N Okado

Summary

Affiliation: University of Tsukuba
Country: Japan

Publications

  1. ncbi request reprint A biogenic amine-synapse mechanism for mental retardation and developmental disabilities
    N Okado
    Neurobiology Laboratory, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305 8577, Tsukuba, Japan
    Brain Dev 23:S11-5. 2001
  2. ncbi request reprint A serotonin malfunction hypothesis by finding clear mutual relationships between several risk factors and symptoms associated with sudden infant death syndrome
    N Okado
    Neurobiology Laboratory, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    Med Hypotheses 58:232-6. 2002
  3. ncbi request reprint Identification of adrenoceptor subtype-mediated changes in the density of synapses in the rat visual cortex
    K Nakadate
    Department of Anatomy, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Neuroscience 138:37-46. 2006
  4. ncbi request reprint Selective serotonin reuptake inhibitor treatment of early postnatal mice reverses their prenatal stress-induced brain dysfunction
    H Ishiwata
    Department of Anatomy, Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8577, Japan
    Neuroscience 133:893-901. 2005
  5. ncbi request reprint Synaptic loss following depletion of noradrenaline and/or serotonin in the rat visual cortex: a quantitative electron microscopic study
    M Matsukawa
    Department of Anatomy, Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1, Tennoudai, Tsukuba, Ibaraki 305 8577, Japan
    Neuroscience 122:627-35. 2003
  6. ncbi request reprint Effects of single and repeated phencyclidine administration on the expression of metabotropic glutamate receptor subtype mRNAs in rat brain
    S Abe
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Neuropsychopharmacology 25:173-84. 2001
  7. ncbi request reprint Immunohistochemical demonstration of nerve fibers in the synovial fold of the human cervical facet joint
    S Inami
    Department of Orthopaedic Surgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    J Orthop Res 19:593-6. 2001
  8. ncbi request reprint Serotonin transporter gene variation is a risk factor for sudden infant death syndrome in the Japanese population
    N Narita
    Department of Pediatrics, Dokkyo University, School of Medicine, Koshigaya Hospital, Saitama, Japan
    Pediatrics 107:690-2. 2001
  9. ncbi request reprint Alteration of serotonergic receptors in the brain stems of human patients with respiratory disorders
    Y Ozawa
    Department of Neonatology, Toho University School of Medicine, Ohta, Tokyo, Japan
    Neuropediatrics 33:142-9. 2002

Collaborators

Detail Information

Publications9

  1. ncbi request reprint A biogenic amine-synapse mechanism for mental retardation and developmental disabilities
    N Okado
    Neurobiology Laboratory, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305 8577, Tsukuba, Japan
    Brain Dev 23:S11-5. 2001
    ..A cascade appears to exist from either the child neurological disorders or the environmental factors to mental retardation and developmental disabilities by decreases in the levels of biogenic amines and synaptic density...
  2. ncbi request reprint A serotonin malfunction hypothesis by finding clear mutual relationships between several risk factors and symptoms associated with sudden infant death syndrome
    N Okado
    Neurobiology Laboratory, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    Med Hypotheses 58:232-6. 2002
    ..Now the pathophysiological mechanisms and symptoms of SIDS are explained by decreased levels of 5-HT...
  3. ncbi request reprint Identification of adrenoceptor subtype-mediated changes in the density of synapses in the rat visual cortex
    K Nakadate
    Department of Anatomy, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Neuroscience 138:37-46. 2006
    ..Both serotonin(2A) and alpha1 receptors are known to couple with phospholipase C, which has been shown to increase intracellular calcium. It may help us to understand the underlying mechanisms for synaptic plasticity in the CNS...
  4. ncbi request reprint Selective serotonin reuptake inhibitor treatment of early postnatal mice reverses their prenatal stress-induced brain dysfunction
    H Ishiwata
    Department of Anatomy, Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8577, Japan
    Neuroscience 133:893-901. 2005
    ..Concomitantly, such treatment partially restored their ability to learn spatial information...
  5. ncbi request reprint Synaptic loss following depletion of noradrenaline and/or serotonin in the rat visual cortex: a quantitative electron microscopic study
    M Matsukawa
    Department of Anatomy, Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1, Tennoudai, Tsukuba, Ibaraki 305 8577, Japan
    Neuroscience 122:627-35. 2003
    ..We suggest that both serotonin and noradrenaline are necessary for synapse formation during the early stages of development of the rat visual cortex...
  6. ncbi request reprint Effects of single and repeated phencyclidine administration on the expression of metabotropic glutamate receptor subtype mRNAs in rat brain
    S Abe
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Neuropsychopharmacology 25:173-84. 2001
    ..Single and repeated administrations of PCP independently regulate the expression of mGluR subtypes of mRNA in the brain...
  7. ncbi request reprint Immunohistochemical demonstration of nerve fibers in the synovial fold of the human cervical facet joint
    S Inami
    Department of Orthopaedic Surgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    J Orthop Res 19:593-6. 2001
    ..The presence of putative nociceptive fibers in cervical synovial folds supports a possible role for these structures as a source of cervical facet joint pain...
  8. ncbi request reprint Serotonin transporter gene variation is a risk factor for sudden infant death syndrome in the Japanese population
    N Narita
    Department of Pediatrics, Dokkyo University, School of Medicine, Koshigaya Hospital, Saitama, Japan
    Pediatrics 107:690-2. 2001
    ..Therefore, we aimed to identify the possibility that specific allele variants of the 5-HTT gene can be found as a genetic background for sudden infant death syndrome (SIDS)...
  9. ncbi request reprint Alteration of serotonergic receptors in the brain stems of human patients with respiratory disorders
    Y Ozawa
    Department of Neonatology, Toho University School of Medicine, Ohta, Tokyo, Japan
    Neuropediatrics 33:142-9. 2002
    ..There was no abnormal expression of 5-HT1 A and 5-HT2 A receptors in CCHS brain stems, and so the pathophysiology seems to be different between SIDS and CCHS patients...