Y Sadzuka

Summary

Affiliation: University of Shizuoka
Country: Japan

Publications

  1. ncbi request reprint Effects of glutamate transporter inhibitors on the antitumor activity of doxorubicin
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Clin Cancer Res 8:3943-7. 2002
  2. ncbi request reprint Effects of intraperitoneal administration of liposomes and methods of preparing liposomes for local therapy
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, shi, Shizuoka ken 422 8526, Shizuoka, Japan
    Toxicol Lett 126:83-90. 2002
  3. ncbi request reprint Effects of theanine on alcohol metabolism and hepatic toxicity
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Biol Pharm Bull 28:1702-6. 2005
  4. ncbi request reprint Effects of mixed polyethyleneglycol modification on fixed aqueous layer thickness and antitumor activity of doxorubicin containing liposome
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Int J Pharm 238:171-80. 2002
  5. ncbi request reprint Effects of xanthine derivatives on the influx and efflux of doxorubicin in P388 and DOX-resistant P388 leukemia cells
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, 422 8526, Shizuoka, Japan
    Toxicol Lett 135:137-44. 2002
  6. ncbi request reprint Efficacy of theanine is connected with theanine metabolism by any enzyme, not only drug metabolizing enzymes
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Food Chem Toxicol 44:286-92. 2006
  7. ncbi request reprint [Glutamate transporter mediated increase of antitumor activity by theanine, an amino acid in green tea]
    Yasuyuki Sadzuka
    University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Yakugaku Zasshi 122:995-9. 2002
  8. ncbi request reprint [Characterization and cytotoxicity of mixed PEG-DSG modified liposomes]
    Yasuyuki Sadzuka
    Department of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Yakugaku Zasshi 125:149-57. 2005
  9. ncbi request reprint Effect of polyethyleneglycol (PEG) chain on cell uptake of PEG-modified liposomes
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    J Liposome Res 13:157-72. 2003
  10. ncbi request reprint Study on the characterization of mixed polyethyleneglycol modified liposomes containing doxorubicin
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Control Release 91:271-80. 2003

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Effects of glutamate transporter inhibitors on the antitumor activity of doxorubicin
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Clin Cancer Res 8:3943-7. 2002
    ..Furthermore, the effects of inhibitors varied among cells expressing different isoforms. Notably, a low concentration of L-serine-O-sulfate actually increased the uptake of glutamate in P388 leukemia cells...
  2. ncbi request reprint Effects of intraperitoneal administration of liposomes and methods of preparing liposomes for local therapy
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, shi, Shizuoka ken 422 8526, Shizuoka, Japan
    Toxicol Lett 126:83-90. 2002
    ..The method of preparation is an important factor affecting the properties of liposomes, and for local therapy, DMPC containing BLDOX is most effective because of its leaky property...
  3. ncbi request reprint Effects of theanine on alcohol metabolism and hepatic toxicity
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Biol Pharm Bull 28:1702-6. 2005
    ..In conclusion, it was indicated that theanine was effective against alcoholic liver injury...
  4. ncbi request reprint Effects of mixed polyethyleneglycol modification on fixed aqueous layer thickness and antitumor activity of doxorubicin containing liposome
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Int J Pharm 238:171-80. 2002
    ..As a result, the connection among increase of FALT and improvement of circulation in blood, the involvement of antitumor activity of DOX of these liposomes was suggested...
  5. ncbi request reprint Effects of xanthine derivatives on the influx and efflux of doxorubicin in P388 and DOX-resistant P388 leukemia cells
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, 422 8526, Shizuoka, Japan
    Toxicol Lett 135:137-44. 2002
    ..We suspect that XT-141 is a useful biochemical modulator of DOX in DOX-resistant tumors with over-expression of P-gp in addition in DOX-sensitive tumors...
  6. ncbi request reprint Efficacy of theanine is connected with theanine metabolism by any enzyme, not only drug metabolizing enzymes
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Food Chem Toxicol 44:286-92. 2006
    ..In conclusion, it appeared that theanine does not change the biodistribution of combined drugs but it modulates biodistribution or damage to the relative site of GSH, and shows preventive effects in tissue...
  7. ncbi request reprint [Glutamate transporter mediated increase of antitumor activity by theanine, an amino acid in green tea]
    Yasuyuki Sadzuka
    University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Yakugaku Zasshi 122:995-9. 2002
    ..Therefore theanine enhances the antitumor activity not only of DOX but also of cisplatin or CPT-11...
  8. ncbi request reprint [Characterization and cytotoxicity of mixed PEG-DSG modified liposomes]
    Yasuyuki Sadzuka
    Department of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Yakugaku Zasshi 125:149-57. 2005
    ..In conclusion, it was suggested that mixed PEG liposome (PEG-2000:PEG-900=2:1) was useful for cancer chemotherapy...
