Jun Ooi

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Second allogeneic hematopoietic stem cell transplantation for leukemia relapse after first allogeneic transplantation: outcome of 16 patients in a single institution
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Japan
    Int J Hematol 75:318-23. 2002
  2. ncbi request reprint Unrelated cord blood transplantation for adult patients with myelodysplastic syndrome-related secondary acute myeloid leukaemia
    J Ooi
    Department of Haematology and Oncology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Br J Haematol 114:834-6. 2001
  3. ncbi request reprint Unrelated cord blood transplantation after myeloablative conditioning in patients over the age of 45 years
    Jun Ooi
    Department of Haematology and Oncology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Br J Haematol 126:711-4. 2004
  4. doi request reprint Unrelated cord blood transplantation after myeloablative conditioning in adults with ALL
    J Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Bone Marrow Transplant 43:455-9. 2009
  5. ncbi request reprint The efficacy of unrelated cord blood transplantation for adult myelodysplastic syndrome
    Jun Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Leuk Lymphoma 47:599-602. 2006
  6. ncbi request reprint Unrelated cord blood transplantation for adult patients with de novo acute myeloid leukemia
    Jun Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Blood 103:489-91. 2004
  7. ncbi request reprint Unrelated cord blood transplantation after myeloablative conditioning for adult patients with refractory anemia
    Jun Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int J Hematol 81:424-7. 2005
  8. doi request reprint Unrelated cord blood transplantation after myeloablative conditioning in adults with acute myelogenous leukemia
    Jun Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Biol Blood Marrow Transplant 14:1341-7. 2008
  9. ncbi request reprint Unrelated cord blood transplantation for adult patients with advanced myelodysplastic syndrome
    Jun Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Japan
    Blood 101:4711-3. 2003
  10. ncbi request reprint A clinical comparison of unrelated cord blood transplantation and unrelated bone marrow transplantation for adult patients with acute leukaemia in complete remission
    Jun Ooi
    Department of Haematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Br J Haematol 118:140-3. 2002

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Second allogeneic hematopoietic stem cell transplantation for leukemia relapse after first allogeneic transplantation: outcome of 16 patients in a single institution
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Japan
    Int J Hematol 75:318-23. 2002
    ..HSCT2 is considered to be beneficial for select patients. Preparative regimens, GVHD prophylaxis, and donor choice for HSCT2 need to be studied to obtain a more successful outcome for HSCT2...
  2. ncbi request reprint Unrelated cord blood transplantation for adult patients with myelodysplastic syndrome-related secondary acute myeloid leukaemia
    J Ooi
    Department of Haematology and Oncology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Br J Haematol 114:834-6. 2001
    ..These preliminary results suggest that adult MDS-related secondary AML patients without suitable related or unrelated bone marrow donors should be considered as candidates for CBT...
  3. ncbi request reprint Unrelated cord blood transplantation after myeloablative conditioning in patients over the age of 45 years
    Jun Ooi
    Department of Haematology and Oncology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Br J Haematol 126:711-4. 2004
    ..4%. These results suggest that patients over 45 years of age without suitable related or unrelated bone marrow donors should be considered as candidates for CBT...
  4. doi request reprint Unrelated cord blood transplantation after myeloablative conditioning in adults with ALL
    J Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Bone Marrow Transplant 43:455-9. 2009
    ..2%. The 5-year cumulative incidence of TRM and relapse was 3.7 and 27.4%, respectively. These results suggest that unrelated CBT after myeloablative conditioning could be safely and effectively used for adult patients with ALL...
  5. ncbi request reprint The efficacy of unrelated cord blood transplantation for adult myelodysplastic syndrome
    Jun Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Leuk Lymphoma 47:599-602. 2006
    ..0%. These results suggest that adult MDS patients without suitable related or unrelated bone marrow donors should be considered as candidates for CBT...
  6. ncbi request reprint Unrelated cord blood transplantation for adult patients with de novo acute myeloid leukemia
    Jun Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Blood 103:489-91. 2004
    ..The probability of disease-free survival at 2 years was 76.6%. These results suggest that adult AML patients without suitable related or unrelated bone marrow donors should be considered as candidates for CBT...
  7. ncbi request reprint Unrelated cord blood transplantation after myeloablative conditioning for adult patients with refractory anemia
    Jun Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int J Hematol 81:424-7. 2005
    ..All patients are alive and free of disease at between 17 and 39 months after CBT. These results suggest that adult MDS-RA patients without suitable related or unrelated bone marrow donors should be considered as candidates for CBT...
  8. doi request reprint Unrelated cord blood transplantation after myeloablative conditioning in adults with acute myelogenous leukemia
    Jun Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Biol Blood Marrow Transplant 14:1341-7. 2008
    ..These results suggest that unrelated CBT after myeloablative conditioning could be safely and effectively used for adult patients with AML...
