Yutaka Osuga

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Proteinase-activated receptors in the endometrium and endometriosis
    Yutaka Osuga
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Front Biosci (Schol Ed) 4:1201-12. 2012
  2. ncbi request reprint Proteinase-activated receptors in the endometrium and endometriosis
    Yutaka Osuga
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Front Biosci (Elite Ed) 4:755-67. 2012
  3. ncbi request reprint Successful emergency endometrial ablation for intractable uterine bleeding in a postmenopausal woman complicated with liver cirrhosis and morbid obesity
    Y Osuga
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Tokyo, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Endosc 15:898. 2001
  4. doi request reprint Lymphocytes in endometriosis
    Yutaka Osuga
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo, Tokyo, Japan
    Am J Reprod Immunol 65:1-10. 2011
  5. ncbi request reprint A case of hydrosalpinx associated with the menstrual cycle
    Yutaka Osuga
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Fertil Steril 90:199.e9-11. 2008
  6. ncbi request reprint Basic and translational research on proteinase-activated receptors: proteinase-activated receptors in female reproductive tissues and endometriosis
    Yutaka Osuga
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan
    J Pharmacol Sci 108:422-5. 2008
  7. doi request reprint Novel therapeutic strategies for endometriosis: a pathophysiological perspective
    Yutaka Osuga
    Department of Obstetrics and Gynecology, University of Tokyo, Faculty of Medicine, Tokyo, Japan
    Gynecol Obstet Invest 66:3-9. 2008
  8. ncbi request reprint Dysmenorrhea in Japanese women
    Y Osuga
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Gynaecol Obstet 88:82-3. 2005
  9. ncbi request reprint Role of laparoscopy in the treatment of endometriosis-associated infertility
    Yutaka Osuga
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Gynecol Obstet Invest 53:33-9. 2002
  10. ncbi request reprint Activation of protease-activated receptor 2 stimulates proliferation and interleukin (IL)-6 and IL-8 secretion of endometriotic stromal cells
    Yasushi Hirota
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Tokyo, 113 8655, Japan
    Hum Reprod 20:3547-53. 2005

Collaborators

Detail Information

Publications90

  1. ncbi request reprint Proteinase-activated receptors in the endometrium and endometriosis
    Yutaka Osuga
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Front Biosci (Schol Ed) 4:1201-12. 2012
    ..These findings indicate a wide range of function of PAR1 and PAR2 in the endometrium and endometriosis, and suggest PAR1 and PAR2 as possible therapeutic targets for endometriosis...
  2. ncbi request reprint Proteinase-activated receptors in the endometrium and endometriosis
    Yutaka Osuga
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Front Biosci (Elite Ed) 4:755-67. 2012
    ..These findings indicate a wide range of function of PAR₁ and PAR₂ in the endometrium and endometriosis, and suggest PAR₁ and PAR₂ as possible therapeutic targets for endometriosis...
  3. ncbi request reprint Successful emergency endometrial ablation for intractable uterine bleeding in a postmenopausal woman complicated with liver cirrhosis and morbid obesity
    Y Osuga
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Tokyo, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Endosc 15:898. 2001
    ..The bleeding was successfully halted through emergency endometrial ablation after failure of uterine artery embolization...
  4. doi request reprint Lymphocytes in endometriosis
    Yutaka Osuga
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo, Tokyo, Japan
    Am J Reprod Immunol 65:1-10. 2011
    ..These alterations are suggested to be induced by various manners and promote the disease. Understanding of these immune aspects in endometriosis is thus expected to benefit the treatment of the disease...
  5. ncbi request reprint A case of hydrosalpinx associated with the menstrual cycle
    Yutaka Osuga
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Fertil Steril 90:199.e9-11. 2008
    ..To describe a case report of hydrosalpinx that changed dramatically in size during the menstrual cycle...
  6. ncbi request reprint Basic and translational research on proteinase-activated receptors: proteinase-activated receptors in female reproductive tissues and endometriosis
    Yutaka Osuga
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan
    J Pharmacol Sci 108:422-5. 2008
    ..Taken together, PARs appear to play diverse roles in the human reproductive organs...
