K Ogura

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil
    K Ogura
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Exp Med 192:1601-10. 2000
  2. pmc Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori
    S Maeda
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Mol Pathol 55:286-93. 2002
  3. pmc Helicobacter pylori activates the cyclin D1 gene through mitogen-activated protein kinase pathway in gastric cancer cells
    Y Hirata
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Infect Immun 69:3965-71. 2001
  4. ncbi request reprint Expression of vascular endothelial growth factor at the human gastric ulcer margin and in cultured gastric fibroblasts: a new angiogenic factor for gastric ulcer healing
    M Takahashi
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo ku, Japan
    Biochem Biophys Res Commun 234:493-8. 1997
  5. ncbi request reprint H. pylori activates NF-kappaB through a signaling pathway involving IkappaB kinases, NF-kappaB-inducing kinase, TRAF2, and TRAF6 in gastric cancer cells
    S Maeda
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Gastroenterology 119:97-108. 2000
  6. ncbi request reprint CagA protein secreted by the intact type IV secretion system leads to gastric epithelial inflammation in the Mongolian gerbil model
    W Shibata
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Pathol 210:306-14. 2006
  7. pmc Helicobacter pylori induced transactivation of SRE and AP-1 through the ERK signalling pathway in gastric cancer cells
    Y Mitsuno
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Gut 49:18-22. 2001
  8. pmc Determination of Helicobacter pylori virulence by simple gene analysis of the cag pathogenicity island
    T Ikenoue
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Clin Diagn Lab Immunol 8:181-6. 2001
  9. pmc Detection of clarithromycin-resistant helicobacter pylori strains by a preferential homoduplex formation assay
    S Maeda
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    J Clin Microbiol 38:210-4. 2000
  10. ncbi request reprint Distinct mechanism of Helicobacter pylori-mediated NF-kappa B activation between gastric cancer cells and monocytic cells
    S Maeda
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Biol Chem 276:44856-64. 2001

