Shigeru Saito

Summary

Affiliation: University of Toyama
Country: Japan

Publications

  1. doi request reprint Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    Am J Reprod Immunol 63:601-10. 2010
  2. doi request reprint A review of the mechanism for poor placentation in early-onset preeclampsia: the role of autophagy in trophoblast invasion and vascular remodeling
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan Electronic address
    J Reprod Immunol 101:80-8. 2014
  3. doi request reprint Review: The role of autophagy in extravillous trophoblast function under hypoxia
    S Saito
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Placenta 34:S79-84. 2013
  4. doi request reprint Which types of regulatory T cells play important roles in implantation and pregnancy maintenance?
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    Am J Reprod Immunol 69:340-5. 2013
  5. ncbi request reprint Inadequate tolerance induction may induce pre-eclampsia
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama, Japan Center of Excellence COE 21st Program, Japan
    J Reprod Immunol 76:30-9. 2007
  6. pmc What is the role of regulatory T cells in the success of implantation and early pregnancy?
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama, 930 0194, Japan
    J Assist Reprod Genet 24:379-86. 2007
  7. ncbi request reprint Regulatory T cells and regulatory natural killer (NK) cells play important roles in feto-maternal tolerance
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Semin Immunopathol 29:115-22. 2007
  8. ncbi request reprint The balance between cytotoxic NK cells and regulatory NK cells in human pregnancy
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    J Reprod Immunol 77:14-22. 2008
  9. ncbi request reprint The role of the immune system in preeclampsia
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Mol Aspects Med 28:192-209. 2007
  10. doi request reprint Future directions of studies for recurrent miscarriage associated with immune etiologies
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Reprod Immunol 90:91-5. 2011

Detail Information

Publications90

  1. doi request reprint Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    Am J Reprod Immunol 63:601-10. 2010
    ..Here, we will review the immunological environment in normal pregnancy and complicated pregnancy, such as implantation failure, abortion, preterm labor, and preeclampsia from the viewpoint of the new Th1/Th2/Th17 and Treg paradigms...
  2. doi request reprint A review of the mechanism for poor placentation in early-onset preeclampsia: the role of autophagy in trophoblast invasion and vascular remodeling
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan Electronic address
    J Reprod Immunol 101:80-8. 2014
    ..In this review, we discuss the relationship between inadequate autophagy and poor placentation in preeclampsia. ..
  3. doi request reprint Review: The role of autophagy in extravillous trophoblast function under hypoxia
    S Saito
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Placenta 34:S79-84. 2013
    ..Recent findings suggest that impaired autophagy might induce poor placentation in preeclamptic cases. In this review, we discuss the role of autophagy and summarize the role of autophagy-related genes in placentas...
  4. doi request reprint Which types of regulatory T cells play important roles in implantation and pregnancy maintenance?
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    Am J Reprod Immunol 69:340-5. 2013
    ..Therefore, we should evaluate the true Treg level and clarify which types of Treg cells play important roles in implantation and pregnancy maintenance in mice and humans...
  5. ncbi request reprint Inadequate tolerance induction may induce pre-eclampsia
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama, Japan Center of Excellence COE 21st Program, Japan
    J Reprod Immunol 76:30-9. 2007
    ..In this process, CD4(+)CD25(+) regulatory T (Treg)-cells play central roles. In this review, we discuss the relationship between the risk of pre-eclampsia and tolerance induction...
  6. pmc What is the role of regulatory T cells in the success of implantation and early pregnancy?
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama, 930 0194, Japan
    J Assist Reprod Genet 24:379-86. 2007
    ..CD4(+)CD25(+) regulatory T (Treg) cells and an enzyme called indoleamine-2, 3-dioxygenase (IDO) mediate maternal tolerance of the allogeneic fetus. Treg cells, therefore, may prevent early pregnancy loss due to maternal 'rejection.'..
  7. ncbi request reprint Regulatory T cells and regulatory natural killer (NK) cells play important roles in feto-maternal tolerance
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Semin Immunopathol 29:115-22. 2007
    ..Not only Treg cells but also regulatory NK cells may inhibit maternal T cell or NK cell fetal attack...
  8. ncbi request reprint The balance between cytotoxic NK cells and regulatory NK cells in human pregnancy
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    J Reprod Immunol 77:14-22. 2008
    ..We summarize the progress in studying NK reg cells and focus on how NK reg cells and cytotoxic NK cells affect the reproductive immune response...