  7. doi request reprint Novel therapeutic strategies for endometriosis: a pathophysiological perspective
    Yutaka Osuga
    Department of Obstetrics and Gynecology, University of Tokyo, Faculty of Medicine, Tokyo, Japan
    Gynecol Obstet Invest 66:3-9. 2008
    ....
  8. ncbi request reprint Dysmenorrhea in Japanese women
    Y Osuga
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Gynaecol Obstet 88:82-3. 2005
  9. ncbi request reprint Role of laparoscopy in the treatment of endometriosis-associated infertility
    Yutaka Osuga
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Gynecol Obstet Invest 53:33-9. 2002
    ..On the other hand, IVF-ET outcome of patients who previously underwent laparoscopy was not influenced by preexisiting tubal adhesions and endometriosis...
  10. ncbi request reprint Activation of protease-activated receptor 2 stimulates proliferation and interleukin (IL)-6 and IL-8 secretion of endometriotic stromal cells
    Yasushi Hirota
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Tokyo, 113 8655, Japan
    Hum Reprod 20:3547-53. 2005
    ..We studied whether the protease-activated receptor 2 (PAR2), which is activated by enzymes from neutrophils and mast cells, in endometriotic stromal cells (ESC) has any implication in the development of the disease...
  11. ncbi request reprint Possible pathophysiological roles of mitogen-activated protein kinases (MAPKs) in endometriosis
    Osamu Yoshino
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo
    Am J Reprod Immunol 52:306-11. 2004
    ..e. extracellular signal-regulated kinase (ERK), p38 MAPK (p38) and c-Jun N-terminal kinase (JNK) in endometriotic stromal cells, and their possible pathophysiological roles in endometriosis in relation to proinflammatory substances...
  12. ncbi request reprint Evidence for the presence of protease-activated receptor 2 and its possible implication in remodeling of human endometrium
    Yasushi Hirota
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo 113 8655, Japan
    J Clin Endocrinol Metab 90:1662-9. 2005
    ..MAPKs may mediate PAR2 functions in these processes...
  13. ncbi request reprint Mechanical stretch stimulates interleukin-8 production in endometrial stromal cells: possible implications in endometrium-related events
    Miyuki Harada
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    J Clin Endocrinol Metab 90:1144-8. 2005
    ..These findings imply that uterine movement has an impact on endometrium-related physiology and pathology by stimulating the production of a biochemical mediator(s) in the endometrium...
  14. doi request reprint Expression and regulation of cholesterol sulfotransferase (SULT2B1b) in human endometrium
    Minako Koizumi
    Department of Obstetrics and Gynecology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Fertil Steril 93:1538-44. 2010
    ..To investigate the hormonal regulation of SULT2B1b in human endometrium...
  15. ncbi request reprint The expression and possible roles of chemokine CXCL11 and its receptor CXCR3 in the human endometrium
    Yasushi Hirota
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Immunol 177:8813-21. 2006
    ..These findings suggest that IFN-gamma promotes implantation by stimulating EEC to produce CXCL11, which induces migration of trophoblast cells and T cells, proliferation of ESC, and apoptosis of EEC...
  16. ncbi request reprint Expression of adiponectin receptors and its possible implication in the human endometrium
    Yuri Takemura
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Endocrinology 147:3203-10. 2006
    ....
  17. doi request reprint Recruitment of CCR6-expressing Th17 cells by CCL 20 secreted from IL-1 beta-, TNF-alpha-, and IL-17A-stimulated endometriotic stromal cells
    Tetsuya Hirata
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Endocrinology 151:5468-76. 2010
    ....
  18. ncbi request reprint Metformin suppresses interleukin (IL)-1beta-induced IL-8 production, aromatase activation, and proliferation of endometriotic stromal cells
    Yuri Takemura
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Clin Endocrinol Metab 92:3213-8. 2007
    ....
  19. ncbi request reprint Expression of toll-like receptors 2, 3, 4, and 9 genes in the human endometrium during the menstrual cycle
    Tetsuya Hirata
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    J Reprod Immunol 74:53-60. 2007
    ..These findings imply that differential spatio-temporal expression patterns of TLRs subserve proper innate immunity of the endometrium...
