H Okuno

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. doi request reprint Regulation and function of immediate-early genes in the brain: beyond neuronal activity markers
    Hiroyuki Okuno
    Department of Neurochemistry, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Neurosci Res 69:175-86. 2011
  2. doi request reprint Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKII╬▓
    Hiroyuki Okuno
    Department of Neurochemistry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Japan
    Cell 149:886-98. 2012
  3. ncbi request reprint [Synaptic activity-dependent regulation of neuronal gene expression]
    Hiroyuki Okuno
    Tanpakushitsu Kakusan Koso 49:411-8. 2004
  4. ncbi request reprint Quantitative evaluation of neurotrophin and trk mRNA expression in visual and limbic areas along the occipito-temporo-hippocampal pathway in adult macaque monkeys
    H Okuno
    Department of Physiology, University of Tokyo School of Medicine, Hongo, Japan
    J Comp Neurol 408:378-98. 1999
  5. ncbi request reprint Highest trkB mRNA expression in the entorhinal cortex among hippocampal subregions in the adult rat: contrasting pattern with BDNF mRNA expression
    W Tokuyama
    Department of Physiology, University of Tokyo School of Medicine, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Brain Res Mol Brain Res 62:206-15. 1998
  6. ncbi request reprint Expression of the transcription factor Zif268 in the temporal cortex of monkeys during visual paired associate learning
    H Okuno
    Department of Physiology, University of Tokyo School of Medicine, Japan
    Eur J Neurosci 8:2118-28. 1996
  7. ncbi request reprint Subdivision-specific expression of ZIF268 in the hippocampal formation of the macaque monkey
    H Okuno
    Department of Physiology, University of Tokyo School of Medicine, Japan
    Neuroscience 66:829-45. 1995
  8. ncbi request reprint Layer-specific differential regulation of transcription factors Zif268 and Jun-D in visual cortex V1 and V2 of macaque monkeys
    H Okuno
    Department of Physiology, University of Tokyo School of Medicine, Japan
    Neuroscience 81:653-66. 1997
  9. ncbi request reprint Quantification of neurotrophin-3 mRNA in the rat hippocampal subregions using the RT-PCR-based coamplification method
    W Tokuyama
    Department of Physiology, University of Tokyo School of Medicine, Hongo 7 3 1, Bunkyo ku, Tokyo, Japan
    Brain Res Brain Res Protoc 4:407-14. 1999
  10. pmc Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons
    Takashi Kawashima
    Department of Neurochemistry, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 106:316-21. 2009

Collaborators

Detail Information

Publications14

  1. doi request reprint Regulation and function of immediate-early genes in the brain: beyond neuronal activity markers
    Hiroyuki Okuno
    Department of Neurochemistry, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Neurosci Res 69:175-86. 2011
    ..1. This review provides a conceptual framework in which various immediate-early genes underlie several distinct processes required for long-term synaptic changes and memory formation...
  2. doi request reprint Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKII╬▓
    Hiroyuki Okuno
    Department of Neurochemistry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Japan
    Cell 149:886-98. 2012
    ....
  3. ncbi request reprint [Synaptic activity-dependent regulation of neuronal gene expression]
    Hiroyuki Okuno
    Tanpakushitsu Kakusan Koso 49:411-8. 2004
  4. ncbi request reprint Quantitative evaluation of neurotrophin and trk mRNA expression in visual and limbic areas along the occipito-temporo-hippocampal pathway in adult macaque monkeys
    H Okuno
    Department of Physiology, University of Tokyo School of Medicine, Hongo, Japan
    J Comp Neurol 408:378-98. 1999
    ....
  5. ncbi request reprint Highest trkB mRNA expression in the entorhinal cortex among hippocampal subregions in the adult rat: contrasting pattern with BDNF mRNA expression
    W Tokuyama
    Department of Physiology, University of Tokyo School of Medicine, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Brain Res Mol Brain Res 62:206-15. 1998
    ..These results suggest regional differences in BDNF/TrkB signaling for maintenance and modifiability of neuronal connections in the hippocampal formation...
  6. ncbi request reprint Expression of the transcription factor Zif268 in the temporal cortex of monkeys during visual paired associate learning
    H Okuno
    Department of Physiology, University of Tokyo School of Medicine, Japan
    Eur J Neurosci 8:2118-28. 1996
    ..These results suggest that Zif268 activates a gene cascade related to the formation of long-term memory in the primate...
  7. ncbi request reprint Subdivision-specific expression of ZIF268 in the hippocampal formation of the macaque monkey
    H Okuno
    Department of Physiology, University of Tokyo School of Medicine, Japan
    Neuroscience 66:829-45. 1995
    ..These subdivision-specific patterns of Zif268 expression may reflect differences in synaptic activities in these regions...
  8. ncbi request reprint Layer-specific differential regulation of transcription factors Zif268 and Jun-D in visual cortex V1 and V2 of macaque monkeys
    H Okuno
    Department of Physiology, University of Tokyo School of Medicine, Japan
    Neuroscience 81:653-66. 1997
    ....
  9. ncbi request reprint Quantification of neurotrophin-3 mRNA in the rat hippocampal subregions using the RT-PCR-based coamplification method
    W Tokuyama
    Department of Physiology, University of Tokyo School of Medicine, Hongo 7 3 1, Bunkyo ku, Tokyo, Japan
    Brain Res Brain Res Protoc 4:407-14. 1999
    ..Our method can serve as a useful quantification method to investigate molecular signaling cascades in a specific cortical region...
  10. pmc Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons
    Takashi Kawashima
    Department of Neurochemistry, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 106:316-21. 2009
    ..Taken together, our work uncovers a novel transcriptional mechanism by which a critical 100-bp element, SARE, mediates a predominant component of the synapse-to-nucleus signaling in ensembles of Arc/Arg-3.1-positive activated neurons...
  11. ncbi request reprint Selective zif268 mRNA induction in the perirhinal cortex of macaque monkeys during formation of visual pair-association memory
    Wataru Tokuyama
    Department of Physiology, University of Tokyo School of Medicine, Japan
    J Neurochem 81:60-70. 2002
    ....
  12. ncbi request reprint Regulation of dendritogenesis via a lipid-raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIgamma
    Sayaka Takemoto-Kimura
    Department of Neurochemistry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Neuron 54:755-70. 2007
    ..Thus, CL3 may represent a key element in the Ca(2+)-dependent and lipid-raft-delineated switch that turns on extrinsic activity-regulated dendrite formation in developing cortical neurons...
  13. ncbi request reprint Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV
    Shogo Ohmae
    Department of Pharmacology, Kyoto University Faculty of Medicine, Yoshida Konoecho, Sakyo ku, Kyoto 606 8315, Japan
    J Biol Chem 281:20427-39. 2006
    ....
  14. pmc Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking
    Shoaib Chowdhury
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 52:445-59. 2006
    ..These findings reveal a novel molecular pathway that is regulated by Arc/Arg3.1 and likely contributes to late-phase synaptic plasticity and memory consolidation...