  9. ncbi request reprint The role of the immune system in preeclampsia
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Mol Aspects Med 28:192-209. 2007
    ..Furthermore, the immunoregulatory system is down-regulated in preeclampsia and persistent inflammation reduces regulatory T cell function. Therefore, systematical immunoactivation may be one cause of preeclampsia...
  10. doi request reprint Future directions of studies for recurrent miscarriage associated with immune etiologies
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Reprod Immunol 90:91-5. 2011
    ..Careful examination of the immune system at the decidua basalis in an early-stage abortion in RPL cases with normal fetal chromosome may reveal useful information...
  11. doi request reprint Clinical implication of recent advances in our understanding of IL-17 and reproductive immunology
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama shi, Toyama 930 0194, Japan
    Expert Rev Clin Immunol 7:649-57. 2011
    ..Recent data show the reciprocal development of pathways between Th1/Th17 subsets and between Th17/Treg subsets, and the imbalance of Th17/Treg development has been reported in recurrent pregnancy loss and preeclampsia...
  12. pmc Granulysin produced by uterine natural killer cells induces apoptosis of extravillous trophoblasts in spontaneous abortion
    Akitoshi Nakashima
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, 930 0194, Japan
    Am J Pathol 173:653-64. 2008
    ..These data support a new apoptosis pathway for trophoblasts via uNK-derived granulysin, suggesting that granulysin is involved in spontaneous abortion...
  13. doi request reprint A role for IL-17 in induction of an inflammation at the fetomaternal interface in preterm labour
    Mika Ito
    Department of Obstetrics and Gynecology, University of Toyama, Toyama shi, Toyama, Japan
    J Reprod Immunol 84:75-85. 2010
    ..These results indicate that IL-17, produced by T cells, promotes inflammation at the fetomaternal interface in preterm delivery...
  14. ncbi request reprint Mirimostim (macrophage colony-stimulating factor; M-CSF) improves chemotherapy-induced impaired natural killer cell activity, Th1/Th2 balance, and granulocyte function
    Takao Hidaka
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Sugitani, Toyoma shi, Toyama 930 0194, Japan
    Cancer Sci 94:814-20. 2003
    ..These results indicate that chemotherapy markedly impaired the immunological functions, and that the administration of M-CSF significantly improved the impaired immunological functions...
  15. ncbi request reprint HER2 is frequently over-expressed in ovarian clear cell adenocarcinoma: possible novel treatment modality using recombinant monoclonal antibody against HER2, trastuzumab
    Masaki Fujimura
    Department of Obstetrics and Gynecology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama City
    Jpn J Cancer Res 93:1250-7. 2002
    ..The survival period of trastuzumab-treated mice was longer than that of the control group. From these findings, trastuzumab appears to be a candidate as a treatment modality for HER2 over-expressing ovarian CCA...
  16. doi request reprint Accumulation of IL-17-positive cells in decidua of inevitable abortion cases
    Akitoshi Nakashima
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, Toyama, Japan
    Am J Reprod Immunol 64:4-11. 2010
    ..It is, however, still unknown how Th17 cells affect pregnancy outcome. We investigated the expression of IL-17-producing cells in human spontaneous abortion...
  17. ncbi request reprint Circulating and decidual Th17 cell levels in healthy pregnancy
    Akitoshi Nakashima
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    Am J Reprod Immunol 63:104-9. 2010
    ..However, the level of Th17 cells during pregnancy is still unclear. We investigated the level of peripheral Th17 cells in healthy pregnancy subjects...
  18. doi request reprint Ovarian squamous cell carcinoma which metastasized 8 years after cervical conization for early microinvasive cervical cancer: a case report
    Takao Hidaka
    Department of Obstetrics and Gynecology, University of Toyama, 2630, Sugitani, Toyama shi, Toyama 930 0194, Japan
    Jpn J Clin Oncol 41:807-10. 2011
    ....
  19. pmc Autophagy induced by HIF1α overexpression supports trophoblast invasion by supplying cellular energy
    Mikiko Yamanaka-Tatematsu
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, Toyama, Japan
    PLoS ONE 8:e76605. 2013
    ..These results suggest that autophagy plays a role in maintaining homeostasis by countervailing HIF1α-mediated cellular energy consumption in EVTs. ..
  20. ncbi request reprint Characterization of regulatory T cells in decidua of miscarriage cases with abnormal or normal fetal chromosomal content
    Kumiko Inada
    Department of Obstetrics and Gynecology, University of Toyama, Toyama 930 0194, Japan
    J Reprod Immunol 97:104-11. 2013
    ....
