Katsunori Nonogaki

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. Nonogaki K, Kaji T. Hypothalamic orexin and pro-opiomelanocortin activities are essential for the anorexic effects of m-chlorophenylpiperazine in mice. Int J Neuropsychopharmacol. 2010;13:1261-7 pubmed publisher
    ..These findings suggest that functional hypothalamic POMC and orexin activity has a critical role in satiety signalling of mCPP in mice. ..
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    Nonogaki K, Ohashi Nozue K, Oka Y. A negative feedback system between brain serotonin systems and plasma active ghrelin levels in mice. Biochem Biophys Res Commun. 2006;341:703-7 pubmed
    ..These results suggest that there is a negative feedback system between brain 5-HT systems and plasma active ghrelin levels in energy homeostasis in mice. ..
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    Nonogaki K, Ohashi Nozue K, Oka Y. Induction of hypothalamic serum- and glucocorticoid-induced protein kinase-1 gene expression and its relation to plasma des-acyl ghrelin in energy homeostasis in mice. Biochem Biophys Res Commun. 2006;344:696-9 pubmed
    ..These results suggest that hypothalamic SGK-1 gene is a novel candidate gene involving in energy homeostasis in mice. ..
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    Nonogaki K, Nozue K, Takahashi Y, Yamashita N, Hiraoka S, Kumano H, et al. Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT2C receptor inactivation induce appetite-suppressing effects in mice via 5-HT1B receptors. Int J Neuropsychopharmacol. 2007;10:675-81 pubmed
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    Nonogaki K, Nozue K, Oka Y. Hyperphagia alters expression of hypothalamic 5-HT2C and 5-HT1B receptor genes and plasma des-acyl ghrelin levels in Ay mice. Endocrinology. 2006;147:5893-900 pubmed
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    Nonogaki K, Nozue K, Oka Y. Increased hypothalamic 5-HT2A receptor gene expression and effects of pharmacologic 5-HT2A receptor inactivation in obese Ay mice. Biochem Biophys Res Commun. 2006;351:1078-82 pubmed
    ..These results suggest that obesity increases hypothalamic 5-HT2A receptor gene expression, and pharmacologic inactivation of 5-HT2A receptors inhibits overfeeding and obesity in A(y) mice, but did not increase plasma adiponectin levels. ..
  7. Nonogaki K, Ohba Y, Sumii M, Oka Y. Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice. Biochem Biophys Res Commun. 2008;372:186-90 pubmed publisher
    ..These findings suggest that 5-HT systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors, and induce anorexia via a leptin-independent pathway in mice. ..
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    Nonogaki K, Nozue K, Oka Y. Social isolation affects the development of obesity and type 2 diabetes in mice. Endocrinology. 2007;148:4658-66 pubmed
    ..Thus, social isolation can be included in the environmental factors that contribute to the development of obesity and type 2 diabetes. ..
  9. Nonogaki K, Kaji T, Ohba Y, Sumii M, Wakameda M, Tamari T. Serotonin 5-HT2C receptor-independent expression of hypothalamic NOR1, a novel modulator of food intake and energy balance, in mice. Biochem Biophys Res Commun. 2009;386:311-5 pubmed publisher
    ..These findings suggest that 5-HT2C receptor-independent proopiomelanocortin-derived peptides regulate the expression of hypothalamic NOR1, which is a novel modulator of feeding behavior and energy balance. ..