Hiroaki Nozawa

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Detection of cancer cells in mesenteric vein and peripheral vessels by measuring telomerase activity in patients with colorectal cancer
    Hiroaki Nozawa
    Department of Surgical Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Surgery 134:791-8. 2003
  2. ncbi request reprint Phosphorylation of ribosomal p70 S6 kinase and rapamycin sensitivity in human colorectal cancer
    Hiroaki Nozawa
    Department of Surgical Oncology, University of Tokyo, 7 3 1 Hongo, Bunkyu ku, Tokyo 113 8655, Japan
    Cancer Lett 251:105-13. 2007
  3. doi request reprint Metachronous tubulovillous and tubular adenomas of the anal canal
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Diagn Pathol 10:139. 2015
  4. ncbi request reprint Large Colorectal Carcinoma Is Predictive of Recurrence After Adjuvant Chemotherapy Using Oxaliplatin
    Hiroaki Nozawa
    Department of Surgical Oncology, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Anticancer Res 35:5073-8. 2015
  5. doi request reprint Outcome of salvage surgery for colorectal cancer initially treated by upfront endoscopic therapy
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan Electronic address
    Surgery 159:713-20. 2016
  6. pmc Laparoscopic resection of a gastrointestinal stromal tumor of the lower rectum in a patient with coronary artery disease following long-term neoadjuvant imatinib treatment and anticoagulation therapy
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    World J Surg Oncol 12:211. 2014
  7. doi request reprint Impact of chronic kidney disease on outcomes of surgical resection for primary colorectal cancer: a retrospective cohort review
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Dis Colon Rectum 55:948-56. 2012
  8. doi request reprint FOLFOX as adjuvant chemotherapy after curative resection of distant metastases in patients with colorectal cancer
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    Oncology 80:84-91. 2011
  9. doi request reprint Double primary adenocarcinomas of the jejunum and descending colon with lung metastases presenting rare immunohistochemical phenotypes: a case report
    Hiroaki Nozawa
    Department of Surgery, Odaira Memorial Tokyo Hitachi Hospital, Yushima, Bunkyo ku, Tokyo 113 0034, Japan
    Eur J Gastroenterol Hepatol 22:228-33. 2010
  10. doi request reprint Ischemic colitis following colonoscopy in an elderly patient on cardiovascular medication
    H Nozawa
    Department of Surgery, Odaira Memorial Tokyo Hitachi Hospital, Japan
    Endoscopy 39:E344-5. 2007

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Detection of cancer cells in mesenteric vein and peripheral vessels by measuring telomerase activity in patients with colorectal cancer
    Hiroaki Nozawa
    Department of Surgical Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Surgery 134:791-8. 2003
    ..The objective of this study was to assess whether colorectal cancer cells in the drainage veins can be detected by measuring telomerase activity and its detection is correlated with liver metastasis...
  2. ncbi request reprint Phosphorylation of ribosomal p70 S6 kinase and rapamycin sensitivity in human colorectal cancer
    Hiroaki Nozawa
    Department of Surgical Oncology, University of Tokyo, 7 3 1 Hongo, Bunkyu ku, Tokyo 113 8655, Japan
    Cancer Lett 251:105-13. 2007
    ..By immunohistochemical study, nearly 40% of adenomas and carcinomas of the colorectum exhibited either partial or whole positive staining for phospho-S6K, suggestive of rapamycin-sensitive lesions...
  3. doi request reprint Metachronous tubulovillous and tubular adenomas of the anal canal
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Diagn Pathol 10:139. 2015
    ..Our case report underscores the importance of careful observations throughout colonoscopy to detect precancerous lesions, particularly in anatomically narrow segments. ..
  4. ncbi request reprint Large Colorectal Carcinoma Is Predictive of Recurrence After Adjuvant Chemotherapy Using Oxaliplatin
    Hiroaki Nozawa
    Department of Surgical Oncology, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Anticancer Res 35:5073-8. 2015
    ..However, factors associated with recurrence despite adjuvant therapy are largely unknown...
  5. doi request reprint Outcome of salvage surgery for colorectal cancer initially treated by upfront endoscopic therapy
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan Electronic address
    Surgery 159:713-20. 2016
    ..The aim of our study was to evaluate the outcomes of salvage surgery in CRC patients treated initially by advanced therapeutic endoscopy...
