Takao Ohta

Summary

Affiliation: University of the Ryukyus
Country: Japan

Publications

  1. ncbi request reprint Soluble vascular cell-adhesion molecule-1 and soluble intercellular adhesion molecule-1 correlate with lipid and apolipoprotein risk factors for coronary artery disease in children
    T Ohta
    Department of Paediatrics, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Eur J Pediatr 158:592-8. 1999
  2. ncbi request reprint Novel mutations of the chloride channel Kb gene in two Japanese patients clinically diagnosed as Bartter syndrome with hypocalciuria
    Shigeru Fukuyama
    Department of Pediatrics, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0125 Japan
    J Clin Endocrinol Metab 89:5847-50. 2004
  3. ncbi request reprint Dyslipidemia in young Japanese children: its relation to familial hypercholesterolemia and familial combined hyperlipidemia
    Takao Ohta
    Department of Pediatrics, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Pediatr Int 44:602-7. 2002
  4. ncbi request reprint The influence of the acyl-CoA:cholesterol acyltransferase-1 gene (-77G-->A) polymorphisms on plasma lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects
    Takao Ohta
    Department of Pediatrics, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0125, Japan
    Biochim Biophys Acta 1682:56-62. 2004
  5. ncbi request reprint Bisphosphonate incadronate inhibits growth of human T-cell leukaemia virus type I-infected T-cell lines and primary adult T-cell leukaemia cells by interfering with the mevalonate pathway
    Chie Ishikawa
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of Ryukyus, Nishihara, Japan
    Br J Haematol 136:424-32. 2007
  6. ncbi request reprint Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells
    Mariko Tomita
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan
    Int J Cancer 118:765-72. 2006
  7. ncbi request reprint Fucoidan extracted from Cladosiphon okamuranus Tokida induces apoptosis of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells
    Kaori Haneji
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Nutr Cancer 52:189-201. 2005
  8. ncbi request reprint Curcumin suppresses constitutive activation of AP-1 by downregulation of JunD protein in HTLV-1-infected T-cell lines
    Mariko Tomita
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Leuk Res 30:313-21. 2006
  9. doi request reprint Anti-adult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol
    Chie Ishikawa
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Int J Cancer 123:2702-12. 2008
  10. pmc Dengue virus-induced apoptosis in hepatic cells is partly mediated by Apo2 ligand/tumour necrosis factor-related apoptosis-inducing ligand
    Takehiro Matsuda
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Uehara 207, Nishihara, Okinawa 903 0215, Japan
    J Gen Virol 86:1055-65. 2005

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Soluble vascular cell-adhesion molecule-1 and soluble intercellular adhesion molecule-1 correlate with lipid and apolipoprotein risk factors for coronary artery disease in children
    T Ohta
    Department of Paediatrics, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Eur J Pediatr 158:592-8. 1999
    ..Furthermore, the soluble ICAM-1 level was inversely correlated with LpA-I level, LDL size (in boys) and HDL cholesterol level (in girls). Soluble P-selectin levels were not correlated with these parameters...
  2. ncbi request reprint Novel mutations of the chloride channel Kb gene in two Japanese patients clinically diagnosed as Bartter syndrome with hypocalciuria
    Shigeru Fukuyama
    Department of Pediatrics, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0125 Japan
    J Clin Endocrinol Metab 89:5847-50. 2004
    ..We did not find any mutations in the other three genes. Our present data suggest that some ClC-Kb mutations may affect calcium handling in renal tubular cells...
  3. ncbi request reprint Dyslipidemia in young Japanese children: its relation to familial hypercholesterolemia and familial combined hyperlipidemia
    Takao Ohta
    Department of Pediatrics, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Pediatr Int 44:602-7. 2002
    ..Most cases of dyslipidemia found in adults are non-familial. However, in children, especially young children, dyslipidemias other than familial hypercholesterolemia (FH) have not yet been characterized...
  4. ncbi request reprint The influence of the acyl-CoA:cholesterol acyltransferase-1 gene (-77G-->A) polymorphisms on plasma lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects
    Takao Ohta
    Department of Pediatrics, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0125, Japan
    Biochim Biophys Acta 1682:56-62. 2004
    ..In humans, an ACAT inhibitor was shown to have a lipid-lowering effect. The present study was carried out to clarify the relationship between ACAT-1 gene variants and hyperlipidemia...