  9. ncbi request reprint Unrelated cord blood transplantation for adult patients with advanced myelodysplastic syndrome
    Jun Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Japan
    Blood 101:4711-3. 2003
    ..The probability of disease-free survival at 2 years was 76.2%. These results suggest that adult advanced MDS patients without suitable related or unrelated bone marrow donors should be considered as candidates for CBT...
  10. ncbi request reprint A clinical comparison of unrelated cord blood transplantation and unrelated bone marrow transplantation for adult patients with acute leukaemia in complete remission
    Jun Ooi
    Department of Haematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Br J Haematol 118:140-3. 2002
    ..The probability of 2 year disease-free survival was similar between the two groups. These results suggest that adult acute leukaemia patients in CR without a suitable donor should be considered as candidates for UCBT...
  11. ncbi request reprint Successful unrelated cord blood transplantation for relapse after autologous transplantation in non-Hodgkin's lymphoma
    Jun Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Japan
    Leuk Lymphoma 43:653-5. 2002
    ..After a follow-up period of 16 months, the patient is alive and free of disease. To our knowledge this is the first report of a successful unrelated CBT for an adult NHL patient who relapsed after autologous transplantation...
  12. doi request reprint Cord blood transplantation in adults
    J Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Bone Marrow Transplant 44:661-6. 2009
    ..In this review, we focus on recent results of myeloablative CBT in adults...
  13. ncbi request reprint Using related donors other than genotypically HLA-matched siblings in allogeneic hematopoietic stem cell transplantation for hematologic disease: a single institution experience in Japan
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Int J Hematol 76:354-9. 2002
    ....
  14. ncbi request reprint Impact of cytomegalovirus serostatus on outcome of unrelated cord blood transplantation for adults: a single-institute experience in Japan
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Eur J Haematol 80:251-7. 2008
    ..This might be due to effective antiviral therapy for CMV infection. Large-scale studies are needed to determine the impact of recipient CMV serostatus on the outcome of CBT for adults...
  15. ncbi request reprint Cord blood transplantation for acute myelogenous leukemia using a conditioning regimen consisting of granulocyte colony-stimulating factor-combined high-dose cytarabine, fludarabine, and total body irradiation
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Eur J Haematol 77:46-50. 2006
    ..Large-scale studies will be needed to determine the efficacy and safety of the conditioning regimen in CBT...
  16. ncbi request reprint Varicella-zoster virus infection in adult patients after unrelated cord blood transplantation: a single institute experience in Japan
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Br J Haematol 122:802-5. 2003
    ..01). These results suggest that recovery of VZV-specific immune responses after CBT is delayed even in patients without severe acute GVHD...
  17. doi request reprint Second myeloablative allogeneic stem cell transplantation (SCT) using cord blood for leukemia relapsed after initial allogeneic SCT
    Takaaki Konuma
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Leuk Res 33:840-2. 2009
    ..We conclude that second myeloablative allo-SCT using CB may be feasible in selected patients with the relatively younger age, less organ damage and longer time interval between first and second allo-SCT...
  18. ncbi request reprint Comparative single-institute analysis of cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem-cell transplants from related donors in adult patients with hematologic malignancies after myeloablative conditioning regim
    Satoshi Takahashi
    Division of Molecular Therapy, Institute of Medical Science, Department of Biostatistics Epidemiology and Preventive Health Sciences, School of Health Sciences and Nursing, University of Tokyo, Japan
    Blood 109:1322-30. 2007
    ..These data suggest that unrelated cord blood could be as safe and effective a stem-cell source as related bone marrow or mobilized peripheral blood for adult patients when it is used as a primary unrelated stem-cell source...
  19. doi request reprint Recipient-derived cells after cord blood transplantation: dynamics elucidated by multicolor FACS, reflecting graft failure and relapse
    Nobukazu Watanabe
    FACS Core Laboratory, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Biol Blood Marrow Transplant 14:693-701. 2008
    ..Multicolor HLA-fFlow analysis and cell sorting in early diagnosis of graft failure and relapse was confirmed as valuable in 14 patients who had received HLA-mismatched CBT...
  20. doi request reprint Myeloablative unrelated cord blood transplantation for acute leukemia patients between 50 and 55 years of age: single institutional retrospective comparison with patients younger than 50 years of age
    Takaaki Konuma
    Department of Hematology Oncology, University of Tokyo, Tokyo, Japan
    Ann Hematol 88:581-8. 2009
    ..These results suggest that, in patients with acute leukemia, myeloablative CBT might be as safe and effective in patients aged between 50 and 55 years as in younger patients...
