M Okada

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Adenosine A1 and A2 receptors modulate extracellular dopamine levels in rat striatum
    M Okada
    Department of Neuropsychiatry, Hirosaki University, Japan
    Neurosci Lett 212:53-6. 1996
  2. ncbi request reprint Differential effects of adenosine receptor subtypes on release and reuptake of hippocampal serotonin
    M Okada
    Department of Neuropsychiatry, Hirosaki University, Japan
    Eur J Neurosci 11:1-9. 1999
  3. ncbi request reprint Adenosine receptor subtypes modulate two major functional pathways for hippocampal serotonin release
    M Okada
    Department of Neuropsychiatry, Hirosaki University, Hirosaki 036 8216, Japan
    J Neurosci 21:628-40. 2001
  4. ncbi request reprint Determination of the effects of caffeine and carbamazepine on striatal dopamine release by in vivo microdialysis
    M Okada
    Department of Neuropsychiatry, Hirosaki University, Japan
    Eur J Pharmacol 321:181-8. 1997
  5. ncbi request reprint Pharmacological interactions between magnesium ion and adenosine on monoaminergic system in the central nervous system
    M Okada
    Department of Neuropsychiatry, Hirosaki University, Japan
    Magnes Res 11:289-305. 1998
  6. ncbi request reprint Effects of carbamazepine on hippocampal serotonergic system
    M Okada
    Department of Neuropsychiatry, School of Medicine, Hirosaki University, Japan
    Epilepsy Res 31:187-98. 1998
  7. ncbi request reprint Biphasic effects of carbamazepine on the dopaminergic system in rat striatum and hippocampus
    M Okada
    Department of Neuropsychiatry, Hirosaki University, Japan
    Epilepsy Res 28:143-53. 1997
  8. ncbi request reprint Interaction between purinoceptor subtypes on hippocampal serotonergic transmission using in vivo microdialysis
    M Okada
    Department of Neuropsychiatry, Hirosaki University, Japan
    Neuropharmacology 38:707-15. 1999
  9. ncbi request reprint Biphasic effects of zonisamide on serotonergic system in rat hippocampus
    M Okada
    Department of Neuropsychiatry, School of Medicine, Hirosaki University, Japan
    Epilepsy Res 34:187-97. 1999
  10. pmc Pharmacological discrimination between effects of carbamazepine on hippocampal basal, Ca(2+)- and K(+)-evoked serotonin release
    Y Kawata
    Department of Neuropsychiatry, School of Medicine, Hirosaki University, Hirosaki 036-8562, Japan
    Br J Pharmacol 133:557-67. 2001

Detail Information

Publications65

  1. ncbi request reprint Adenosine A1 and A2 receptors modulate extracellular dopamine levels in rat striatum
    M Okada
    Department of Neuropsychiatry, Hirosaki University, Japan
    Neurosci Lett 212:53-6. 1996
    ..These results indicate that the stimulatory effects of the A2 receptor on striatal extracellular dopamine levels are masked by the inhibitory effects of the A1 receptor...
  2. ncbi request reprint Differential effects of adenosine receptor subtypes on release and reuptake of hippocampal serotonin
    M Okada
    Department of Neuropsychiatry, Hirosaki University, Japan
    Eur J Neurosci 11:1-9. 1999
    ..In addition, hippocampal serotonergic transmission might be modulated by hippocampal presynaptic adenosine receptor subtypes, and hippocampal 5-HT reuptake activity might be modulated by hippocampal A3 receptor...
  3. ncbi request reprint Adenosine receptor subtypes modulate two major functional pathways for hippocampal serotonin release
    M Okada
    Department of Neuropsychiatry, Hirosaki University, Hirosaki 036 8216, Japan
    J Neurosci 21:628-40. 2001
    ..Therefore, PKA activity plays an important role in the interaction between A1-R and A2-R on hippocampal serotonin release...
  4. ncbi request reprint Determination of the effects of caffeine and carbamazepine on striatal dopamine release by in vivo microdialysis
    M Okada
    Department of Neuropsychiatry, Hirosaki University, Japan
    Eur J Pharmacol 321:181-8. 1997
    ..These properties support the hypothesis that the central actions of both carbamazepine and caffeine result from effects on both adenosine A1 and A2 receptors...