  21. ncbi request reprint Interleukin-8 and glucose in amniotic fluid, fetal fibronectin in vaginal secretions and preterm labor index based on clinical variables are optimal predictive markers for preterm delivery in patients with intact membranes
    Satoshi Yoneda
    Department of Obstetrics and Gynecology, Toyama University, Toyama, Japan
    J Obstet Gynaecol Res 33:38-44. 2007
    ..Various predictive markers for preterm delivery have been proposed in previous studies. We investigated which marker is most reliable...
  22. ncbi request reprint The ratio of interleukin (IL)-18 to IL-12 secreted by peripheral blood mononuclear cells is increased in normal pregnant subjects and decreased in pre-eclamptic patients
    Masatoshi Sakai
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama shi Toyama 930 0194, Japan
    J Reprod Immunol 61:133-43. 2004
    ....
  23. ncbi request reprint Evaluation of effectiveness of prophylactic cerclage of a short cervix according to interleukin-8 in cervical mucus
    Masatoshi Sakai
    Department of Obstetrics, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Am J Obstet Gynecol 194:14-9. 2006
    ..This study was undertaken to compare rates of preterm delivery according to cervical mucus interleukin-8 (IL-8) among women who underwent cerclage because of a short cervix...
  24. pmc Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia
    Akitoshi Nakashima
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, Toyama, Japan
    Autophagy 9:303-16. 2013
    ..This is the first report showing that impaired autophagy in EVT contributes to the pathophysiology of preeclampsia...
  25. ncbi request reprint Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late pregnancy in allogeneic mice
    Tomoko Shima
    Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama shi, Toyama 930 0194, Japan
    J Reprod Immunol 85:121-9. 2010
    ....
  26. ncbi request reprint Predominance of Th2-promoting dendritic cells in early human pregnancy decidua
    Satomi Miyazaki
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Japan
    J Leukoc Biol 74:514-22. 2003
    ..This finding was abolished by exogenous IL-12 administration with decidual myeloid DCs. Thus, the DCs in the decidua could regulate the Th1/Th2 balance to maintain a Th2-dominant state, leading to maintenance of pregnancy...
  27. doi request reprint Prediction of exact delivery time in patients with preterm labor and intact membranes at admission by amniotic fluid interleukin-8 level and preterm labor index
    Satoshi Yoneda
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    J Obstet Gynaecol Res 37:861-6. 2011
    ..To examine whether delivery time for preterm labor can be predicted by clinical and biochemical markers at admission...
  28. pmc Establishment and characterization of immortalized human amniotic epithelial cells
    Kaixuan Zhou
    Department of Regenerative Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
    Cell Reprogram 15:55-67. 2013
    ..In conclusion, the immortalization of HAEs with the characteristics of stem cells has been established, allowing these iHAEs to become useful for cell therapy and regenerative medicine...
  29. doi request reprint Comparison of risk factors for major obstetric complications between Western countries and Japan: a case-cohort study
    Arihiro Shiozaki
    Department of Obstetrics and Gynecology, University of Toyama, Sugitani, Toyama
    J Obstet Gynaecol Res 37:1447-54. 2011
    ..The aim of this study was to demonstrate the differences in risk factors for obstetrical complications between Japan and Western countries...
  30. ncbi request reprint Expression of indoleamine 2, 3-dioxygenase and the recruitment of Foxp3-expressing regulatory T cells in the development and progression of uterine cervical cancer
    Takafumi Nakamura
    Department of Obstetrics and Gynecology, University of Toyama, Toyama 930 0194, Japan
    Cancer Sci 98:874-81. 2007
    ..IDO expression at the invasive front of cancer cells and APC, and the localization of Foxp3(+) Treg cells in front of cancer tissues, may create a network between IDO and Treg for the induction of immune escape...
  31. ncbi request reprint Prostaglandin D2 and reproduction
    Shigeru Saito
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama shi, Japan
    Am J Reprod Immunol 47:295-302. 2002
    ..PGD2 might appear to contribute to the maintenance of pregnancy by controlling the Th1/Th2 balance and antigen presentation by DCs through its dual receptor systems, CRTH2 and DP...
  32. doi request reprint Stemness of human Wharton's jelly mesenchymal cells is maintained by floating cultivation
    Osamu Higuchi
    Department of Regenerative Medicine, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan
    Cell Reprogram 14:448-55. 2012
    ....
  33. ncbi request reprint IDO expression on decidual and peripheral blood dendritic cells and monocytes/macrophages after treatment with CTLA-4 or interferon-gamma increase in normal pregnancy but decrease in spontaneous abortion
    Naoko Miwa
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Mol Hum Reprod 11:865-70. 2005
    ..These data suggest that CTLA-4 on Treg cells up-regulates IDO expression on decidual and peripheral blood DC and monocytes by the induction of IFN-gamma production...
