Ryuichi Nishinakamura

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice
    Minoru Takasato
    Division of Stem Cell Regulation, The Institute of Medical Science, The University of Tokyo, 4-6-1 Minato-ku Shirokanedai, Tokyo 108-8639, Japan
    Mech Dev 121:547-57. 2004
  2. ncbi Kidney development conserved over species: essential roles of Sall1
    Ryuichi Nishinakamura
    Division of Stem Cell Regulation, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Semin Cell Dev Biol 14:241-7. 2003
  3. ncbi Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay
    Kenji Osafune
    Division of Stem Cell Regulation, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
    Development 133:151-61. 2006
  4. ncbi Sall1, a causative gene for Townes-Brocks syndrome, enhances the canonical Wnt signaling by localizing to heterochromatin
    Akira Sato
    Department of Stem Cell Regulation, The Institute of Medical Science, The University of Tokyo, Japan
    Biochem Biophys Res Commun 319:103-13. 2004
  5. ncbi Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells
    Tsunekazu Oikawa
    Division of Stem Cell Therapy, Center for Stem Cell and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Gastroenterology 136:1000-11. 2009
  6. ncbi Zinc finger protein sall2 is not essential for embryonic and kidney development
    Akira Sato
    Division of Stem Cell Regulation, The Institute of Medical Science, The University of Tokyo, Japan
    Mol Cell Biol 23:62-9. 2003
  7. ncbi A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage
    Naoki Nakayama
    Department of Metabolic Disorders, Amgen, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Development 131:229-40. 2004
  8. ncbi [Characteristics of stem cells in the kidney]
    Masaji Sakaguchi
    Nippon Jinzo Gakkai Shi 50:577-80. 2008
  9. ncbi Trb2, a mouse homolog of tribbles, is dispensable for kidney and mouse development
    Minoru Takasato
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Biochem Biophys Res Commun 373:648-52. 2008
  10. ncbi Sall1 regulates mitral cell development and olfactory nerve extension in the developing olfactory bulb
    Susan J Harrison
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cereb Cortex 18:1604-17. 2008

Collaborators

  • Takashi Yokota
  • Hiromitsu Nakauchi
  • Akihide Kamiya
  • M Asashima
  • Naoki Nakayama
  • B Bolon
  • Akira Kikuchi
  • Minoru Takasato
  • Akira Sato
  • Kenji Osafune
  • Kazunari Yamashita
  • Nobuaki Yoshida
  • Yuko Matsumoto
  • Tsunekazu Oikawa
  • Susan J Harrison
  • Masaji Sakaguchi
  • Chiyoko Kobayashi
  • Hiroki Kobayashi
  • Yukako Uchiyama
  • Masayo Sakaki-Yumoto
  • Shunsuke Yuri
  • Tatsuhiko Kodama
  • Hiroyuki Aburatani
  • Yuki Kataoka
  • Mikio Zeniya
  • Hisao Tajiri
  • Sei Kakinuma
  • Hiroshi Kiyonari
  • Naoko Oshima
  • Koji Okabayashi
  • A Paula Monaghan
  • Kiyoshi Kawakami
  • Pi-chao Wang
  • Pi Chao Wang
  • Andreas Kispert
  • Sayoko Fujimura
  • Shosei Kishida
  • Hiroko Meguro
  • Toshiya Tanaka
  • Urara Koide
  • Shinji Komazaki