  5. ncbi request reprint Bisphosphonate incadronate inhibits growth of human T-cell leukaemia virus type I-infected T-cell lines and primary adult T-cell leukaemia cells by interfering with the mevalonate pathway
    Chie Ishikawa
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of Ryukyus, Nishihara, Japan
    Br J Haematol 136:424-32. 2007
    ..These findings suggest that incadronate could be potentially useful for the treatment of ATL...
  6. ncbi request reprint Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells
    Mariko Tomita
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan
    Int J Cancer 118:765-72. 2006
    ..Curcumin inhibited the growth of HTLV-I-infected T-cell tumors implanted subcutaneously in SCID mice. Our results indicate that curcumin has tumor-suppressive activity against ATL...
  7. ncbi request reprint Fucoidan extracted from Cladosiphon okamuranus Tokida induces apoptosis of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells
    Kaori Haneji
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Nutr Cancer 52:189-201. 2005
    ..Our results indicate that fucoidan is a potentially useful therapeutic agent for patients with ATL...
  8. ncbi request reprint Curcumin suppresses constitutive activation of AP-1 by downregulation of JunD protein in HTLV-1-infected T-cell lines
    Mariko Tomita
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Leuk Res 30:313-21. 2006
    ..Inhibition of AP-1 activity by curcumin may be one of the mechanisms responsible for the anti-ATL effect of curcumin. We propose that curcumin is a potentially promising compound for the treatment of ATL...
  9. doi request reprint Anti-adult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol
    Chie Ishikawa
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Int J Cancer 123:2702-12. 2008
    ..Our preclinical data suggest that fucoxanthin and fucoxanthinol could be potentially useful therapeutic agents for patients with ATL...
  10. pmc Dengue virus-induced apoptosis in hepatic cells is partly mediated by Apo2 ligand/tumour necrosis factor-related apoptosis-inducing ligand
    Takehiro Matsuda
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Uehara 207, Nishihara, Okinawa 903 0215, Japan
    J Gen Virol 86:1055-65. 2005
    ..It was proposed that DEN infection promotes apoptosis partly through the induction of Apo2L/TRAIL expression...
  11. ncbi request reprint Transactivation of the ICAM-1 gene by CD30 in Hodgkin's lymphoma
    Jun Nosuke Uchihara
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Int J Cancer 118:1098-107. 2006
    ....
  12. ncbi request reprint Transcriptional activation of survivin through the NF-kappaB pathway by human T-cell leukemia virus type I tax
    Hirochika Kawakami
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan
    Int J Cancer 115:967-74. 2005
    ..Our findings suggest that activated NF-kappaB signaling contributes directly to malignant progression of ATL by preventing apoptosis, acting through the prosurvival protein survivin...
  13. ncbi request reprint Relationship between lipid abnormalities and insulin resistance in Japanese school children
    Yoshihide Asato
    Department of Department of Child Health and Welfare, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0125 Japan
    Arterioscler Thromb Vasc Biol 26:2781-6. 2006
    ..To help prevent the development of CHD, it may be useful to understand the relationship between lipid abnormalities and IR during childhood...
  14. ncbi request reprint Effects of a new single-nucleotide polymorphism in the Acyl-CoA:cholesterol acyltransferase-2 gene on plasma lipids and apolipoproteins in patients with hyperlipidemia
    Keisuke Katsuren
    Department of Pediatrics, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    J Atheroscler Thromb 10:32-6. 2003
    ..Although further studies are needed, our data suggest that the ACAT-2 gene may not affect lipid levels in humans...
  15. ncbi request reprint Human T cell leukemia virus type I-infected patients with Hashimoto's thyroiditis and Graves' disease
    Takehiro Matsuda
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0215, Japan
    J Clin Endocrinol Metab 90:5704-10. 2005
    ....
  16. doi request reprint Early weight changes after birth and serum high-molecular-weight adiponectin level in preterm infants
    Tomohide Yoshida
    Department of Pediatrics, Faculty of Medicine, University of Ryukyus, Uehara, Nishihara, Okinawa, Japan
    Pediatr Int 53:926-9. 2011
    ..The aim of the present study was to examine the relationship between early weight change after birth in preterm infants and adiponectin (adn) multimeric complexes...