  5. ncbi request reprint Pharmacological interactions between magnesium ion and adenosine on monoaminergic system in the central nervous system
    M Okada
    Department of Neuropsychiatry, Hirosaki University, Japan
    Magnes Res 11:289-305. 1998
    ..In addition, an increase in [Mg2+]o enhances and reduces the effects of adenosine receptor agonists and antagonists on extracellular monoamine levels, respectively...
  6. ncbi request reprint Effects of carbamazepine on hippocampal serotonergic system
    M Okada
    Department of Neuropsychiatry, School of Medicine, Hirosaki University, Japan
    Epilepsy Res 31:187-98. 1998
    ..These effects of CBZ on serotonergic systems may be, at least partially, involved in the mechanisms of action of CBZ...
  7. ncbi request reprint Biphasic effects of carbamazepine on the dopaminergic system in rat striatum and hippocampus
    M Okada
    Department of Neuropsychiatry, Hirosaki University, Japan
    Epilepsy Res 28:143-53. 1997
    ..These effects of CBZ on dopaminergic systems may be, at least partially, involved in the mechanisms of action of CBZ...
  8. ncbi request reprint Interaction between purinoceptor subtypes on hippocampal serotonergic transmission using in vivo microdialysis
    M Okada
    Department of Neuropsychiatry, Hirosaki University, Japan
    Neuropharmacology 38:707-15. 1999
    ....
  9. ncbi request reprint Biphasic effects of zonisamide on serotonergic system in rat hippocampus
    M Okada
    Department of Neuropsychiatry, School of Medicine, Hirosaki University, Japan
    Epilepsy Res 34:187-97. 1999
    ..These biphasic effects of ZNS on the 5-HT system may be involved in the mechanisms of action of the antiepileptic and psychotropic effects, and side effects of ZNS...
  10. pmc Pharmacological discrimination between effects of carbamazepine on hippocampal basal, Ca(2+)- and K(+)-evoked serotonin release
    Y Kawata
    Department of Neuropsychiatry, School of Medicine, Hirosaki University, Hirosaki 036-8562, Japan
    Br J Pharmacol 133:557-67. 2001
    ....
  11. ncbi request reprint Effects of non-toxic and toxic concentrations of phenytoin on monoamines levels in rat brain
    M Okada
    Department of Neuropsychiatry, Hirosaki University, Japan
    Epilepsy Res 28:155-63. 1997
    ..Thus, the present study suggests that 'Paradoxical Intoxication' induced by toxic concentrations of PHT, at least partially, can be mediated by hypo-monoaminergic function in the brain...
  12. pmc Determination of effects of antiepileptic drugs on SNAREs-mediated hippocampal monoamine release using in vivo microdialysis
    T Murakami
    Department of Neuropsychiatry, Hirosaki University, Hirosaki 036-8216, Japan
    Br J Pharmacol 134:507-20. 2001
    ....
  13. ncbi request reprint Sociomedical aspects of epileptic patients: their employment and marital status
    K Wada
    Department of Neuropsychiatry, Hirosaki University, Hirosaki, Japan
    Psychiatry Clin Neurosci 55:141-6. 2001
    ..Seven cases (two males and five females) had answered that epilepsy had been the reason for their divorce. We conclude that epilepsy or epileptic seizures have various negative effects on the patient's social life...
  14. ncbi request reprint Biphasic actions of topiramate on monoamine exocytosis associated with both soluble N-ethylmaleimide-sensitive factor attachment protein receptors and Ca(2+)-induced Ca(2+)-releasing systems
    M Okada
    Department of Neuropsychiatry, School of Medicine, Hirosaki University, Hirosaki 036 8562, Japan
    Neuroscience 134:233-46. 2005
    ....
  15. ncbi request reprint SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus
    K Shimizu
    Division of Protein Metabolism, Institute for Protein Research, Osaka University, Suita, Japan
    FEBS Lett 458:363-9. 1999
    ..The structural feature of SCOP protein suggests its role in the intracellular signaling in the SCN...