Collaborators

Detail Information

Publications30

  1. pmc Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil
    K Ogura
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Exp Med 192:1601-10. 2000
    ..In conclusion, the knocking out of the cagE gene deprived wild-type H. pylori of the pathogenicity for gastritis and gastric ulcer, suggesting that the secretion system encoded by cag pathogenicity island genes plays an essential role...
  2. pmc Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori
    S Maeda
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Mol Pathol 55:286-93. 2002
    ..Although it is reported that Helicobacter pylori induces apoptosis on gastric epithelial cells, the mechanism remains unknown. Antiapoptotic effects generated by H pylori have not yet been evaluated...
  3. pmc Helicobacter pylori activates the cyclin D1 gene through mitogen-activated protein kinase pathway in gastric cancer cells
    Y Hirata
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Infect Immun 69:3965-71. 2001
    ..pylori activates cyclin D1 through the mitogen-activated protein kinase pathway and not through NF-kappaB activation in AGS cells. This activation of cyclin D1 is partly dependent on the cag pathogenicity island but not on vacA...
  4. ncbi request reprint Expression of vascular endothelial growth factor at the human gastric ulcer margin and in cultured gastric fibroblasts: a new angiogenic factor for gastric ulcer healing
    M Takahashi
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo ku, Japan
    Biochem Biophys Res Commun 234:493-8. 1997
    ..We further demonstrate the expression of VEGF by cultured human gastric fibroblasts which is enhanced by tumor necrosis factor-alpha. These data suggest that VEGF may play a role in angiogenesis in the process of gastric ulcer healing...
  5. ncbi request reprint H. pylori activates NF-kappaB through a signaling pathway involving IkappaB kinases, NF-kappaB-inducing kinase, TRAF2, and TRAF6 in gastric cancer cells
    S Maeda
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Gastroenterology 119:97-108. 2000
    ..The aim of this study was to analyze the molecular mechanism responsible for H. pylori-mediated NF-kappaB activation on gastric cancer cells...
  6. ncbi request reprint CagA protein secreted by the intact type IV secretion system leads to gastric epithelial inflammation in the Mongolian gerbil model
    W Shibata
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Pathol 210:306-14. 2006
    ..It is concluded that CagA protein may be essential for the induction of severe gastritis in the Mongolian gerbil model...
  7. pmc Helicobacter pylori induced transactivation of SRE and AP-1 through the ERK signalling pathway in gastric cancer cells
    Y Mitsuno
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Gut 49:18-22. 2001
    ..c-Fos is important for transactivation of AP-1 which has SRE in the promoter region. We conducted this study to confirm H pylori induced transactivation of these binding sites...
  8. pmc Determination of Helicobacter pylori virulence by simple gene analysis of the cag pathogenicity island
    T Ikenoue
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Clin Diagn Lab Immunol 8:181-6. 2001
    ..The cagE gene was a more accurate marker of an intact cag PAI than the cagA gene, and cagE seemed to be more useful in discriminating between H. pylori strains causing different rates of disease progression...
  9. pmc Detection of clarithromycin-resistant helicobacter pylori strains by a preferential homoduplex formation assay
    S Maeda
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    J Clin Microbiol 38:210-4. 2000
    ..1 mg/liter). Therefore, PHFA can detect clarithromycin-resistant H. pylori strains, even in patients with mixed infections with the wild type, that are not detectable by the agar dilution method...
  10. ncbi request reprint Distinct mechanism of Helicobacter pylori-mediated NF-kappa B activation between gastric cancer cells and monocytic cells
    S Maeda
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Biol Chem 276:44856-64. 2001
    ..pylori-induced NF-kappaB activation in epithelial cells is dependent on cag PAI and contact but does not involve CD14 and IRAK, whereas in macrophage/monocytic cells it is independent of cag PAI or contact but involves CD14 and TLR4...
  11. ncbi request reprint Clarithromycin-based triple therapy for non-resistant Helicobacter pylori infection. How long should it be given?
    K Ogura
    Dept of Gastroenterology, Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo, Tokyo 113 8655, Japan
    Scand J Gastroenterol 36:584-8. 2001
    ..The aim of this study is to assess the efficacy of clarithromycin-based triple therapy in patients infected exclusively with wild-type strains as determined by PCR-PHFA...
  12. ncbi request reprint Determination of the optimal cut-off value for the [13C]-urea breath test based on a Helicobacter pylori-specific polymerase chain reaction assay
    H Yoshida
    Department of Gastroenterology, University of Tokyo, Bunkyo, Japan
    J Gastroenterol Hepatol 15:155-60. 2000
    ....
  13. ncbi request reprint Promoters of epithelialization induce expression of vascular endothelial growth factor in human gastric epithelial cells in primary culture
    M Takahashi
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    FEBS Lett 418:115-8. 1997
    ..HGF and EGF receptors were expressed by the cells, suggesting that regulation may be mediated through specific receptors...
  14. pmc Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori
    S Maeda
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Gut 50:771-8. 2002
    ..Although it is reported that Helicobacter pylori induces apoptosis on gastric epithelial cells, the mechanism remains unknown. Antiapoptotic effects generated by H pylori have not yet been evaluated...
  15. ncbi request reprint Efficacy and safety of endoscopic submucosal dissection for gastric cancer in patients with liver cirrhosis
    K Ogura
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Endoscopy 40:443-5. 2008