  20. doi request reprint Expression and possible implication of growth hormone-releasing hormone receptor splice variant 1 in endometriosis
    Li Fu
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Fertil Steril 92:47-53. 2009
    ..To determine possible involvement of splice variant 1 (SV1), a variant of the pituitary growth hormone-releasing hormone (GHRH) receptor, in the development of endometriosis...
  21. doi request reprint Progesterone decreases bone morphogenetic protein (BMP) 7 expression and BMP7 inhibits decidualization and proliferation in endometrial stromal cells
    Ako Kodama
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Hum Reprod 25:751-6. 2010
    ..In the present study, we examined the expression of BMP7 in the endometrium and the effect of BMP7 on decidualization and proliferation of endometrial stromal cells (ESC)...
  22. ncbi request reprint Interleukin (IL)-17A stimulates IL-8 secretion, cyclooxygensase-2 expression, and cell proliferation of endometriotic stromal cells
    Tetsuya Hirata
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Endocrinology 149:1260-7. 2008
    ..IL-17A also enhanced the expression of cyclooxygensase-2 mRNA and proliferation of ESCs. IL-17A may play a role in the development of endometriosis by stimulating inflammatory responses and proliferation of ESCs...
  23. ncbi request reprint Possible involvement of thrombin/protease-activated receptor 1 system in the pathogenesis of endometriosis
    Yasushi Hirota
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo 113 8655, Japan
    J Clin Endocrinol Metab 90:3673-9. 2005
    ..These findings imply that the thrombin system might be involved in the pathophysiology of endometriosis, stimulating inflammatory responses of endometriotic cells and their mitogenic activity...
  24. ncbi request reprint The presence of midkine and its possible implication in human ovarian follicles
    Yasushi Hirota
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Am J Reprod Immunol 58:367-73. 2007
    ..Midkine (MK) is a heparin-binding growth factor that has angiogenic, mitogenic, and chemotactic activities. In the present study, we investigated the presence of MK and its possible role in human ovarian follicles...
  25. ncbi request reprint Evidence for the presence of toll-like receptor 4 system in the human endometrium
    Tetsuya Hirata
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Clin Endocrinol Metab 90:548-56. 2005
    ..Altogether, the results imply that the TLR4 system might represent local immunity in the human endometrium with differential modes of TLR4 actions between ESCs and EECs...
  26. doi request reprint The localization and regulation of proprotein convertase subtilisin/kexin (PCSK) 6 in human ovary
    Ikumi Akiyama
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo 113 8655, Japan
    Am J Reprod Immunol 68:491-8. 2012
    ..The aim of this study is to evaluate the expression and regulation of proprotein convertase subtilisin/kexin (PCSK) 6, which is known to be an important factor in the production of bone morphogenetic protein (BMP) cytokines in human ovary...
  27. doi request reprint Thrombin enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts; possible involvement in the pathogenesis of preeclampsia
    Yin Zhao
    Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan
    Fertil Steril 98:917-21. 2012
    ..To investigate the possible impact of thrombin on soluble Fms-like tyrosine kinase 1 (sFlt-1) expression in trophoblasts...
  28. doi request reprint Interleukin-17A is present in neutrophils in endometrioma and stimulates the secretion of growth-regulated oncogene-α (Gro-α) from endometrioma stromal cells
    Masashi Takamura
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Fertil Steril 98:1218-24.e1-2. 2012
    ..To investigate a new role of interleukin (IL)-17A in endometriosis...
  29. doi request reprint Bone morphogenetic protein-2 (BMP-2) increases gene expression of FSH receptor and aromatase and decreases gene expression of LH receptor and StAR in human granulosa cells
    Jia Shi
    Department of Obstetrics and Gynecology, University of Tokyo, Japan
    Am J Reprod Immunol 65:421-7. 2011
    ..BMP-2 is known to be expressed in the ovary of many species. In the present study, we examined the expression and function of BMP-2 in the human ovary...
  30. ncbi request reprint GnRH II as a possible cytostatic regulator in the development of endometriosis
    Chieko Morimoto
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Hum Reprod 20:3212-8. 2005
    ..In the present study, we studied the possible implication of GnRH II in endometriosis...
  31. ncbi request reprint Serum adiponectin concentrations are decreased in women with endometriosis
    Yuri Takemura
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Tokyo, 113 8655, Japan
    Hum Reprod 20:3510-3. 2005
    ..We thus addressed the relevance of adiponectin to endometriosis, an estrogen-dependent disease, in the present study...