  16. ncbi request reprint A novel protein interacts with a clock-related protein, rPer1
    T Matsuki
    Division of Protein Metabolism, Institute for Protein Research, Osaka University, 3 2 Yamada Oka, Suita, Osaka 565 0871, Japan
    Brain Res 916:1-10. 2001
    ..Thus, these findings suggest a possibility that PIPS is involved in the feedback loop or output mechanism of circadian rhythm through interacting with Per1 in the SCN...
  17. ncbi request reprint Muscle architectural characteristics in young and elderly men and women
    K Kubo
    Department of Life Science Sports Sciences, University of Tokyo, Komaba 3 8 1, Meguro ku, Tokyo 153 8902, Japan
    Int J Sports Med 24:125-30. 2003
    ..028 for elderly). These results suggest that the decrease of thickness of the vastus lateralis muscle with aging is significant, and that there is the gender difference in the fascicle length of the vastus lateralis muscle...
  18. ncbi request reprint Numerical modelling of the petroleum oil penetration into sandy beach sediments
    M Sagehashi
    Institute of Industrial Science, University of Tokyo, 4 6 1 Komaba, Meguro, Tokyo, 153 8505, Japan
    Water Sci Technol 47:9-14. 2003
    ....
  19. ncbi request reprint Cloning and characterization of rat casein kinase 1epsilon
    A Takano
    Division of Protein Metabolism, Institute for Protein Research, Osaka University, 3 2 Yamado Oka, Suita, Osaka, Japan
    FEBS Lett 477:106-12. 2000
    ....
  20. ncbi request reprint Effects of spilled oil on the tidal flat ecosystem--evaluation of wave and tidal actions using a tidal flat simulator
    C J Cheong
    Department of Environmental Science, Faculty of Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima, 739-0046, Japan
    Water Sci Technol 43:171-7. 2001
    ..This result indicates that the penetrated oil diminishes infiltration of seawater into the sediments and thus results in the reduction in the supply of oxygen, nutrients, and organic matter to the benthic organisms in tidal flat...
  21. ncbi request reprint Effect of exercise on the metabolism of vitamin B6 and some PLP-dependent enzymes in young rats fed a restricted vitamin B6 diet
    M Okada
    Faculty of Health and Living Sciences, Naruto University of Education, Takashima, Japan
    J Nutr Sci Vitaminol (Tokyo) 47:116-21. 2001
    ..From the data obtained, it has been suggested that the red and white portions of the gastrocnemius muscle seemed to be more important in metabolizing amino acids and hydrolyze glycogen, respectively...
  22. ncbi request reprint Changes in pattern of immunoglobulin heavy chain gene rearrangement and MIB-1 staining before and after eradication of Helicobacter pylori in gastric mucosa-associated lymphoid tissue (MALT) lymphoma
    M Kanda
    First Department of Pathology, School of Medicine, Fukuoka University, School of Medicine, Japan
    Leuk Lymphoma 42:639-47. 2001
    ....
  23. ncbi request reprint Neutralization of interleukin-1beta in the acute phase of myocardial infarction promotes the progression of left ventricular remodeling
    M W Hwang
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Am Coll Cardiol 38:1546-53. 2001
    ..In the acute phase of MI, IL-1beta appears to play a protective role...
  24. ncbi request reprint Extinguishing Egr-1-dependent inflammatory and thrombotic cascades after lung transplantation
    M Okada
    College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA; and, Harvard Medical School, Boston, Massachusetts 02115, USA
    FASEB J 15:2757-9. 2001
    ..Blocking expression of a proximal transcription factor, which activates deleterious inflammatory and coagulant effector mechanisms, is an effective molecular strategy to improve organ preservation...
  25. ncbi request reprint [Effectiveness of Saiko-Keishi-To (TJ-10, a Kampo herbal medicine) for trigeminal neuralgia in rats]
    M Sunagawa
    Department of Physiology, School of Medicine, Showa University, Tokyo 142-8555
    Masui 50:486-90. 2001
    ..These findings suggest that TJ-10 is effective for controlling the manifestation of pain in ligatured nerves, by local effect, not by general analgesic effect...
  26. ncbi request reprint [Susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (1999)]
    K Shimada
    Tokyo Senbai Hospital
    Jpn J Antibiot 54:331-64. 2001
    ..However, that of H. influenzae was decreased to 7.1% after administration within 3 days, and many H. influenzae were isolated after completion of administration as 21.4%...
