Masao Omata

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Percutaneous radiofrequency ablation for hepatocellular carcinoma. An analysis of 1000 cases
    Ryosuke Tateishi
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Cancer 103:1201-9. 2005
  2. ncbi request reprint Clinical features, etiology, and survival of hepatocellular carcinoma among different countries
    Masao Omata
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine, Japan
    J Gastroenterol Hepatol 17:S40-9. 2002
  3. ncbi request reprint Prevention and treatment of hepatocellular carcinoma
    Masao Omata
    Department of Gastroenterology, University of Tokyo, Japan
    Liver Transpl 10:S111-4. 2004
  4. pmc A large-scale, multicentre, double-blind trial of ursodeoxycholic acid in patients with chronic hepatitis C
    Masao Omata
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine, Hongo 7 3 1, Bunkyo, Tokyo 113 8655, Japan
    Gut 56:1747-53. 2007
  5. ncbi request reprint Treatment of hepatocellular carcinoma by percutaneous tumor ablation methods: Ethanol injection therapy and radiofrequency ablation
    Masao Omata
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Gastroenterology 127:S159-66. 2004
  6. ncbi request reprint Progression from chronic hepatitis to hepatocellular carcinoma: natural course and treatments
    Masao Omata
    Department of Medicine II, Tokyo University Hospital, Tokyo, Japan
    J Gastroenterol Hepatol 17:S434-6. 2002
  7. ncbi request reprint Prevention of hepatocellular carcinoma and its recurrence in chronic hepatitis C patients by interferon therapy
    Masao Omata
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Clin Gastroenterol Hepatol 3:S141-3. 2005
  8. doi request reprint Gain of GRHL2 is associated with early recurrence of hepatocellular carcinoma
    Yasuo Tanaka
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    J Hepatol 49:746-57. 2008
  9. doi request reprint Apoptosis signal-regulating kinase 1 regulates colitis and colitis-associated tumorigenesis by the innate immune responses
    Yoku Hayakawa
    Department of Gastroenterology, University of Tokyo, Tokyo 113 8655, Japan
    Gastroenterology 138:1055-67.e1-4. 2010
  10. ncbi request reprint Different effects of point mutations within the B-Raf glycine-rich loop in colorectal tumors on mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase and nuclear factor kappaB pathway and cellular tra
    Tsuneo Ikenoue
    Division of Gastroenterology, The Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan
    Cancer Res 64:3428-35. 2004

Detail Information

Publications115 found, 100 shown here

  1. ncbi request reprint Percutaneous radiofrequency ablation for hepatocellular carcinoma. An analysis of 1000 cases
    Ryosuke Tateishi
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Cancer 103:1201-9. 2005
    ..Previously reported treatment efficacy and complication rates have varied considerably...
  2. ncbi request reprint Clinical features, etiology, and survival of hepatocellular carcinoma among different countries
    Masao Omata
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine, Japan
    J Gastroenterol Hepatol 17:S40-9. 2002
  3. ncbi request reprint Prevention and treatment of hepatocellular carcinoma
    Masao Omata
    Department of Gastroenterology, University of Tokyo, Japan
    Liver Transpl 10:S111-4. 2004
    ..An effective treatment of HCC should include measures to control de novo carcinogenesis...
  4. pmc A large-scale, multicentre, double-blind trial of ursodeoxycholic acid in patients with chronic hepatitis C
    Masao Omata
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine, Hongo 7 3 1, Bunkyo, Tokyo 113 8655, Japan
    Gut 56:1747-53. 2007
    ..We assessed oral ursodeoxycholic acid (UDCA) on serum biomarkers as a possible treatment for interferon non-responders...
  5. ncbi request reprint Treatment of hepatocellular carcinoma by percutaneous tumor ablation methods: Ethanol injection therapy and radiofrequency ablation
    Masao Omata
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Gastroenterology 127:S159-66. 2004
    ..We initiated a prospective controlled study to evaluate treatment with PTA and interferon. Results suggest that if the virus is eradicated, a 5-year survival rate as high as 80% can be expected...
  6. ncbi request reprint Progression from chronic hepatitis to hepatocellular carcinoma: natural course and treatments
    Masao Omata
    Department of Medicine II, Tokyo University Hospital, Tokyo, Japan
    J Gastroenterol Hepatol 17:S434-6. 2002
  7. ncbi request reprint Prevention of hepatocellular carcinoma and its recurrence in chronic hepatitis C patients by interferon therapy
    Masao Omata
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Clin Gastroenterol Hepatol 3:S141-3. 2005
    ..Further improvement in prognosis may be expected in the future because the current combination therapy of pegylated interferon and ribavirin shows higher efficiency than interferon alone...
