Satomi Onoue

Summary

Affiliation: University of Shizuoka
Country: Japan

Publications

  1. ncbi request reprint Structural transition of glucagon in the concentrated solution observed by electrophoretic and spectroscopic techniques
    Satomi Onoue
    Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274 8510, Japan
    J Chromatogr A 1109:167-73. 2006
  2. ncbi request reprint Drug-induced phototoxicity; an early in vitro identification of phototoxic potential of new drug entities in drug discovery and development
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Curr Drug Saf 4:123-36. 2009
  3. ncbi request reprint Self-micellizing solid dispersion of cyclosporine A with improved dissolution and oral bioavailability
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1, Yada, Suruga ku, Shizuoka 422 8526, Japan Electronic address
    Eur J Pharm Sci 62:16-22. 2014
  4. pmc Nanodrugs: pharmacokinetics and safety
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Int J Nanomedicine 9:1025-37. 2014
  5. ncbi request reprint Intra-/inter-laboratory validation study on reactive oxygen species assay for chemical photosafety evaluation using two different solar simulators
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan Electronic address
    Toxicol In Vitro 28:515-23. 2014
  6. ncbi request reprint Microenvironmental pH-modification to improve dissolution behavior and oral absorption for drugs with pH-dependent solubility
    Chika Taniguchi
    University of Shizuoka, School of Pharmaceutical Sciences, Department of Pharmacokinetics and Pharmacodynamics, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan 81 54 264 5633 81 54 264 5635
    Expert Opin Drug Deliv 11:505-16. 2014
  7. doi request reprint Biopharmaceutical characterization of nanocrystalline solid dispersion of coenzyme Q10 prepared with cold wet-milling system
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan Electronic address
    Eur J Pharm Sci 53:118-25. 2014
  8. ncbi request reprint In vitro/in vivo characterization of nanocrystalline formulation of tranilast with improved dissolution and hepatoprotective properties
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan Electronic address
    Eur J Pharm Biopharm 85:952-7. 2013
  9. ncbi request reprint Non-animal photosafety assessment approaches for cosmetics based on the photochemical and photobiochemical properties
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan Electronic address
    Toxicol In Vitro 27:2316-24. 2013
  10. doi request reprint Physicochemical and biopharmaceutical characterization of amorphous solid dispersion of nobiletin, a citrus polymethoxylated flavone, with improved hepatoprotective effects
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Eur J Pharm Sci 49:453-60. 2013

Collaborators

Detail Information

Publications86

  1. ncbi request reprint Structural transition of glucagon in the concentrated solution observed by electrophoretic and spectroscopic techniques
    Satomi Onoue
    Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274 8510, Japan
    J Chromatogr A 1109:167-73. 2006
    ..004/h and 0.080 +/- 0.011/h for aging at pH 2.0 and 3.5, respectively, suggesting the pH dependence of self-association. CE showed the potential to separate and detect the glucagon aggregates and intermediates during aging process...
  2. ncbi request reprint Drug-induced phototoxicity; an early in vitro identification of phototoxic potential of new drug entities in drug discovery and development
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Curr Drug Saf 4:123-36. 2009
    ....
  3. ncbi request reprint Self-micellizing solid dispersion of cyclosporine A with improved dissolution and oral bioavailability
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1, Yada, Suruga ku, Shizuoka 422 8526, Japan Electronic address
    Eur J Pharm Sci 62:16-22. 2014
    ..11- and 42-fold, respectively, compared with those of amorphous CsA. The poly[MPC-co-BMA]-based SMSD formulation system might be an efficacious dosage option for CsA to achieve improvements in oral bioavailability. ..
  4. pmc Nanodrugs: pharmacokinetics and safety
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Int J Nanomedicine 9:1025-37. 2014
    ..This review highlights the recent progress in nanodrug system development, with a focus on the pharmacokinetic advantages and safety challenges. ..
  5. ncbi request reprint Intra-/inter-laboratory validation study on reactive oxygen species assay for chemical photosafety evaluation using two different solar simulators
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan Electronic address
    Toxicol In Vitro 28:515-23. 2014
    ..A multi-center validation study on the ROS assay demonstrated satisfactory transferability, accuracy, precision, and predictivity, as well as the availability of other solar simulators. ..