  27. ncbi request reprint Effect of the adenovirus E1A gene on nitric oxide production in alveolar epithelial cells
    Y Higashimoto
    Department of Internal Medicine, Wakayama Medical University, Kihoku Hospital, Ito gun, Wakayama Prefecture, Japan
    Clin Microbiol Infect 11:644-50. 2005
    ..This inhibition of NO production may enable the virus to persist in human tissue, since NO is an antiviral effector of the innate immune system...
  28. ncbi request reprint Progesterone stimulates the expression of aminopeptidase A/angiotensinase in human choriocarcinoma cells
    Y Katsumata
    Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya 466-8550, Japan
    Placenta 22:831-6. 2001
    ..These findings may serve as a useful model to study the effects of progesterone on angiotensin II metabolism in placenta, although the physiological validity of these studies remains to be clarified...
  29. ncbi request reprint Effect of non-aqueous phase liquid on biodegradation of PAHs in spilled oil on tidal flat
    T Kose
    Department Material Science and Chemical System Engineering, Graduate School of Engineering, Hiroshima University, 1 4 1 Kagamiyama, Higashi Hiroshima, Hiroshima 739 8527 Japan
    Water Sci Technol 47:243-50. 2003
    ..The smaller decrease rate of fuel oil C than crude oil was due to higher viscosity of fuel oil C. Therefore, not only the dissolution rate of PAHs but also the decrease rates of NAPL were important factors for the biodegradation of PAHs...
  30. ncbi request reprint Edg-8 receptors are preferentially expressed in oligodendrocyte lineage cells of the rat CNS
    K Terai
    Neuroscience Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba, Ibaraki, Japan
    Neuroscience 116:1053-62. 2003
    ....
  31. ncbi request reprint Preparation of agricultural residue anion exchangers and its nitrate maximum adsorption capacity
    U S Orlando
    Chemosphere 48:1041-6. 2002
    ..Similar preparation from pure cellulose and pure alkaline lignin demonstrated that the EDM method could not produce anion exchangers from pure lignin due to its solubilization after the reaction with epichlorohydrin...
  32. ncbi request reprint Molecular epidemiology and phylogenetic analysis of Sapporo-like viruses
    M Okada
    Division of Virology, Public Health Institute of Chiba Prefecture, Japan
    Arch Virol 147:1445-51. 2002
    ..The RT-PCR used in this study appeared to be capable of widely detecting SLV genogroups, and it was seen to be powerful enough for molecular epidemiological as well as phylogenetic studies on SLV...
  33. ncbi request reprint Influence of oral health attitude of mothers on the gingival health of their school age children
    M Okada
    Department of Pediatric Dentistry, Hiroshima University Faculty of Dentistry, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    ASDC J Dent Child 68:379-83, 303. 2001
    ..We concluded that the gingival health of children could be significantly influenced by the oral health attitude of their mothers up to approximately ten years of age...
  34. ncbi request reprint Nutritional effects of cyclodextrins on liver and serum lipids and cecal organic acids in rats
    S Kaewprasert
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    J Nutr Sci Vitaminol (Tokyo) 47:335-9. 2001
    ..It seems likely that the suppression of serum cholesterol levels by alpha- and beta-cyclodextrins might be due to the increasing acetate and propionate productions in the cecum. cecal organic acid, cyclodextrin, serum cholesterol, rats..
  35. ncbi request reprint Possible role of DNA hypomethylation in the induction of SLE: relationship to the transcription of human endogenous retroviruses
    H Ogasawara
    Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
    Clin Exp Rheumatol 21:733-8. 2003
    ..We investigated the contribution of DNA methyltransferase activity to the transcription of human endogenous retroviruses (HERV), which have been reported to be a plausible causative agent for systemic lupus erythematosus (SLE)...
