Manabu Okumura

Summary

Affiliation: University of Miyazaki
Country: Japan

Publications

  1. doi request reprint Hepatocyte growth factor suppresses the anticancer effect of irinotecan by decreasing the level of active metabolite in HepG2 cells
    Manabu Okumura
    Department of Pharmacy, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake cho, Miyazaki 889 1692, Japan
    Biochem Pharmacol 82:1720-30. 2011
  2. ncbi request reprint Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats
    Muneaki Hidaka
    Department of Pharmacy, Miyazaki Medical College Hospital, Kiyotake cho, Miyazaki gun, Japan
    Drug Metab Dispos 33:644-8. 2005
  3. ncbi request reprint Transient inhibition of cyp3a in rats by star fruit juice
    Muneaki Hidaka
    Department of Pharmacy, Miyazaki Medical College Hospital, 5200 Kihara, Kiyotake cho, Miyazaki gun, 889 1692, Japan
    Drug Metab Dispos 34:343-5. 2006
  4. ncbi request reprint Adsorption of irinotecan onto oral adsorbent AST-120 (Kremezin) for preventing delayed diarrhea
    Muneaki Hidaka
    Department of Pharmacy, Miyazaki Medical College Hospital, 5200 Kihara, Kiyotake cho, Miyazaki gun, Miyazaki, 889 1692, Japan
    Cancer Chemother Pharmacol 59:321-8. 2007
  5. ncbi request reprint Potent inhibition by star fruit of human cytochrome P450 3A (CYP3A) activity
    Muneaki Hidaka
    Department of Pharmacy, Miyazaki Medical College Hospital, 5200 Kihara, Kiyotake cho, Miyazaki gun, 889 1692, Japan
    Drug Metab Dispos 32:581-3. 2004
  6. ncbi request reprint Hepatocyte growth factor increases uptake of estradiol 17beta-D-glucuronide and Oatp1 protein level in rat hepatocytes
    Tomomi Iwakiri
    Department of Pharmacy, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Miyazaki 889 1692, Japan
    Eur J Pharmacol 580:19-26. 2008
  7. ncbi request reprint Caffeine increases the antitumor effect of Cisplatin in human hepatocellular carcinoma cells
    Yohei Kawano
    Department of Pharmacy, University of Miyazaki Hospital, Kiyotake cho, Miyazaki, Japan
    Biol Pharm Bull 35:400-7. 2012
  8. doi request reprint Hepatic fibrosis does not affect the pharmacokinetics of 5-fluorouracil in rats
    Masashi Nagata
    Department of Pharmacy, University of Miyazaki Hospital, and Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake cho, Miyazaki 889 1692, Japan
    Biopharm Drug Dispos 32:126-30. 2011
  9. doi request reprint Effect of acute hepatic failure on the hepatic first-pass effect of 5-fluorouracil in rats
    Masashi Nagata
    Department of Pharmacy, University of Miyazaki Hospital, Kiyotake cho, Miyazaki
    J Pharm Pharmacol 62:598-603. 2010
  10. ncbi request reprint Inhibition of carrier-mediated uptake of epirubicin reduces cytotoxicity in primary culture of rat hepatocytes
    Tomomi Iwakiri
    Department of Pharmacy, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake cho, Miyazaki 889 1692, Japan
    J Appl Toxicol 28:329-36. 2008