  6. ncbi request reprint Microenvironmental pH-modification to improve dissolution behavior and oral absorption for drugs with pH-dependent solubility
    Chika Taniguchi
    University of Shizuoka, School of Pharmaceutical Sciences, Department of Pharmacokinetics and Pharmacodynamics, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan 81 54 264 5633 81 54 264 5635
    Expert Opin Drug Deliv 11:505-16. 2014
    ..The pH-modification of a formulation could be a promising approach to overcome the poor oral absorption of drugs with pH-dependent solubility...
  7. doi request reprint Biopharmaceutical characterization of nanocrystalline solid dispersion of coenzyme Q10 prepared with cold wet-milling system
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan Electronic address
    Eur J Pharm Sci 53:118-25. 2014
    ..The CSD approach with the new CWM system might be a promising dosage option for improving the nutraceutical values of CoQ10...
  8. ncbi request reprint In vitro/in vivo characterization of nanocrystalline formulation of tranilast with improved dissolution and hepatoprotective properties
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan Electronic address
    Eur J Pharm Biopharm 85:952-7. 2013
    ..Strategic application of NC formulation technology might be an efficacious approach for enhancing the therapeutic potential of TL to treat liver dysfunction...
  9. ncbi request reprint Non-animal photosafety assessment approaches for cosmetics based on the photochemical and photobiochemical properties
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan Electronic address
    Toxicol In Vitro 27:2316-24. 2013
    ..The combined use of in vitro assays might enable simple and fast non-animal photosafety evaluation of cosmetic ingredients. ..
  10. doi request reprint Physicochemical and biopharmaceutical characterization of amorphous solid dispersion of nobiletin, a citrus polymethoxylated flavone, with improved hepatoprotective effects
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Eur J Pharm Sci 49:453-60. 2013
    ..Given the improved physicochemical and biopharmaceutical properties, the SD formulation strategy might be efficacious for enhancing the therapeutic potential of NOB...
  11. doi request reprint Development of novel solid dispersion of tranilast using amphiphilic block copolymer for improved oral bioavailability
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 452:220-6. 2013
    ..From these findings, pMB-based SD formulation approach might be an efficacious approach for enhancing the therapeutic potential of TL...
  12. doi request reprint Chemical synthesis and formulation design of a PEGylated vasoactive intestinal peptide derivative with improved metabolic stability
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Eur J Pharm Sci 49:382-9. 2013
    ..From these findings, PEGylation of a VIP derivative, as well as its strategic application to the RP formulation, may be a viable approach to improve its therapeutic potential for the treatment of airway inflammatory diseases...
  13. doi request reprint Inhalable powder formulation of pirfenidone with reduced phototoxic risk for treatment of pulmonary fibrosis
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Pharm Res 30:1586-96. 2013
    ..Orally-taken pirfenidone (PFD), an idiopathic pulmonary fibrosis drug, often causes severe phototoxicity. Present study aimed to develop a respirable powder formulation for PFD (PFD-RP) to minimize phototoxic risk...
  14. ncbi request reprint [Strategic formulation study on dry powder inhalation system based on modulated molecular properties and controlled pharmacokinetics]
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Yakugaku Zasshi 133:93-8. 2013
    ..From these findings, combination use of CsA-loaded ASD and DPI systems might be a promising approach for the treatment of airway inflammatory diseases with improved pharmacodynamics and lower systemic exposure...
  15. ncbi request reprint Physicochemical and pharmacokinetic characterization of amorphous solid dispersion of tranilast with enhanced solubility in gastric fluid and improved oral bioavailability
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Drug Metab Pharmacokinet 27:379-87. 2012
    ..With these data, the ASD approach could be a viable formulation strategy for enhancing the wettability and oral bioavailability of TL, resulting in improved therapeutic potential of TL for the treatment of inflammatory diseases...
  16. doi request reprint Novel solid self-emulsifying drug delivery system of coenzyme Q₁₀ with improved photochemical and pharmacokinetic behaviors
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Eur J Pharm Sci 46:492-9. 2012
    ..From the improved physicochemical and pharmacokinetic data, the s-SEDDS approach upon spray-drying might be a suitable dosage option for enhancing nutraceutical and pharmaceutical values of CoQ(10)...
  17. doi request reprint Inhalable sustained-release formulation of long-acting vasoactive intestinal peptide derivative alleviates acute airway inflammation
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka, Japan
    Peptides 35:182-9. 2012
    ..From these findings, newly prepared IK312532/NS-RP might be of clinical importance in improving duration of action and medication compliance for treatment of airway inflammatory diseases...