  36. ncbi request reprint Concentrations and fluxes of chloronaphthalenes in sediment from Lake Kitaura in Japan in past 15 centuries
    Y Horii
    National Institute of Advanced Industrial Science and Technology AIST, EMTECH, Ibaraki, Tsukuba, Japan
    J Environ Sci Health A Tox Hazard Subst Environ Eng 39:587-609. 2004
    ..073-0.31 pg/cm2 before 1926, increased to 5.5-14 pg/cm2 in 1963-1970 and next sharply increased to 50-107 pg/ cm2 in 1971-1985, and after that decreased to 17 pg/cm2 in 1997-2000...
  37. ncbi request reprint A boy with Japanese Dent's disease exhibiting abnormal calcium metabolism and osseous disorder of the spine: defective megalin expression at the brushborder of renal proximal tubules
    H Yanagida
    Department of Pediatrics, Kinki University School of Medicine, Osaka Sayama, Japan
    Clin Nephrol 62:306-12. 2004
    ..Thus, clinical manifestations and prognosis may vary in Japanese Dent's disease. Reduced megalin expression may have disturbed calcium homeostasis, leading to osseous disorder in our patient...
  38. ncbi request reprint Retinoic acid suppresses endothelin-1 gene expression at the transcription level in endothelial cells
    J Yokota
    Department of Cardiology, The Heart Institute of Japan, Tokyo Women's Medical University, 8-1 Kawadacho, Shinjuku-ku, 162-8666, Tokyo, Japan
    Atherosclerosis 159:491-6. 2001
    ..Taken together, retinoids may be another modulator of endothelial cell function through regulation of vasoactive substances at the transcription level...
  39. ncbi request reprint Effects of alpha-linked galactooligosaccharide on adjuvant-induced arthritis in Wistar rats and type II collagen-induced arthritis in DBA/1J mice
    C Abe
    Department of Medicine, St Marianna University School of Medicine, Kawasaki, Japan
    Int J Tissue React 26:65-73. 2004
    ..Thus, alpha-GOS is a potential functional food for the treatment of human rheumatoid arthritis...
  40. ncbi request reprint The detection of human sapoviruses with universal and genogroup-specific primers
    M Okada
    Division of Virology, Chiba Prefectural Institute of Public Health, Chuo Ku, Chiba shi, Chiba, Japan
    Arch Virol 151:2503-9. 2006
    ..These genogroup-specific primers were also used as inner primers for the nested PCR. These two simple RT-PCR methods are powerful tools for both detection and epidemiological studies of human SV...
  41. ncbi request reprint The circadian blood pressure rhythm in non-diabetic hemodialysis patients
    I Narita
    Department of Medicine II, Niigata University School of Medicine, Japan
    Hypertens Res 24:111-7. 2001
    ..The increased dRen observed only in ID patients may reflect occult cardiovascular damage or functional disturbances in aortic and carotid baroreflexes caused by arterial structural changes...
  42. ncbi request reprint Non-receptor tyrosine kinases in mammalian neurogenesis
    S Aizawa
    Laboratory of Molecular Oncology Tsukuba Life Science Center, Ibaraki, Japan
    Princess Takamatsu Symp 24:323-37. 1994
    ..The signaling pathway through Src-family kinases during neurulation is also discussed...
  43. ncbi request reprint Nucleotide sequence of a principal sigma factor gene (hrdB) of Streptomyces griseus
    H Shinkawa
    Department of Fermentation Technology, Faculty of Engineering, Hiroshima University
    J Biochem 118:494-9. 1995
    ..griseus. The promoter region was identified by using a promoter-probe vector and by means of primer extensions experiments. The transcription start point is located 158-bp upstream of the initiation codon...
  44. ncbi request reprint Genomic organization and isoforms of the mouse ELP gene
    Y Ninomiya
    Department of Molecular Pathology, Hiroshima University
    J Biochem 118:380-9. 1995
    ..Complex patterns of expression of these isoforms were observed in various tissues. All four ELP isoforms were expressed only in EC cells...
  45. pmc Cloning, sequencing, and expression in Escherichia coli of the Bacillus subtilis gene for phosphatidylserine synthase
    M Okada
    Department of Biochemistry, Faculty of Science, Saitama University, Urawa, Japan
    J Bacteriol 176:7456-61. 1994
    ..coli counterpart. This finding suggested that the unusual cytoplasmic localization of the E. coli phosphatidylserine synthase plays a role in the regulation of the phospholipid polar headgroup composition in this organism...
