Yosuke Osawa

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc Tumor necrosis factor-α promotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of metalloproteinase-1 production in hepatic stellate cells
    Yosuke Osawa
    Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Gifu, Japan
    PLoS ONE 8:e65251. 2013
  2. pmc Liver acid sphingomyelinase inhibits growth of metastatic colon cancer
    Yosuke Osawa
    Department of Pharmacology, Gifu University Graduate School of Medicine, 1 1 Yanagido Gifu 501 1194, Japan
    J Clin Invest 123:834-43. 2013
  3. pmc L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin
    Yosuke Osawa
    Departments of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    J Biol Chem 286:34800-8. 2011
  4. pmc Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression
    Yosuke Osawa
    Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    FASEB J 25:1133-44. 2011
  5. doi request reprint Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice
    Yosuke Osawa
    Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Hepatology 51:237-45. 2010
  6. doi request reprint Ability of IDO to attenuate liver injury in alpha-galactosylceramide-induced hepatitis model
    Hiroyasu Ito
    Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    J Immunol 185:4554-60. 2010
  7. ncbi request reprint Normal liver regeneration and liver cell apoptosis after partial hepatectomy in tumor necrosis factor-alpha-deficient mice
    Hideki Hayashi
    First Department of Internal Medicine, Gifu University School of Medicine, Gifu 501 1194, Japan
    Liver Int 25:162-70. 2005
  8. ncbi request reprint Leflunomide protects from T-cell-mediated liver injury in mice through inhibition of nuclear factor kappaB
    Motoaki Imose
    First Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    Hepatology 40:1160-9. 2004
  9. pmc High susceptibility to lipopolysaccharide-induced lethal shock in encephalomyocarditis virus-infected mice
    Hirofumi Ohtaki
    Department of Informative Clinical Medicine, First Department of Internal Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Sci Rep 2:367. 2012
  10. doi request reprint L-tryptophan-kynurenine pathway metabolites regulate type I IFNs of acute viral myocarditis in mice
    Masato Hoshi
    Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    J Immunol 188:3980-7. 2012