  18. doi request reprint Improved dissolution and pharmacokinetic behavior of dipyridamole formulation with microenvironmental pH-modifier under hypochlorhydria
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 426:61-6. 2012
    ..Given the improved systemic exposure early after oral administration in hypochlorhydric rats, the DPG/FA might provide better clinical outcomes in hypochlorhydric patients...
  19. ncbi request reprint Novel dry powder inhaler formulation of glucagon with addition of citric acid for enhanced pulmonary delivery
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 382:144-50. 2009
    ..Based on these physicochemical and pharmacological characterization, the dry powder inhaler of glucagon with addition of citric acid would be of use as an alternative to injection form...
  20. ncbi request reprint In vitro photochemical and phototoxicological characterization of major constituents in St. John's Wort (Hypericum perforatum) extracts
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Phytochemistry 72:1814-20. 2011
    ..In conclusion, our results suggested that hypericin, pseudohypericin, and hyperforin might be responsible for the in vitro phototoxic effects of SJW extract...
  21. doi request reprint Formulation design and photochemical studies on nanocrystal solid dispersion of curcumin with improved oral bioavailability
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Pharm Sci 99:1871-81. 2010
    ..On the basis of these observations, taken together with dissolution and pharmacokinetic behaviors, CSD strategy would be efficacious to enhance bioavailability of curcumin with high photochemical stability...
  22. doi request reprint Self-assembled micellar formulation of chafuroside A with improved anti-inflammatory effects in experimental asthma/COPD-model rats
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1, Yada, Suruga ku, Shizuoka 422 8526, Japan
    Eur J Pharm Sci 45:184-9. 2012
    ..From these observations, the SAM formulation might be an efficacious approach for enhancing the therapeutic potential of CFA for treatment of inflammatory diseases...
  23. doi request reprint Inhalable dry-emulsion formulation of cyclosporine A with improved anti-inflammatory effects in experimental asthma/COPD-model rats
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, University of Shizuoka, Shizuoka, Japan
    Eur J Pharm Biopharm 80:54-60. 2012
    ..From these findings, use of inhalable DE formulation of CsA might be a promising approach for the treatment of airway inflammatory diseases with improved pharmacodynamics and lower systemic exposure...
  24. doi request reprint High-throughput screening system for identifying phototoxic potential of drug candidates based on derivatives of reactive oxygen metabolites
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka, 422 8526, Japan
    Pharm Res 27:1610-9. 2010
    ..The present study aimed to develop a high-throughput screening strategy for predicting the phototoxic potential of pharmaceutical substances, using a derivatives-of-reactive-oxygen-metabolites (D-ROM) assay...
  25. doi request reprint Development of PACAP38 analogue with improved stability: physicochemical and in vitro/in vivo pharmacological characterization
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Mol Neurosci 43:85-93. 2011
    ....
  26. doi request reprint Development of inhalable nanocrystalline solid dispersion of tranilast for airway inflammatory diseases
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka, Japan
    J Pharm Sci 100:622-33. 2011
    ....
  27. doi request reprint Improved dissolution and pharmacokinetic behavior of cyclosporine A using high-energy amorphous solid dispersion approach
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka, Japan
    Int J Pharm 399:94-101. 2010
    ..From the improved dissolution and pharmacokinetic data, the amorphous SD approach using wet-milling technology should lead to consistent and enhanced bioavailability, leading to an improved therapeutic potential of CsA...
  28. doi request reprint Inhalable powder formulation of vasoactive intestinal peptide derivative, [R15,20,21, L17]-VIP-GRR, attenuated neutrophilic airway inflammation in cigarette smoke-exposed rats
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka 422 8526, Japan
    Eur J Pharm Sci 41:508-14. 2010
    ..The present findings suggest that an inhalable formulation of IK312532 might be efficacious as a therapy for COPD or other airway inflammatory diseases because of its potent immunomodulating activities...
  29. doi request reprint Development of (-)-epigallocatechin-3-gallate (EGCG)-loaded enteric microparticles with intestinal mucoadhesive property
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 410:111-3. 2011
    ..From these findings, newly prepared EGCG/MS might be of clinical importance in both stabilizing and delivering EGCG for treatment of intestinal diseases...
  30. doi request reprint Formulation design and in vivo evaluation of dry powder inhalation system of new vasoactive intestinal peptide derivative ([R(15, 20, 21), L(17), A(24,25), des-N(28)]-VIP-GRR) in experimental asthma/COPD model rats
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 410:54-60. 2011
    ..Thus, respirable powder formulation of IK312548 might be a promising medication for asthma, COPD, and other airway inflammatory diseases...
