Ryusuke Niwa

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi CYP306A1, a cytochrome P450 enzyme, is essential for ecdysteroid biosynthesis in the prothoracic glands of Bombyx and Drosophila
    Ryusuke Niwa
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, 5 1 5 Kashiwanoha, Kashiwa, Chiba 277 8562, USA
    J Biol Chem 279:35942-9. 2004
  2. ncbi Neverland is an evolutionally conserved Rieske-domain protein that is essential for ecdysone synthesis and insect growth
    Takuji Yoshiyama
    Department of Integrated Biosciences, Rm201, Graduate School of Frontier Sciences, The University of Tokyo, 5 1 5 Kashiwanoha, Kashiwa, Chiba 277 8562, Japan
    Development 133:2565-74. 2006
  3. ncbi A basic-HLH transcription factor, HLH54F, is highly expressed in the prothoracic gland in the silkworm Bombyx mori and the fruit fly Drosophila melanogaster
    Toshiki Namiki
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan
    Biosci Biotechnol Biochem 73:762-5. 2009
  4. ncbi Differential regulation of ecdysteroidogenic P450 gene expression in the silkworm, Bombyx mori
    Naoki Yamanaka
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Japan
    Biosci Biotechnol Biochem 71:2808-14. 2007
  5. ncbi Cytochrome P450 CYP307A1/Spook: a regulator for ecdysone synthesis in insects
    Toshiki Namiki
    Department of Integrated Biosciences, Rm 201, Graduate School of Frontier Sciences, The University of Tokyo, 5 1 5 Kashiwanoha, Kashiwa, Chiba 277 8562, Japan
    Biochem Biophys Res Commun 337:367-74. 2005
  6. ncbi Identification of a novel prothoracicostatic hormone and its receptor in the silkworm Bombyx mori
    Naoki Yamanaka
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 277 8562, Japan
    J Biol Chem 280:14684-90. 2005
  7. ncbi Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion
    Michiru Nishita
    Department of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi 980 8578, USA
    J Biol Chem 279:7193-8. 2004
  8. ncbi Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells
    Noriko Kaji
    Department of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi 980 8578, Japan
    J Biol Chem 278:33450-5. 2003
  9. ncbi Juvenile hormone acid O-methyltransferase in Drosophila melanogaster
    Ryusuke Niwa
    Initiative for the Promotion of Young Scientists Independent Research, Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8572, Japan
    Insect Biochem Mol Biol 38:714-20. 2008
  10. ncbi Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin
    Ryusuke Niwa
    Department of Molecular Genetics, The Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Cell 108:233-46. 2002

Collaborators

  • Akira Mizoguchi
  • Kazuei Mita
  • Hideaki Takeuchi
  • Tetsuro Shinoda
  • Toshiki Namiki
  • Hiroshi Kataoka
  • Naoki Yamanaka
  • Takuji Yoshiyama
  • Michiru Nishita
  • Kensaku Mizuno
  • Tadashi Uemura
  • Noriko Kaji
  • Atsushi Higuchi
  • Noe Osato
  • Naoko Honda
  • Yue Jin Hua
  • Ken-Ichi Shirai
  • Ken Ichi Shirai
  • Yoshiaki Tanaka
  • Ken Watanabe
  • Yue-Jin Hua
  • Takashi Sakudoh
  • Akira Suzuki
  • Yan Wang
  • Chinatsu Tomizawa
  • Kazumasa Ohashi
  • Mika Shuin

Detail Information

Publications10

  1. ncbi CYP306A1, a cytochrome P450 enzyme, is essential for ecdysteroid biosynthesis in the prothoracic glands of Bombyx and Drosophila
    Ryusuke Niwa
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, 5 1 5 Kashiwanoha, Kashiwa, Chiba 277 8562, USA
    J Biol Chem 279:35942-9. 2004
    ..These results strongly suggest that CYP306A1 functions as a carbon 25 hydroxylase and has an essential role in ecdysteroid biosynthesis during insect development...
  2. ncbi Neverland is an evolutionally conserved Rieske-domain protein that is essential for ecdysone synthesis and insect growth
    Takuji Yoshiyama
    Department of Integrated Biosciences, Rm201, Graduate School of Frontier Sciences, The University of Tokyo, 5 1 5 Kashiwanoha, Kashiwa, Chiba 277 8562, Japan
    Development 133:2565-74. 2006
    ..Given that the nvd family is evolutionally conserved, these results suggest that Nvd is an essential regulator of cholesterol metabolism or trafficking in steroid synthesis across animal phyla...
  3. ncbi A basic-HLH transcription factor, HLH54F, is highly expressed in the prothoracic gland in the silkworm Bombyx mori and the fruit fly Drosophila melanogaster
    Toshiki Namiki
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan
    Biosci Biotechnol Biochem 73:762-5. 2009
    ..HLH54F was uncovered by the use of an expressed sequence tag database of the silkworm Bombyx mori. It was also highly expressed in the prothoracic gland of the fruit fly Drosophila melanogaster...
  4. ncbi Differential regulation of ecdysteroidogenic P450 gene expression in the silkworm, Bombyx mori
    Naoki Yamanaka
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Japan
    Biosci Biotechnol Biochem 71:2808-14. 2007
    ..These results explain well the developmental fluctuation patterns of the P450 gene transcripts in the PG, indicating that multiple factors coordinate to regulate basal PG activity during insect development...
  5. ncbi Cytochrome P450 CYP307A1/Spook: a regulator for ecdysone synthesis in insects
    Toshiki Namiki
    Department of Integrated Biosciences, Rm 201, Graduate School of Frontier Sciences, The University of Tokyo, 5 1 5 Kashiwanoha, Kashiwa, Chiba 277 8562, Japan
    Biochem Biophys Res Commun 337:367-74. 2005
    ..These results suggest a difference in the ecdysone synthesis pathways during larval development in these insects...
  6. ncbi Identification of a novel prothoracicostatic hormone and its receptor in the silkworm Bombyx mori
    Naoki Yamanaka
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 277 8562, Japan
    J Biol Chem 280:14684-90. 2005
    ..All these results suggest that Bommo-myosuppressin functions as a prothoracicostatic hormone and plays an important role in controlling insect development...
  7. ncbi Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion
    Michiru Nishita
    Department of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi 980 8578, USA
    J Biol Chem 279:7193-8. 2004
    ..These findings suggest that SSH1L is activated downstream of PI3K and plays a critical role in insulin-induced membrane protrusion by dephosphorylating and activating cofilin...
  8. ncbi Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells
    Noriko Kaji
    Department of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi 980 8578, Japan
    J Biol Chem 278:33450-5. 2003
    ..These results suggest that SSH1 plays a critical role in cytokinesis by dephosphorylating and reactivating cofilin in later stages of mitosis...
  9. ncbi Juvenile hormone acid O-methyltransferase in Drosophila melanogaster
    Ryusuke Niwa
    Initiative for the Promotion of Young Scientists Independent Research, Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8572, Japan
    Insect Biochem Mol Biol 38:714-20. 2008
    ....
  10. ncbi Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin
    Ryusuke Niwa
    Department of Molecular Genetics, The Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Cell 108:233-46. 2002
    ..Furthermore, SSH and the hSSHs dephosphorylated P cofilin in cultured cells and in cell-free assays. Our results strongly suggest that the SSH family plays a pivotal role in actin dynamics by reactivating ADF/cofilin in vivo...