkworm, Bombyx mori
    Kazuei Mita
    Genome Research Department, National Institute of Agrobiological Sciences, 1 2 Owashi, Tsukuba, Ibaraki 305 8634, Japan
    DNA Res 11:27-35. 2004
    ..A search for Bombyx orthologs to Drosophila genes controlling sex determination in the WGS data revealed 11 Bombyx genes and suggested that the sex-determining systems differ profoundly between the two species...