Research Topics
| K OguraSummaryAffiliation: University of Tokyo Country: Japan Publications
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Detail Information
Publications
Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbilK Ogura
Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
J Exp Med 192:1601-10. 2000..In conclusion, the knocking out of the cagE gene deprived wild-type H. pylori of the pathogenicity for gastritis and gastric ulcer, suggesting that the secretion system encoded by cag pathogenicity island genes plays an essential role...- Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pyloriS Maeda
Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Mol Pathol 55:286-93. 2002..Although it is reported that Helicobacter pylori induces apoptosis on gastric epithelial cells, the mechanism remains unknown. Antiapoptotic effects generated by H pylori have not yet been evaluated... - Helicobacter pylori activates the cyclin D1 gene through mitogen-activated protein kinase pathway in gastric cancer cellsY Hirata
Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Infect Immun 69:3965-71. 2001..pylori activates cyclin D1 through the mitogen-activated protein kinase pathway and not through NF-kappaB activation in AGS cells. This activation of cyclin D1 is partly dependent on the cag pathogenicity island but not on vacA... 
Expression of vascular endothelial growth factor at the human gastric ulcer margin and in cultured gastric fibroblasts: a new angiogenic factor for gastric ulcer healingM Takahashi
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo ku, Japan
Biochem Biophys Res Commun 234:493-8. 1997..We further demonstrate the expression of VEGF by cultured human gastric fibroblasts which is enhanced by tumor necrosis factor-alpha. These data suggest that VEGF may play a role in angiogenesis in the process of gastric ulcer healing...- H. pylori activates NF-kappaB through a signaling pathway involving IkappaB kinases, NF-kappaB-inducing kinase, TRAF2, and TRAF6 in gastric cancer cellsS Maeda
Department of Gastroenterology, University of Tokyo, Tokyo, Japan
Gastroenterology 119:97-108. 2000..The aim of this study was to analyze the molecular mechanism responsible for H. pylori-mediated NF-kappaB activation on gastric cancer cells... - CagA protein secreted by the intact type IV secretion system leads to gastric epithelial inflammation in the Mongolian gerbil modelW Shibata
Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
J Pathol 210:306-14. 2006..It is concluded that CagA protein may be essential for the induction of severe gastritis in the Mongolian gerbil model... - Helicobacter pylori induced transactivation of SRE and AP-1 through the ERK signalling pathway in gastric cancer cellsY Mitsuno
Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Gut 49:18-22. 2001..c-Fos is important for transactivation of AP-1 which has SRE in the promoter region. We conducted this study to confirm H pylori induced transactivation of these binding sites... - Determination of Helicobacter pylori virulence by simple gene analysis of the cag pathogenicity islandT Ikenoue
Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Clin Diagn Lab Immunol 8:181-6. 2001..The cagE gene was a more accurate marker of an intact cag PAI than the cagA gene, and cagE seemed to be more useful in discriminating between H. pylori strains causing different rates of disease progression... - Detection of clarithromycin-resistant helicobacter pylori strains by a preferential homoduplex formation assayS Maeda
Department of Gastroenterology, University of Tokyo, Tokyo, Japan
J Clin Microbiol 38:210-4. 2000..1 mg/liter). Therefore, PHFA can detect clarithromycin-resistant H. pylori strains, even in patients with mixed infections with the wild type, that are not detectable by the agar dilution method... - Distinct mechanism of Helicobacter pylori-mediated NF-kappa B activation between gastric cancer cells and monocytic cellsS Maeda
Department of Gastroenterology, Faculty of Medicine, University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
J Biol Chem 276:44856-64. 2001..pylori-induced NF-kappaB activation in epithelial cells is dependent on cag PAI and contact but does not involve CD14 and IRAK, whereas in macrophage/monocytic cells it is independent of cag PAI or contact but involves CD14 and TLR4... - Clarithromycin-based triple therapy for non-resistant Helicobacter pylori infection. How long should it be given?K Ogura
Dept of Gastroenterology, Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo, Tokyo 113 8655, Japan
Scand J Gastroenterol 36:584-8. 2001..The aim of this study is to assess the efficacy of clarithromycin-based triple therapy in patients infected exclusively with wild-type strains as determined by PCR-PHFA... - Determination of the optimal cut-off value for the [13C]-urea breath test based on a Helicobacter pylori-specific polymerase chain reaction assayH Yoshida
Department of Gastroenterology, University of Tokyo, Bunkyo, Japan
J Gastroenterol Hepatol 15:155-60. 2000..7% at 20 min had the longest distance, being separated by 3.16 SD from the two mean values. Using this cut-off value, the urea breath test showed 100% specificity and 98% sensitivity for the diagnosis of Helicobacter pylori infection... - Efficacy and safety of endoscopic submucosal dissection for gastric cancer in patients with liver cirrhosisK Ogura
Department of Gastroenterology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Endoscopy 40:443-5. 2008..4 months, excluding three patients in whom additional endoscopic resection or surgery was carried out. ESD can be safely performed for gastric cancer in patients with cirrhosis, resulting in a high en bloc resection rate... - Promoters of epithelialization induce expression of vascular endothelial growth factor in human gastric epithelial cells in primary cultureM Takahashi
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
FEBS Lett 418:115-8. 1997..HGF and EGF receptors were expressed by the cells, suggesting that regulation may be mediated through specific receptors... - Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pyloriS Maeda
Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Gut 50:771-8. 2002..Although it is reported that Helicobacter pylori induces apoptosis on gastric epithelial cells, the mechanism remains unknown. Antiapoptotic effects generated by H pylori have not yet been evaluated... 