Collaborators

Detail Information

Publications18

  1. pmc Tumor necrosis factor-α promotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of metalloproteinase-1 production in hepatic stellate cells
    Yosuke Osawa
    Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Gifu, Japan
    PLoS ONE 8:e65251. 2013
    ..Thus, targeting TNF-α and TIMP-1 may become a new therapeutic strategy for treating liver fibrosis in cholestatic liver injury...
  2. pmc Liver acid sphingomyelinase inhibits growth of metastatic colon cancer
    Yosuke Osawa
    Department of Pharmacology, Gifu University Graduate School of Medicine, 1 1 Yanagido Gifu 501 1194, Japan
    J Clin Invest 123:834-43. 2013
    ..Targeting ASM may represent a new therapeutic strategy for treating liver metastasis of colon cancer...
  3. pmc L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin
    Yosuke Osawa
    Departments of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    J Biol Chem 286:34800-8. 2011
    ..These results suggest the importance of mTOR activation for the exacerbation of hepatic steatosis. In conclusion, L-tryptophan exacerbates hepatic steatosis induced by HFHFD through serotonin-mediated activation of mTOR...
  4. pmc Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression
    Yosuke Osawa
    Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    FASEB J 25:1133-44. 2011
    ..This result is consistent with glucose intolerance in ASM(-/-) mice. In conclusion, ASM modulates AKT activation and AMPK inactivation, thus regulating glucose and lipid metabolism in the liver...
  5. doi request reprint Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice
    Yosuke Osawa
    Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Hepatology 51:237-45. 2010
    ..In these mice, AKT activation, the tolerance for TNF-alpha-induced apoptosis, and the regenerative responses were attenuated in hepatocytes after BDL...
  6. doi request reprint Ability of IDO to attenuate liver injury in alpha-galactosylceramide-induced hepatitis model
    Hiroyasu Ito
    Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    J Immunol 185:4554-60. 2010
    ..IDO induced by proinflammatory cytokines may decrease the number of TNF-α-producing immune cells in the liver. Thus, IDO may suppress overactive immune response in the α-GalCer-induced hepatitis model...
  7. ncbi request reprint Normal liver regeneration and liver cell apoptosis after partial hepatectomy in tumor necrosis factor-alpha-deficient mice
    Hideki Hayashi
    First Department of Internal Medicine, Gifu University School of Medicine, Gifu 501 1194, Japan
    Liver Int 25:162-70. 2005
    ..The aim of this study was to assess the mechanism by which TNF-alpha influences liver cell apoptosis and regeneration following PH in TNF-alpha-deficient (TNF-alpha(-/-)) mice...
  8. ncbi request reprint Leflunomide protects from T-cell-mediated liver injury in mice through inhibition of nuclear factor kappaB
    Motoaki Imose
    First Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    Hepatology 40:1160-9. 2004
    ....
  9. pmc High susceptibility to lipopolysaccharide-induced lethal shock in encephalomyocarditis virus-infected mice
    Hirofumi Ohtaki
    Department of Informative Clinical Medicine, First Department of Internal Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Sci Rep 2:367. 2012
    ..This new experimental model can help define the mechanism by which secondary bacterial infection causes a lethal shock in viral encephalomyocarditis...
  10. doi request reprint L-tryptophan-kynurenine pathway metabolites regulate type I IFNs of acute viral myocarditis in mice
    Masato Hoshi
    Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    J Immunol 188:3980-7. 2012
    ..Specifically, IDO increases the accumulation of Kyn pathway metabolites, which suppress type I IFNs production and enhance viral replication. We concluded that inhibition of the Trp-Kyn pathway ameliorates acute viral myocarditis...
  11. ncbi request reprint Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice
    Motoaki Imose
    First Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    Liver Int 23:386-96. 2003
    ..Here, we focused on the roles of NF-kappaB and phosphatidylinositol 3-kinase (PI3K)-regulated serine/threonine kinase Akt...
  12. doi request reprint The absence of IDO upregulates type I IFN production, resulting in suppression of viral replication in the retrovirus-infected mouse
    Masato Hoshi
    Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu City, Gifu Prefecture, Japan
    J Immunol 185:3305-12. 2010
    ....
  13. doi request reprint Extracellular matrix is required for the survival and differentiation of transplanted hepatic progenitor cells
    Yoshihiko Tsukada
    Department of Gastroenterology, Gifu University Graduate School of Medicine, Japan
    Biochem Biophys Res Commun 381:733-7. 2009
    ..These findings demonstrate that EHS gel supports cytodifferentiation from immature progenitor cells to hepatocytes and maintain its differentiated phenotypes in vitro and in vivo...
  14. pmc Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation
    Satoshi Nemoto
    Department of Cell Signaling, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    J Biol Chem 284:10422-32. 2009
    ..These findings indicate that SPHK isoforms and neutral sphingomyelinase contribute to the regulation of chemosensitivity by controlling ceramide formation and the downstream Akt pathway in human colon cancer cells...
  15. doi request reprint Interaction between LPS-induced NO production and IDO activity in mouse peritoneal cells in the presence of activated Valpha14 NKT cells
    Hirofumi Ohtaki
    Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Biochem Biophys Res Commun 389:229-34. 2009
    ..IDO is well known to play an important role in immunosuppression during inflammatory disease. Therefore, the inhibition of IDO by NO may exacerbate inflammation in the peritoneal cavity...
  16. doi request reprint (-)-Epigallocatechin gallate prevents carbon tetrachloride-induced rat hepatic fibrosis by inhibiting the expression of the PDGFRbeta and IGF-1R
    Yoichi Yasuda
    Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Chem Biol Interact 182:159-64. 2009
    ..These findings suggest that EGCG can exert, at least in part, an anti-fibrotic effect on the liver by targeting PDGFRbeta and IGF-1R. EGCG might therefore be useful in both the prevention and treatment of hepatic fibrosis...
  17. ncbi request reprint Immediate early gene IEX-1 induces astrocytic differentiation of U87-MG human glioma cells
    Fukka You
    Department of Cell Signaling, Division of Cell and Molecular Biology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    J Cell Biochem 100:256-65. 2007
    ..These results indicate that IEX-1 plays an important role in astrocytic differentiation of human glioma cells and that IEX-1 functions at downstream of PKA...
  18. ncbi request reprint Expression of the NF-kappa B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activation
    Yosuke Osawa
    First Department of Internal Medicine, Gifu University School of Medicine, Tsukasamachi, Gifu, Japan
    J Immunol 170:4053-60. 2003
    ..Moreover, the reciprocal cross-talk between IEX-1S and PI3K/Akt may closely be involved in the regulation of TNF-alpha-induced hepatocyte apoptosis...