  34. doi request reprint Stage I ovarian cancer cases during early, mid and late pregnancy periods: three case reports and review of the literature
    Toru Hasegawa
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, Toyama, Japan
    J Obstet Gynaecol Res 37:650-5. 2011
    ..Even with stage Ia ovarian cancer, restaging laparotomy at cesarean section or post-delivery may be important to determine the treatment plan because staging during pregnancy is rarely complete...
  35. ncbi request reprint A Th2 chemokine, TARC, produced by trophoblasts and endometrial gland cells, regulates the infiltration of CCR4+ T lymphocytes into human decidua at early pregnancy
    Hiroshi Tsuda
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Sugitani Toyama, Japan
    Am J Reprod Immunol 48:1-8. 2002
    ..We examined the distribution of CCR4 expressing CD4+ and CD8+-T cells in human decidua at early pregnancy, and localized TARC in the decidual tissue and chorionic tissue...
  36. ncbi request reprint Interleukin 2 receptor gamma chain (gamma(c)) knockout mice show less regularity in estrous cycle but achieve normal pregnancy without fetal compromise
    Satomi Miyazaki
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Japan
    Am J Reprod Immunol 47:222-30. 2002
    ....
  37. ncbi request reprint Th1/Th2 balance in preeclampsia
    Shigeru Saito
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama shi, 930 0194 Toyama, Japan
    J Reprod Immunol 59:161-73. 2003
    ..In this review, we discuss that Th1 predominant immunity is closely related to inflammation, endothelial dysfunction and poor placentation...
  38. doi request reprint Outcomes of infants exposed to oseltamivir or zanamivir in utero during pandemic (H1N1) 2009
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    Am J Obstet Gynecol 209:130.e1-9. 2013
    ..To assess adverse fetal outcomes and short-term prognoses of infants exposed to oseltamivir or zanamivir in utero during pandemic (H1N1) 2009 in Japan...
  39. doi request reprint Comparison of risk factors for gestational hypertension and preeclampsia in Japanese singleton pregnancies
    Arihiro Shiozaki
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    J Obstet Gynaecol Res 39:492-9. 2013
    ..To demonstrate the difference between risk factors for gestational hypertension (GH) and preeclampsia (PE)...
  40. doi request reprint Comparison of risk factors for placental abruption and placenta previa: case-cohort study
    Yoshio Matsuda
    Department of Obstetrics and Gynecology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    J Obstet Gynaecol Res 37:538-46. 2011
    ..A case-cohort study was performed to clarify and compare the risk factors for placental abruption and placenta previa...
  41. doi request reprint Aberrant methylation of H19-DMR acquired after implantation was dissimilar in soma versus placenta of patients with Beckwith-Wiedemann syndrome
    Ken Higashimoto
    Division of Molecular Genetics and Epigenetics, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan
    Am J Med Genet A 158:1670-5. 2012
    ..In addition, of 16 primary imprinted DMRs analyzed, only H19-DMR was aberrantly methylated, except for NNAT DMR in the placental chorangioma of Patient 2. To our knowledge, these are the first data suggesting when GOM of H19-DMR occurs...
  42. doi request reprint Anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian immature teratoma
    Azusa Sameshima
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    J Obstet Gynaecol Res 37:1883-6. 2011
    ..We present a case of anti-NMDAR encephalitis associated with ovarian immature teratoma. The symptoms were dramatically relieved by tumor resection and immunotherapy...
  43. ncbi request reprint Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells
    Isaya Hashimoto
    Department of Surgery II, Faculty of Medicine, University of Toyama, Toyama, Japan
    Eur J Cancer 44:1022-9. 2008
    ..Therefore, blocking on the CXCR4/mTOR signalling pathway may be useful for the future development of a more effective therapeutic strategy for gastric cancer involved in peritoneal dissemination...
  44. ncbi request reprint Paclitaxel/carboplatin versus cyclophosphamide/adriamycin/cisplatin as postoperative adjuvant chemotherapy for advanced endometrial adenocarcinoma
    Takao Hidaka
    Department of Obstetrics and Gynecology, Toyama University School of Medicine, Toyama, Japan
    J Obstet Gynaecol Res 32:330-7. 2006
    ..However, since October 1999 a paclitaxel/carboplatin regimen has been substituted for CAP. To evaluate the antitumor activity and toxic effects of those regimens, we retrospectively reviewed cases that were treated in our hospital...