  31. doi request reprint Inhalable sustained-release formulation of glucagon: in vitro amyloidogenic and inhalation properties, and in vivo absorption and bioactivity
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Pharm Res 28:1157-66. 2011
    ..The present study aimed to develop novel glucagon-loaded PLGA nanospheres without cytotoxic fibril formation for chronic glucagon replacement therapy...
  32. ncbi request reprint Pharmacokinetic study of nicotine and its metabolite cotinine to clarify possible association between smoking and voiding dysfunction in rats using UPLC/ESI-MS
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Drug Metab Pharmacokinet 26:416-22. 2011
    ..The results of the pharmacokinetic study using the UPLC/ESI-MS method further support the possible involvement of nicotine in increased risk of urinary dysfunction in smokers...
  33. ncbi request reprint New treatments for chronic obstructive pulmonary disease and viable formulation/device options for inhalation therapy
    Satomi Onoue
    University of Shizuoka, School of Pharmaceutical Sciences, Department of Pharmacokinetics and Pharmacodynamics, Global Center of Excellence COE Program, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Expert Opin Drug Deliv 6:793-811. 2009
    ..This article aims to review recent developments in COPD drugs and the delivery systems for inhalation therapy, with particular emphasis on device options and formulations of DPI systems...
  34. ncbi request reprint High-throughput reactive oxygen species (ROS) assay: an enabling technology for screening the phototoxic potential of pharmaceutical substances
    Satomi Onoue
    Analytical Research and Development, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Japan Inc, 5 2 Taketoyo, Aichi 470 2393, Japan
    J Pharm Biomed Anal 46:187-93. 2008
    ..The developed assay system will be an effective tool for predicting the phototoxic potential of pharmaceutical candidates in early stage of pharmaceutical development...
  35. ncbi request reprint Structure-activity relationship of vasoactive intestinal peptide (VIP): potent agonists and potential clinical applications
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka, 422 8526, Japan
    Naunyn Schmiedebergs Arch Pharmacol 377:579-90. 2008
    ....
  36. ncbi request reprint In vitro phototoxic potential and photochemical properties of imidazopyridine derivative: a novel 5-HT4 partial agonist
    Satomi Onoue
    Worldwide Pharmaceutical Sciences, Pfizer Global Research and Development PGRD, Nagoya Laboratories, Pfizer Japan, Inc, 5 2 Taketoyo, Aichi 470 2393, Japan
    J Pharm Sci 97:4307-18. 2008
    ..These results suggest the phototoxic risk of newly synthesized imidazopyridine derivative and also verify the usefulness of ROS assay for phototoxicity prediction...
  37. ncbi request reprint Reactive oxygen species assay-based risk assessment of drug-induced phototoxicity: classification criteria and application to drug candidates
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Pharm Biomed Anal 47:967-72. 2008
    ..These results verify the usefulness of the ROS assay for understanding the phototoxicity risk of pharmaceutical substances, and the ROS assay can be used for screening purposes in the drug discovery stage...
  38. ncbi request reprint Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    FEBS J 275:5542-51. 2008
    ..The data obtained suggest the anti-apoptotic role of PACAP in streptozotocin-treated RIN-m5F cells through the regulation of pro-apoptotic and pro-survival factors...
  39. ncbi request reprint Novel methodology for predicting photogenotoxic risk of pharmaceutical substances based on reactive oxygen species (ROS) and DNA-binding assay
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    J Pharm Sci 98:3647-58. 2009
    ..The combination use of ROS assay and DNA-binding assay could be fast and reliable prediction for the photogenotoxic potential of a large number of drug candidates at the drug-discovery stage...
  40. ncbi request reprint Analytical studies on photochemical behavior of phototoxic substances; effect of detergent additives on singlet oxygen generation
    Satomi Onoue
    Analytical Research and Development, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Japan Inc, 5 2 Taketoyo, Aichi, 470 2393, Japan
    Pharm Res 25:861-8. 2008
    ..The aim of this investigation was to clarify the possible role of biomimetic vehicle systems on the photochemical properties of phototoxic compounds, focusing on the singlet oxygen generation...
  41. doi request reprint Physicochemical and pharmacological characterization of novel vasoactive intestinal peptide derivatives with improved stability
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, University of Shizuoka, Shizuoka, Japan
    Eur J Pharm Biopharm 73:95-101. 2009
    ....
  42. doi request reprint In vitro and in vivo characterization on amorphous solid dispersion of cyclosporine A for inhalation therapy
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Control Release 138:16-23. 2009
    ..Upon these findings, WM/CsA-RP would be efficacious dosage form for clinical treatment of airway inflammations with minimal systemic side effects...