  8. doi request reprint Gain of GRHL2 is associated with early recurrence of hepatocellular carcinoma
    Yasuo Tanaka
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    J Hepatol 49:746-57. 2008
    ..The aim of this study is to identify genomic changes that might be implicated in hepatocellular carcinoma (HCC) progression, and evaluate the associations with clinico-pathological features...
  9. doi request reprint Apoptosis signal-regulating kinase 1 regulates colitis and colitis-associated tumorigenesis by the innate immune responses
    Yoku Hayakawa
    Department of Gastroenterology, University of Tokyo, Tokyo 113 8655, Japan
    Gastroenterology 138:1055-67.e1-4. 2010
    ..Apoptosis signal-regulating kinase 1 (ASK1) is a MAPK kinase kinase; little is known about the role of ASK1 in colonic disease. We assessed the involvement of ASK1 in the development of intestinal inflammation and CAC...
  10. ncbi request reprint Different effects of point mutations within the B-Raf glycine-rich loop in colorectal tumors on mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase and nuclear factor kappaB pathway and cellular tra
    Tsuneo Ikenoue
    Division of Gastroenterology, The Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan
    Cancer Res 64:3428-35. 2004
    ..These results suggest that some of the B-Raf G loop mutations reported in colorectal tumors do not increase kinase or transforming activities but might contribute to carcinogenesis via other mechanisms or be irrelevant to carcinogenesis...
  11. doi request reprint The effect of Helicobacter pylori eradication on reducing the incidence of gastric cancer
    Keiji Ogura
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Clin Gastroenterol 42:279-83. 2008
    ..017) between the groups, but not for undifferentiated cancer (P=0.847). The results of the current study suggest that the eradication of H. pylori infection reduces the incidence of gastric cancer...
  12. pmc Identification of a suppressive mechanism for Hedgehog signaling through a novel interaction of Gli with 14-3-3
    Yoshinari Asaoka
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 285:4185-94. 2010
    ....
  13. doi request reprint Erlotinib prolongs survival in pancreatic cancer by blocking gemcitabine-induced MAPK signals
    Koji Miyabayashi
    Department of Gastroetnterology, Graduate School of Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Cancer Res 73:2221-34. 2013
    ..Overall, our findings suggest a significant role of ERBB in PDAC treatment...
  14. doi request reprint Gastric cancer risk according to the distribution of intestinal metaplasia and neutrophil infiltration
    Kosuke Sakitani
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 26:1570-5. 2011
    ..We aimed to elucidate the association between gastric cancer risk and the distribution of precancerous lesions in the stomach by histological analyses...
  15. ncbi request reprint Gene expressions associated with chemosensitivity in human hepatoma cells
    Yujin Hoshida
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Hepatogastroenterology 54:489-92. 2007
    ..Only limited patients with hepatoma benefit from chemotherapy without a clear explanation. We aimed to identify genes associated with chemosensitivity using transcriptional profiles...
  16. doi request reprint Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer
    Motoko Seto
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Mol Carcinog 48:703-12. 2009
    ..Our results suggest that the KRAS-MEK-ERK cascade has a positive regulatory role in GLI transcriptional activity in gastric cancer...
  17. ncbi request reprint TRAIL-induced cell death cooperates with IFN-gamma activation in the graft-versus-tumor effect against colon tumors
    Keisuke Tateishi
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Int J Cancer 118:2237-46. 2006
    ..The findings indicate that GVT activity against subcutaneous colon tumors is efficiently induced by preconditioning with irradiation and allogeneic DLI, and that TRAIL and IFN-gamma act cooperatively in the antitumor effect...
  18. ncbi request reprint Proteomic analysis of the TGF-beta signaling pathway in pancreatic carcinoma cells using stable RNA interference to silence Smad4 expression
    Takaaki Imamura
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 318:289-96. 2004
    ..These proteins function in processes such as cytoskeletal regulation, cell cycle, and oxidative stress. Introducing siRNA-mediated gene silencing into proteomics revealed a novel TGF-beta signal pathway that did not involve Smad4...
  19. doi request reprint Evaluation of molecular targeted cancer drug by changes in tumor marker doubling times
    Kenichiro Enooku
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 47:71-8. 2012
    ..We evaluated the usefulness of tumor marker doubling time (DT) as an efficacy indicator of a molecular targeted anticancer agent...
  20. doi request reprint Newly designed large cell Niti-S stent for malignant hilar biliary obstruction: a pilot study
    Hirofumi Kogure
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Endosc 25:463-7. 2011
    ..This study evaluated the feasibility and efficacy of the Niti-S large cell D-type biliary stent (LCD) with a uniform large cell for both uni- and bilateral drainage of malignant hilar biliary obstruction...