  17. ncbi request reprint Serum C-reactive protein and its relation to cardiovascular risk factors and adipocytokines in Japanese children
    Tomohide Yoshida
    Department of Child Health and Welfare, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0125, Japan
    J Clin Endocrinol Metab 91:2133-7. 2006
    ..C-Reactive protein (CRP) is an independent risk factor for atherosclerotic coronary heart diseases (ACHD) in adults. To help prevent ACHD, it may be useful to understand risk factors during childhood...
  18. pmc Resistance to Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis and constitutive expression of Apo2L/TRAIL in human T-cell leukemia virus type 1-infected T-cell lines
    Takehiro Matsuda
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    J Virol 79:1367-78. 2005
    ....
  19. doi request reprint The ratio of high-molecular weight adiponectin and total adiponectin differs in preterm and term infants
    Tomohide Yoshida
    Department of Pediatrics, University of the Ryukyus, Nishihara, Okinawa 903 0125, Japan
    Pediatr Res 65:580-3. 2009
    ..Postnatal growth accompanying adipose tissue similar to TI may be important for PI to prevent future development of cardiovascular disease...
  20. ncbi request reprint Birthweight and risk factors for cardiovascular diseases in Japanese schoolchildren
    Takuya Kaneshi
    Department of Pediatrics, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Pediatr Int 49:138-43. 2007
    ..However, little information is currently available on the relationship between birthweight (BW) and risk factors for ACHD in children...
  21. ncbi request reprint Effect of Trp64Arg mutation of the beta3-adrenergic receptor gene and C161T substitution of the peroxisome proliferator activated receptor gamma gene on obesity in Japanese children
    Rina Arashiro
    Department of Pediatrics, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0125 Japan
    Pediatr Int 45:135-41. 2003
    ..For this reason, we studied the effects of Trp64Arg mutation of the beta3-AR gene and C161T substitution of the PPARgamma gene on obesity in Japanese children...
  22. ncbi request reprint Analysis of renal tubular electrolyte transporter genes in seven patients with hypokalemic metabolic alkalosis
    Shigeru Fukuyama
    Department of Pediatrics, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Kidney Int 64:808-16. 2003
    ..Thus, to clarify the interaction of these transporter genes, in the present study we investigated all 4 transporter genes in 7 patients with hypokalemic metabolic alkalosis...
  23. doi request reprint Effect of body mass index-z score on adverse levels of cardiovascular disease risk factors
    Keisuke Katsuren
    Department of Pediatrics, Faculty of Medicine, University of Ryukyus, Okinawa, Japan
    Pediatr Int 54:200-4. 2012
    ..The aim of this study was to evaluate the association between adverse levels of CVD risk factors and BMISD, and the effect of IR on these associations in schoolchildren...
  24. ncbi request reprint Low-density lipoprotein particle size and its regulatory factors in school children
    Tadao Shimabukuro
    Department of Pediatrics, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa 903 0125, Japan
    J Clin Endocrinol Metab 89:2923-7. 2004
    ....
  25. ncbi request reprint Elevated expression of CCL5/RANTES in adult T-cell leukemia cells: possible transactivation of the CCL5 gene by human T-cell leukemia virus type I tax
    Naoki Mori
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan
    Int J Cancer 111:548-57. 2004
    ..Aberrant expression of CCL5 by HTLV-I-infected T cells may impact on the pathophysiology of HTLV-I-associated diseases...
  26. pmc Apoptosis induced by the histone deacetylase inhibitor FR901228 in human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells
    Naoki Mori
    Division of Molecular Virology and Oncology, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa 903 0215, Japan
    J Virol 78:4582-90. 2004
    ..Our results indicated that FR901228 could induce apoptosis of these cells and suppress the expression of NF-kappaB and AP-1 and suggest that FR901228 could be therapeutically effective in ATL...
  27. ncbi request reprint An 11-year-old boy with familial hypercholesterolemia showing multiple xanthomas and advanced atherosclerosis, who responded to lipid-lowering therapy using statin
    Tadashi Ohshiro
    Department of Pediatrics, Faculty of Medicine, University of the Ryukyus, Japan
    J Atheroscler Thromb 16:698-701. 2009
    ..However, based on his advanced atherosclerosis, we cannot exclude the possibility that our patient may be accompanying dyslipidemia due to causes in addition to heterozygous FH...