Endoscopic full-thickness resection of a lateral spreading rectal tumor after unplanned injection of dilute hyaluronic acid into the subserosal layer (with video)H Konuma
Department of Gastroenterology, Juntendo University Nerima Hospital, 3 1 10 Nerimatakanodai, Nerima, Tokyo, 177 8521, Japan
Tech Coloproctol 16:247-50. 2012..We describe how to promptly recognize this complication during colonoscopy, in order to achieve immediate closure of the defect, with the identification of a "mirror target sign" on the colonic wall...- Presence of alpha-fetoprotein mRNA in blood correlates with outcome in patients with hepatocellular carcinomaM Matsumura
The Institute for Adult Diseases, Asahi Life Foundation, Department of Internal Medicine, University of Tokyo, Japan
J Hepatol 31:332-9. 1999.... - Spontaneous complete regression of a rectal cancerS Sakamoto
Department of Gastroenterology, Juntendo Univerity Nerima Hospital, Tokyo 177 8521, Japan
Endoscopy 41:910-2. 2009..Furthermore, the surgically removed specimen showed that the flat lesion had transformed to a depressed lesion, and surprisingly, no cancerous tissue was detected histologically... - Triterpenoid CDDO-Im downregulates PML/RARalpha expression in acute promyelocytic leukemia cellsT Ikeda
Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Cell Death Differ 12:523-31. 2005..Our findings indicate that CDDO-Im may be effective in the treatment of APL by: (i) downregulation of PML/RARalpha; (ii) enhancement of ATRA-induced differentiation; and (iii) sensitization of ATO-induced APL cell death... - Involvement of nuclear transcription factor Sp1 in regulating glucose transporter-1 gene expression during rat trophoblast differentiationY Okamoto
Department of Obstetrics and Gynecology, Osaka University, Faculty of Medicine, 2 2 Yamadaoka Suita, Osaka, 565 0871, Japan
Biochem Biophys Res Commun 288:940-8. 2001..Furthermore, the decreased level of GLUT1 may result from a decreased level of Sp1 during differentiation. These findings suggest that Sp1 is involved in the regulation of rGLUT1 gene expression during rat trophoblast differentiation... - Structure and ligand recognition of the PB1 domain: a novel protein module binding to the PC motifH Terasawa
Tokyo Metropolitan Institute of Medical Science, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan
EMBO J 20:3947-56. 2001..A structural database search reveals close similarity between the Bem1p PB1 domain and the c-Raf1 Ras-binding domain. However, these domains are functionally distinct from each other... - Novel recognition mode between Vav and Grb2 SH3 domainsM Nishida
Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N-12, Kita-ku, Sapporo 060-0812, CREST, Japan
EMBO J 20:2995-3007. 2001..The structure reveals how GrbS discriminates VavS specifically from other signaling molecules without binding to the proline-rich motif... - Genomic organization and tissue-specific expression of splice variants of mouse organic anion transporting polypeptide 2K Ogura
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
Biochem Biophys Res Commun 281:431-9. 2001..The mouse oatp2 gene consists of 17 exons, including three noncoding exons, and 16 introns. All of the introns are flanked by GT-AG splice sequences except for intron 10 that is flanked by GC-AG splice sequence... - Solution structure of Grb2 reveals extensive flexibility necessary for target recognitionS Yuzawa
Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan
J Mol Biol 306:527-37. 2001..Binding experiments on Grb2 and peptides containing two different proline-rich sequences indicate that Grb2 adapts the relative position and orientation of the two SH3 domains to bind bivalently to the target peptide sequences... - Cloning, expression, and ontogeny of mouse organic anion-transporting polypeptide-5, a kidney-specific organic anion transporterS Choudhuri
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7417, USA
Biochem Biophys Res Commun 280:92-8. 2001..Phylogenetic analysis reveals that mouse Oatp-5 is an ortholog of rat Oatp-5... - Cloning of the full-length coding sequence of rat liver-specific organic anion transporter-1 (rlst-1) and a splice variant and partial characterization of the rat lst-1 geneS Choudhuri
Department of Pharmacology, Toxicology and Therapeutics, Kansas City, Kansas 66160 7417, USA
Biochem Biophys Res Commun 274:79-86. 2000.... - Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (lst-1)K Ogura
Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City 66160 7417, USA
Biochem Biophys Res Commun 272:563-70. 2000.... - Mutational analysis of the RET proto-oncogene in 71 Japanese patients with medullary thyroid carcinomaS Shirahama
Center for Molecular Biology and Cytogenetics, SRL Inc, Tokyo, Japan
J Hum Genet 43:101-6. 1998.... - Tertiary structure of destrin and structural similarity between two actin-regulating protein familiesH Hatanaka
Tokyo Metropolitan Institute of Medical Science, Japan
Cell 85:1047-55. 1996.... - Solution structure and ligand-binding site of the carboxy-terminal SH3 domain of GRB2D Kohda
Department of Molecular Physiology, Tokyo Metropolitan Institute of Medical Science, Japan
Structure 2:1029-40. 1994..Thus, GRB2 mediates signal transduction from growth factor receptors to Ras and is thought to be a key molecule in signal transduction...