  32. doi request reprint Expression of retinoic acid-related orphan receptor alpha and its responsive genes in human endometrium regulated by cholesterol sulfate
    Fumiko Zenri
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    J Steroid Biochem Mol Biol 128:21-8. 2012
    ..Our results suggest that CS regulates the expression of RORA responsive genes in human endometrial cells but not as a ligand for RORA...
  33. ncbi request reprint Concentration of adiponectin in peritoneal fluid is decreased in women with endometriosis
    Yuri Takemura
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Am J Reprod Immunol 54:217-21. 2005
    ..Recent studies have indicated that adiponectin suppresses inflammation, angiogenesis, and fibrosis, which are central pathogenic factors for endometriosis. We addressed the possibility that adiponectin is implicated in endometriosis...
  34. ncbi request reprint Mechanical stretch upregulates IGFBP-1 secretion from decidualized endometrial stromal cells
    Miyuki Harada
    Dept of Obstetrics and Gynecology, Faculty of Medicine, Univ of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Am J Physiol Endocrinol Metab 290:E268-72. 2006
    ..These findings imply that uterine movement modulates decidualization of the endometrium and has a regulatory effect on reproduction...
  35. ncbi request reprint Possible implication of midkine in the development of endometriosis
    Yasushi Hirota
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Tokyo, 113 8655, Japan
    Hum Reprod 20:1084-9. 2005
    ..The present study was conducted to assess whether midkine (MK), a multifunctional molecule known to stimulate tumor growth, may be involved in the development of endometriosis...
  36. doi request reprint TGF-β1 induces proteinase-activated receptor 2 (PAR2) expression in endometriotic stromal cells and stimulates PAR2 activation-induced secretion of IL-6
    Ako Saito
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan
    Hum Reprod 26:1892-8. 2011
    ..Our objective was to study the mechanism by which PAR2 expression may be regulated in endometriotic lesions...
  37. doi request reprint Interleukin (IL)-1beta stimulates migration and survival of first-trimester villous cytotrophoblast cells through endometrial epithelial cell-derived IL-8
    Yasushi Hirota
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Tokyo 113 8655, Japan
    Endocrinology 150:350-6. 2009
    ..These findings suggest that IL-1 promotes implantation by stimulating EECs to produce IL-8, which subsequently induces migration of vCTs and contributes to survival of vCTs...
  38. ncbi request reprint FR 167653, a p38 mitogen-activated protein kinase inhibitor, suppresses the development of endometriosis in a murine model
    Osamu Yoshino
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Reprod Immunol 72:85-93. 2006
    ..These findings suggest that FR 167653 may inhibit the development of endometriosis possibly by suppressing peritoneal inflammatory status...
  39. pmc Interleukin-4 stimulates proliferation of endometriotic stromal cells
    Zhuo OuYang
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Am J Pathol 173:463-9. 2008
    ..These findings suggest that proliferation of endometriotic stromal cells induced by locally produced IL-4 is involved in the development of endometriosis...
  40. doi request reprint Follistatin is induced by IL-1β and TNF-α in stromal cells from endometrioma
    Ikumi Akiyama
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan
    Reprod Sci 20:675-9. 2013
    ..8 ± 1.4 ng/mL. Although follistatin was present in the cystic fluid of endometrioma, the activity of activin, which is an exacerbation factor of endometriosis, was predominant in vivo...
  41. doi request reprint Activin-A is induced by interleukin-1β and tumor necrosis factor-α and enhances the mRNA expression of interleukin-6 and protease-activated receptor-2 and proliferation of stromal cells from endometrioma
    Osamu Yoshino
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan
    Fertil Steril 96:118-21. 2011
    ..To examine the regulation and the function of activin-A in stromal cells derived from endometrioma...
  42. doi request reprint Cyclic stretch augments production of neutrophil chemokines and matrix metalloproteinase-1 in human uterine smooth muscle cells
    Yin Zhao
    Departmaent of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan
    Am J Reprod Immunol 69:240-7. 2013
    ..The aim of this study was to investigate the impact of uterine contraction on the immune environment within the uterus during parturition...