Detail Information

Publications21

  1. ncbi Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice
    Minoru Takasato
    Division of Stem Cell Regulation, The Institute of Medical Science, The University of Tokyo, 4-6-1 Minato-ku Shirokanedai, Tokyo 108-8639, Japan
    Mech Dev 121:547-57. 2004
    ..Therefore a combination of microarray technology and Sall1-GFP mice is useful for systematic identification of genes expressed in the developing kidney...
  2. ncbi Kidney development conserved over species: essential roles of Sall1
    Ryuichi Nishinakamura
    Division of Stem Cell Regulation, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Semin Cell Dev Biol 14:241-7. 2003
    ..Using this system, we isolated Sall1 that is essential for the initial step in metanephros formation. The potential mechanisms involved and future directions regarding kidney development are discussed...
  3. ncbi Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay
    Kenji Osafune
    Division of Stem Cell Regulation, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
    Development 133:151-61. 2006
    ..Thus our colony-forming assay, which identifies multipotent progenitors in the embryonic mouse kidney, can be used for examining mechanisms of renal progenitor differentiation...
  4. ncbi Sall1, a causative gene for Townes-Brocks syndrome, enhances the canonical Wnt signaling by localizing to heterochromatin
    Akira Sato
    Department of Stem Cell Regulation, The Institute of Medical Science, The University of Tokyo, Japan
    Biochem Biophys Res Commun 319:103-13. 2004
    ..Thus, we propose a new mechanism for Wnt signaling activation, that is the heterochromatin localization of Sall1...
  5. ncbi Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells
    Tsunekazu Oikawa
    Division of Stem Cell Therapy, Center for Stem Cell and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Gastroenterology 136:1000-11. 2009
    ..The expression and functional roles of Sall4 during liver development have not been elucidated. We here provide their first description in hepatoblasts...
  6. ncbi Zinc finger protein sall2 is not essential for embryonic and kidney development
    Akira Sato
    Division of Stem Cell Regulation, The Institute of Medical Science, The University of Tokyo, Japan
    Mol Cell Biol 23:62-9. 2003
    ..Mice lacking both Sall1 and Sall2 show kidney phenotypes comparable to those of Sall1 knockout, thereby demonstrating the dispensable roles of Sall2 in embryonic and kidney development...
  7. ncbi A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage
    Naoki Nakayama
    Department of Metabolic Disorders, Amgen, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Development 131:229-40. 2004
    ..Thus, CHL2 may play negative roles in the (re)generation and maturation of articular chondrocytes in the hyaline cartilage of both developing and degenerated joints...
  8. ncbi [Characteristics of stem cells in the kidney]
    Masaji Sakaguchi
    Nippon Jinzo Gakkai Shi 50:577-80. 2008
  9. ncbi Trb2, a mouse homolog of tribbles, is dispensable for kidney and mouse development
    Minoru Takasato
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Biochem Biophys Res Commun 373:648-52. 2008
    ..However, Trb2 mutant mice did not display any apparent phenotypes and no proteinuria was observed, indicating normal glomerular functions. These results suggest that Trb2 plays minimal roles during kidney and mouse development...
  10. ncbi Sall1 regulates mitral cell development and olfactory nerve extension in the developing olfactory bulb
    Susan J Harrison
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cereb Cortex 18:1604-17. 2008
    ..In Sall1-mutant animals, these patterns of neurogenesis were disrupted. These findings suggest a role for Sall1 in regulating neuronal differentiation and maturation in developing neural structures...
  11. ncbi [Kidney development and induction of renal lineage]
    Yukako Uchiyama
    Tanpakushitsu Kakusan Koso 52:1413-8. 2007
  12. ncbi Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects
    Hiroki Kobayashi
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Mech Dev 124:290-303. 2007
    ..These results highlight the fact that Six1 and Six4 have collaborative functions in the metanephros but not in the mesonephros...
  13. ncbi Mouse homolog of SALL1, a causative gene for Townes-Brocks syndrome, binds to A/T-rich sequences in pericentric heterochromatin via its C-terminal zinc finger domains
    Kazunari Yamashita
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan
    Genes Cells 12:171-82. 2007
    ..Thus Sall1 may bind to A/T-rich sequences of the major satellite DNA via its C-terminal double zinc fingers, thereby mediating its localization to heterochromatin...
  14. ncbi Essential roles of Sall family genes in kidney development
    Ryuichi Nishinakamura
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Honjo, Kumamoto, Japan
    J Physiol Sci 56:131-6. 2006
    ..Thus our colony-forming assay, which identifies multipotent progenitors in the embryonic mouse kidney, can be used for examining mechanisms of renal progenitor differentiation...
  15. ncbi The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development
    Masayo Sakaki-Yumoto
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan
    Development 133:3005-13. 2006
    ..Sall4 and Sall1 formed heterodimers, and a truncated Sall1 caused mislocalization of Sall4 in the heterochromatin; thus, some symptoms of Townes-Brocks syndrome caused by SALL1 truncations could result from SALL4 inhibition...
  16. ncbi [Early development of the kidney]
    Shunsuke Yuri
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University
    Nippon Rinsho 64:33-7. 2006
  17. ncbi Essential roles of Sall1 in kidney development
    Ryuichi Nishinakamura
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics Kumamoto University, Honjo, Japan
    Kidney Int 68:1948-50. 2005
    ..Thus a combination of microarray technology and Sall1-GFP mice is useful for systematic identification of genes expressed in the developing kidney...
  18. ncbi [Renal development and its molecular mechanism]
    Kazunari Yamashita
    Tanpakushitsu Kakusan Koso 50:644-9. 2005
  19. ncbi [Molecular structure associated with the development of the kidney]
    Minoru Takasato
    Nippon Naika Gakkai Zasshi 94:138-44. 2005
  20. ncbi [Genetic programs in development of three-dimensional organs]
    Ryuichi Nishinakamura
    Division of Stem Cell Regulation, Institute of Medical Science, University of Tokyo
    Nippon Rinsho 61:370-4. 2003
    ..Mimicking what is happening in embryonic development could lead to a breakthrough for generating functional organs in vitro. This review provides an overview on how three-dimensional organs are formed...
  21. ncbi In vitro induction of the pronephric duct in Xenopus explants
    Kenji Osafune
    Department of Life Sciences (Biology, Graduate School of Arts and Sciences, University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan
    Dev Growth Differ 44:161-7. 2002
    ....