Collaborators

Detail Information

Publications13

  1. doi request reprint Hepatocyte growth factor suppresses the anticancer effect of irinotecan by decreasing the level of active metabolite in HepG2 cells
    Manabu Okumura
    Department of Pharmacy, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake cho, Miyazaki 889 1692, Japan
    Biochem Pharmacol 82:1720-30. 2011
    ..Additional treatment using c-Met and/or EGFR inhibitors could be a novel strategy to overcome resistance...
  2. ncbi request reprint Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats
    Muneaki Hidaka
    Department of Pharmacy, Miyazaki Medical College Hospital, Kiyotake cho, Miyazaki gun, Japan
    Drug Metab Dispos 33:644-8. 2005
    ..Thus, we discovered that a component(s) of pomegranate inhibits the human CYP3A-mediated metabolism of carbamazepine. Furthermore, pomegranate juice alters the carbamazepine pharmacokinetics in rats...
  3. ncbi request reprint Transient inhibition of cyp3a in rats by star fruit juice
    Muneaki Hidaka
    Department of Pharmacy, Miyazaki Medical College Hospital, 5200 Kihara, Kiyotake cho, Miyazaki gun, 889 1692, Japan
    Drug Metab Dispos 34:343-5. 2006
    ..These data suggest that the effect of star fruit juice is mainly reversible and transient. Thus, we discovered that star fruit juice alters the carbamazepine pharmacokinetics in rats...
  4. ncbi request reprint Adsorption of irinotecan onto oral adsorbent AST-120 (Kremezin) for preventing delayed diarrhea
    Muneaki Hidaka
    Department of Pharmacy, Miyazaki Medical College Hospital, 5200 Kihara, Kiyotake cho, Miyazaki gun, Miyazaki, 889 1692, Japan
    Cancer Chemother Pharmacol 59:321-8. 2007
    ..To evaluate whether Kremezin can prevent the diarrhea induced by CPT-11, we investigated the adsorption characteristics of CPT-11 and its metabolites onto Kremezin in vitro and in vivo...
  5. ncbi request reprint Potent inhibition by star fruit of human cytochrome P450 3A (CYP3A) activity
    Muneaki Hidaka
    Department of Pharmacy, Miyazaki Medical College Hospital, 5200 Kihara, Kiyotake cho, Miyazaki gun, 889 1692, Japan
    Drug Metab Dispos 32:581-3. 2004
    ..Thus, we discovered filtered extracts of star fruit juice to be inhibitors of human CYP3A activity in vitro...
  6. ncbi request reprint Hepatocyte growth factor increases uptake of estradiol 17beta-D-glucuronide and Oatp1 protein level in rat hepatocytes
    Tomomi Iwakiri
    Department of Pharmacy, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Miyazaki 889 1692, Japan
    Eur J Pharmacol 580:19-26. 2008
    ....
  7. ncbi request reprint Caffeine increases the antitumor effect of Cisplatin in human hepatocellular carcinoma cells
    Yohei Kawano
    Department of Pharmacy, University of Miyazaki Hospital, Kiyotake cho, Miyazaki, Japan
    Biol Pharm Bull 35:400-7. 2012
    ..Moreover, this effect was dependent on the amount of exposure to caffeine. These results suggest that caffeine-assisted chemotherapy is useful for HCC treatment...
  8. doi request reprint Hepatic fibrosis does not affect the pharmacokinetics of 5-fluorouracil in rats
    Masashi Nagata
    Department of Pharmacy, University of Miyazaki Hospital, and Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake cho, Miyazaki 889 1692, Japan
    Biopharm Drug Dispos 32:126-30. 2011
    ..In conclusion, the pharmacokinetics of 5-FU is not affected by hepatic fibrosis, unlike that of many hepatically metabolized drugs...
  9. doi request reprint Effect of acute hepatic failure on the hepatic first-pass effect of 5-fluorouracil in rats
    Masashi Nagata
    Department of Pharmacy, University of Miyazaki Hospital, Kiyotake cho, Miyazaki
    J Pharm Pharmacol 62:598-603. 2010
    ..In this study, we have investigated the effect of acute hepatic failure on the first-pass effect of 5-fluorouracil in rats...
  10. ncbi request reprint Inhibition of carrier-mediated uptake of epirubicin reduces cytotoxicity in primary culture of rat hepatocytes
    Tomomi Iwakiri
    Department of Pharmacy, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake cho, Miyazaki 889 1692, Japan
    J Appl Toxicol 28:329-36. 2008
    ....
  11. ncbi request reprint Inhibitory effects of amino-acid fluids on drug binding to site II of human serum albumin in vitro
    Keishi Yamasaki
    Department of Pharmacy, Miyazaki Medical College Hospital, Kihara, Miyazaki gun, Japan
    Biol Pharm Bull 28:549-52. 2005
    ..Based on the comparison between the effects of amino-acid fluids and L-tryptophan solutions, we confirmed that L-tryptophan in amino-acid fluids specifically inhibits drug binding to site II of HSA...
  12. ncbi request reprint Inhibitory effects of citrus fruits on cytochrome P450 3A (CYP3A) activity in humans
    Ken ichi Fujita
    Department of Pharmacy, Miyazaki Medical College Hospital, Miyazaki gun, Japan
    Biol Pharm Bull 26:1371-3. 2003
    ..Thus, we discovered ingredients of banpeiyu to be inhibitor(s) or mechanism-based inhibitor(s) of human CYP3A activity, but the inhibitory effects of them were somewhat lower than those of grapefruit...
  13. ncbi request reprint Effect of P-glycoprotein modulator, cyclosporin A, on the gastrointestinal excretion of irinotecan and its metabolite SN-38 in rats
    Kazuhiko Arimori
    Department of Pharmacy, Miyazaki Medical College, 5200 Kihara, Kiyotake cho, Miyazaki gun, Miyazaki 889 1692, Japan
    Pharm Res 20:910-7. 2003
    ..Cyclosporin A (CsA) was used to modulate P-gp and cMOAT/MRP2...