  43. ncbi request reprint Akt as a possible intracellular mediator for decidualization in human endometrial stromal cells
    Osamu Yoshino
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo 113 8655, Japan
    Mol Hum Reprod 9:265-9. 2003
    ..We further suggest that Akt phosphorylation through the cAMP/PKA signal transduction pathway may regulate cellular functions coupled with decidualization...
  44. ncbi request reprint Upregulation of interleukin-8 by hypoxia in human ovaries
    Osamu Yoshino
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Am J Reprod Immunol 50:286-90. 2003
    ..To evaluate the effect of hypoxia on interleukin (IL)-8 expression in human ovarian follicles...
  45. doi request reprint Dienogest, a new conservative strategy for extragenital endometriosis: a pilot study
    Miyuki Harada
    Faculty of Medicine, Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan
    Gynecol Endocrinol 27:717-20. 2011
    ..This report suggests that dienogest can be a novel conservative alternative for extragenital endometriosis...
  46. ncbi request reprint Cellular mechanisms of growth inhibition of human endometrial cancer cell line by an antagonist of growth hormone-releasing hormone
    Lin Zhao
    Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Int J Oncol 32:593-601. 2008
    ....
  47. doi request reprint Bone morphogenetic protein-6 stimulates gene expression of follicle-stimulating hormone receptor, inhibin/activin beta subunits, and anti-Müllerian hormone in human granulosa cells
    Jia Shi
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan
    Fertil Steril 92:1794-8. 2009
    ....
  48. doi request reprint Interleukin-1β stimulates the secretion of thymic stromal lymphopoietin (TSLP) from endometrioma stromal cells: possible involvement of TSLP in endometriosis
    Yoko Urata
    Department of Obstetrics and Gynecology, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, Japan
    Hum Reprod 27:3028-35. 2012
    ..Is thymic stromal lymphopoietin (TSLP) involved in the pathophysiology of endometriosis?..
  49. doi request reprint Interleukin-4 and prostaglandin E2 synergistically up-regulate 3β-hydroxysteroid dehydrogenase type 2 in endometrioma stromal cells
    Yoko Urata
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Clin Endocrinol Metab 98:1583-90. 2013
    ..On the other hand, an accumulating amount of evidence suggests that IL-4, a typical Th2 cytokine, plays important roles in the disease...
  50. doi request reprint Interleukin-17F increases the secretion of interleukin-8 and the expression of cyclooxygenase 2 in endometriosis
    Tetsuya Hirata
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan
    Fertil Steril 96:113-7. 2011
    ..To examine the effects of interleukin (IL)-17F on the secretion of IL-8 and the gene expression of cyclooxygenase 2 (COX2) in endometriotic stromal cells...
  51. ncbi request reprint Concentrations of interferon-gamma-induced protein-10 (IP-10), an antiangiogenic substance, are decreased in peritoneal fluid of women with advanced endometriosis
    Osamu Yoshino
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan
    Am J Reprod Immunol 50:60-5. 2003
    ..To assess whether interferon-gamma-induced protein-10 (IP-10), a chemokine that has antiangiogenic activities, may be involved in the pathogenesis of endometriosis...
  52. doi request reprint Case of chronic ectopic pregnancy diagnosed in which the complete shape of the fetus was visible by ultrasonography
    Miyuki Harada
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Obstet Gynaecol Res 36:462-5. 2010
    ..This case was unique because chronic ectopic pregnancy was detected at an early stage before absorption of the conceptus occurred, which coincidentally is an appropriate time for morphological diagnosis...
  53. ncbi request reprint Elevated serum bisphenol A levels under hyperandrogenic conditions may be caused by decreased UDP-glucuronosyltransferase activity
    Toru Takeuchi
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan
    Endocr J 53:485-91. 2006
    ..The clearance of BPA may be slowed in a TP dose-dependent manner, resulting in an increase of serum BPA concentration under hyperandrogenemic conditions...
  54. doi request reprint Growth differentiation factor 3 is induced by bone morphogenetic protein 6 (BMP-6) and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells
    Jia Shi
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan
    Fertil Steril 97:979-83. 2012
    ..To examine the relevance of growth differentiation factor 3 (GDF-3) and bone morphogenetic protein (BMP) cytokines in human ovary...
