S Sakuda

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. doi request reprint Inhibitory effects of respiration inhibitors on aflatoxin production
    Shohei Sakuda
    Department of Applied Biological Chemistry, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Toxins (Basel) 6:1193-200. 2014
  2. pmc Correlation of ATP citrate lyase and acetyl CoA levels with trichothecene production in Fusarium graminearum
    Naoko Sakamoto
    Department of Applied Biological Chemistry, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Toxins (Basel) 5:2258-69. 2013
  3. doi request reprint Novel biological activities of allosamidins
    Shohei Sakuda
    Department of Applied Biological Chemistry, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Molecules 18:6952-68. 2013
  4. ncbi request reprint Biosynthetic studies on the cyclopentane ring formation of allosamizoline, an aminocyclitol component of the chitinase inhibitor allosamidin
    S Sakuda
    Department of Applied Biological Chemistry, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    J Org Chem 66:3356-61. 2001
  5. ncbi request reprint Absolute configuration of a polyol fragment of blasticidin A, a specific inhibitor of aflatoxin production
    Shohei Sakuda
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Biosci Biotechnol Biochem 68:407-12. 2004
  6. ncbi request reprint Gelatinase biosynthesis-activating pheromone: a peptide lactone that mediates a quorum sensing in Enterococcus faecalis
    J Nakayama
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Mol Microbiol 41:145-54. 2001
  7. pmc Molecular mechanism of peptide-specific pheromone signaling in Enterococcus faecalis: functions of pheromone receptor TraA and pheromone-binding protein TraC encoded by plasmid pPD1
    J Nakayama
    Department of Applied Biological Chemistry, Graduate School of Agriculture and Life Sciences, University of Tokyo, Japan
    J Bacteriol 180:449-56. 1998
  8. ncbi request reprint Inhibitory effect of aflastatin A on melanin biosynthesis by Colletotrichum lagenarium
    S Okamoto
    Department of Applied Biological Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
    Microbiology 147:2623-8. 2001
  9. ncbi request reprint Preparation of biotinylated allosamidins with strong chitinase inhibitory activities
    S Sakuda
    Department of Applied Biological Chemistry, University of Tokyo, Japan
    Bioorg Med Chem Lett 8:2987-90. 1998
  10. ncbi request reprint Family 19 chitinases of Streptomyces species: characterization and distribution
    T Watanabe
    Department of Applied Biological Chemistry, Faculty of Agriculture, Niigata University, Japan
    Microbiology 145:3353-63. 1999

