Affiliation: University of Tsukuba
- A biogenic amine-synapse mechanism for mental retardation and developmental disabilitiesN Okado
Neurobiology Laboratory, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305 8577, Tsukuba, Japan
Brain Dev 23:S11-5. 2001..A cascade appears to exist from either the child neurological disorders or the environmental factors to mental retardation and developmental disabilities by decreases in the levels of biogenic amines and synaptic density...
- A serotonin malfunction hypothesis by finding clear mutual relationships between several risk factors and symptoms associated with sudden infant death syndromeN Okado
Neurobiology Laboratory, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
Med Hypotheses 58:232-6. 2002..Now the pathophysiological mechanisms and symptoms of SIDS are explained by decreased levels of 5-HT...
- Identification of adrenoceptor subtype-mediated changes in the density of synapses in the rat visual cortexK Nakadate
Department of Anatomy, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
Neuroscience 138:37-46. 2006..Both serotonin(2A) and alpha1 receptors are known to couple with phospholipase C, which has been shown to increase intracellular calcium. It may help us to understand the underlying mechanisms for synaptic plasticity in the CNS...
- Selective serotonin reuptake inhibitor treatment of early postnatal mice reverses their prenatal stress-induced brain dysfunctionH Ishiwata
Department of Anatomy, Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8577, Japan
Neuroscience 133:893-901. 2005..Concomitantly, such treatment partially restored their ability to learn spatial information...
- Synaptic loss following depletion of noradrenaline and/or serotonin in the rat visual cortex: a quantitative electron microscopic studyM Matsukawa
Department of Anatomy, Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1, Tennoudai, Tsukuba, Ibaraki 305 8577, Japan
Neuroscience 122:627-35. 2003..We suggest that both serotonin and noradrenaline are necessary for synapse formation during the early stages of development of the rat visual cortex...
- Effects of single and repeated phencyclidine administration on the expression of metabotropic glutamate receptor subtype mRNAs in rat brainS Abe
Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
Neuropsychopharmacology 25:173-84. 2001..Single and repeated administrations of PCP independently regulate the expression of mGluR subtypes of mRNA in the brain...
- Immunohistochemical demonstration of nerve fibers in the synovial fold of the human cervical facet jointS Inami
Department of Orthopaedic Surgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
J Orthop Res 19:593-6. 2001..The presence of putative nociceptive fibers in cervical synovial folds supports a possible role for these structures as a source of cervical facet joint pain...
- Serotonin transporter gene variation is a risk factor for sudden infant death syndrome in the Japanese populationN Narita
Department of Pediatrics, Dokkyo University, School of Medicine, Koshigaya Hospital, Saitama, Japan
Pediatrics 107:690-2. 2001..Therefore, we aimed to identify the possibility that specific allele variants of the 5-HTT gene can be found as a genetic background for sudden infant death syndrome (SIDS)...
- Alteration of serotonergic receptors in the brain stems of human patients with respiratory disordersY Ozawa
Department of Neonatology, Toho University School of Medicine, Ohta, Tokyo, Japan
Neuropediatrics 33:142-9. 2002..There was no abnormal expression of 5-HT1 A and 5-HT2 A receptors in CCHS brain stems, and so the pathophysiology seems to be different between SIDS and CCHS patients...