  21. ncbi request reprint Hemorrhagic cystitis in adults after unrelated cord blood transplantation: a single-institution experience in Japan
    Akira Tomonari
    Department of Hematology Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Int J Hematol 84:268-71. 2006
    ..8% at 1 year. The incidence of AdV-induced severe HC after CBT may be relatively low among Japanese adults. The role of other viruses, including BK virus, in the pathogenesis of HC after CBT needs to be examined...
  22. ncbi request reprint Ganciclovir-related neutropenia after preemptive therapy for cytomegalovirus infection: comparison between cord blood and bone marrow transplantation
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, 4 6 1, Shirokanedai, Minato ku, 108 8639 Tokyo, Japan
    Ann Hematol 83:573-7. 2004
    ..No risk factors for GCV-related neutropenia were found in BMT patients. These results suggest that GCV may be less toxic to myeloid progenitor cells from cord blood than those from bone marrow...
  23. doi request reprint Unrelated cord blood transplantation after myeloablative conditioning regimen in adolescent and young adult patients with hematologic malignancies: a single institute analysis
    Yasuhiro Ebihara
    Department of Pediatric Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Leuk Res 36:128-31. 2012
    ..2% and 48.6%, respectively, comparable to adult or childhood cases. Adolescents and young adult patients with hematologic malignancies who have no HLA-matched adult donors could be considered as candidates for CBT...
  24. ncbi request reprint Human herpesvirus 6 variant B infection in adult patients after unrelated cord blood transplantation
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Int J Hematol 81:352-5. 2005
    ..05). In contrast, positive HHV-6B DNAemia at week 2 was associated with neither skin rash nor aGVHD. Prospective large-scale studies are needed to determine the role of HHV-6 infection in CBT patients...
  25. doi request reprint Early renal injury after myeloablative cord blood transplantation in adults
    Hiroshi Mae
    Department of Pharmacy, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Leuk Lymphoma 49:538-42. 2008
    ..01). Our result suggests that it is important to monitor VCM dosing more strictly with pharmacokinetic assessment, especially in days 11 - 20, when the most frequently observed declining renal function...
  26. ncbi request reprint Cytomegalovirus infection following unrelated cord blood transplantation for adult patients: a single institute experience in Japan
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Br J Haematol 121:304-11. 2003
    ..024, 0.032 and 0.017 respectively). These results suggest that recovery of CMV-specific immunity after CBT is delayed when compared with BMT...
  27. ncbi request reprint Pancreatic hyperamylasemia and hyperlipasemia in association with cytomegalovirus infection following unrelated cord blood transplantation for acute myelogenous leukemia
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Int J Hematol 84:438-40. 2006
    ..The present report indicates that CMV infection should be included in the differential diagnosis for patients with pancreatic hyperamylasemia after SCT...
  28. ncbi request reprint Bacterial bloodstream infection in neutropenic adult patients after myeloablative cord blood transplantation: experience of a single institution in Japan
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Int J Hematol 85:238-41. 2007
    ..Early diagnosis of bacterial BSI and prompt treatment with effective antibiotics are necessary for neutropenic adult patients after myeloablative CBT...
  29. ncbi request reprint Unrelated cord blood transplantation with a reduced-intensity conditioning regimen following autologous transplantation for multiple myeloma
    Toshiki Yamada
    Department of Hematology Oncology, The Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Int J Hematol 80:377-80. 2004
    ..These results suggested that CBT with a reduced-intensity conditioning regimen after high-dose chemotherapy with ASCT is a new promising approach for the treatment of multiple myeloma...
  30. ncbi request reprint Posttransplantation engraftment and safety of cord blood transplantation with grafts containing relatively low cell doses in adults
    Satoshi Takahashi
    Division of Molecular Therapy, Advanced Clinical Research Center, School of Health Sciences and Nursing, University of Tokyo, Tokyo, Japan
    Int J Hematol 84:359-62. 2006
    ..Based on these preliminary results, cord blood grafts containing less than 2.0 X 10(7) cells/kg may be useful for cases where no grafts with higher cell doses or other stem cell sources are available...
  31. ncbi request reprint Fatal acute tumor lysis syndrome following intrathecal chemotherapy for acute lymphoblastic leukemia with meningeal involvement
    Takaaki Konuma
    Department of Hematology Oncology, Institute of Medical Science, University of Tokyo, Tokyo
    Intern Med 47:1987-8. 2008
    ..This case indicates that intrathecal chemotherapy alone may be sufficient to induce ATLS. Close monitoring and prevention of ATLS are also warranted following intrathecal chemotherapy alone...
  32. ncbi request reprint Severe immune dysfunction after lethal neutron irradiation in a JCO nuclear facility accident victim
    Hitomi Nagayama
    Institute of Medical Science, University of Tokyo, Japan
    Int J Hematol 76:157-64. 2002
    ..The roles of transplantation, autologous hematopoietic recovery, chimerism, immune suppression, and immune function are discussed...
