Tomoko Saito


Affiliation: University of Tsukuba
Country: Japan


  1. request reprint
    Saito T, Oishi T, Yanai K, Shimamoto Y, Fukamizu A. Cloning and characterization of a novel splicing isoform of USF1. Int J Mol Med. 2003;12:161-7 pubmed
    ..In vitro translated USF1/BD possessed DNA binding activity as a homodimer and a heterodimer with USF1 (wt). These results suggest that USF1/BD plays a role as a modulator of USF1 to control the expression of target genes. ..
  2. Hada K, Hirota K, Inanobe A, Kako K, Miyata M, Araoi S, et al. Tricarboxylic acid cycle activity suppresses acetylation of mitochondrial proteins during early embryonic development in Caenorhabditis elegans. J Biol Chem. 2019;294:3091-3099 pubmed publisher
    ..Taken together, these results suggest the possibility that during early embryogenesis, acetyl-CoA consumption by the TCA cycle in C. elegans prevents protein hyperacetylation and thereby protects mitochondrial function. ..
  3. Murata K, Lu W, Hashimoto M, Ono N, Muratani M, Nishikata K, et al. PRMT1 Deficiency in Mouse Juvenile Heart Induces Dilated Cardiomyopathy and Reveals Cryptic Alternative Splicing Products. iScience. 2018;8:200-213 pubmed publisher
    ..These findings highlight the essential roles of PRMT1 in cardiac homeostasis and alternative splicing regulation. ..
  4. Sato A, Kim J, Mizukami H, Nakashima M, Kako K, Ishida J, et al. Gestational changes in PRMT1 expression of murine placentas. Placenta. 2018;65:47-54 pubmed publisher
    ..These findings provide fundamental information regarding placental PRMT1-mediated arginine methylation during the development. ..
  5. Hamada J, Baasanjav A, Ono N, Murata K, Kako K, Ishida J, et al. Possible involvement of downregulation of the apelin-APJ system in doxorubicin-induced cardiotoxicity. Am J Physiol Heart Circ Physiol. 2015;308:H931-41 pubmed publisher
    ..Modulation of the apelin-APJ system may hold promise for the treatment of Dox-induced cardiotoxicity. ..
  6. Ohkuro M, Kim J, Kuboi Y, Hayashi Y, Mizukami H, Kobayashi Kuramochi H, et al. Calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease. Nat Commun. 2018;9:1982 pubmed publisher
    ..We propose that leukocytes infiltration via the binding of CRT to ITGAs is necessary for the onset and development of the colitis and the inhibition of this interaction may be a novel therapeutic strategy for the treatment of IBD. ..
  7. Murata K, Baasanjav A, Kwon C, Hashimoto M, Ishida J, Fukamizu A. Angiotensin II accelerates mammary gland development independently of high blood pressure in pregnancy-associated hypertensive mice. Physiol Rep. 2015;3: pubmed publisher
    ..These data suggest that AngII-AT1 receptor-induced signaling accelerates mammary gland√ā¬†development during pregnancy through hypertension-independent mechanism. ..
  8. Kako K, Nakamura A, Nagashima Y, Ishida J, Fukamizu A. Detection of ethanolamine altering in fetuses of pregnancy-associated hypertensive mice treated with vasodepressors by using UPLC and MALDI-TOF/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;1006:93-98 pubmed publisher
    ..Mass spectrometric analyses indicated that the molecular mass of this amine was 61.2, which was identified as ethanolamine. ..
  9. Daitoku H, Kaneko Y, Yoshimochi K, Matsumoto K, Araoi S, Sakamaki J, et al. Non-transcriptional Function of FOXO1/DAF-16 Contributes to Translesion DNA Synthesis. Mol Cell Biol. 2016;36:2755-2766 pubmed publisher
    ..Thus, our findings demonstrate that FOXO1/DAF-16 is a functional component in TLS independently of its transactivation activity. ..

More Information


  1. Sha L, Daitoku H, Araoi S, Kaneko Y, Takahashi Y, Kako K, et al. Asymmetric Arginine Dimethylation Modulates Mitochondrial Energy Metabolism and Homeostasis in Caenorhabditis elegans. Mol Cell Biol. 2017;37: pubmed publisher
    ..These findings add a new layer of complexity to the posttranslational regulation of mitochondrial function and provide clues for understanding the physiological roles of PRMT-1 in multicellular organisms. ..
  2. Hashimoto M, Murata K, Ishida J, Kanou A, Kasuya Y, Fukamizu A. Severe Hypomyelination and Developmental Defects Are Caused in Mice Lacking Protein Arginine Methyltransferase 1 (PRMT1) in the Central Nervous System. J Biol Chem. 2016;291:2237-45 pubmed publisher
    ..Our findings provide evidence that PRMT1 is required for CNS development, especially for oligodendrocyte maturation processes. ..
  3. Murata K, Ishida J, Ishimaru T, Mizukami H, Hamada J, Saito C, et al. Lactation Is a Risk Factor of Postpartum Heart Failure in Mice with Cardiomyocyte-specific Apelin Receptor (APJ) Overexpression. J Biol Chem. 2016;291:11241-51 pubmed publisher