  21. doi request reprint Double-stranded RNA-activated protein kinase inhibits hepatitis C virus replication but may be not essential in interferon treatment
    Jin Hai Chang
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Liver Int 30:311-8. 2010
    ..Activated PKR phosphorylates the alpha subunit of eukaryotic initiation factor-2 to inhibit the translation of viral protein...
  22. doi request reprint Reduced expression of RAS protein activator like-1 in gastric cancer
    Motoko Seto
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Int J Cancer 128:1293-302. 2011
    ..Our findings demonstrate that reduced RASAL1 expression, partly due to genetic and epigenetic changes, contributes to gastric carcinogenesis, and also re-emphasize the importance of RAS signaling in gastric cancer development...
  23. doi request reprint Management of occluded uncovered metallic stents in patients with malignant distal biliary obstructions using covered metallic stents
    Osamu Togawa
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Gastroenterol 42:546-9. 2008
    ..Currently, there is no consensus on the management of occluded EMSs. We evaluated the efficacy of a covered EMS as a second endoprosthesis in patients with an occluded EMS...
  24. doi request reprint Obesity is an independent risk factor for hepatocellular carcinoma development in chronic hepatitis C patients
    Takamasa Ohki
    Department of Gastroenterology, University of Tokyo, Hongo, Tokyo, Japan
    Clin Gastroenterol Hepatol 6:459-64. 2008
    ..The aim of this study was to investigate the relationship between body weight and risk of hepatocarcinogenesis in chronic hepatitis C patients...
  25. doi request reprint Covered metallic stents in the management of malignant and benign pancreatobiliary strictures
    Hiroyuki Isayama
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Hepatobiliary Pancreat Surg 16:624-7. 2009
    ..AF is particularly important when developing CMSs because of related complications...
  26. pmc Radiofrequency ablation for hepatocellular carcinoma: 10-year outcome and prognostic factors
    Shuichiro Shiina
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Am J Gastroenterol 107:569-77; quiz 578. 2012
    ..However, there has been no report on 10-year outcome of RFA. The objective of this study was to report a 10-year consecutive case series at a tertiary referral center...
  27. ncbi request reprint Evaluation of transcatheter arterial embolization prior to percutaneous tumor ablation in patients with hepatocellular carcinoma: a randomized controlled trial
    Masatoshi Akamatsu
    Department of Gastroenterology, The University of Tokyo Hospital, Tokyo, Japan
    Liver Int 24:625-9. 2004
    ..We continued the study after the introduction of RFA and compared TAE combined with RFA (TAE/RFA) with RFA only...
  28. pmc Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2
    Hitoshi Ikeda
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Lipid Res 50:556-64. 2009
    ..Thus, S1P plays a significant role in regeneration and fibrosis after liver injury via S1P(2)...
  29. doi request reprint Ikappa B kinasebeta/nuclear factor-kappaB activation controls the development of liver metastasis by way of interleukin-6 expression
    Shin Maeda
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Hepatology 50:1851-60. 2009
    ..IL-6(-/-) mice and treatment with anti-IL-6 receptor antibody showed a lesser degree of metastatic tumor, indicating that IL-6 is associated with liver metastasis...
  30. ncbi request reprint Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma
    Ryosuke Muroyama
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Hepatol 45:805-12. 2006
    ..In this study, we investigated whether nucleotide changes in the X gene of genotype C are associated with the development of HCC...
  31. doi request reprint Effectiveness of IkappaB kinase inhibitors in murine colitis-associated tumorigenesis
    Yoku Hayakawa
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Gastroenterol 44:935-43. 2009
    ..This study investigated whether inhibitors of IKKbeta, which is a critical kinase for NF-kappaB activation, reduce colitis-associated tumorigenesis in mice...
  32. ncbi request reprint Hepatic gene expression profiles associated with fibrosis progression and hepatocarcinogenesis in hepatitis C patients
    Run Xuan Shao
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1, Hongo, Tokyo 113 8655, Japan
    World J Gastroenterol 11:1995-9. 2005
    ..To determine fibrosis progression and hepatocellular carcinoma (HCC), using simultaneous gene expression analysis...
  33. doi request reprint Prognostic factors in patients with advanced biliary tract cancer receiving chemotherapy
    Takashi Sasaki
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Cancer Chemother Pharmacol 67:847-53. 2011
    ..Gallbladder cancer and intra-hepatic cholangiocarcinoma are previously reported prognostic factors of poor prognosis; however, tumor volume has not been analyzed in these previous reports...