  33. ncbi request reprint Cytogenetic remissions induced by interferon alpha and imatinib mesylate are immunologically distinct in chronic myeloid leukemia
    Shin Nakayama
    Department of Hematology Oncology, Research Hospital, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Int J Hematol 86:208-11. 2007
    ..Collectively, the 2 therapeutic agents induce a distinct immunologic status in CML patients whose hematopoiesis has returned to normal levels...
  34. ncbi request reprint Atypical hypersensitivity to mosquito bites without natural killer cell proliferative disease in an adult patient
    Takaaki Konuma
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Int J Hematol 82:441-4. 2005
    ..Peripheral NK cell lymphocytosis and EBV-associated lymphoproliferative disease did not develop. These findings suggest that some patients with chronic EBV infection may develop HMB without NK cell proliferative disease...
  35. ncbi request reprint Severe aplastic anemia with autoimmune thyroiditis showing no hematological response to intensive immunosuppressive therapy
    Akira Tomonari
    Department of Hematology Oncology, Institute of Medical Science, University of Tokyo, Japan
    Acta Haematol 109:90-4. 2003
    ..Other therapies such as hematopoietic stem cell transplantation or more intensified repeated ATG therapy may be necessary for such patients...
  36. doi request reprint Single-unit cord blood transplantation after granulocyte colony-stimulating factor-combined myeloablative conditioning for myeloid malignancies not in remission
    Takaaki Konuma
    Department of Hematology Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan Electronic address
    Biol Blood Marrow Transplant 20:396-401. 2014
    ..These data demonstrate that CBT after G-CSF-combined myeloablative conditioning is a promising curative option for patients with myeloid malignancies not in remission. ..
  37. ncbi request reprint Acquired pulmonary alveolar proteinosis after umbilical cord blood transplantation for acute myeloid leukemia
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Am J Hematol 70:154-7. 2002
    ..The bone marrow was hypocellular without the leukemic cells. The impaired immunity during the period of leukopenia as well as the impaired clearance of surfactant proteins might contribute to the development of PAP...
  38. ncbi request reprint Central nervous system leukemia on magnetic resonance imaging
    Takaaki Konuma
    Department of Hematology and Oncology, Institute of Medical Science University of Tokyo
    Intern Med 47:477. 2008
  39. ncbi request reprint Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies
    Satoshi Takahashi
    Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, 6 1, Shirokanedai 4, Minato ku, Tokyo 108 8639 Japan
    Blood 104:3813-20. 2004
    ..01, respectively), despite the higher human leukocyte antigen mismatching rate and lower number of infused cells. These data strongly suggest that CBT could be safely and effectively used for adult patients with hematologic malignancies...
  40. ncbi request reprint Resolution of Beh├žet's disease after HLA-mismatched unrelated cord blood transplantation for myelodysplastic syndrome
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Japan
    Ann Hematol 83:464-6. 2004
    ..These observations suggest that allogeneic hematopoietic stem cell transplantation, which encompasses CBT, may be an effective therapy in patients with high-risk aggressive BD...
  41. ncbi request reprint Acute myelogenous leukemia M5b developed during clinical remission of Castleman disease
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Japan
    Int J Hematol 77:274-6. 2003
    ..His bone marrow aspirate showed that approximately 80% of cells were leukemic, including well-differentiated monocytic cells A diagnosis of AML M5b was made. The patient died of invasive pulmonary aspergillosis after chemotherapy...
  42. ncbi request reprint Early-onset pulmonary complication showing organizing pneumonia pattern following cord blood transplantation in adults
    Akira Tomonari
    Int J Hematol 85:364-6. 2007
  43. ncbi request reprint Varicella-zoster virus encephalitis in a patient undergoing unrelated cord blood transplantation for myelodysplastic syndrome-overt leukemia
    Kenji Fukuno
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Shirokanidae, Tokyo
    Int J Hematol 84:79-82. 2006
    ..MRI scans showed substantial resolution but with mild residual lesions. The present report indicates that VZV should be considered as a possible causative agent in patients who develop multifocal neurologic symptoms of the CNS after SCT...
  44. ncbi request reprint Early-onset thyrotoxicosis after unrelated cord blood transplantation for acute myelogenous leukemia
    Takaaki Konuma
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Japan
    Int J Hematol 83:348-50. 2006
    ..The present study shows that thyrotoxicosis can occur during very early periods after CBT...
  45. doi request reprint Myeloablative unrelated cord blood transplantation for adult acute myeloid leukemia patients with 11q23 abnormalities
    Takaaki Konuma
    Eur J Haematol 80:545-8. 2008
  46. ncbi request reprint Allogeneic stem cell transplantation for hepatosplenic gammadelta T-cell lymphoma
    Takaaki Konuma
    Leuk Lymphoma 48:630-2. 2007