    ..4 months, excluding three patients in whom additional endoscopic resection or surgery was carried out. ESD can be safely performed for gastric cancer in patients with cirrhosis, resulting in a high en bloc resection rate...
  16. doi request reprint Endoscopic full-thickness resection of a lateral spreading rectal tumor after unplanned injection of dilute hyaluronic acid into the subserosal layer (with video)
    H Konuma
    Department of Gastroenterology, Juntendo University Nerima Hospital, 3 1 10 Nerimatakanodai, Nerima, Tokyo, 177 8521, Japan
    Tech Coloproctol 16:247-50. 2012
    ..We describe how to promptly recognize this complication during colonoscopy, in order to achieve immediate closure of the defect, with the identification of a "mirror target sign" on the colonic wall...
  17. ncbi request reprint Presence of alpha-fetoprotein mRNA in blood correlates with outcome in patients with hepatocellular carcinoma
    M Matsumura
    The Institute for Adult Diseases, Asahi Life Foundation, Department of Internal Medicine, University of Tokyo, Japan
    J Hepatol 31:332-9. 1999
    ....
  18. doi request reprint Spontaneous complete regression of a rectal cancer
    S Sakamoto
    Department of Gastroenterology, Juntendo Univerity Nerima Hospital, Tokyo 177 8521, Japan
    Endoscopy 41:910-2. 2009
    ..Furthermore, the surgically removed specimen showed that the flat lesion had transformed to a depressed lesion, and surprisingly, no cancerous tissue was detected histologically...
  19. ncbi request reprint Triterpenoid CDDO-Im downregulates PML/RARalpha expression in acute promyelocytic leukemia cells
    T Ikeda
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell Death Differ 12:523-31. 2005
    ..Our findings indicate that CDDO-Im may be effective in the treatment of APL by: (i) downregulation of PML/RARalpha; (ii) enhancement of ATRA-induced differentiation; and (iii) sensitization of ATO-induced APL cell death...
  20. ncbi request reprint Involvement of nuclear transcription factor Sp1 in regulating glucose transporter-1 gene expression during rat trophoblast differentiation
    Y Okamoto
    Department of Obstetrics and Gynecology, Osaka University, Faculty of Medicine, 2 2 Yamadaoka Suita, Osaka, 565 0871, Japan
    Biochem Biophys Res Commun 288:940-8. 2001
    ..Furthermore, the decreased level of GLUT1 may result from a decreased level of Sp1 during differentiation. These findings suggest that Sp1 is involved in the regulation of rGLUT1 gene expression during rat trophoblast differentiation...
  21. pmc Structure and ligand recognition of the PB1 domain: a novel protein module binding to the PC motif
    H Terasawa
    Tokyo Metropolitan Institute of Medical Science, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan
    EMBO J 20:3947-56. 2001
    ..A structural database search reveals close similarity between the Bem1p PB1 domain and the c-Raf1 Ras-binding domain. However, these domains are functionally distinct from each other...
  22. pmc Novel recognition mode between Vav and Grb2 SH3 domains
    M Nishida
    Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N-12, Kita-ku, Sapporo 060-0812, CREST, Japan
    EMBO J 20:2995-3007. 2001
    ..The structure reveals how GrbS discriminates VavS specifically from other signaling molecules without binding to the proline-rich motif...
  23. ncbi request reprint Genomic organization and tissue-specific expression of splice variants of mouse organic anion transporting polypeptide 2
    K Ogura
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
    Biochem Biophys Res Commun 281:431-9. 2001
    ..The mouse oatp2 gene consists of 17 exons, including three noncoding exons, and 16 introns. All of the introns are flanked by GT-AG splice sequences except for intron 10 that is flanked by GC-AG splice sequence...
  24. ncbi request reprint Solution structure of Grb2 reveals extensive flexibility necessary for target recognition
    S Yuzawa
    Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan
    J Mol Biol 306:527-37. 2001
    ..Binding experiments on Grb2 and peptides containing two different proline-rich sequences indicate that Grb2 adapts the relative position and orientation of the two SH3 domains to bind bivalently to the target peptide sequences...
  25. ncbi request reprint Cloning, expression, and ontogeny of mouse organic anion-transporting polypeptide-5, a kidney-specific organic anion transporter
    S Choudhuri
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7417, USA
    Biochem Biophys Res Commun 280:92-8. 2001
    ..Phylogenetic analysis reveals that mouse Oatp-5 is an ortholog of rat Oatp-5...
  26. ncbi request reprint Cloning of the full-length coding sequence of rat liver-specific organic anion transporter-1 (rlst-1) and a splice variant and partial characterization of the rat lst-1 gene
    S Choudhuri
    Department of Pharmacology, Toxicology and Therapeutics, Kansas City, Kansas 66160 7417, USA
    Biochem Biophys Res Commun 274:79-86. 2000
    ....
  27. ncbi request reprint Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (lst-1)
    K Ogura
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City 66160 7417, USA
    Biochem Biophys Res Commun 272:563-70. 2000
    ....
  28. ncbi request reprint Mutational analysis of the RET proto-oncogene in 71 Japanese patients with medullary thyroid carcinoma
    S Shirahama
    Center for Molecular Biology and Cytogenetics, SRL Inc, Tokyo, Japan
    J Hum Genet 43:101-6. 1998
    ....
  29. ncbi request reprint Tertiary structure of destrin and structural similarity between two actin-regulating protein families
    H Hatanaka
    Tokyo Metropolitan Institute of Medical Science, Japan
    Cell 85:1047-55. 1996
    ....
  30. ncbi request reprint Solution structure and ligand-binding site of the carboxy-terminal SH3 domain of GRB2
    D Kohda
    Department of Molecular Physiology, Tokyo Metropolitan Institute of Medical Science, Japan
    Structure 2:1029-40. 1994
    ..Thus, GRB2 mediates signal transduction from growth factor receptors to Ras and is thought to be a key molecule in signal transduction...