  34. doi request reprint Specific increase in serum autotaxin activity in patients with pancreatic cancer
    Yousuke Nakai
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Clin Biochem 44:576-81. 2011
    ..To evaluate the potential clinical significance of serum autotaxin (ATX) level in patients with cancers of the digestive system...
  35. doi request reprint Autotaxin as a novel serum marker of liver fibrosis
    Hayato Nakagawa
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Clin Chim Acta 412:1201-6. 2011
    ..Serum ATX enzymatic activity reportedly increases in parallel with liver fibrosis and exhibits a gender difference...
  36. ncbi request reprint Submucosal injection of normal saline may prevent tissue damage from argon plasma coagulation: an experimental study using resected porcine esophagus, stomach, and colon
    Mitsuhiro Fujishiro
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Surg Laparosc Endosc Percutan Tech 16:307-11. 2006
    ..05) shallower than those of the control groups that reached the deeper submucosal layer in all the organs. Submucosal injection of normal saline before the application of APC may limit tissue damage and prevent perforation and deformity...
  37. doi request reprint Impact of S-1 in patients with gemcitabine-refractory pancreatic cancer in Japan
    Yousuke Nakai
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo 113 8655, Japan
    Jpn J Clin Oncol 40:774-80. 2010
    ..We investigated the impact of S-1 on the prognosis of patients with gemcitabine-refractory pancreatic cancer...
  38. doi request reprint Hepatocellular carcinoma with extrahepatic metastasis: clinical features and prognostic factors
    Koji Uchino
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Cancer 117:4475-83. 2011
    ..The objective of this study was to further elucidate the clinical course and prognostic determinants of patients with this disease...
  39. ncbi request reprint Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner
    Bayasi Guleng
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Hongo, Japan
    Cancer Res 65:5864-71. 2005
    ....
  40. doi request reprint Potential contribution of tumor suppressor p53 in the host defense against hepatitis C virus
    Narayan Dharel
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Hepatology 47:1136-49. 2008
    ..Conclusion: These observations underscore the potential contributions of the tumor suppressor p53 in cellular antiviral immunity against HCV with possible therapeutic implications...
  41. doi request reprint Endoscopic papillary balloon dilation for the management of bile duct stones in patients 85 years of age and older
    Yukiko Ito
    Department of Gastroenterology, Japanese Red Cross Medical Center, University of Tokyo, Japan
    Gastrointest Endosc 68:477-82. 2008
    ..Endoscopic papillary balloon dilation (EPBD) is a possible alternative to endoscopic sphincterotomy for the treatment of bile duct stones. However, little information is available in the elderly...
  42. ncbi request reprint Management of late biliary complications in patients with gallbladder stones in situ after endoscopic papillary balloon dilation
    Takeshi Tsujino
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Eur J Gastroenterol Hepatol 21:466-70. 2009
    ..The aim of this study was to evaluate the outcome of late biliary complications in patients with gallbladder stones in situ after EPBD...
  43. ncbi request reprint Efficacy and safety of low-pressured and short-time dilation in endoscopic papillary balloon dilation for bile duct stone removal
    Takeshi Tsujino
    Departments of Gastroenterology, Japanese Red Cross Medical Center, Tokyo, Japan
    J Gastroenterol Hepatol 23:867-71. 2008
    ..Pancreatitis after EPBD is believed to be related to papillary damage after balloon dilation. We changed the dilation method to a theoretically less hazardous one. This modified dilation method was compared with the initial method...
  44. doi request reprint Efficacy and safety of covered self-expandable metal stents for management of distal malignant biliary obstruction due to lymph node metastases
    Kazumichi Kawakubo
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Surg Endosc 25:3094-100. 2011
    ..However, the role of covered self-expandable metal stents (SEMS) in treating MBO has not been studied. The aim of this study was to evaluate the efficacy and safety of covered SEMS for the treatment of distal MBO due to LNM...
  45. ncbi request reprint Prediction of recurrence of hepatocellular carcinoma after curative ablation using three tumor markers
    Ryosuke Tateishi
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Hepatology 44:1518-27. 2006
    ..In conclusion, tumor markers pre- and post-ablation were significant predictors for HCC recurrence and can complement imaging modalities in the evaluation of treatment efficacy...
  46. doi request reprint Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis
    Takeharu Asano
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Gastroenterol Hepatol 24:1669-76. 2009
    ..We used adiponectin KO mice fed a high fat (HF) diet, and investigated the effect of adiponectin on the progression of steatohepatitis and carcinogenesis in vivo...
  47. doi request reprint Efficacy and safety of metallic stents in patients with unresectable pancreatic cancer receiving gemcitabine
    Yousuke Nakai
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Pancreas 37:405-10. 2008
    ..Expandable metallic stents (EMSs) are widely used to palliate unresectable malignant biliary obstructions. The efficacy and safety of EMS in patients receiving gemcitabine (GEM) for unresectable pancreatic cancer is evaluated...
