Katsunori Nonogaki

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. doi request reprint Hypothalamic orexin and pro-opiomelanocortin activities are essential for the anorexic effects of m-chlorophenylpiperazine in mice
    Katsunori Nonogaki
    Department of Lifestyle Medicine, Biomedical Engineering Center, Tohoku University Hospital, Aoba ku, Sendai, Japan
    Int J Neuropsychopharmacol 13:1261-7. 2010
  2. ncbi request reprint Social isolation affects the development of obesity and type 2 diabetes in mice
    Katsunori Nonogaki
    Associate Professor, Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 2 1 Seiryou machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Endocrinology 148:4658-66. 2007
  3. doi request reprint Fluvoxamine exerts anorexic effect in 5-HT2C receptor mutant mice with heterozygous mutation of beta-endorphin gene
    Katsunori Nonogaki
    Centre of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Int J Neuropsychopharmacol 12:547-52. 2009
  4. doi request reprint Serotonin 5-HT2C receptor-independent expression of hypothalamic NOR1, a novel modulator of food intake and energy balance, in mice
    Katsunori Nonogaki
    Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Biochem Biophys Res Commun 386:311-5. 2009
  5. ncbi request reprint Milnacipran, a serotonin and norepinephrine reuptake inhibitor, induces appetite-suppressing effects without inducing hypothalamic stress responses in mice
    Katsunori Nonogaki
    Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku Univ Graduate School of Medicine, 2 1 Seiryo machi, Sendai, Japan
    Am J Physiol Regul Integr Comp Physiol 292:R1775-81. 2007
  6. ncbi request reprint Increased hypothalamic 5-HT2A receptor gene expression and effects of pharmacologic 5-HT2A receptor inactivation in obese Ay mice
    Katsunori Nonogaki
    Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Biochem Biophys Res Commun 351:1078-82. 2006
  7. ncbi request reprint Hyperphagia alters expression of hypothalamic 5-HT2C and 5-HT1B receptor genes and plasma des-acyl ghrelin levels in Ay mice
    Katsunori Nonogaki
    Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 2 1 Seiryou machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Endocrinology 147:5893-900. 2006
  8. ncbi request reprint Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT2C receptor inactivation induce appetite-suppressing effects in mice via 5-HT1B receptors
    Katsunori Nonogaki
    Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Japan
    Int J Neuropsychopharmacol 10:675-81. 2007
  9. ncbi request reprint Induction of hypothalamic serum- and glucocorticoid-induced protein kinase-1 gene expression and its relation to plasma des-acyl ghrelin in energy homeostasis in mice
    Katsunori Nonogaki
    Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 344:696-9. 2006
  10. ncbi request reprint A negative feedback system between brain serotonin systems and plasma active ghrelin levels in mice
    Katsunori Nonogaki
    Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Japan
    Biochem Biophys Res Commun 341:703-7. 2006