  43. ncbi request reprint Capillary electrophoretic studies on the photogenotoxic potential of pharmaceutical substances
    Satomi Onoue
    Analytical Research and Development, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Japan Inc, 5 2 Taketoyo, Aichi 470 2393, Japan
    J Chromatogr A 1188:50-6. 2008
    ....
  44. ncbi request reprint Physicochemical and pharmacological characterization of alpha-tocopherol-loaded nano-emulsion system
    Junya Hatanaka
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1, Yada, Suruga ku, Shizuoka, 422 8526, Japan
    Int J Pharm 396:188-93. 2010
    ..With these findings, the NE approach might be efficacious to improve the oral bioavailability and anti-oxidative activities of alpha-TC...
  45. doi request reprint Novel dry powder formulation of ovalbumin for development of COPD-like animal model: Physicochemical characterization and biomarker profiling in rats
    Shingen Misaka
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1, Yada, Suruga ku, Shizuoka, 422 8526, Japan
    Eur J Pharm Sci 37:469-76. 2009
    ..Upon these findings, OVA-DPI can be useful and reproducible research tool for the development of experimental asthma/COPD model...
  46. doi request reprint Comparative studies on physicochemical stability of cyclosporine A-loaded amorphous solid dispersions
    Hideyuki Sato
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 426:302-6. 2012
    ..From these findings, stability on CsA-loaded SD might be variable depending on the preparation methodology, and the wet-milling approach could be a viable option for preparing efficacious SD formulations with improved stability...
  47. doi request reprint Stable dry powder inhaler formulation of tranilast attenuated antigen-evoked airway inflammation in rats
    Yohei Kawabata
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, University of Shizuoka, Shizuoka, Japan
    Eur J Pharm Biopharm 77:178-81. 2011
    ..Given these findings, inhalable TL formulation might be an interesting alternative to oral therapy for the treatment of asthma and other airway inflammatory diseases with sufficient dispersing stability...
  48. ncbi request reprint Liposomal formulations of glucagon-like peptide-1: improved bioavailability and anti-diabetic effect
    Junko Hanato
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 382:111-6. 2009
    ..Upon these findings, anionic liposomal formulation of GLP-1 would provide the improved pharmacokinetics and insulinotropic action, possibly leading to efficacious anti-diabetic medication...
  49. doi request reprint Novel formulations of dipyridamole with microenvironmental pH-modifiers for improved dissolution and bioavailability under hypochlorhydria
    Chika Taniguchi
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 434:148-54. 2012
    ..From these findings, the addition of TS as a microenvironmental pH-modifier in DP formulation might be beneficial in expanding the therapeutic potential of DP in hypochlorhydric patients...
  50. doi request reprint Inhalable powder formulation of a stabilized vasoactive intestinal peptide (VIP) derivative: anti-inflammatory effect in experimental asthmatic rats
    Shingen Misaka
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka, Japan
    Peptides 31:72-8. 2010
    ..Thus, inhalable powder formulation of IK312532 exerts its anti-inflammatory activity by suppressing granulocyte recruitment to the lung and epithelial hyperplasia, followed by the reduction of cytotoxic peroxidases...
  51. ncbi request reprint In vitro phototoxicity of dihydropyridine derivatives: a photochemical and photobiological study
    Satomi Onoue
    Worldwide Pharmaceutical Sciences, Pfizer Global Research and Development PGRD, Nagoya Laboratories, Pfizer Japan Inc, 5 2 Taketoyo, Aichi 470 2393, Japan
    Eur J Pharm Sci 33:262-70. 2008
    ..These findings also support the usefulness of the ROS assay for the risk assessment studies on the drug-induced phototoxicity even at the early stages of pharmaceutical development...
  52. doi request reprint Development of high-energy amorphous solid dispersion of nanosized nobiletin, a citrus polymethoxylated flavone, with improved oral bioavailability
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    J Pharm Sci 100:3793-801. 2011
    ..These findings suggest that an amorphous, nanosized SD could be a viable option for enhancing the bioavailability and CNS delivery of NOB...
  53. doi request reprint Physicochemical and pharmacokinetic characterization of water-soluble Coenzyme Q(10) formulations
    Junya Hatanaka
    Department of Pharmacokinetics and Pharmacodynamics, Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka, Japan
    Int J Pharm 363:112-7. 2008
    ..Although similar kinetic values were seen with T(max) of 1.5 and 1.7h, respectively, for NE and crystalline CoQ(10), NE exhibited ca 1.7-fold higher AUC and C(max) than the crystalline CoQ(10)...