  9. ncbi request reprint Effect of polyethyleneglycol (PEG) chain on cell uptake of PEG-modified liposomes
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    J Liposome Res 13:157-72. 2003
    ..In other words, PEG 2,000-DPG, which had a high rate of residual PEG-Lipid on liposomal membrane depending on the re-uptake to liposomal membrane, met to this requirement...
  10. ncbi request reprint Study on the characterization of mixed polyethyleneglycol modified liposomes containing doxorubicin
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Control Release 91:271-80. 2003
    ..While, it has been suggested that mixed PEG-modified liposomes are effective in vitro, too, because of the lower leakage and same level of doxorubicin (DOX) uptake as plain liposomal DOX...
  11. ncbi request reprint Increased effects of MPDAX, a novel xanthine derivative, on antitumor activity of doxorubicin
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Toxicol Lett 150:341-9. 2004
    ..MPDAX, acting via nucleoside transporters, increases the DOX-induced antitumor activity toward many tumor types and is an useful biochemical modulator...
  12. ncbi request reprint Liposomalization of SN-38 as active metabolite of CPT-11
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Control Release 108:453-9. 2005
    ..Thus, it is expected that SN-38 liposome can be applied as an injection. This preparation method is useful if application is possible in the other insolubility drugs...
  13. ncbi request reprint The phototoxicity of photofrin was enhanced by PEGylated liposome in vitro
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Cancer Lett 241:42-8. 2006
    ..It is expected that formation of a fixed aqueous layer on the liposome membrane by PEGylation physically changed it into the stable state of PF-PEG-Lip...
  14. ncbi request reprint Screening of biochemical modulator by tumor cell permeability of doxorubicin
    Yasuyuki Sadzuka
    Laboratory of Pharmaceutical Engineering, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 354:63-9. 2008
    ..In conclusion, the combination of cucurbitacin E with DOX may be an effective tool with treated application in the cancer chemotherapy...
  15. ncbi request reprint Effects of 1-methyl-3-propyl-7-butylxanthine (MPBX) on idarubicin-induced antitumor activity and bone marrow suppression
    Y Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Jpn J Cancer Res 91:651-7. 2000
    ..In conclusion, the combination of MPBX with IDA increased the antitumor activity and decreased the bone marrow suppression. Therefore, we expect that the combination of MPBX with IDA will be useful for leukemia chemotherapy...
  16. ncbi request reprint Anserine induced advantage effects on the antitumor activity of doxorubicin
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada Suruga ku, Shizuoka 422 8526, Japan
    Food Chem Toxicol 45:985-9. 2007
    ..Namely, it was expected that anserine increased the antitumor activity of DOX by the change of the DOX concentration without the changing metabolism of DOX...
  17. ncbi request reprint Characterization and cytotoxicity of mixed polyethyleneglycol modified liposomes containing doxorubicin
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 312:83-9. 2006
    ..Thus, liposomes covered with PEG-DSG and PEG-CHO have an enhanced cytotoxicity. In conclusion, it was confirmed that mix-modified liposomes using PEG-lipid with different anchors were superior...
  18. ncbi request reprint Enhancement of the activity of doxorubicin by inhibition of glutamate transporter
    Y Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, 422 8526, Shizuoka, Japan
    Toxicol Lett 123:159-67. 2001
    ..Namely, theanine increases the concentration of DOX in a tumor in vivo through inhibition of the glutamate transporter via the GS-X pump...
  19. ncbi request reprint Efficacies of tea components on doxorubicin induced antitumor activity and reversal of multidrug resistance
    Y Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka, Japan
    Toxicol Lett 114:155-62. 2000
    ..Theanine attacked the same transport process for DOX in both types of cells, elevated the DOX concentration and increased the DOX induced antitumor activity...
  20. ncbi request reprint Improvement of idarubicin induced antitumor activity and bone marrow suppression by theanine, a component of tea
    Y Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, 422 8526, Shizuoka, Japan
    Cancer Lett 158:119-24. 2000
    ..Until recently, the antitumor activity and related toxicities of this chemotherapeutic agent in leukemia could not be distinguished. Theanine increases the IDA-induced antitumor activity and ameliorates the toxicities...
  21. ncbi request reprint Enhanced efficacy of 1-methyl-3-propyl-7-butylxanthine on the antitumor activity of doxorubicin against doxorubicin-resistant P388 leukemia
    Y Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Cancer Lett 138:5-11. 1999
    ..e. the inhibitory order of DOX efflux caused by the inhibitor of P-glycoprotein was P388 < P388/DOX. However, the effect of MPBX was P388 > P388/DOX. Therefore, we expect that the site of attack by MPBX is not P-glycoprotein...
