Naoko Nukumi

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi Reduction of tumorigenesis and invasion of human breast cancer cells by whey acidic protein (WAP)
    Naoko Nukumi
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 8657, Japan
    Cancer Lett 252:65-74. 2007
  2. ncbi Whey acidic protein (WAP) regulates the proliferation of mammary epithelial cells by preventing serine protease from degrading laminin
    Naoko Nukumi
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Cell Physiol 213:793-800. 2007
  3. ncbi Regulatory function of whey acidic protein in the proliferation of mouse mammary epithelial cells in vivo and in vitro
    Naoko Nukumi
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan
    Dev Biol 274:31-44. 2004
  4. ncbi Whey acidic protein (WAP) depresses the proliferation of mouse (MMT) and human (MCF-7) mammary tumor cells
    Naoko Nukumi
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan
    J Reprod Dev 51:649-56. 2005
  5. ncbi Aberrant development of mammary glands, but precocious expression of beta-casein in transgenic females ubiquitously expressing whey acidic protein transgene
    Tokuko Iwamori
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan
    J Reprod Dev 51:579-92. 2005
  6. ncbi Identification of whey acidic protein (WAP) in dog milk
    Mami Seki
    Laboratory of Applied Genetics, The University of Tokyo, Japan
    Exp Anim 61:67-70. 2012
  7. ncbi Bacteriostatic activity of Whey Acidic Protein (WAP)
    Tokuko Iwamori
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo, Japan
    J Vet Med Sci 72:621-5. 2010
  8. ncbi Analysis of the promoter of mutated human whey acidic protein (WAP) gene
    Naoko Nukumi
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Reprod Dev 52:315-20. 2006
  9. ncbi Inhibitory function of whey acidic protein in the cell-cycle progression of mouse mammary epithelial cells (EpH4/K6 cells)
    Kayoko Ikeda
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Reprod Dev 50:87-96. 2004

Collaborators

Detail Information

Publications9

  1. ncbi Reduction of tumorigenesis and invasion of human breast cancer cells by whey acidic protein (WAP)
    Naoko Nukumi
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 8657, Japan
    Cancer Lett 252:65-74. 2007
    ..These data suggest that WAP has a protease-inhibitory function on the progression of breast cancer cells. It is therefore possible to utilize WAP as therapeutic protein against tumorigenesis of breast cancer...
  2. ncbi Whey acidic protein (WAP) regulates the proliferation of mammary epithelial cells by preventing serine protease from degrading laminin
    Naoko Nukumi
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Cell Physiol 213:793-800. 2007
    ..We concluded that WAP plays some role in regulating the proliferation of mammary epithelial cells by preventing elastase-type serine protease from carrying out laminin degradation and thereby suppressing the MAP kinase signal pathway...
  3. ncbi Regulatory function of whey acidic protein in the proliferation of mouse mammary epithelial cells in vivo and in vitro
    Naoko Nukumi
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan
    Dev Biol 274:31-44. 2004
    ..The present results provide the first documented evidence that WAP plays a negative regulatory role in the cell cycle progression of mammary epithelial cells through an autocrine or paracrine mechanism in vivo...
  4. ncbi Whey acidic protein (WAP) depresses the proliferation of mouse (MMT) and human (MCF-7) mammary tumor cells
    Naoko Nukumi
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan
    J Reprod Dev 51:649-56. 2005
    ..The present results indicate that WAP plays a negative regulatory role in the cell-cycle progression of mammary tumor cells via a paracrine mechanism...
  5. ncbi Aberrant development of mammary glands, but precocious expression of beta-casein in transgenic females ubiquitously expressing whey acidic protein transgene
    Tokuko Iwamori
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan
    J Reprod Dev 51:579-92. 2005
    ..In vitro experiments using HC11 cells with forced expression of exogenous WAP demonstrated the inhibitory function of WAP on proliferation of mammary epithelial cells...
  6. ncbi Identification of whey acidic protein (WAP) in dog milk
    Mami Seki
    Laboratory of Applied Genetics, The University of Tokyo, Japan
    Exp Anim 61:67-70. 2012
    ..Biochemical analysis of milk protein by reverse-phase HPLC and Western blotting demonstrated the presence of WAP in dog milk...
  7. ncbi Bacteriostatic activity of Whey Acidic Protein (WAP)
    Tokuko Iwamori
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo, Japan
    J Vet Med Sci 72:621-5. 2010
    ..The bacteriostatic activity of WAP was highest at pH 6.6 and was not affected by the presence of 150 mM NaCl. A scanning electron micrograph of bacteria treated with WAP exhibited the disruption of the bacterial cell walls...
  8. ncbi Analysis of the promoter of mutated human whey acidic protein (WAP) gene
    Naoko Nukumi
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Reprod Dev 52:315-20. 2006
    ..The human WAP promoter was significantly more active in MCF-7 cells than the mouse WAP promoter (2.4 kb). The present results provide us with important information on the molecular evolution of milk protein genes...
  9. ncbi Inhibitory function of whey acidic protein in the cell-cycle progression of mouse mammary epithelial cells (EpH4/K6 cells)
    Kayoko Ikeda
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Reprod Dev 50:87-96. 2004
    ..The present results indicate that WAP plays a negative regulatory role in the cell-cycle progression of mammary epithelial cells through an autocrine/paracrine mechanism...