  48. doi request reprint S-1 monotherapy in patients with advanced biliary tract cancer
    Takashi Sasaki
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Oncology 77:71-4. 2009
    ..The aim of this study was to evaluate the efficacy and safety of single-agent S-1 in patients with advanced biliary tract cancer...
  49. ncbi request reprint Blockade of endogenous cytokines mitigates neointimal formation in obese Zucker rats
    Ryo Takeda
    Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Circulation 111:1398-406. 2005
    ..Nevertheless, the mechanisms by which diabetes mellitus is often associated with vascular diseases remain unclear...
  50. doi request reprint Assessment of liver stiffness in patients after living donor liver transplantation by transient elastography
    Ryota Masuzaki
    Department of Gastroenterology, University of Tokyo, Japan
    Scand J Gastroenterol 44:1115-20. 2009
    ..The aim of this study was to evaluate the usefulness of transient elastography for the assessment of fibrosis in patients after living donor LT...
  51. pmc Improvement of prognosis for unresectable biliary tract cancer
    Takashi Sasaki
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    World J Gastroenterol 19:72-7. 2013
    ..To evaluate the chemotherapeutic outcomes and confirm the recent improvement of prognosis for unresectable biliary tract cancer...
  52. ncbi request reprint Frequent loss of Brm expression in gastric cancer correlates with histologic features and differentiation state
    Nobutake Yamamichi
    Division of Host Parasite Interaction, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Cancer Res 67:10727-35. 2007
    ..Via regulating such genes important for gut differentiation, Brm should play significant roles in determining the histologic features of gastric malignancy...
  53. doi request reprint Multicenter phase II study of S-1 monotherapy as second-line chemotherapy for advanced biliary tract cancer refractory to gemcitabine
    Takashi Sasaki
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Invest New Drugs 30:708-13. 2012
    ..The most common non-hematological toxicities were nausea (27%), anorexia (55%), and pigmentation (32%). In conclusion, S-1 monotherapy is feasible and moderately efficacious second-line chemotherapy for advanced BTC...
  54. doi request reprint Feasibility study of gemcitabine and cisplatin combination chemotherapy for patients with refractory biliary tract cancer
    Takashi Sasaki
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Invest New Drugs 29:1488-93. 2011
    ..Two patients treated for approximately 1 year developed cisplatin-related toxicities. In conclusion, gemcitabine and cisplatin combination chemotherapy produces a limited tumor response in BTC, but may prolong patient's survival...
  55. doi request reprint Duodenal invasion is a risk factor for the early dysfunction of biliary metal stents in unresectable pancreatic cancer
    Tsuyoshi Hamada
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Gastrointest Endosc 74:548-55. 2011
    ..Although the placement of self-expandable metal stents (SEMSs) has been widely accepted as palliation for distal malignant biliary obstruction, the risk factors for their early dysfunction remain unclear...
  56. ncbi request reprint Stimulation by glutamine and proline of HGF production in hepatic stellate cells
    Takako Nishikawa
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 363:978-82. 2007
    ..Glutamine and proline may have the potential to stimulate HGF production but the mechanism underlying this stimulation seems not to be through the mTOR-dependent signaling pathway...
  57. doi request reprint Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation
    Hayato Nakagawa
    Department of Gastroenterology, University of Tokyo, Hongo, Bunkyo ku, Tokyo
    Gastroenterology 135:1311-21. 2008
    ..We tested the hypothesis that ASK1 was involved in APAP-induced JNK activation and liver injury...
  58. ncbi request reprint Assessment of the risk factors for colonic diverticular hemorrhage
    Atsuo Yamada
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Dis Colon Rectum 51:116-20. 2008
    ..Studies about risk factors, other than nonsteroidal anti-inflammatory drugs, for colonic diverticular hemorrhage are limited. We conducted the present study to elucidate their significance as a risk factor...
  59. doi request reprint Down-regulation of hedgehog-interacting protein through genetic and epigenetic alterations in human hepatocellular carcinoma
    Motohisa Tada
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Clin Cancer Res 14:3768-76. 2008
    ..However, the mechanisms of Hh signaling activation in hepatocellular carcinoma (HCC) have not been fully elucidated. We analyzed the involvement of Hh-interacting protein (HHIP) gene, a negative regulator of Hh signaling, in HCC...
  60. ncbi request reprint Acyclic retinoid inhibits human hepatoma cell growth by suppressing fibroblast growth factor-mediated signaling pathways
    Run Xuan Shao
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Gastroenterology 128:86-95. 2005
    ..In this study, we clarified the molecular targets of ACR...