  6. pmc Laparoscopic resection of a gastrointestinal stromal tumor of the lower rectum in a patient with coronary artery disease following long-term neoadjuvant imatinib treatment and anticoagulation therapy
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    World J Surg Oncol 12:211. 2014
    ..En bloc resection of the GIST was performed laparoscopically, which preserved the anus. The patient is currently alive without any evidence of relapse for 12 months after surgery. ..
  7. doi request reprint Impact of chronic kidney disease on outcomes of surgical resection for primary colorectal cancer: a retrospective cohort review
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Dis Colon Rectum 55:948-56. 2012
    ..Chronic kidney disease, a disease entity increasing in number, may be an obstacle in various aspects of treatment for malignant neoplasm, such as perisurgical management and implementation of chemotherapy...
  8. doi request reprint FOLFOX as adjuvant chemotherapy after curative resection of distant metastases in patients with colorectal cancer
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    Oncology 80:84-91. 2011
    ..The prophylactic effect of FOLFOX regimen, a standard regimen for unresectable colorectal cancer (CRC), was investigated in the adjuvant setting of CRC cases with distant metastases...
  9. doi request reprint Double primary adenocarcinomas of the jejunum and descending colon with lung metastases presenting rare immunohistochemical phenotypes: a case report
    Hiroaki Nozawa
    Department of Surgery, Odaira Memorial Tokyo Hitachi Hospital, Yushima, Bunkyo ku, Tokyo 113 0034, Japan
    Eur J Gastroenterol Hepatol 22:228-33. 2010
    ..Moreover, postoperative oxaliplatin, including chemotherapy, significantly reduced the lung metastases, suggesting that this regimen is a promising treatment option for advanced small bowel adenocarcinoma...
  10. doi request reprint Ischemic colitis following colonoscopy in an elderly patient on cardiovascular medication
    H Nozawa
    Department of Surgery, Odaira Memorial Tokyo Hitachi Hospital, Japan
    Endoscopy 39:E344-5. 2007
  11. pmc Pelvic actinomycosis presenting with a large abscess and bowel stenosis with marked response to conservative treatment: a case report
    Hiroaki Nozawa
    Department of Surgery, Odaira Memorial Tokyo Hitachi Hospital, Tokyo, Japan
    J Med Case Reports 1:141. 2007
    ..This is a successful case of symptomatic pelvic actinomycosis that was correctly diagnosed and treated without unnecessary surgical intervention...
  12. ncbi request reprint [FOLFOX as adjuvant chemotherapy after curative resection of distant metastatic lesions in patients with colorectal cancer]
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    Gan To Kagaku Ryoho 38:1627-32. 2011
    ..03, p=0. 007, respectively). In conclusion, the FOLFOX regimen is more beneficial for CRC patients with synchronous metastasis as adjuvant chemotherapy than 5-FU (+LV) or other followup strategies...
  13. doi request reprint Hepatic steatosis is associated with lower incidence of liver metastasis from colorectal cancer
    Koji Murono
    Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Colorectal Dis 28:1065-72. 2013
    ..The liver is the most frequent site of distant metastasis of CRC; however, the impact of HS on the incidence of liver metastasis of CRC is not clearly defined. Then, the correlation with the presence or absence of HS was analyzed...
  14. doi request reprint Incidence of neoplasias and effectiveness of postoperative surveillance endoscopy for patients with ulcerative colitis: comparison of ileorectal anastomosis and ileal pouch-anal anastomosis
    Hiroaki Ishii
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Tokyo, 113 0033, Japan
    World J Surg Oncol 14:75. 2016
    ....
  15. doi request reprint Laparoscopic surgery for ulcerative colitis: a review of the literature
    Keisuke Hata
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Today 45:933-8. 2015
    ..Some surgeons favor laparoscopic surgery even for severe acute colitis. More efforts are being made to develop newer laparoscopic methods, such as reduced port surgery, including single incision laparoscopic surgery and robotic surgery. ..
  16. doi request reprint Prognostic significance of the lymph node ratio in stage IV colorectal cancer patients who have undergone curative resection
    Tsuyoshi Ozawa
    Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo, 113 8655, Japan
    Ann Surg Oncol 22:1513-9. 2015
    ..The purpose of this study was to evaluate the prognostic impact of the LNR in Stage IV CRC patients who have undergone curative resection...
  17. doi request reprint The preoperative platelet to lymphocyte ratio is a prognostic marker in patients with stage II colorectal cancer
    Tsuyoshi Ozawa
    Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo, 113 8655, Japan
    Int J Colorectal Dis 30:1165-71. 2015
    ..The aim of this study was to evaluate the prognostic impact of the PLR in patients with stage II colorectal cancer (CRC) who have undergone curative resection but not adjuvant chemotherapy...