  22. ncbi request reprint Inhibition of glutamate transporter by theanine enhances the therapeutic efficacy of doxorubicin
    T Sugiyama
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, 422 8526, Shizuoka, Japan
    Toxicol Lett 121:89-96. 2001
    ..We revealed the novel mechanism of enhancement of the antitumor efficacy of DOX via the inhibition of glutamate transporters by theanine...
  23. ncbi request reprint Intraperitoneal administration of doxorubicin encapsulating liposomes against peritoneal dissemination
    Y Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Toxicol Lett 116:51-9. 2000
    ..Liposomes, both small and large in size appear to be effective against solid tumors except in the abdominal cavity, and against peritoneal dissemination in the abdominal cavity, respectively...
  24. ncbi request reprint Enhancing effects of green tea components on the antitumor activity of adriamycin against M5076 ovarian sarcoma
    T Sugiyama
    School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Cancer Lett 133:19-26. 1998
    ..We have found that the modulating action of theanine is useful in clinical cancer chemotherapy...
  25. ncbi request reprint Applicability of anti-neovascular therapy to drug-resistant tumor: suppression of drug-resistant P388 tumor growth with neovessel-targeted liposomal adriamycin
    K Shimizu
    Department of Medical Biochemistry and COE Program in the 21st Century, University of Shizuoka School of Pharmaceutical Sciences, 52 1 Yada, Shizuoka 422 8526, Japan
    Int J Pharm 296:133-41. 2005
    ..These data suggest that APRPG-LipADM is applicable to various kinds of tumor including drug-resistant tumor since it targets angiogenic endothelial cells instead of tumor cells, and eradicates tumor cells through damaging the neovessels...
  26. ncbi request reprint Effective irinotecan (CPT-11)-containing liposomes: intraliposomal conversion to the active metabolite SN-38
    Y Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka
    Jpn J Cancer Res 90:226-32. 1999
    ..It is therefore considered that a part of CPT-11 is converted to SN-38 in the intact liposomes...
  27. ncbi request reprint Effect of dihydrokainate on the antitumor activity of doxorubicin
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka, Japan
    Cancer Lett 179:157-63. 2002
    ..Thus, the results suggest that DHK is a novel and useful modulator for inducing enhancement of antitumor activity...
  28. ncbi request reprint Theanine and glutamate transporter inhibitors enhance the antitumor efficacy of chemotherapeutic agents
    Tomomi Sugiyama
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, 422 8526 Shizuoka, Japan
    Biochim Biophys Acta 1653:47-59. 2003
    ..Consequently, the modulating effect of theanine on the efficacy of antitumor agents is expected to be applicable in clinical cancer chemotherapy...
  29. ncbi request reprint Preparation and dissolution characteristics of griseofulvin solid dispersions with saccharides
    Masataka Saito
    School of Pharmaceutical Science, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Int J Pharm 249:71-9. 2002
    ..These results indicated that the solubility of GF was markedly improved in the roll mixtures. It was suggested that the saccharides with a high molecular weight are useful carriers for solid dispersions...
  30. ncbi request reprint Physical characteristics of freeze-dried griseofulvin-lipids nanoparticles
    Seitaro Kamiya
    School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Chem Pharm Bull (Tokyo) 54:181-4. 2006
    ..After the rehydration the mean particle size of GFNPs was 55-65 nm. It was found that freeze-dried GFNPs containing sucrose, maltose or trehalose were stable for longer periods than GFNP suspensions...
  31. ncbi request reprint Characterization of novel mixed polyethyleneglycol modified liposomes
    Ikumi Sugiyama
    School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Biol Pharm Bull 30:208-11. 2007
    ..In conclusion, it is expected that novel PEG-modified liposomes with PEG2000-DSG and PEG2000-CHO (3:1) had superior physicochemical properties...
  32. ncbi request reprint A dosage design of mitomycin C tablets containing finely powdered green tea
    Takurou Kurita
    Department of Pharmaceutical Engineering, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Int J Pharm 275:279-83. 2004
    ..PT and epigallocatechin gallate (EGCG) increased significantly in MMC uptake in Ehrlich ascites carcinoma cells as compared with the control dose-dependently in vitro...
  33. doi request reprint A liposomal formulation study of 2,7-dichlorodihydrofluorescein for detection of reactive oxygen species
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 356:300-5. 2008
    ..Therefore, it is likely that the liposomalization of DCDHF has selectivity for certain radical species. It is hoped that these results can be applied to novel and simple diagnostics for redox detection of conditions in the body...
  34. ncbi request reprint The effect of taurine, a novel biochemical modulator, on the antitumor activity of doxorubicin
    Yasuyuki Sadzuka
    University of Shizuoka, Yada, Suruga ku, Japan
    Biol Pharm Bull 32:1584-7. 2009
    ..Namely, it was clarified that taurine was useful as a modulator to enhance the therapeutic index of cancer patients and improve QOL...