  61. ncbi request reprint Neither hepatitis C virus genotype nor virus load affects survival of patients with hepatocellular carcinoma
    Masatoshi Akamatsu
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Eur J Gastroenterol Hepatol 16:459-66. 2004
    ..This study was conducted to elucidate whether these two factors are capable of predicting the prognosis of patients with HCC...
  62. ncbi request reprint Relevance network between chemosensitivity and transcriptome in human hepatoma cells
    Masaru Moriyama
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Mol Cancer Ther 2:199-205. 2003
    ..Our results suggested the necessity of systematically evaluating the transporting systems that may play a major role in resistance in hepatoma. This may provide useful information to modify anticancer drug action in hepatoma...
  63. ncbi request reprint Synergistic activation of the serum response element-dependent pathway by hepatitis B virus x protein and large-isoform hepatitis delta antigen
    Tadashi Goto
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Infect Dis 187:820-8. 2003
    ..Thus, HBx and LHDAg synergistically activated the SRE-dependent pathway. These results may help us understand clinical phenomena in patients coinfected with HBV and HDV...
  64. ncbi request reprint Functional analysis of PIK3CA gene mutations in human colorectal cancer
    Tsuneo Ikenoue
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo Hospital, Bunkyo ku, Japan
    Cancer Res 65:4562-7. 2005
    ..These results show that almost all the colon cancer-associated PIK3CA mutations are functionally active so that they are likely to be involved in carcinogenesis...
  65. ncbi request reprint A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma
    Shuichiro Shiina
    Department of Gastroenterology, University of Tokyo, Japan
    Gastroenterology 129:122-30. 2005
    ..Percutaneous radiofrequency ablation is a recently introduced treatment for hepatocellular carcinoma, whereas ethanol injection is now a standard therapy. We compared their long-term outcomes...
  66. doi request reprint Macroscopic morphologic subtypes of laterally spreading colorectal tumors showing distinct molecular alterations
    Takafumi Sugimoto
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Int J Cancer 127:1562-9. 2010
    ..05, 95% CI 1.11-14.8). Our data revealed that the 2 subtypes of LST have different molecular characteristics, suggesting that 2 or more different molecular mechanisms result in colorectal tumors with a similar growth pattern...
  67. ncbi request reprint p53-Independent negative regulation of p21/cyclin-dependent kinase-interacting protein 1 by the sonic hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma cells
    Miki Ohta
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Hongo, Japan
    Cancer Res 65:10822-9. 2005
    ....
  68. doi request reprint Constitutive NF-kappaB activation in colorectal carcinoma plays a key role in angiogenesis, promoting tumor growth
    Kei Sakamoto
    Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan
    Clin Cancer Res 15:2248-58. 2009
    ..Constitutive NF-kappaB activation has been noted in many tumors, including colorectal cancers. However, the precise role of this activation in colorectal cancer is unclear...
  69. ncbi request reprint UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma in japanese patients with hepatitis C virus infection
    Yue Wang
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Clin Cancer Res 10:2441-6. 2004
    ..In this study, we evaluated the association of both genes with the risk of HCC in Japanese HCV-infected patients...
  70. ncbi request reprint Involvement of the biliary system in autoimmune pancreatitis: a follow-up study
    Kenji Hirano
    Department of Gastroenterology, University of Tokyo, Japan
    Clin Gastroenterol Hepatol 1:453-64. 2003
    ..The aim of this study was to define the bile duct changes associated with autoimmune pancreatitis...
  71. doi request reprint NOTES and endoscopic pancreatic necrosectomy for the GI endoscopist
    Hiroyuki Isayama
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Hepatobiliary Pancreat Surg 16:270-3. 2009
    ..We believe that endoscopic necrosectomy and NOTES represent a major shift in the treatment paradigm because physicians can treat beyond the gastrointestinal wall and endoscopic procedures will replace surgical treatment...
  72. ncbi request reprint [Cost-effectiveness of antiviral therapy for chronic hepatitis C patients in prevention of hepatocellular cancer ]
    Haruhiko Yoshida
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine
    Nihon Rinsho 62:511-4. 2004
  73. doi request reprint Hepatocellular carcinoma in viral hepatitis: improving standard therapy
    Ryota Masuzaki
    Department of Gastroenterology, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Best Pract Res Clin Gastroenterol 22:1137-51. 2008
    ..Prevention of HCC recurrence, or tertiary prevention, is one of the most challenging tasks in current hepatology...