  18. ncbi request reprint CD133 Expression in Lymph Node Metastases Is Associated with Tumor Aggressiveness During Lymph Node Metastasis in Colorectal Cancer
    Shinsuke Kazama
    Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Anticancer Res 35:6599-605. 2015
    ..However, the expression of CD133 in lymph node metastases as well as in primary tumors in CRC remains to be elucidated...
  19. doi request reprint Nomograms for colorectal cancer: A systematic review
    Kazushige Kawai
    Kazushige Kawai, Eiji Sunami, Hironori Yamaguchi, Soichiro Ishihara, Shinsuke Kazama, Hiroaki Nozawa, Keisuke Hata, Tomomichi Kiyomatsu, Junichiro Tanaka, Toshiaki Tanaka, Takeshi Nishikawa, Joji Kitayama, Toshiaki Watanabe, Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
    World J Gastroenterol 21:11877-86. 2015
    ..To assist in the selection of suitable nomograms for obtaining desired predictions in daily clinical practice...
  20. doi request reprint 'Deepness of Response' Is Associated with Overall Survival in Standard Systemic Chemotherapy for Metastatic Colorectal Cancer
    Hiroaki Nozawa
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    Chemotherapy 60:360-7. 2014
    ..We determined whether this concept was universally applicable to diverse standard chemotherapeutic regimens for mCRC...
  21. doi request reprint Temsirolimus and chloroquine cooperatively exhibit a potent antitumor effect against colorectal cancer cells
    Manabu Kaneko
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Cancer Res Clin Oncol 140:769-81. 2014
    ....
  22. doi request reprint One-stage segmental colectomy and primary anastomosis after intraoperative colonic irrigation and total colonoscopy for patients with obstruction due to left-sided colorectal cancer
    Kazuhito Sasaki
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Dis Colon Rectum 55:72-8. 2012
    ....
  23. doi request reprint Recent advances in robotic surgery for rectal cancer
    Soichiro Ishihara
    Department of Surgical Oncology, The University of Tokyo Hospital, 7 3 1, Bunkyo ku, Hongo, Tokyo, 113 8655, Japan
    Int J Clin Oncol 20:633-40. 2015
    ..However, long-term outcomes and the cost-effectiveness of robotic surgery for rectal cancer have not been fully evaluated yet; therefore, large-scale clinical studies are required to evaluate the efficacy of this new technology. ..
  24. doi request reprint Incidence and prognostic significance of positive peritoneal lavage in colorectal cancer
    Takeshi Nishikawa
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Today 45:1073-81. 2015
    ..However, the meaning of positive peritoneal lavage cytology in colorectal cancer is still controversial. The aim of this review is to evaluate the prognostic significance of positive peritoneal lavage cytology in colorectal cancer...
  25. doi request reprint Alpha-fetoprotein-producing early rectal carcinoma: a rare case report and review
    Hiroyuki Anzai
    Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    World J Surg Oncol 13:180. 2015
    ..Alpha-fetoprotein (AFP)-producing rectal cancer is very rare, and this type of cancer frequently metastasizes to the liver with a poor prognosis. To date, only 11 cases of AFP-producing colorectal cancer have been reported...
  26. doi request reprint Prognostic Impact of Histologic Type in Curatively Resected Stage IV Colorectal Cancer: A Japanese Multicenter Retrospective Study
    Junichi Shibata
    Department of Surgical Oncology, University of Tokyo Hospital, The University of Tokyo, Tokyo, Japan
    Ann Surg Oncol 22:621-9. 2015
    ..This study aimed to clarify differences in prognostic factors, metastatic features, and recurrence rates between histologic types in patients with stage 4 colorectal cancer (CRC) who had undergone curative resection...
  27. doi request reprint A patient with gastric cancer with peritoneal carcinomatosis treated with intraperitoneal chemotherapy who survived more than 5 years receiving repeated laparoscopic examinations: a case report
    Hironori Yamaguchi
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Bunkyo ku, Hongo, Tokyo, 113 8655, Japan
    J Med Case Rep 10:14. 2016
    ..This is the first report of a case of a patient with gastric cancer with massive peritoneal metastasis treated with intraperitoneal administration of paclitaxel and repeated laparoscopic examinations who survived more than 5 years...