  46. ncbi request reprint T cell receptor-mediated stimulation of mouse thymocytes induces up-regulation of the GM2/GD2 synthase gene
    K Takamiya
    Department of Oncology, School of Medicine, Nagasaki University, Japan
    FEBS Lett 358:79-83. 1995
    ..In situ hybridization showed an elevation of mRNA levels in medullar thymocytes, suggesting that T cell receptor-mediated signaling induces up-regulation of the GM2/GD2 synthase gene in mature thymocytes...
  47. pmc Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling
    Y Yamanashi
    Department of Oncology, University of Tokyo, Japan
    Proc Natl Acad Sci U S A 90:3631-5. 1993
    ..Thus, p75HS1 may be an important substrate of Lyn and possibly other protein-tyrosine kinases upon B-cell antigen receptor-mediated signaling...
  48. ncbi request reprint Analysis of biological function of poly(ADP-ribosyl)ation in Drosophila melanogaster
    M Miwa
    Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
    Biochimie 77:466-71. 1995
    ..The second approach is to get the mutants which have disruption in the poly(ADP-ribose) polymerase gene and to analyse the phenotypes of these mutants. The characterization of these mutants will be discussed...
  49. ncbi request reprint Molecular cloning of a human apolipoprotein E variant: E5 (Glu3----Lys3)
    H Maeda
    Department of Home Economics, Faculty of Health and Living Sciences, Naruto University of Education, Tokushima
    J Biochem 105:491-3. 1989
    ..In addition, this allele has a base substitution (G----A) which causes the substitution of lysine for glutamic acid at position 3 near the NH2-terminus of the mature apoE. This allele is a new variant, the epsilon apoE5 allele...
  50. ncbi request reprint Effect of pyridoxine-deficiency on degradation of cytosolic aspartate aminotransferase in rat liver lysosomes
    A Sato
    Department of Nutritional Chemistry, School of Medicine, University of Tokushima, Japan
    J Nutr Sci Vitaminol (Tokyo) 37:419-24. 1991
    ..On the basis of these observations, it was concluded that the increased rate of degradation of cAspAT in the liver of the pyridoxine-deficient rats is brought about by the increased rate of sequestration of cAspAT into lysosomes...
  51. ncbi request reprint Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src
    S Nada
    Division of Protein Metabolism, Osaka University, Japan
    Nature 351:69-72. 1991
    ..These results suggest that this protein-tyrosine kinase, which might negatively regulate p60c-src, represents a new type of tyrosine kinase...
  52. ncbi request reprint Expression cloning of rat cDNA encoding UDP-galactose:GD2 beta1,3-galactosyltransferase that determines the expression of GD1b/GM1/GA1
    H Miyazaki
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsuramai, Nagoya 466, Japan
    J Biol Chem 272:24794-9. 1997
    ..On the other hand, this gene was expressed at high levels in the rat brain of embryonal day 12, and reached a peak at around birth, then fell to low level in the adult brain...
  53. ncbi request reprint PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons
    T Hirose
    Division of Protein Metabolism, Institute for Protein Research, Osaka University, Suita, Japan
    Eur J Biochem 249:481-8. 1997
    ..These findings suggest that PCTAIRE 2 is a Ser/Thr kinase that might play a unique role in terminally differentiated neurons...
  54. pmc Cloning, sequencing, and disruption of the Bacillus subtilis psd gene coding for phosphatidylserine decarboxylase
    K Matsumoto
    Department of Biochemistry and Molecular Biology, Faculty of Science, Saitama University, Urawa, Japan
    J Bacteriol 180:100-6. 1998
    ..The results suggest that the lack of phosphatidylethanolamine in the B. subtilis membrane may be compensated for by the increases in the contents of glucosyldiacylglycerols by an unknown mechanism...
  55. ncbi request reprint Cloning and characterization of mouse glutamine:fructose-6-phosphate amidotransferase 2 gene promoter
    K Yamazaki
    Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3, Tokodai, Tsukuba, 300 2635, Ibaraki, Japan
    Gene 261:329-36. 2000
    ..Electrophoretic mobility shift assay showed DNA-protein binding at both Sp1 sites. We also compared the promoter activities of mouse GFAT1 and GFAT2 in several cell lines...