Collaborators

Detail Information

Publications31

  1. doi request reprint Inhibitory effects of respiration inhibitors on aflatoxin production
    Shohei Sakuda
    Department of Applied Biological Chemistry, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Toxins (Basel) 6:1193-200. 2014
    ..This study suggests that respiration inhibitors, including commonly used pesticides, are useful for aflatoxin control. ..
  2. pmc Correlation of ATP citrate lyase and acetyl CoA levels with trichothecene production in Fusarium graminearum
    Naoko Sakamoto
    Department of Applied Biological Chemistry, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Toxins (Basel) 5:2258-69. 2013
    ..These findings also suggest that sucrose is important for the action of cobalt chloride in activating trichothecene production and that precocene II may affect a step down-stream of the target of cobalt chloride. ..
  3. doi request reprint Novel biological activities of allosamidins
    Shohei Sakuda
    Department of Applied Biological Chemistry, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Molecules 18:6952-68. 2013
    ..In this article, recent studies on the novel biological activities of allosamidins are reviewed...
  4. ncbi request reprint Biosynthetic studies on the cyclopentane ring formation of allosamizoline, an aminocyclitol component of the chitinase inhibitor allosamidin
    S Sakuda
    Department of Applied Biological Chemistry, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    J Org Chem 66:3356-61. 2001
    ..The 6-aldehyde intermediate may play a key role in the biosynthetic step(s) of cyclization to form the cyclopentane ring and/or deoxygenation at C-5...
  5. ncbi request reprint Absolute configuration of a polyol fragment of blasticidin A, a specific inhibitor of aflatoxin production
    Shohei Sakuda
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Biosci Biotechnol Biochem 68:407-12. 2004
    ..By using the similar methods, the absolute configuration of the polyol fragment of 2 (4a) was determined, which was the same as that elucidated by J-based and other chemical methods previously...
  6. ncbi request reprint Gelatinase biosynthesis-activating pheromone: a peptide lactone that mediates a quorum sensing in Enterococcus faecalis
    J Nakayama
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Mol Microbiol 41:145-54. 2001
    ..Strains with an insertion mutation in either fsrC or a putative response regulator gene fsrA failed to respond to GBAP, suggesting that the GBAP signal is transduced by a two-component regulatory system...
  7. pmc Molecular mechanism of peptide-specific pheromone signaling in Enterococcus faecalis: functions of pheromone receptor TraA and pheromone-binding protein TraC encoded by plasmid pPD1
    J Nakayama
    Department of Applied Biological Chemistry, Graduate School of Agriculture and Life Sciences, University of Tokyo, Japan
    J Bacteriol 180:449-56. 1998
    ..These results show that TraC, as an extracellular less-specific pheromone-binding protein, supports donor cells to receive cPD1...
  8. ncbi request reprint Inhibitory effect of aflastatin A on melanin biosynthesis by Colletotrichum lagenarium
    S Okamoto
    Department of Applied Biological Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
    Microbiology 147:2623-8. 2001
    ..These results indicate that AsA inhibits an early step in melanin production, which suppresses the expression of PKS1...
  9. ncbi request reprint Preparation of biotinylated allosamidins with strong chitinase inhibitory activities
    S Sakuda
    Department of Applied Biological Chemistry, University of Tokyo, Japan
    Bioorg Med Chem Lett 8:2987-90. 1998
    ..Reduction of 4 by NaBH4 afforded its reduced form 5. Each of these three biotinylated derivatives maintained strong chitinase inhibitory activity. Especially, 6 inhibited a Trichoderma chitinase as strongly as 1...
  10. ncbi request reprint Family 19 chitinases of Streptomyces species: characterization and distribution
    T Watanabe
    Department of Applied Biological Chemistry, Faculty of Agriculture, Niigata University, Japan
    Microbiology 145:3353-63. 1999
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  11. ncbi request reprint Effects of aflastatin A, an inhibitor of aflatoxin production, on aflatoxin biosynthetic pathway and glucose metabolism in Aspergillus parasiticus
    T Kondo
    Department of Applied Biological Chemistry, The University of Tokyo, Japan
    J Antibiot (Tokyo) 54:650-7. 2001
    ..These results suggest that aflastatin A inhibits a very early step in aflatoxin biosynthesis prior to the transcription of aflR and can influence glucose metabolism in the fungus...
  12. doi request reprint Inhibitory activity of blasticidin A, a strong aflatoxin production inhibitor, on protein synthesis of yeast: selective inhibition of aflatoxin production by protein synthesis inhibitors
    Tomoya Yoshinari
    Department of Applied Biological Chemistry, University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Antibiot (Tokyo) 63:309-14. 2010
    ..These results suggested that protein synthesis inhibitors are useful to control aflatoxin production...
  13. pmc Chemical structure of a novel aminophospholipid from Hydrogenobacter thermophilus strain TK-6
    J Yoshino
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Japan
    J Bacteriol 183:6302-4. 2001
    ..Structurally similar phospholipids have been identified in Methanospirillum hungatei, Methanolacinia paynteri, and Methanogenium cariaci, which all belong to the Archaea...
  14. ncbi request reprint Isolation and some characterization of an acidic polysaccharide with anti-calcification activity from coccoliths of a marine alga, Pleurochrysis carterae
    N Ozaki
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Japan
    Biosci Biotechnol Biochem 65:2330-3. 2001
    ..Since PS-2 did not show anti-calcification activity, CMAP was found to be the active principle...
  15. ncbi request reprint Chemical synthesis and biological activity of the gelatinase biosynthesis-activating pheromone of Enterococcus faecalis and its analogs
    J Nakayama
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Biosci Biotechnol Biochem 65:2322-5. 2001
    ..In this study, we synthesized GBAP and its analogs and examined their gelatinase biosynthesis-inducing activity. This study on the structure-activity relationship shows that a lactone ring was indispensable for the activity...
  16. ncbi request reprint Isolation of abikoviromycin and dihydroabikoviromycin as inhibitors of polyketide synthase involved in melanin biosynthesis by Colletotrichum lagenarium
    Hiroki Maruyama
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    J Antibiot (Tokyo) 56:801-4. 2003
  17. ncbi request reprint Prunustatin A, a novel GRP78 molecular chaperone down-regulator isolated from Streptomyces violaceoniger