  35. ncbi request reprint Effective prodrug liposome and conversion to active metabolite
    Y Sadzuka
    University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Curr Drug Metab 1:31-48. 2000
    ..Although the liposomes induce the improved tissue distribution of the prodrug, the tissue distribution of active metabolites do not always improve. However, CPT-11 entrapped liposome was useful...
  36. ncbi request reprint Study on liposomalization of zinc-coproporphyrin I as a novel drug in photodynamic therapy
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 338:306-9. 2007
    ..6) treatment were shown to be higher than that in other groups. In conclusion, it is considered that the ZnCPI liposome (pH 4.6) had the effective antitumor activity with laser irradiation without the adverse reactions...
  37. ncbi request reprint Anti-neovascular therapy by liposomal drug targeted to membrane type-1 matrix metalloproteinase
    Masami Kondo
    Department of Medical Biochemistry and COE Program in the 21st Century, University of Shizuoka School of Pharmaceutical Sciences, Shizuoka, Japan
    Int J Cancer 108:301-6. 2004
    ..These results suggest that DPP-CNDAC-liposomes modified with MT1-MMP-targeted peptide are useful for cancer anti-neovascular therapy (ANET), namely, tumor growth suppression by damage to angiogenic endothelial cells...
  38. ncbi request reprint Glycerin fatty acid esters as a new lubricant of tablets
    Hiroyuki Aoshima
    Department of Pharmaceutical Sciences, University of Shizuoka, 51 1 Yada, Shizuoka 422 8526, Japan
    Int J Pharm 293:25-34. 2005
    ..When the effects of these lubricants on the stability of acetylsalicylic acid (ASA) were compared, Mg-St promoted its hydrolysis, but TR-FB or TR-HB did not affect its stability...
  39. ncbi request reprint Restoration of connexin 43 by Bowman-Birk protease inhibitor in M5076 bearing mice
    Kazuyuki Suzuki
    Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Oncol Rep 13:1247-50. 2005
    ..05, r(2)=0.351). Therefore, it suggests that the anti-carcinogenic effects of BBI induced negative growth control caused by the expression of Cx43 genes in mice with M5076 ovarian sarcoma...
  40. ncbi request reprint Anti-neovascular therapy by use of tumor neovasculature-targeted long-circulating liposome
    Noriyuki Maeda
    Department of Medical Biochemistry and COE Program in the 21st Century, University of Shizuoka School of Pharmaceutical Sciences, 52 1 Yada, Shizuoka 422 8526, Japan
    J Control Release 100:41-52. 2004
    ..The present results demonstrate the beneficial usage of APRPG-PEG for the active-targeting of drug carriers to angiogenic site in the novel modality of tumor treatment, namely ANET...
  41. ncbi request reprint Theanine, a specific glutamate derivative in green tea, reduces the adverse reactions of doxorubicin by changing the glutathione level
    Tomomi Sugiyama
    Department of Food Science Research for Health, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Cancer Lett 212:177-84. 2004
    ..Therefore, these results suggested that theanine attenuated the DOX-induced adverse reactions involved in oxidative damage, due to increase in glutamate and the recovery of GSH levels in normal tissues...
  42. ncbi request reprint Liposomal photofrin enhances therapeutic efficacy of photodynamic therapy against the human gastric cancer
    Akira Igarashi
    Second Department of Surgery II, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Toxicol Lett 145:133-41. 2003
    ..The apoptotic index of the tumor was also significantly higher in the LPF group. In conclusion, the liposomalization of the photosensitizer increased its tumor accumulation, with a resulting enhancement of the therapeutic effect of PDT...
  43. doi request reprint Influence of load on particle size distribution of lactose-crystalline cellulose mixed powder
    Takahiko Nakamori
    Rohto Pharmaceutical Co, Ltd, 1 8 1 Tatsumi Nishi, Ikuno ku, Osaka, 544 8666 Japan
    Int J Pharm 354:255-9. 2008
    ..These results suggest that particle formation and aggregation under loads are dependent on the mixing rate and that there is a range of mixing rates in which no changes in the particle size distribution are observed...
  44. ncbi request reprint Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice
    Tatsuhiro Ishida
    Department of Pharmacokinetics and Biopharmaceutics, Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1 78 1, Sho machi, Tokushima 770 8505, Japan
    J Control Release 95:403-12. 2004
    ..The results reported herein have a considerable impact on the design and engineering of liposomal formulations for use in multiple drug therapy as well as in therapy that involves the use of liposomal drugs...
  45. ncbi request reprint Relationships between the in vitro cytotoxicity and transport characteristics of pirarubicin and doxorubicin in M5076 ovarian sarcoma cells, and comparison with those in Ehrlich ascites carcinoma cells
    Katsuhito Nagai
    Department of Environmental Biochemistry, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, 5 Nakauchi cho, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    Cancer Chemother Pharmacol 49:244-50. 2002
    ....