  54. pmc Combined use of in vitro phototoxic assessments and cassette dosing pharmacokinetic study for phototoxicity characterization of fluoroquinolones
    Yoshiki Seto
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Japan
    AAPS J 13:482-92. 2011
    ..Combined use of in vitro photobiochemical and cassette dosing PK data will be useful for predicting in vivo phototoxic potentials of drug candidates with high productivity and reliability...
  55. doi request reprint Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: basic approaches and practical applications
    Yohei Kawabata
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 420:1-10. 2011
    ..A better understanding of the physicochemical and biopharmaceutical properties of drug substances and the limitations of each delivery option should lead to efficient formulation development for poorly water-soluble drugs...
  56. doi request reprint In vitro and in vivo characterization of new formulations of St. John's Wort extract with improved pharmacokinetics and anti-nociceptive effect
    Junya Hatanaka
    Department of Pharmacokinetics and Pharmacodynamics School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Drug Metab Pharmacokinet 26:551-8. 2011
    ..From these findings, the NE approach might be efficacious in improving the oral bioavailability and anti-nociceptive effect of SJW extract...
  57. ncbi request reprint Development of dry powder inhalation system of novel vasoactive intestinal peptide (VIP) analogue for pulmonary administration
    Yuki Ohmori
    Department of Pharmacokinetics and Pharmacodynamics and COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Life Sci 79:138-43. 2006
    ..This effect by IK312532-DPI compared with VIP-DPI lasted for a longer period. Thus, IK312532-DPI may be a pharmacologically useful drug delivery system for the VIP therapy of pulmonary diseases such as asthma...
  58. ncbi request reprint New dipyridamole salt with improved dissolution and oral bioavailability under hypochlorhydric conditions
    Chika Taniguchi
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka
    Drug Metab Pharmacokinet 28:383-90. 2013
    ..The newly developed DP/TS might provide better therapeutic efficacy in clinical use for hypochlorhydric patients...
  59. ncbi request reprint Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes
    Shingen Misaka
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Drug Metab Pharmacokinet 28:244-9. 2013
    ..1 µM, respectively. EGCG moderately inhibited CYP3A activity in a noncompetitive manner. These results suggest that green tea catechins cause clinically relevant interactions with substrates for CYP2B6 and CYP2C8 in addition to CYP3A...
  60. doi request reprint Development of cyclosporine A-loaded dry-emulsion formulation using highly purified glycerol monooleate for safe inhalation therapy
    Hideyuki Sato
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 448:282-9. 2013
    ..Thus, the strategic use of hpGMO would improve oxidative stability and local toxicity compared with a GMO-based DE formulation, and its application to RP formulation could be a promising approach for effective inhalation therapy...
  61. ncbi request reprint Analytical studies on the prediction of photosensitive/phototoxic potential of pharmaceutical substances
    Satomi Onoue
    Analytical Research and Development, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Japan Inc, 5 2 Taketoyo, Aichi, 470 2393, Japan
    Pharm Res 23:156-64. 2006
    ..In this work, we characterize the photochemical/photobiological properties of model compounds to develop an effective screening method for the prediction of phototoxic/photosensitive potential...
  62. doi request reprint In vitro photobiochemical characterization of sulfobutylether-β-cyclodextrin formulation of bufexamac
    Yoshiki Seto
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Pharm Biomed Anal 55:591-6. 2011
    ..The phototoxic risk of bufexamac might be attenuated by SBECD complexation, and cyclodextrin inclusion complexes might be a useful approach for modulating the phototoxicity of drugs...
  63. doi request reprint Development of micellar reactive oxygen species assay for photosafety evaluation of poorly water-soluble chemicals
    Yoshiki Seto
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Toxicol In Vitro 27:1838-46. 2013
    ..Considering the pros and cons of these assays, strategic combined use of the ROS and mROS assays might be efficacious for reliable photosafety assessment with high applicability and predictivity...
  64. doi request reprint Novel crystalline solid dispersion of tranilast with high photostability and improved oral bioavailability
    Yohei Kawabata
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Eur J Pharm Sci 39:256-62. 2010
    ..According to these observations, taken together with dissolution and pharmacokinetic behaviors, crystalline solid dispersion strategy would be efficacious to enhance bioavailability of TL with high photochemical stability...