  55. ncbi request reprint Concentration of osteoprotegerin (OPG) in peritoneal fluid is increased in women with endometriosis
    Miyuki Harada
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Hum Reprod 19:2188-91. 2004
    ..In the present study, we addressed the possibility that the TRAIL/OPG system is involved in the pathogenesis of endometriosis...
  56. ncbi request reprint Dienogest inhibits BrdU uptake with G0/G1 arrest in cultured endometriotic stromal cells
    Li Fu
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Fertil Steril 89:1344-7. 2008
    ..To investigate the effect of dienogest on the proliferation of endometriotic stromal cells...
  57. ncbi request reprint Cytotrophoblasts up-regulate soluble fms-like tyrosine kinase-1 expression under reduced oxygen: an implication for the placental vascular development and the pathophysiology of preeclampsia
    Takeshi Nagamatsu
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Endocrinology 145:4838-45. 2004
    ..The presented findings might provide a framework with which to understand the mechanism of uterine vascular remodeling and its perturbations as exemplified in preeclampsia...
  58. ncbi request reprint Elevated interleukin-16 levels in the peritoneal fluid of women with endometriosis may be a mechanism for inflammatory reactions associated with endometriosis
    Kaori Koga
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113 8655, Japan
    Fertil Steril 83:878-82. 2005
    ..To investigate the role of interleukin (IL)-16 in peritoneal fluid in the pathogenesis of endometriosis...
  59. ncbi request reprint Possible roles of thrombin-induced activation of protease-activated receptor 1 in human luteinized granulosa cells
    Yasushi Hirota
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo 113 8655, Japan
    J Clin Endocrinol Metab 88:3952-7. 2003
    ..These findings suggest that thrombin plays physiological roles in ovulation by enhancing the production of chemoattractive and gelatinolytic substances by granulosa cells by a mechanism involving PAR 1...
  60. ncbi request reprint Development of an experimental model of endometriosis using mice that ubiquitously express green fluorescent protein
    Tetsuya Hirata
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Hum Reprod 20:2092-6. 2005
    ..Aiming at improving an animal model of endometriosis, we developed a homologous mouse model using 'green mice' that ubiquitously express green fluorescent protein...
  61. doi request reprint Interleukin-4 induces expression of eotaxin in endometriotic stromal cells
    Zhuo OuYang
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Fertil Steril 94:58-62. 2010
    ..To study the relationship between eotaxin and interleukin-4 (IL-4) in the pathophysiology of endometriosis...
  62. ncbi request reprint Expression and regulation of periostin/OSF-2 gene in rat uterus and human endometrium
    Hisahiko Hiroi
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Hongo, Japan
    Endocr J 55:183-9. 2008
    ..This study demonstrated that the expression of periostin/OSF-2 is regulated by ovarian steroid hormones in rat uterus and human endometrium...
  63. ncbi request reprint Endometrial stromal cells undergoing decidualization down-regulate their properties to produce proinflammatory cytokines in response to interleukin-1 beta via reduced p38 mitogen-activated protein kinase phosphorylation
    Osamu Yoshino
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Clin Endocrinol Metab 88:2236-41. 2003
    ..The altered property of decidualized cells is thought to be caused by attenuation of IL-1 beta-induced p38 MAPK phosphorylation in a way that involves the activation of the cAMP/protein kinase A pathway...
  64. doi request reprint Tunicamycin enhances the apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand in endometriotic stromal cells
    Akiko Hasegawa
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Hum Reprod 24:408-14. 2009
    ..In the present study, the effect of tunicamycin, a possible apoptosis enhancer, on TRAIL-induced apoptosis in endometriotic stromal cells (ESC) was determined...
  65. ncbi request reprint Cross-Talk between Fas/Fas ligand system and nitric oxide in the pathway subserving granulosa cell apoptosis: a possible regulatory mechanism for ovarian follicle atresia
    Qiumei Chen
    Associate Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Endocrinology 146:808-15. 2005
    ....
  66. doi request reprint High mobility group box 1 (HMGB1) levels in the placenta and in serum in preeclampsia
    Bo Wang
    Department of Obstetrics and Gynecology, University of Tokyo, 7 3 1 Hongo, Tokyo, Japan
    Am J Reprod Immunol 66:143-8. 2011
    ..The aim of this study was to analyze placental and serum HMGB1 levels in normal pregnancy and preeclampsia...