  45. ncbi request reprint CD4(+)CD25high regulatory T cells in human pregnancy
    Shigeru Saito
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama shi, Toyama 930 0194, Japan
    J Reprod Immunol 65:111-20. 2005
    ..Here, we review the differences between humans and mouse Treg cells and the role of CD4(+)CD25+Treg during pregnancy...
  46. ncbi request reprint Endometrioid adenocarcinoma of the vagina with a microglandular pattern arising from endometriosis after hysterectomy
    Kazuhiro Nomoto
    Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, Toyama, University of Toyama, Toyama City, Toyama 930 0194, Japan
    Pathol Int 60:636-41. 2010
    ..Pathologists are encouraged to be aware of the occurrence of endometrioid adenocarcinoma associated with endometriosis in the vaginal stump after hysterectomy, and microglandular morphology which might be a source of misinterpretation...
  47. ncbi request reprint Carcinomatous meningitis associated with ovarian cancer complicated by SIADH
    Toru Hasegawa
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Japan
    Gan To Kagaku Ryoho 37:739-42. 2010
    ..Clinicians should consider carcinomatous meningitis when there are findings of SIADH...
  48. ncbi request reprint Relationship between cervical mucus interleukin-8 concentrations and vaginal bacteria in pregnancy
    Masatoshi Sakai
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyoma, Japan
    Am J Reprod Immunol 52:106-12. 2004
    ..High interleukin (IL)-8 concentration in cervical mucus in the second trimester is a risk factor for premature birth. We investigated the relationship between vaginal pathogens and IL-8 in cervical mucus...
  49. ncbi request reprint Interleukin (IL)-17A stimulates IL-8 secretion, cyclooxygensase-2 expression, and cell proliferation of endometriotic stromal cells
    Tetsuya Hirata
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Endocrinology 149:1260-7. 2008
    ..IL-17A also enhanced the expression of cyclooxygensase-2 mRNA and proliferation of ESCs. IL-17A may play a role in the development of endometriosis by stimulating inflammatory responses and proliferation of ESCs...
  50. doi request reprint Herbal medicine Shakuyaku-kanzo-to reduces paclitaxel-induced painful peripheral neuropathy in mice
    Takao Hidaka
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, 2630, Sugitani, Toyama shi, Toyama 930 0194, Japan
    Eur J Pain 13:22-7. 2009
    ..To ascertain the effectiveness of Shakuyaku-kanzo-to on paclitaxel-induced pain, we investigated the effects of Shakuyaku-kanzo-to and its constituent herbal medicines in a mouse model...
  51. ncbi request reprint Characterization of ventricular myocardial performance in the fetus by tissue Doppler imaging
    Sayaka Watanabe
    Department of Pediatrics, School of Medicine, University of Toyama, Toyama, Japan
    Circ J 73:943-7. 2009
    ..Clinically useful indices of fetal cardiac function have not been fully delineated for tissue Doppler imaging (TDI)...
  52. doi request reprint Impact of fetal sex in pregnancy-induced hypertension and preeclampsia in Japan
    Arihiro Shiozaki
    Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Reprod Immunol 89:133-9. 2011
    ..The male antigen and the increased number of MHC mismatches in DD twin pregnancies were not a risk factor for PIH and preeclampsia. Female fetal sex was a risk factor for PIH and preeclampsia...
  53. doi request reprint The balance of the immune system between T cells and NK cells in miscarriage
    Akitoshi Nakashima
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, Japan
    Am J Reprod Immunol 67:304-10. 2012
    ..This paper aimed at finding a cause of RPL by analyzing the balance of the immune system between T cells and NK cells in an early-stage miscarriage...
  54. ncbi request reprint Central versus peripheral impact of estradiol on the impaired glucose metabolism in ovariectomized mice on a high-fat diet
    Rika Yonezawa
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    Am J Physiol Endocrinol Metab 303:E445-56. 2012
    ....
  55. ncbi request reprint The incidence of pre-eclampsia among couples consisting of Japanese women and Caucasian men
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    J Reprod Immunol 70:93-8. 2006
    ..Trowsdale, I., Moffett, A., 2004. Combinations of maternal KIR and fetal HLA-C genes influence the risk of pre-eclampsia and reproductive success. J. Exp. Med. 200, 957-965], although we did not check the haplotypes for HLA-C and KIR...
  56. doi request reprint Alpha 1 antitrypsin activity is decreased in human amnion in premature rupture of the fetal membranes
    Noriko Izumi-Yoneda
    Department of Regenerative Medicine, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan
    Mol Hum Reprod 15:49-57. 2009
    ....