  74. ncbi request reprint Interferon therapy after tumor ablation improves prognosis in patients with hepatocellular carcinoma associated with hepatitis C virus
    Yasushi Shiratori
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113, Japan
    Ann Intern Med 138:299-306. 2003
    ..Even after the surgical or medical treatment of hepatocellular carcinoma, tumors frequently develop at new foci, leading to a poor prognosis...
  75. ncbi request reprint [NF-kappaB and MAPK-signaling pathways contribute to the gene expression and host response induced by Helicobacter pylori infection]
    Wataru Shibata
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo
    Nihon Rinsho 63:132-7. 2005
  76. ncbi request reprint [Multicenter study on the inhibition of hepatocarcinogenesis by interferon therapy (IHIT)]
    Haruhiko Yoshida
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine
    Nihon Rinsho 62:463-6. 2004
  77. ncbi request reprint The Brm gene suppressed at the post-transcriptional level in various human cell lines is inducible by transient HDAC inhibitor treatment, which exhibits antioncogenic potential
    Nobutake Yamamichi
    Department of Microbiology and Immunology, Division of Host Parasite Interaction, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Oncogene 24:5471-81. 2005
    ....
  78. ncbi request reprint Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C
    Naoko Watanabe
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Clin Gastroenterol 41:616-23. 2007
    ..Autotaxin (ATX), originally purified as an autocrine motility factor for melanoma cells, was revealed to be a key enzyme in LPA synthesis. We determined LPA and ATX levels in the blood of patients with liver disease...
  79. ncbi request reprint Hepatitis C virus core protein upregulates transforming growth factor-beta 1 transcription
    Hiroyoshi Taniguchi
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Med Virol 72:52-9. 2004
    ....
  80. ncbi request reprint Identification of genes associated with sensitivity to 5-fluorouracil and cisplatin in hepatoma cells
    Yujin Hoshida
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 37:92-5. 2002
    ..In this study, we aimed to identify genes associated with sensitivity to 5-fluorouracil and cisplatin, drugs widely used in treatment, using gene expression profiles...
  81. doi request reprint Efficacy and safety of entecavir in lamivudine-refractory patients with chronic hepatitis B: randomized controlled trial in Japanese patients
    Fumitaka Suzuki
    Department of Hepatology, Toranomon Hospital, Tokyo, Japan
    J Gastroenterol Hepatol 23:1320-6. 2008
    ..We conducted a randomized, double-blind, multicenter study in Japan (ETV-052) evaluating the efficacy and safety of two doses of entecavir in adult patients with lamivudine-refractory chronic hepatitis B infection...
  82. ncbi request reprint [Progression and risk factors for hepatocarcinogenesis in hepatitis C-related cirrhosis--viral factors, host factors, and others]
    Yujin Hoshida
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo
    Nihon Rinsho 62:596-9. 2004
  83. ncbi request reprint Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses
    Motoyuki Otsuka
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Japan
    Hepatology 41:1004-12. 2005
    ..In conclusion, these results suggest the mechanisms of the inhibition of the innate immune responses of HCV infection by NS3 protein...
  84. pmc Inhibitor of kappaB kinase beta regulates gastric carcinogenesis via interleukin-1alpha expression
    Kei Sakamoto
    Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan
    Gastroenterology 139:226-38.e6. 2010
    ..Nuclear factor-kappaB (NF-kappaB) is an important transcription factor involved in various biological processes, including carcinogenesis. However, it is unknown whether NF-kappaB activation is involved in gastric carcinogenesis...
  85. ncbi request reprint [Effectiveness of long-acting interferon (peginterferon)]
    Yuji Kondo
    Department of Gastroenterology, University of Tokyo
    Nihon Rinsho 62:515-8. 2004
  86. ncbi request reprint Analysis of the beta-catenin/T cell factor signaling pathway in 36 gastrointestinal and liver cancer cells
    Tsuneo Ikenoue
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Jpn J Cancer Res 93:1213-20. 2002
    ..The presence of signaling-upregulated gastric cancer cell lines with intact APC and beta-catenin suggests the involvement of other mechanisms than mutations of APC or beta-catenin...
  87. ncbi request reprint Calcineurin promotes the expression of monocyte chemoattractant protein-1 in vascular myocytes and mediates vascular inflammation
    Hiroshi Satonaka
    Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Circ Res 94:693-700. 2004
    ..These results suggested that calcineurin mediates vascular inflammation via stimulation of MCP-1 expression in VSMCs and macrophage infiltration...
  88. ncbi request reprint [Mechanisms and significance of apoptosis suppression by HCV core protein]
    Motoyuki Otsuka
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo
    Nihon Rinsho 62:185-90. 2004
  89. doi request reprint Interferon reduces the risk of hepatocellular carcinoma in hepatitis C virus-related chronic hepatitis/liver cirrhosis
    Ryota Masuzaki
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Oncology 78:17-23. 2010
    ..The prevention of the recurrence of HCC, or tertiary prevention, is currently one of the most challenging tasks in hepatology...