  28. ncbi request reprint Sanfilippo type B syndrome: five patients with an R565P homozygous mutation in the alpha-N-acetylglucosaminidase gene from the Okinawa islands in Japan
    Yasutsugu Chinen
    Department of Pediatrics, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0125, Japan
    J Hum Genet 50:357-9. 2005
    ..These results suggest that there may be a founder effect that results in the accumulation of R565P mutation in this area...
  29. ncbi request reprint Transactivation of the CCL5/RANTES gene by Epstein-Barr virus latent membrane protein 1
    Jun Nosuke Uchihara
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan
    Int J Cancer 114:747-55. 2005
    ..These results indicate that the activation of the NF-kappaB pathway by LMP-1 is required for the activation of CCL5 expression...
  30. ncbi request reprint Congenital atresia of the left main coronary artery: successful surgical treatment (myocardial revascularisation and mitral valve repair) in a 1-year-old boy
    Makoto Sunagawa
    Department of Paediatrics, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, 903 0125 Okinawa, Japan
    Eur J Pediatr 164:461-2. 2005
  31. ncbi request reprint Childhood blastic NK cell leukemia successfully treated with L-asparagenase and allogeneic bone marrow transplantation
    Nobuyuki Hyakuna
    Department of Pediatrics, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Pediatr Blood Cancer 42:631-4. 2004
    ....
  32. ncbi request reprint Two newly identified genomic mutations in a Japanese female patient with fructose-1,6-bisphosphatase (FBPase) deficiency
    Toshinobu Matsuura
    Department of Pediatrics, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0125, Japan
    Mol Genet Metab 76:207-10. 2002
    ..As both Phe194 and Pro284 of FBPase are highly conserved in many species and close to crucial amino acid residues to FBPase functions, these mutations could be responsible for the loss of FBPase activities...
  33. pmc Importance of murine Vdelta1gammadelta T cells expressing interferon-gamma and interleukin-17A in innate protection against Listeria monocytogenes infection
    Satoru Hamada
    Molecular Microbiology Group, Centre of Molecular Biosciences, University of the Ryukyus, Okinawa, Japan
    Immunology 125:170-7. 2008
    ..monocytogenes infection through production of the proinflammatory cytokines interferon-gamma and interleukin-17A in the infected liver...
  34. ncbi request reprint Opitz trigonocephaly C syndrome in a boy with a de novo balanced reciprocal translocation t(3;18)(q13.13;q12.1)
    Yasutsugu Chinen
    Department of Pediatrics, University of the Ryukyus School of Medicine, Okinawa, Japan
    Am J Med Genet A 140:1655-7. 2006
    ..13q12.1). His phenotype is a mild form with mild developmental delay and no severe visceral anomalies. Our findings suggest the possible existence of a new locus responsible for OTCS either on 3q13.13 or 18q12.1...
  35. pmc IL-17A produced by gammadelta T cells plays a critical role in innate immunity against listeria monocytogenes infection in the liver
    Satoru Hamada
    Molecular Microbiology Group, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    J Immunol 181:3456-63. 2008
    ..All the results suggest that IL-17A is a newly discovered effector molecule produced by TCR gammadelta T cells, which is important in innate immunity in the liver...
  36. ncbi request reprint A 7-year-old boy with mycoplasmal infection requiring extracorporeal membrane oxygenation
    Tomohide Yoshida
    Department of Paediatrics, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0125 Japan
    Eur J Pediatr 162:44-6. 2003
    ..Initially, mechanical ventilation and nitric oxide inhalation were used, but these did not improve the alveolar-arterial oxygen gradient. Extracorporeal membrane oxygenation for 152 h improved the lung condition...
  37. ncbi request reprint Molecular genetic study in Japanese patients with Alexander disease: a novel mutation, R79L
    Naohide Shiroma
    Department of Inherited Metabolic Disease, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Tokyo, Japan
    Brain Dev 25:116-21. 2003
    ..We conclude that molecular genetic analysis of the GFAP gene is feasible for antemortem diagnosis of Alexander disease in Japanese patients...
  38. ncbi request reprint Proposed guidelines for hypertriglyceridemia in Japan with non-HDL cholesterol as the second target
    Hitoshi Shimano
    The Research Committee for Primary Hyperlipidemia, Research on Measures for Intractable Diseases by the Ministry for Health, Labor, and Welfare in Japan
    J Atheroscler Thromb 15:116-21. 2008
    ....