  57. ncbi request reprint Selective inhibition of the epidermal growth factor receptor by ZD1839 decreases the growth and invasion of ovarian clear cell adenocarcinoma cells
    Masaki Fujimura
    Department of Obstetrics and Gynecology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Clin Cancer Res 8:2448-54. 2002
    ..Severe combined immunodeficient mice bearing RMG-1 xenografts treated with ZD1839 survived for longer than the untreated control group. From these findings, we conclude that ZD1839 may offer a new and effective treatment for ovarian CCA...
  58. ncbi request reprint Cytokine profile of natural killer cells in early human pregnancy
    Subaru Higuma-Myojo
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Am J Reprod Immunol 54:21-9. 2005
    ..To examine whether the NK1/NK2/NK3/NKr1 paradigm can be adapted in natural killer (NK) cells...
  59. ncbi request reprint Interleukin-12 secretion by peripheral blood mononuclear cells is decreased in normal pregnant subjects and increased in preeclamptic patients
    Masatoshi Sakai
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Sugitani Toyama shi, Toyama, Japan
    Am J Reprod Immunol 47:91-7. 2002
    ..Peripheral blood mononuclear cell (PBMC) production of interleukin (IL)-12, which induce Th1 responses, has not been compared between these clinical states...
  60. doi request reprint Effects of laparoscopic radical surgery for deep endometriosis on endometriosis-related pelvic pain
    Takao Hidaka
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, Toyama, Japan
    Minim Invasive Ther Allied Technol 21:355-61. 2012
    ..Although the surgical procedure is technically demanding, the levels of peri-operative complications and morbidity are acceptable...
  61. ncbi request reprint Effect of the Fukushima nuclear power plant accident on radioiodine (¹³¹ I) content in human breast milk
    Nobuya Unno
    Department of Obstetrics and Gynecology, Kitasato University, School of Medicine, Sagamihara, Japan
    J Obstet Gynaecol Res 38:772-9. 2012
    ..Whether environmental pollution with (131) I can contaminate human breast milk has not been documented...
  62. doi request reprint Massive postpartum hemorrhage after chemotherapy in a patient with acute promyelocytic leukemia
    Aiko Aoki
    Department of Obstetrics and Gynecology Third Department of Internal Medicine, University of Toyama, Toyama, Japan
    J Obstet Gynaecol Res 37:1759-63. 2011
    ..As administration of cytotoxic agents may induce disseminated intravascular coagulation, we should take care to avoid uterine bleeding after chemotherapy in acute promyelocytic leukemia cases treated soon after delivery...
  63. ncbi request reprint The preterm labor index and fetal fibronectin for prediction of preterm delivery with intact membranes
    Masatoshi Sakai
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Obstet Gynecol 101:123-8. 2003
    ..To compare the preterm labor index with the biochemical marker fetal fibronectin in predicting preterm delivery...
  64. ncbi request reprint Maternal total parenteral nutrition and fetal subdural hematoma
    Masatoshi Sakai
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Obstet Gynecol 101:1142-4. 2003
    ..Fetal subdural hematoma is rare, and no case resulting from vitamin K deficiency secondary to maternal total parenteral nutrition has been reported...
  65. ncbi request reprint Accumulation of CRTH2-positive T-helper 2 and T-cytotoxic 2 cells at implantation sites of human decidua in a prostaglandin D(2)-mediated manner
    Toshihiko Michimata
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930 0194, Japan
    Mol Hum Reprod 8:181-7. 2002
    ....
  66. ncbi request reprint Macrophage colony-stimulating factor (M-CSF) prevents infectious death induced by chemotherapy in mice, while granulocyte-CSF does not
    Takao Hidaka
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Jpn J Cancer Res 93:426-35. 2002
    ..05). These results demonstrated that it is important not only to increase the granulocyte counts, but also to improve granulocyte functions for preventing infection under myelosuppression after chemotherapy...
  67. ncbi request reprint Low adjusted serum ionized calcium concentration shortly after birth predicts poor outcome in neonatal hypoxic-ischemic encephalopathy
    Satoshi Yoneda
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Obstet Gynaecol Res 31:57-64. 2005
    ..The aim of this study was to investigate whether or not the serum ionized calcium concentration in neonates with hypoxic-ischemic encephalopathy (HIE) could be used to predict their outcome...
  68. ncbi request reprint Elevated interleukin-8 in cervical mucus as an indicator for treatment to prevent premature birth and preterm, pre-labor rupture of membranes: a prospective study
    Masatoshi Sakai
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Am J Reprod Immunol 51:220-5. 2004
    ..We investigated whether cervical shortening and high interleukin (IL)-8 in cervical mucus were valuable indications for treatment to prevent premature birth and preterm, pre-labor rupture of membranes (pPROM)...