  56. ncbi request reprint Molecular characterization and nuclear localization of rat timeless-like gene product
    S Sakamoto
    Laboratory of Molecular Biology, Medical Research Center, Kochi Medical School, Okoh, Nankoku, Kochi 783 8505, Japan
    Biochem Biophys Res Commun 279:131-8. 2000
    ..6% of transfected cells. These results suggest that the interaction of rPER2 with rTLP may influence the regulation of circadian clock components in nucleus after rPER2 is translocated into the nucleus...
  57. ncbi request reprint Constitutive activation of Src family kinases in mouse embryos that lack Csk
    S Nada
    Laboratory of Molecular Oncology, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Cell 73:1125-35. 1993
    ..Thus, these results suggest that Csk indeed acts as an indispensable negative regulator of Src family kinases in vivo...
  58. ncbi request reprint Changes in circadian period and morphology of the hypothalamic suprachiasmatic nucleus in fyn kinase-deficient mice
    T Shima
    Division of Protein Metabolism, Institute for Protein Research, Osaka University, 3 2 Yamada Oka, Suita, 565 0871, Osaka, Japan
    Brain Res 870:36-43. 2000
    ..The mechanism of the implication of Fyn discussed with the Fyn's roles in neural network formation and cellular signal transduction pathway...
  59. ncbi request reprint Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases
    M Kawabuchi
    Division of Protein Metabolism, Institute for Protein Research, Osaka University, Suita, Japan
    Nature 404:999-1003. 2000
    ..These findings reveal Cbp as a new component of the regulatory mechanism controlling the activity of membrane-associated Src-PTKs...
  60. ncbi request reprint Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain
    T Hirose
    Division of Protein Metabolism, Institute for Protein Research, Osaka University, Japan
    Eur J Biochem 267:2113-21. 2000
    ..These findings suggest that Trap is a physiological partner of PCTAIRE 2 in terminally differentiated neurons...
  61. ncbi request reprint Structural organization of the 5'-end and chromosomal assignment of human placental leucine aminopeptidase/insulin-regulated membrane aminopeptidase gene
    J Horio
    Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya, 466 8550, Japan
    Biochem Biophys Res Commun 262:269-74. 1999
    ..2-q15 of the human chromosome. This study establishes the genetic basis for P-LAP gene research, thereby leading to better understanding of the molecular mechanism underlying the P-LAP gene...
  62. ncbi request reprint Attenuation of interleukin 2 signal in the spleen cells of complex ganglioside-lacking mice
    J Zhao
    Department of Oncology, Nagasaki University School of Medicine, 514 0001 Japan
    J Biol Chem 274:13744-7. 1999
    ....
  63. ncbi request reprint cDNA cloning and mapping of a novel subtype of glutamine:fructose-6-phosphate amidotransferase (GFAT2) in human and mouse
    T Oki
    Tsukuba Research Laboratories, Eisai Company, Ltd, 5 1 3, Tokodai, Tsukuba, Ibaraki, 300 2635, Japan
    Genomics 57:227-34. 1999
    ..GFAT2 can provide insights into understanding the roles of the hexosamine pathway in various tissues, particularly with the development of glucose toxicity and diabetes complications...
  64. pmc Chromatin remodeling mediated by Drosophila GAGA factor and ISWI activates fushi tarazu gene transcription in vitro
    M Okada
    Department of Genetics, The Graduate University for Advanced Studies, National Institute of Genetics, Mishima, Shizuoka ken, Japan
    Mol Cell Biol 18:2455-61. 1998
    ..These results demonstrate that GAGA factor- and ISWI-mediated disruption of the chromatin structure within the promoter region of ftz activates transcription on the chromatin template...
  65. pmc Molecular cloning and expression of chicken C-terminal Src kinase: lack of stable association with c-Src protein
    H Sabe
    Laboratory of Molecular Oncology, Rockefeller University, New York, NY 10021 6399
    Proc Natl Acad Sci U S A 89:2190-4. 1992
    ..Although some portions of CSK were found in a membrane fraction, no complex formation between CSK and c-Src was observed, suggesting that the src homology 2 domain of CSK does not play a role in the direct interaction of c-Src...