    Yukiko Umeda
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    J Antibiot (Tokyo) 58:206-9. 2005
    ..Prunustatin A inhibited the expression of GRP78 induced by 2-deoxyglucose in human fibrosarcoma HT1080 cells accompanied by global cell death without showing cytotoxicity under normal nutrient condition...
  18. doi request reprint Spiroethers of German chamomile inhibit production of aflatoxin G and trichothecene mycotoxin by inhibiting cytochrome P450 monooxygenases involved in their biosynthesis
    Tomoya Yoshinari
    Department of Applied Biological Chemistry, The University of Tokyo, Tokyo, Japan
    FEMS Microbiol Lett 284:184-90. 2008
    ..1 and 103 microM, respectively. Our results suggest that the spiroethers inhibited AFG(1) and 3-ADON production by inhibiting CYPA and TRI4, respectively...
  19. ncbi request reprint Absolute structure of prunustatin A, a novel GRP78 molecular chaperone down-regulator
    Yukiko Umeda
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Org Lett 9:4239-42. 2007
    ..Its absolute stereochemistry was established to be 2R, 4S, 6S, 7R, 9S, and 29S by analyzing chemically degraded components obtained from the derivative of prunustatin A...
  20. ncbi request reprint Dillapiol and Apiol as specific inhibitors of the biosynthesis of aflatoxin G1 in Aspergillus parasiticus
    Mehdi Razzaghi-Abyaneh
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Biosci Biotechnol Biochem 71:2329-32. 2007
    ..15 microM without inhibiting aflatoxin B1 production or fungal growth. Apiol and myristicin, congeners of dillapiol, showed similar activity with IC50 values of 0.24 and 3.5 microM, respectively...
  21. ncbi request reprint Dioctatin A is a strong inhibitor of aflatoxin production by Aspergillus parasiticus
    Tomoya Yoshinari
    Department of Applied Biological Chemistry, The University of Tokyo, Tokyo 113 8657, Japan
    Microbiology 153:2774-80. 2007
    ..These results indicate that DotA has pleiotropic effects on regulatory mechanisms of fungal secondary metabolite production and differentiation, leading to inhibition of aflatoxin production...
  22. ncbi request reprint Chitinase inhibitor allosamidin promotes chitinase production of Streptomyces generally
    Shigeo Suzuki
    Department of Applied Biological Chemistry, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Int J Biol Macromol 43:13-9. 2008
    ..These observations suggested that allosamidin can affect the common regulatory system for production of a chitinase with a two-component regulatory system in Streptomyces...
  23. ncbi request reprint Chitinase inhibitor allosamidin is a signal molecule for chitinase production in its producing Streptomyces II. Mechanism for regulation of chitinase production by allosamidin through a two-component regulatory system
    Shigeo Suzuki
    Department of Applied Biological Chemistry, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    J Antibiot (Tokyo) 59:410-7. 2006
    ..These results show that allosamidin can activate transcription of the chitinase gene through the two-component regulatory system in the presence of N, N'-diacetylchitobiose...
  24. ncbi request reprint Chitinase inhibitor allosamidin is a signal molecule for chitinase production in its producing Streptomyces I. Analysis of the chitinase whose production is promoted by allosamidin and growth accelerating activity of allosamidin
    Shigeo Suzuki
    Department of Applied Biological Chemistry, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    J Antibiot (Tokyo) 59:402-9. 2006
    ..These results show that allosamidin acts as a key signal molecule for chitinase production in its producing strain, which may be useful for its growth in chitin-rich environment...
  25. ncbi request reprint Nucleotide sequences of genes encoding allosamidin-sensitive and -insensitive chitinases produced by allosamidin-producing Streptomyces
    Hiroshi Matsuura
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Biosci Biotechnol Biochem 67:2002-5. 2003
    ..AJ9463. In this study, we cloned and sequenced the genes encoding the two chitinases, which clarified that chitinase S and IS belong to the family 18 and 19 chitinase, respectively...
  26. ncbi request reprint Novel benzene ring biosynthesis from C(3) and C(4) primary metabolites by two enzymes
    Hirokazu Suzuki
    Department of Biotechnology and Applied Biological Chemistry, Graduate School of Agriculture and Life Sciences, University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    J Biol Chem 281:36944-51. 2006
    ..This pathway is independent of the shikimate pathway, representing a novel, simple enzyme system responsible for the synthesis of a benzene ring from the C(3) and C(4) primary metabolites...
  27. doi request reprint Inhibitory effects of Satureja hortensis L. essential oil on growth and aflatoxin production by Aspergillus parasiticus
    Mehdi Razzaghi-Abyaneh
    Department of Mycology, Pasteur Institute of Iran, Tehran 13164, Iran
    Int J Food Microbiol 123:228-33. 2008
    ..hortensis L. as strong inhibition of aflatoxin production by A. parasiticus. Carvacrol and thymol, the effective constituents of S. hortensis L., may be useful to control aflatoxin contamination of susceptible crops in the field...
  28. ncbi request reprint Desferrioxamine E produced by Streptomyces griseus stimulates growth and development of Streptomyces tanashiensis
    Kazuki Yamanaka
    Life Science Research Center, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa 252 8510, Japan
    Microbiology 151:2899-905. 2005
    ..Similar to several pathogenic bacteria and fungi, S. tanashiensis may be defective in the production of siderophores; however, it can utilize the siderophores excreted by other organisms...
  29. ncbi request reprint Crystal structures of allosamidin derivatives in complex with human macrophage chitinase
    Francesco V Rao
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Scotland
    J Biol Chem 278:20110-6. 2003
    ..The data reported here represent a first step toward structure-based design of specific allosamidin derivatives...
  30. ncbi request reprint [Studies on allosamidin and aflastatin, novel inhibitors of important metabolic pathways, from microorganisms]
    Shohei Sakuda
    Jpn J Antibiot 55:311-8. 2002
  31. ncbi request reprint Development of a genetic system in chitinase-producing streptomyces and the application of an allosamidin-insensitive chitinase gene to homologous overexpression
    Ryu Kawachi
    Department of Biological Chemistry, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Mol Biotechnol 26:179-86. 2004
    ..Moreover, the pYK1-introduced strain gave a five-fold higher chitinase activity than the wild-type, suggesting that this system can be widely applied for the overexpression and gene functional analysis...