  69. pmc Systemic lymphadenectomy cannot be recommended for low-risk corpus cancer
    Takao Hidaka
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, Toyama 930 0194, Japan
    Obstet Gynecol Int 2010:490219. 2010
    ..Conclusion. Omission of lymphadenectomy did not worsen the DFS or OS. The present findings suggest that systemic lymphadenectomy could be omitted in low-risk endometrial carcinoma...
  70. ncbi request reprint Immature NK cells suppress dendritic cell functions during the development of leukemia in a mouse model
    Kazumi Ebata
    The Third Department of Internal Medicine, Faculty of Medicine, University of Toyama, Japan
    J Immunol 176:4113-24. 2006
    ..In conclusion, we identified circulating immature NK cells with immunosuppressive activities. These cells may be important for understanding the involvement of the host immune system during the development of leukemia...
  71. ncbi request reprint Cerebral metastasis from a primary adenocarcinoma of the fallopian tube
    Takao Hidaka
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930 0194 Toyama shi, Japan
    Gynecol Oncol 95:260-3. 2004
    ..Primary adenocarcinoma of the fallopian tube is a rare disease, and cerebral metastasis from this tumor is an extremely rare event...
  72. ncbi request reprint Treatment for patients with postmenopausal osteoporosis who have been placed on HRT and show a decrease in bone mineral density: effects of concomitant administration of vitamin K(2)
    Takao Hidaka
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Bone Miner Metab 20:235-9. 2002
    ..Therefore, as a supplementary drug for postmenopausal osteoporosis, vitamin K(2) is a good therapeutic option for patients who are placed on HRT...
  73. ncbi request reprint A free radical initiator, 2,2'-azobis (2-aminopropane) dihydrochloride enhances hyperthermia-induced apoptosis in human uterine cervical cancer cell lines
    Hiroyoshi Yuki
    Department of Obstetrics and Gynecology, Yukiguniyamato General Hospital, 4415 Urasa, Yamato machi, Niigata 949 7302, Japan
    Free Radic Res 37:631-43. 2003
    ..Since it is known that cancer cells are generally resistant to physical and chemical stress-induced apoptosis, free radical generators like AAPH appear to be a useful thermosensitizer for hyperthermic cancer therapy...
  74. ncbi request reprint Cisplatin enhances the p53-independent apoptosis induced by a topoisomerase I inhibitor (CPT-11) in the lens epithelial tumors in transgenic mice
    Takafumi Nakamura
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Oncol Rep 12:253-8. 2004
    ..Apoptosis in the p53-wild-type alphaT3 tumors was observed in a Cisplatin dose-dependent manner. In addition, it was found that Cisplatin augmented CPT-11-induced p53-independent apoptosis in p53-deficient alphaT3 mice...
  75. ncbi request reprint [Regulatory T cells and regulatory NK cells play essential roles for maintenance of pregnancy]
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama
    Nihon Rinsho Meneki Gakkai Kaishi 35:424-8. 2012
    ..Both Treg cells and regulatory NK cells play important roles for maintenance of pregnancy...
  76. ncbi request reprint Advanced malignant solitary fibrous tumor in pelvis responding to radiation therapy
    Shinobu Kawamura
    Laboratory of Pathology, Toyama University Hospital, Sugitani, Toyama, Japan
    Pathol Int 57:213-8. 2007
    ..Afterwards, improvement was observed radiologically and pathologically in the 12 months' follow up after the radiation therapy. This is the first report related to therapeutic remarks on advanced malignant SFT...
  77. doi request reprint Beckwith-Wiedemann syndrome with placental chorangioma due to H19-differentially methylated region hypermethylation: a case report
    Aiko Aoki
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    J Obstet Gynaecol Res 37:1872-6. 2011
    ..This is the first report of BWS with placental tumor due to H19-differentially methylated region hypermethylation...
  78. doi request reprint Subsequent pregnancy outcomes in recurrent miscarriage patients with a paternal or maternal carrier of a structural chromosome rearrangement
    Mayumi Sugiura-Ogasawara
    Department of Obstetrics and Gynecology, Nagoya City University Medical School, Mizuho ku, Nagoya, 467, Japan
    J Hum Genet 53:622-8. 2008
    ..Explanation of the success rate with natural conception should be provided before the subsequent pregnancy after ascertainment of carrier status...