  67. doi request reprint Toll-like receptor-3 ligation-induced indoleamine 2, 3-dioxygenase expression in human trophoblasts
    Bo Wang
    Department of Obstetrics and Gynecology, University of Tokyo, 7 3 1 Hongo Bunkyo Tokyo, 113 8655, Japan
    Endocrinology 152:4984-92. 2011
    ..These findings suggest that upon viral infection, trophoblasts induce IDO and in turn contribute to antimicrobial activity and maintenance of fetomaternal tolerance...
  68. doi request reprint Myomectomy decreases abnormal uterine peristalsis and increases pregnancy rate
    Osamu Yoshino
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan
    J Minim Invasive Gynecol 19:63-7. 2012
    ..In the present study, we further investigated whether myomectomy for patients in the high peristalsis group is a constructive method to normalize uterine peristalsis...
  69. doi request reprint Elevated serum soluble fms-like tyrosine kinase 1 (sFlt1) level in women with hydatidiform mole
    Kaori Koga
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Fertil Steril 94:305-8. 2010
    ..To show soluble fms-like tyrosine kinase 1 (sFlt1) levels in sera from patients with hydatidiform mole, which is known to predispose women to severe early-onset preeclampsia...
  70. ncbi request reprint Selective increase in high molecular weight adiponectin concentration in serum of women with preeclampsia
    Yuri Takemura
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Reprod Immunol 73:60-5. 2007
    ..3%, 49.5-58.7) than control women (43.0%; 39.8-48.0; P=0.004). Taken together with other reports our findings imply a physiological feedback response to minimize endothelial damage in preeclamptic women...
  71. pmc Human chorionic gonadotropin combined with progesterone for luteal support improves pregnancy rate in patients with low late-midluteal estradiol levels in IVF cycles
    Akihisa Fujimoto
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Assist Reprod Genet 19:550-4. 2002
    ....
  72. ncbi request reprint High soluble CD44 concentration in peritoneal fluid in endometriosis
    Akiko Hasegawa
    Department of Obstetrics and Gynecology, Tokyo University, Tokyo, Japan
    Fertil Steril 89:1267-8. 2008
    ..The concentration of the soluble form of CD44, a competitive inhibitor for CD44 and hyaluronic acid binding, is higher in the peritoneal fluid of patients with endometriosis than in the peritoneal fluid of patients without endometriosis...
  73. ncbi request reprint The activity of bisphenol A depends on both the estrogen receptor subtype and the cell type
    Takako Kurosawa
    Department of Obstetrics and Gynecology, University of Tokyo, Japan
    Endocr J 49:465-71. 2002
    ..Thus, the activity of BPA may depend on the ER subtype and the tissue involved...
  74. doi request reprint Autoamputated adnexa presents as a peritoneal loose body
    Kaori Koga
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan
    Fertil Steril 93:967-8. 2010
    ..We report a case of unilateral adnexal absence with a peritoneal loose body. Laparoscopic findings and medical history suggested that she had adnexal torsion in her childhood followed by its calcification and autoamputation...
  75. ncbi request reprint Characteristic images of deeply infiltrating rectosigmoid endometriosis on transvaginal and transrectal ultrasonography
    Kaori Koga
    Department of Obstetrics and Gynecology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Japan
    Hum Reprod 18:1328-33. 2003
    ..To evaluate the usefulness of transvaginal and transrectal ultrasonography for diagnosis and management of deeply infiltrating rectosigmoid endometriosis...
  76. doi request reprint Conjoined twins in a triplet pregnancy after intracytoplasmic sperm injection and blastocyst transfer: case report and review of the literature
    Tetsuya Hirata
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Fertil Steril 91:933.e9-12. 2009
    ..To describe an exceptional case of conjoined twins in a triplet pregnancy after intracytoplasmic sperm injection (ICSI) and blastocyst transfer...
  77. ncbi request reprint Is endometriosis really associated with pain?
    Mikio Momoeda
    Department of Obstetrics and Gynecology, University of Tokyo, Japan
    Gynecol Obstet Invest 54:18-21; discussion 21-3. 2002
    ....