Detail Information

Publications22

  1. doi request reprint Hypothalamic orexin and pro-opiomelanocortin activities are essential for the anorexic effects of m-chlorophenylpiperazine in mice
    Katsunori Nonogaki
    Department of Lifestyle Medicine, Biomedical Engineering Center, Tohoku University Hospital, Aoba ku, Sendai, Japan
    Int J Neuropsychopharmacol 13:1261-7. 2010
    ..These findings suggest that functional hypothalamic POMC and orexin activity has a critical role in satiety signalling of mCPP in mice...
  2. ncbi request reprint Social isolation affects the development of obesity and type 2 diabetes in mice
    Katsunori Nonogaki
    Associate Professor, Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 2 1 Seiryou machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Endocrinology 148:4658-66. 2007
    ..Thus, social isolation can be included in the environmental factors that contribute to the development of obesity and type 2 diabetes...
  3. doi request reprint Fluvoxamine exerts anorexic effect in 5-HT2C receptor mutant mice with heterozygous mutation of beta-endorphin gene
    Katsunori Nonogaki
    Centre of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Int J Neuropsychopharmacol 12:547-52. 2009
    ....
  4. doi request reprint Serotonin 5-HT2C receptor-independent expression of hypothalamic NOR1, a novel modulator of food intake and energy balance, in mice
    Katsunori Nonogaki
    Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Biochem Biophys Res Commun 386:311-5. 2009
    ..These findings suggest that 5-HT2C receptor-independent proopiomelanocortin-derived peptides regulate the expression of hypothalamic NOR1, which is a novel modulator of feeding behavior and energy balance...
  5. ncbi request reprint Milnacipran, a serotonin and norepinephrine reuptake inhibitor, induces appetite-suppressing effects without inducing hypothalamic stress responses in mice
    Katsunori Nonogaki
    Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku Univ Graduate School of Medicine, 2 1 Seiryo machi, Sendai, Japan
    Am J Physiol Regul Integr Comp Physiol 292:R1775-81. 2007
    ....
  6. ncbi request reprint Increased hypothalamic 5-HT2A receptor gene expression and effects of pharmacologic 5-HT2A receptor inactivation in obese Ay mice
    Katsunori Nonogaki
    Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Biochem Biophys Res Commun 351:1078-82. 2006
    ..These results suggest that obesity increases hypothalamic 5-HT2A receptor gene expression, and pharmacologic inactivation of 5-HT2A receptors inhibits overfeeding and obesity in A(y) mice, but did not increase plasma adiponectin levels...
  7. ncbi request reprint Hyperphagia alters expression of hypothalamic 5-HT2C and 5-HT1B receptor genes and plasma des-acyl ghrelin levels in Ay mice
    Katsunori Nonogaki
    Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 2 1 Seiryou machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Endocrinology 147:5893-900. 2006
    ....
  8. ncbi request reprint Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT2C receptor inactivation induce appetite-suppressing effects in mice via 5-HT1B receptors
    Katsunori Nonogaki
    Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Japan
    Int J Neuropsychopharmacol 10:675-81. 2007
    ....
  9. ncbi request reprint Induction of hypothalamic serum- and glucocorticoid-induced protein kinase-1 gene expression and its relation to plasma des-acyl ghrelin in energy homeostasis in mice
    Katsunori Nonogaki
    Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 344:696-9. 2006
    ..These results suggest that hypothalamic SGK-1 gene is a novel candidate gene involving in energy homeostasis in mice...
  10. ncbi request reprint A negative feedback system between brain serotonin systems and plasma active ghrelin levels in mice
    Katsunori Nonogaki
    Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Japan
    Biochem Biophys Res Commun 341:703-7. 2006
    ..These results suggest that there is a negative feedback system between brain 5-HT systems and plasma active ghrelin levels in energy homeostasis in mice...
  11. doi request reprint Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice
    Katsunori Nonogaki
    Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Biomedical Engineering Center, Tohoku University, 1 1 Seiryou Machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 372:186-90. 2008
    ..These findings suggest that 5-HT systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors, and induce anorexia via a leptin-independent pathway in mice...
  12. ncbi request reprint Contribution of central SGK-1 to the acute phase responses of mice to social isolation
    Takao Kaji
    Department of Lifestyle Medicine, Biomedical Engineering Center, Tohoku University and Metabolic Care Clinic, Tohoku University Hospital, Sendai, Miyagi 980 8574, Japan
    Front Biosci (Elite Ed) 2:1355-61. 2010
    ..SGK-1 might contribute to the isolation stress-induced body weight reductions and increases in plasma active ghrelin levels via, at least partly, altered central autonomic outflow in mice...
  13. doi request reprint Novel modulators for body weight changes induced by fasting and re-feeding in mice
    Katsunori Nonogaki
    Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Japan
    Biochem Biophys Res Commun 378:249-54. 2009
    ..Thus, social isolation, endogenous beta-endorphin, and age can be novel modulators for body weight changes induced by fasting and re-feeding in mice...
  14. ncbi request reprint Role of homeobox genes in the hypothalamic development and energy balance
    Takao Kaji
    Department of Lifestyle Medicine, Translational Research Center, Tohoku University Hospital, 1 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8574, Japan
    Front Biosci (Landmark Ed) 18:740-7. 2013
    ..Thus, the hypothalamic homeobox genes may contribute to the dissociation of food intake and body weight via AgRP-POMC neurons...
  15. doi request reprint The contribution of serotonin 5-HT2C and melanocortin-4 receptors to the satiety signaling of glucagon-like peptide 1 and liraglutide, a glucagon-like peptide 1 receptor agonist, in mice
    Katsunori Nonogaki
    Department of Lifestyle Medicine, Biomedical Engineering Center, Tohoku University, Japan
    Biochem Biophys Res Commun 411:445-8. 2011
    ..These findings suggest that GLP-1 and liraglutide induce anorexia via different central pathways...
  16. doi request reprint Serotonin conflict in sleep-feeding
    Katsunori Nonogaki
    Department of Lifestyle Medicine, Translational Research Center, Tohoku University Hospital, Sendai, Miyagi, Japan
    Vitam Horm 89:223-39. 2012
    ..Thus, the central 5-HT regulation of sleep-feeding can be dissociated. Functional hypothalamic proopiomelanocortin and orexin activities may contribute to the dissociated 5-HT regulation...
  17. ncbi request reprint Ghrelin and feedback systems
    Katsunori Nonogaki
    Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Miyagi, Japan
    Vitam Horm 77:149-70. 2008
    ..Thus, a dysfunction of the ghrelin feedback systems might contribute to the pathophysiology of obesity and eating disorders...
  18. ncbi request reprint Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation
    Lora K Heisler
    Department of Clinical Biochemistry, Addenbrooke s Hospital and the University of Cambridge, Cambridge CB2 2QR, United Kingdom
    J Neurosci 27:6956-64. 2007
    ....
  19. ncbi request reprint Clinical worth of adiponectin levels in obesity and glycemic control of Japanese type 2 diabetic patients
    Katsunori Nonogaki
    Diabetes Care 26:3198. 2003
  20. ncbi request reprint Hyperactivity and reduced energy cost of physical activity in serotonin 5-HT(2C) receptor mutant mice
    Katsunori Nonogaki
    Department of Psychiatry and Center for Neurobiology and Psychiatry, University of California, San Francisco, 94143, USA
    Diabetes 52:315-20. 2003
    ..Moreover, age-dependent reductions in the energy cost of physical activity could contribute to the subsequent development of late-onset obesity in 5-HT(2C) receptor mutant mice...
  21. ncbi request reprint Altered gene expressions involved in energy expenditure in 5-HT(2C) receptor mutant mice
    Katsunori Nonogaki
    Department of Psychiatry and Center for Neurobiology and Psychiatry, University of California, San Francisco, CA 94143, USA
    Biochem Biophys Res Commun 295:249-54. 2002
    ..These results indicate that a mutation of 5-HT(2C) receptor gene leads to a secondary decrease in beta 3-AR gene expression that is related to enhanced adiposity...
  22. ncbi request reprint Isn't this just snacking? The potential adverse effects of night-eating symptoms on treatment adherence and outcomes in patients with diabetes: response to Morse et al
    Katsunori Nonogaki
    Diabetes Care 30:e38; author reply e39. 2007