  79. doi request reprint Exaggerated placental site reaction following an elective abortion
    Toru Hasegawa
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    J Obstet Gynaecol Res 34:609-12. 2008
    ..We present the ultrasonogram and magnetic resonance imaging findings of EPS together with histopathological observations...
  80. ncbi request reprint IX International Congress on Reproductive Immunology, 11-15 October 2004, Hakone, Japan
    Shigeru Saito
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Reprod Immunol 68:121-6. 2005
  81. ncbi request reprint Macrophage colony-stimulating factor restored chemotherapy-induced granulocyte dysfunctions: role of IL-8 production by monocytes
    Akiko Teranishi
    Department of Obstetrics and Gynecology, Nara Medical University, Japan
    Int Immunopharmacol 2:83-94. 2002
    ..These observations suggest that M-CSF enhances the production of IL-8 from monocytes in vivo, thereby improving chemotherapy-induced granulocyte dysfunction...
  82. ncbi request reprint Expansion of alpha-galactosylceramide-stimulated Valpha24+ NKT cells cultured in the absence of animal materials
    Yukie Harada
    Hematopoietic Stem Cell Transplant Immunotherapy Unit, National Cancer Center Hospital, Tokyo 104 0045, Japan
    J Immunother 28:314-21. 2005
    ..Valpha24+ NKT cells can be efficiently expanded from G-CSF-mobilized peripheral blood MNCs in non-FBS culture conditions with alpha-GalCer and IL-2...
  83. ncbi request reprint TSLP-induced placental DC activation and IL-10(+) NK cell expansion: comparative study based on BALB/c x C57BL/6 and NOD/SCID x C57BL/6 pregnant models
    Yi Lin
    Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, Jinan University, Guangzhou, China
    Clin Immunol 126:104-17. 2008
    ..TSLP-DC and NK cell contact appears necessary for IL-10(+)CD49b(+) cell expansion. Placental NK cells from NOD/SCIDxC57BL/6 mice appear less sensitive to TSLP-DC induction...
  84. ncbi request reprint Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells
    Peter Terness
    Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Am J Reprod Immunol 58:238-54. 2007
    ..Is the concept of maternal tolerance preventing rejection of the semi-allogeneic 'fetal allograft' still valid?..
  85. ncbi request reprint Pilot study of the effects of ONO-5046 in patients with acute respiratory distress syndrome
    Yuji Kadoi
    Department of Intensive Care, Gunma University, Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Anesth Analg 99:872-7, table of contents. 2004
    ..Levels of interleukin-6 were lower in the sivelestat group than in the controls at 24, 48, and 72 h after treatment. ONO-5046 apparently did not affect survival or the duration of mechanical ventilation...
  86. ncbi request reprint Relationship between newborn size and mother's blood cadmium levels, Toyama, Japan
    Muneko Nishijo
    Department of Public Health, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Arch Environ Health 59:22-5. 2004
    ..Newborn size might be influenced by maternal blood Cd levels to which infants may be exposed during gestation...
  87. ncbi request reprint Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis
    Ruth Y Lan
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California Davis, Davis, CA 95616, USA
    Hepatology 43:729-37. 2006
    ..001) and early-stage AIH (P < .001). In conclusion, these data provide support for a genetic modulation of Treg frequency and illustrate the role Tregs play in the loss of tolerance in PBC...
  88. ncbi request reprint Toll-like receptor 4: a potential link between "danger signals," the innate immune system, and preeclampsia?
    Yeon Mee Kim
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    Am J Obstet Gynecol 193:921-7. 2005
    ..This study was conducted to determine whether changes in TLR-4 and TLR-2 expressions can be detected in the trophoblasts at the placental bed of women with and without preeclampsia...
  89. pmc Plasma granulysin concentrations and preeclampsia risk
    Chunfang Qiu
    Center for Perinatal Studies, Swedish Medical Center, Seattle, WA 98104, USA
    Clin Biochem 39:1016-21. 2006
    ..Granulysin, a novel biomarker of overall cellular immunity, is secreted by natural killer cells and cytotoxic T lymphocytes, which are associated with graft-host-rejection. Plasma granulysin was elevated in Japanese preeclamptic women...
  90. ncbi request reprint Freeze-thawing procedures have no influence on the phenotypic and functional development of dendritic cells generated from peripheral blood CD14+ monocytes
    Shin Ichi Hori
    Hematopoietic Stem Cell Transplant Immunotherapy Unit, National Cancer Center Hospital, Tokyo, Japan
    J Immunother 27:27-35. 2004
    ..Although this study design was limited with the use of fetal bovine serum, the observation still suggests that freeze-thawing does not affect viability, phenotype, subsequent maturation, or functions of DCs at any stage of maturation...