  65. doi request reprint Novel vasoactive intestinal peptide derivatives with improved stability protect rat alveolar L2 cells from cigarette smoke-induced cytotoxicity and apoptosis
    Shingen Misaka
    Department of Pharmacokinetics, University of Shizuoka, Suruga ku, Shizuoka 422 8526, Japan
    Peptides 32:401-7. 2011
    ..Thus, the present study is the first to demonstrate that novel stabilized VIP derivatives exert anti-apoptotic and cytoprotective effects on CSE-induced cytotoxicity...
  66. ncbi request reprint In vitro/in vivo phototoxic risk assessments of griseofulvin based on photobiochemical and pharmacokinetic behaviors
    Yoshiki Seto
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Eur J Pharm Sci 38:104-11. 2009
    ..The combination use of photobiochemical and pharmacokinetic data would be valuable to provide reliable prediction on phototoxic risk and possible toxic pathways of new drug entities in the early stage of drug discovery...
  67. ncbi request reprint Pharmacological effects and lung-binding characteristics of a novel VIP analogue, [R15, 20, 21, L17]-VIP-GRR (IK312532)
    Yuki Ohmori
    Department of Biopharmaceutical Sciences and COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Regul Pept 123:201-7. 2004
    ..Thus, the formulation of IK312532 as DPI may be a pharmacologically useful drug delivery system for the therapy of pulmonary diseases such as asthma...
  68. ncbi request reprint High-throughput screening strategy for photogenotoxic potential of pharmaceutical substances using fluorescent intercalating dye
    Yoshiki Seto
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Pharm Biomed Anal 52:781-6. 2010
    ..These findings suggest that the IBP assay could be a fast and reliable tool for predicting the photogenotoxic potential of a large number of drug candidates at early stages of drug discovery...
  69. ncbi request reprint Green tea extract affects the cytochrome P450 3A activity and pharmacokinetics of simvastatin in rats
    Shingen Misaka
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka
    Drug Metab Pharmacokinet 28:514-8. 2013
    ..4- and 10.2-fold, respectively, compared with the control. The maximum concentrations of SIM were higher in the GTE (3.3-fold) and TAO (9.5-fold) groups. GTE alters the pharmacokinetics of SIM, probably by inhibiting intestinal CYP3A...
  70. doi request reprint Development of meloxicam salts with improved dissolution and pharmacokinetic behaviors in rats with impaired gastric motility
    Masanori Ochi
    Department of Pharmacokinetics and Pharmacodynamics School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka, 422 8526, Japan
    Pharm Res 30:377-86. 2013
    ..The present study aimed to develop salt forms to overcome these drawbacks...
  71. ncbi request reprint Solid form selection of zwitterionic 5-HT4 receptor agonist
    Takashi Kojima
    Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Japan Inc, Aichi 470 2393, Japan
    Int J Pharm 350:35-42. 2008
    ..BSA-I was quite stable at high relative humidity and provided significant improvement of physical stability compared with ZW-I...
  72. ncbi request reprint Pharmacological effects of saw palmetto extract in the lower urinary tract
    Mayumi Suzuki
    Department of Pharmacokinetics and Pharmacodynamics, Pharmacognosy and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Acta Pharmacol Sin 30:227-81. 2009
    ..This review should contribute to the understanding of the pharmacological effects of SPE in the treatment of patients with BPH and associated lower urinary tract symptoms (LUTS)...
  73. doi request reprint Evaluation of hydrate formation of a pharmaceutical solid by using diffuse reflectance infrared Fourier-transform spectroscopy
    Takashi Kojima
    Science and Technology, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Japan Inc, 5 2 Taketoyo, Aichi 470 2393, Japan
    J Pharm Biomed Anal 46:788-91. 2008
    ..These findings verify the usefulness of DRIFTS for the solid-state characterization of pharmaceutical substances, especially the monitoring of gradual hydration...
  74. ncbi request reprint Photoreactivity of amino acids: tryptophan-induced photochemical events via reactive oxygen species generation
    Naoko Igarashi
    Analytical Research and Development, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Japan Inc, Taketoyo, Aichi, Japan
    Anal Sci 23:943-8. 2007
    ..5): 18 h) and gradual color changes. In addition, photoirradiated Trp generated lipoperoxidant, a causative agent of photoirritation, and this might be associated with ROS generation...
  75. doi request reprint Photosafety assessments on pirfenidone: photochemical, photobiological, and pharmacokinetic characterization
    Yoshiki Seto
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Photochem Photobiol B 120:44-51. 2013
    ..From these findings, a high dose of orally administered PFD might cause phototoxic skin responses, possibly via a ROS-mediated photoirritant pathway...