  90. ncbi request reprint Interaction of the hepatitis B virus X protein (HBx) with heat shock protein 60 enhances HBx-mediated apoptosis
    Yasuo Tanaka
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 318:461-9. 2004
    ..These findings suggest the importance of the molecular chaperon protein Hsp60 to the function of HBV viral proteins...
  91. ncbi request reprint Factors affecting the prognosis of patients with hepatocellular carcinoma invading the portal vein--a retrospective analysis using 952 consecutive HCC patients
    Yukihiro Koike
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Hepatogastroenterology 50:2035-9. 2003
    ..Hepatocellular carcinoma with portal venous invasion has a very poor prognosis. The aim of this study is to clarify the factors contributing to the survival of hepatocellular carcinoma patients with portal venous invasion...
  92. ncbi request reprint A novel mitochondrial Ca2+-dependent solute carrier in the liver identified by mRNA differential display
    Hirosato Mashima
    Department of Gastroenterology, University of Tokyo School of Medicine, Tokyo 113 8655, Japan
    J Biol Chem 278:9520-7. 2003
    ..Taken together, MCSC may play an important role in regulating the function of hepatocytes rather than in differentiation in vivo...
  93. ncbi request reprint Genes associated with human hepatocellular carcinoma cell chemosensitivity to 5-fluorouracil plus interferon-alpha combination chemotherapy
    Masaru Moriyama
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Oncol 25:1279-87. 2004
    ..We also selected genes that play key roles in the synergistic effect of this combination therapy. These gene sets should prove useful in evaluations of the efficacy and underlying molecular mechanisms of this combination therapy...
  94. ncbi request reprint Smad4 silencing in pancreatic cancer cell lines using stable RNA interference and gene expression profiles induced by transforming growth factor-beta
    Amarsanaa Jazag
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Oncogene 24:662-71. 2005
    ..The knock down of a specific gene using stable RNAi appears to be a promising tool for analysing endogenous gene function...
  95. ncbi request reprint Prospective cohort study of transarterial chemoembolization for unresectable hepatocellular carcinoma in 8510 patients
    Kenichi Takayasu
    Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan
    Gastroenterology 131:461-9. 2006
    ..To elucidate the survival of the patients with unresectable hepatocellular carcinoma (HCC) who underwent transcatheter arterial lipiodol chemoembolization (TACE) and to analyze the factors affecting the survivals...
  96. ncbi request reprint Clinical relevance of Helicobacter pylori sabA genotype in Japanese clinical isolates
    Ayako Yanai
    Division of Gastroenterology, The Institute for Adult Diseases, Asahi Life Foundation, Chiyoda ku, Tokyo, Japan
    J Gastroenterol Hepatol 22:2228-32. 2007
    ..The aim of this study was to assess the relationship between the status of H. pylori sialic acid-binding adhesin (sabA) and the severity of gastric inflammation and diseases...
  97. doi request reprint Diagnostic utility of biopsy specimens for autoimmune pancreatitis
    Kenji Hirano
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Gastroenterol 44:765-73. 2009
    ..However, it is undetermined whether needle or forceps biopsy of pancreas or other organs is indeed useful for the diagnosis of AIP. We aimed to clarify this point...
  98. ncbi request reprint Helicobacter pylori activates NF-kappaB via the alternative pathway in B lymphocytes
    Tomoya Ohmae
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Hongo, Tokyo, Japan
    J Immunol 175:7162-9. 2005
    ..The effects on chemokine production and antiapoptosis mediated by H. pylori-induced processing of NF-kappaB2/p100 to p52 may drive lymphocytes to acquire malignant potential...
  99. ncbi request reprint NF-kappaB and ERK-signaling pathways contribute to the gene expression induced by cag PAI-positive-Helicobacter pylori infection
    Wataru Shibata
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    World J Gastroenterol 11:6134-43. 2005
    ....
  100. doi request reprint Intraductal US in the assessment of tumor involvement to the orifice of the cystic duct by malignant biliary obstruction
    Yousuke Nakai
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Gastrointest Endosc 68:78-83. 2008
    ..Tumor involvement to the orifice of the cystic duct (OCD) is a risk factor for cholecystitis after metallic stent (MS) placement...
  101. doi request reprint c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice
    Wataru Shibata
    Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, Chiyoda ku, Tokyo, Japan
    Cancer Res 68:5031-9. 2008
    ..Taken together, JNK seems to be involved in both tumor initiation and promotion and may be an attractive target for the prevention of gastric carcinogenesis...