  28. doi request reprint Patient factors predisposing to complications following laparoscopic surgery for colorectal cancers
    Soichiro Ishihara
    Department of Surgical Oncology, The University of Tokyo Hospital, Hongo, Bunkyo ku Department of Surgery, Teikyo University, Kaga, Itabashi ku, Tokyo, Japan
    Surg Laparosc Endosc Percutan Tech 25:168-72. 2015
    ..91, P=0.0102) and cancer stage (stage 2/stage 4: OR=0.17, P=0.0247) were risk factors for noninfectious complications. This study shows that different patient factors are associated with the risk of different types of complications. ..
  29. doi request reprint Comparison of Functional Outcomes of Patients Who Underwent Hand-Sewn or Stapled Ileal Pouch-Anal Anastomosis for Ulcerative Colitis
    Hiroaki Ishii
    1 Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Int Surg 100:1169-76. 2015
    ..Postoperative complications, functional outcomes, and long-term QOL were similar in patients who had received hand-sewn or stapled IPAA. ..
  30. doi request reprint Mesalazine-induced Pleuropericarditis in a Patient with Crohn's Disease
    Hidemichi Kiyomatsu
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Japan
    Intern Med 54:1605-8. 2015
    ..After the cessation of mesalazine, the clinical symptoms and laboratory findings quickly improved. ..
  31. pmc A case of extraperitoneal stoma-associated internal hernia after abdominoperineal resection
    Yuichiro Yokoyama
    Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    World J Surg Oncol 12:141. 2014
    ..The strangulated portion of the small intestine was recovered, and the orifice of herniation was closed. No recurrence of internal herniation was observed during the follow-up period. ..
  32. ncbi request reprint Phospholipase A2 Group III and Group X Have Opposing Associations with Prognosis in Colorectal Cancer
    Shinsuke Kazama
    Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Anticancer Res 35:2983-90. 2015
    ..Although secretory phospholipase A2 (sPLA2) has been shown to be involved in various biological processes, its specific roles in sub-types of cancer development remain to be elucidated...
  33. doi request reprint Nuclear Notch3 expression is associated with tumor recurrence in patients with stage II and III colorectal cancer
    Tsuyoshi Ozawa
    Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Ann Surg Oncol 21:2650-8. 2014
    ..In the present study, we investigated Notch1 and Notch3 expression in Stage II and III CRC to assess their association with clinicopathological characteristics...
  34. ncbi request reprint Telomerase activity of blood samples and recurrence of colorectal cancer
    Tatsuya Ohnishi
    Department of Surgical Oncology, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Hepatogastroenterology 55:1513-8. 2008
    ....
  35. ncbi request reprint Telomerase subunit immunoreactivity and recurrence in colorectal cancer
    Tatsuya Ohnishi
    Department of Surgical Oncology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Hepatogastroenterology 53:188-91. 2006
    ..In this study we attempted to show by means of immunohistochemistry the association between hTERT expression and recurrence in 128 colorectal cancer patients surgically treated in the University of Tokyo Hospital...
  36. ncbi request reprint High RAD54B expression: an independent predictor of postoperative distant recurrence in colorectal cancer patients
    Yuzo Nagai
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Oncotarget 6:21064-73. 2015
    ..This study first demonstrated RAD54B expression has potential to serve as a novel prognostic biomarker, particularly for distant recurrence in CRC patients. ..
  37. doi request reprint Elevated neutrophil to lymphocyte ratio predicts poor prognosis in advanced colorectal cancer patients receiving oxaliplatin-based chemotherapy
    Manabu Kaneko
    Department of Surgical Oncology, Faculty of Medicine, University of Tokyo, Tokyo, Japan m kaneko fancy ocn ne jp
    Oncology 82:261-8. 2012
    ..The aim of this study was to assess whether the neutrophil to lymphocyte ratio (NLR) and other laboratory markers may predict the prognosis of advanced colorectal cancer (CRC) patients receiving palliative chemotherapy...
  38. doi request reprint Critical role for constitutive type I interferon signaling in the prevention of cellular transformation
    Hui Min Chen
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Cancer Sci 100:449-56. 2009
    ....
  39. ncbi request reprint Dihydropyrimidine dehydrogenase expression in preoperative biopsy and surgically resected specimens of gastric carcinoma
    Hiroaki Nozawa
    Department of Surgery, Tokyo Postal Services Agency Hospital, 2 14 23 Fujimi, Chiyoda ku, Tokyo 102 8798, Japan
    Cancer Chemother Pharmacol 49:267-73. 2002
    ..We investigated preoperative biopsy and surgically resected specimens of gastric carcinomas immunohistochemically for the expression of DPD...