  78. ncbi request reprint Combined phospho-Akt and PTEN expressions associated with post-treatment hysterectomy after conservative progestin therapy in complex atypical hyperplasia and stage Ia, G1 adenocarcinoma of the endometrium
    Takeo Minaguchi
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Cancer Lett 248:112-22. 2007
    ..02). Our observations in vivo suggest that anti-tumor action of MPA may be mediated by dephosphorylation of Akt, and that immunohistochemical evaluation of phospho-Akt and PTEN may be able to predict the outcome of MPA therapy...
  79. doi request reprint Hyaluronic acid reagent suppressed endometriotic lesion formation in a mouse model
    Akiko Hasegawa
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan
    Fertil Steril 93:2757-9. 2010
    ..This effect was found when HA treatment was conducted at the time of endometrial fragment inoculation...
  80. ncbi request reprint [Endometriosis]
    Yutaka Osuga
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
    Nihon Rinsho 64:112-5. 2006
  81. ncbi request reprint Images in reproductive medicine. A case of giant cystic adenomyosis
    Kaori Koga
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan
    Fertil Steril 85:748-9. 2006
    ..We describe a 37-year-old woman with giant cystic adenomyosis who underwent a hysterectomy, providing magnetic resonance imaging and gross and microscopic images...
  82. doi request reprint Bone morphogenetic protein 7 (BMP-7) increases the expression of follicle-stimulating hormone (FSH) receptor in human granulosa cells
    Jia Shi
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo 113 8655, Japan
    Fertil Steril 93:1273-9. 2010
    ..To examine the effect of bone morphogenetic protein 7 (BMP-7) on FSH receptor (FSHR) expression in human granulosa cells...
  83. doi request reprint Aberrant implantation and growth of uterine leiomyoma in the abdominal wall after laparoscopically assisted myomectomy
    Osamu Wada-Hiraike
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Fertil Steril 92:1747.e13-5. 2009
    ..To report a case of aberrant implantation and growth of uterine leiomyoma in the abdominal wall after laparoscopically assisted myomectomy...
  84. doi request reprint Androgen insensitivity syndrome with serous gonadal cyst
    Yoko Yanai
    Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan
    Fertil Steril 90:2018.e9-11. 2008
    ..To present a patient with androgen insensitivity syndrome with serous gonadal cyst who underwent laparoscopic surgery...
  85. ncbi request reprint Sciatic endometriosis diagnosed by computerized tomography-guided biopsy and CD10 immunohistochemical staining
    Kaori Koga
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan
    Fertil Steril 84:1508. 2005
    ..To report a case of sciatic endometriosis diagnosed by computerized tomography (CT)-guided biopsy in combination with CD10 immunohistochemical staining...
  86. ncbi request reprint Cellular mechanisms of growth inhibition of human epithelial ovarian cancer cell line by LH-releasing hormone antagonist Cetrorelix
    Xiaohui Tang
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Clin Endocrinol Metab 87:3721-7. 2002
    ....
  87. ncbi request reprint Bisphenol A induces apoptosis and G2-to-M arrest of ovarian granulosa cells
    Jiping Xu
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 292:456-62. 2002
    ..Up-regulation of Bax and down-regulation of Bcl2 were suggested to be involved in this apoptotic effect...
  88. ncbi request reprint Evidence for the presence of angiogenin in human testis
    Kaori Koga
    Department of Obstetrics and Gynecology, University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    J Androl 25:369-74. 2004
    ..The specific localization of angiogenin in PTMCs suggests that angiogenin plays physiologic roles in the human testis...
  89. ncbi request reprint Genome-wide cDNA microarray analysis of gene-expression profiles involved in ovarian endometriosis
    Takahide Arimoto
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Int J Oncol 22:551-60. 2003
    ..These data should provide useful information for finding candidate genes whose products might serve as molecular targets for diagnosis or treatment of endometriosis...
  90. ncbi request reprint A case of estrogen-producing Brenner tumor with a stromal component as a potential source for estrogen
    Hisahiko Hiroi
    Department of Obstetrics and Gynecology, Hitachi General Hospital, Ibaraki, Japan
    Oncology 63:201-4. 2002
    ..Although Brenner tumors with endocrine activities have been reported, the source or mechanisms for hormone production is poorly known at present...