  76. ncbi request reprint Isolation and pharmacological characterization of fatty acids from saw palmetto extract
    Masayuki Abe
    Department of Pharmacokinetics and Pharmacodynamics, and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, Suruga, Shizuoka 422 8526, Japan
    Anal Sci 25:553-7. 2009
    ..In addition, oleic and lauric acids inhibited 5alpha-reductase, possibly leading to therapeutic effects against benign prostatic hyperplasia and related lower urinary-tract symptoms...
  77. ncbi request reprint Exploratory and regulatory assessments on photosafety of new drug entities
    Yoshiki Seto
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Japan
    Curr Drug Saf 7:140-8. 2012
    ....
  78. ncbi request reprint Respirable dry powder formulation of bleomycin for developing a pulmonary fibrosis animal model
    Yosuke Aoki
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    J Pharm Sci 101:2074-81. 2012
    ..From these findings, the BLM-RP with improved stability could be a beneficial research tool for developing a pulmonary fibrosis model in drug discovery for antifibrotic drug candidates...
  79. ncbi request reprint Up-regulation of nicotinic and muscarinic receptor mRNA in rat bladder by repeated administration of nicotine in relation to the pharmacokinetics
    Noriyuki Yamamoto
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Life Sci 89:343-8. 2011
    ..The current study aimed to investigate the effects of repeated treatment with nicotine on nicotinic and muscarinic receptors in the rat bladder...
  80. doi request reprint Development of rapid and simultaneous quantitative method for green tea catechins on the bioanalytical study using UPLC/ESI-MS
    Shingen Misaka
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Biomed Chromatogr 27:1-6. 2013
    ..From these findings, taken together with the high productivity and precision, the developed method could be a reliable and reproducible tool for the evaluation of pharmacokinetic properties of catechins...
  81. ncbi request reprint Novel approach for preparation of heparins specific to factor Xa using affinity chromatography coupled with synthetic antithrombin III-related peptides
    Satomi Onoue
    Health Science Division, Itoham Foods, Inc, 1 2 1, Kubogaoka, Moriya, Ibaraki 302 0104, Japan
    Peptides 24:821-6. 2003
    ..We prepared a synthetic hAT III (123-139)-coupled affinity chromatography system, and demonstrated that this novel affinity chromatography is useful for fractionation of highly active moieties in LMW-heparins...
  82. ncbi request reprint Effect of spectroscopic properties on photostability of tamoxifen citrate polymorphs
    Takashi Kojima
    Department of Pharmaceutical Technology, Kobe Pharmaceutical University, Higashi Nada, Kobe 658 8558, Japan
    Int J Pharm 336:346-51. 2007
    ..The results obtained suggested that the photodegradation followed by surface color change of form A crystal was caused by the selective absorption of photoenergy of UVA light irradiated by a xenon lamp...
  83. ncbi request reprint Fundamental studies on electrokinetic chromatography with PEGylated phospholipid micelles
    Fumihiko Kitagawa
    Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo, Kyoto 615 8510, Japan
    Anal Sci 24:155-9. 2008
    ..The MEKC separations of anionic and cationic compounds with a DSPE-PEG-2000 micellar solution and the enantioseparation of binaphthyl compounds with mixed micelles containing bile salt are also discussed...
  84. ncbi request reprint Structure-activity relationships of receptor binding of 1,4-dihydropyridine derivatives
    Daiki Takahashi
    Biol Pharm Bull 31:473-9. 2008
    ....
  85. ncbi request reprint Electrophoretic analysis of proteins and enantiomers using capillaries modified by a successive multiple ionic-polymer layer (SMIL) coating technique
    Fumihiko Kitagawa
    Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo ku, Kyoto, 615 8510, Japan
    Anal Bioanal Chem 386:594-601. 2006
    ..Effects of the interaction between oppositely charged ionic polymer layers on the separation efficiency are discussed...
  86. ncbi request reprint Crystalline form information from multiwell plate salt screening by use of Raman microscopy
    Takashi Kojima
    Department of Pharmaceutical Technology, Kobe Pharmaceutical University, Higashi Nada, Kobe, 658 8558, Japan
    Pharm Res 23:806-12. 2006
    ..The purpose of this study was to establish a useful methodology, possibly providing information on the stoichiometry of pharmaceutical drug salts obtained from salt screening by using a multiwell plate and a Raman microscope...