H Okazawa

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc Sox2 transcriptionally regulates PQBP1, an intellectual disability-microcephaly causative gene, in neural stem progenitor cells
    Chan Li
    Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    PLoS ONE 8:e68627. 2013
  2. pmc Ku70 alleviates neurodegeneration in Drosophila models of Huntington's disease
    Takuya Tamura
    Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 6:e27408. 2011
  3. pmc Dynamic changes of the phosphoproteome in postmortem mouse brains
    Tsutomu Oka
    Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 6:e21405. 2011
  4. pmc Mutant huntingtin impairs Ku70-mediated DNA repair
    Yasushi Enokido
    Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    J Cell Biol 189:425-43. 2010
  5. pmc Glial cell lineage expression of mutant ataxin-1 and huntingtin induces developmental and late-onset neuronal pathologies in Drosophila models
    Takuya Tamura
    Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 4:e4262. 2009
  6. pmc Nematode homologue of PQBP1, a mental retardation causative gene, is involved in lipid metabolism
    Keiko Takahashi
    Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 4:e4104. 2009
  7. pmc Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73
    Masataka Hoshino
    Department of Neuropathology, Medical Research Institute and Center of Excellence Program for Brain Integration and Its Disorders, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    J Cell Biol 172:589-604. 2006
  8. ncbi request reprint PQBP-1 (Np/PQ): a polyglutamine tract-binding and nuclear inclusion-forming protein
    H Okazawa
    Department of Neurology, University of Tokyo, Tokyo, Japan
    Brain Res Bull 56:273-80. 2001
  9. ncbi request reprint PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival
    M Waragai
    Group of Molecular Neurobiology, Department of Neurology, Graduate School of Medicine, University of Tokyo, Japan
    Hum Mol Genet 8:977-87. 1999
  10. ncbi request reprint PQBP-1/Npw38, a nuclear protein binding to the polyglutamine tract, interacts with U5-15kD/dim1p via the carboxyl-terminal domain
    M Waragai
    Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Biochem Biophys Res Commun 273:592-5. 2000

Collaborators

Detail Information

Publications14

  1. pmc Sox2 transcriptionally regulates PQBP1, an intellectual disability-microcephaly causative gene, in neural stem progenitor cells
    Chan Li
    Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    PLoS ONE 8:e68627. 2013
    ..Collectively, these results indicated that Sox2 regulated the transcription of PQBP1 in NSPCs. ..
  2. pmc Ku70 alleviates neurodegeneration in Drosophila models of Huntington's disease
    Takuya Tamura
    Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 6:e27408. 2011
    ..These results collectively support that Ku70 is a critical mediator of the HD pathology and a candidate therapeutic target in HD...
  3. pmc Dynamic changes of the phosphoproteome in postmortem mouse brains
    Tsutomu Oka
    Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 6:e21405. 2011
    ..The information obtained in this study will be indispensable for evaluating experimental data with human as well as mouse brain samples...
  4. pmc Mutant huntingtin impairs Ku70-mediated DNA repair
    Yasushi Enokido
    Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    J Cell Biol 189:425-43. 2010
    ..Expression of exogenous Ku70 rescues abnormal behavior and pathological phenotypes in the R6/2 mouse model of Huntington's disease (HD). These results collectively suggest that Ku70 is a critical regulator of DNA damage in HD pathology...
  5. pmc Glial cell lineage expression of mutant ataxin-1 and huntingtin induces developmental and late-onset neuronal pathologies in Drosophila models
    Takuya Tamura
    Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 4:e4262. 2009
    ..However the generality of the non-cell autonomous pathologies derived from glial cells has not been established, and the specificity among different neurodegenerative disorders remains unknown...
  6. pmc Nematode homologue of PQBP1, a mental retardation causative gene, is involved in lipid metabolism
    Keiko Takahashi
    Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 4:e4104. 2009
    ..PQBP1 is a causative gene for X-linked mental retardation (MR) whose patients frequently show lean body. C. elegans has a strictly conserved homologue gene of PQBP1, T21D12.3...
  7. pmc Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73
    Masataka Hoshino
    Department of Neuropathology, Medical Research Institute and Center of Excellence Program for Brain Integration and Its Disorders, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    J Cell Biol 172:589-604. 2006
    ..Collectively, transcriptional repression induces a novel prototype of neuronal death associated with the changes of YAP isoforms and p73, which might be relevant to the HD pathology...
  8. ncbi request reprint PQBP-1 (Np/PQ): a polyglutamine tract-binding and nuclear inclusion-forming protein
    H Okazawa
    Department of Neurology, University of Tokyo, Tokyo, Japan
    Brain Res Bull 56:273-80. 2001
    ..In this review, we discuss the structure and function of the PQBP-1 protein, the relevance of its aggregation and possible roles in normal and disease processes...
  9. ncbi request reprint PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival
    M Waragai
    Group of Molecular Neurobiology, Department of Neurology, Graduate School of Medicine, University of Tokyo, Japan
    Hum Mol Genet 8:977-87. 1999
    ..These results suggest that PQBP-1 mediates important cellular functions under physiological and pathological conditions via its interaction with polyglutamine tracts...
  10. ncbi request reprint PQBP-1/Npw38, a nuclear protein binding to the polyglutamine tract, interacts with U5-15kD/dim1p via the carboxyl-terminal domain
    M Waragai
    Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Biochem Biophys Res Commun 273:592-5. 2000
    ..This finding suggests physiological functions of PQBP-1 in splicing, cell cycle, and ubiquitination, through which we can speculate the pathological roles of PQBP-1 in triplet repeat diseases...
  11. ncbi request reprint Polar amino acid-rich sequences bind to polyglutamine tracts
    I Imafuku
    Department of Neurology, Graduate School of Medicine, University of Tokyo, Japan
    Biochem Biophys Res Commun 253:16-20. 1998
    ..Three of these clones could form polar helical structures. These observations suggest that polar amino acid-rich sequences are essential for binding to the polyglutamine tract...
  12. ncbi request reprint A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells
    K Okamoto
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    Cell 60:461-72. 1990
    ..We suggest that Oct-3 is a novel octamer binding transcription factor that is developmentally regulated during mouse embryogenesis...
  13. ncbi request reprint Molecular cloning and expression of a novel truncated form of chicken trkC
    H Okazawa
    Department of Neurology, Faculty of Medicine, University of Tokyo, Japan
    FEBS Lett 329:171-7. 1993
    ..The truncated form is scarcely expressed during the embryonic stages. The conservation of the truncated trkC beyond species suggests they have specific functions...
  14. pmc The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer
    H Okazawa
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    EMBO J 10:2997-3005. 1991
    ..We suggest that RARE1 is a critical cis element for oct3 gene expression in embryonic stem cells and for the RA-mediated repression...