Satoshi Nishimura

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint [In vivo imaging reveals adipose tissue inflammation in obesity and multi-cellular processes of developing thrombus]
    Satoshi Nishimura
    Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan
    Yakugaku Zasshi 132:425-31. 2012
  2. pmc In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling
    Satoshi Nishimura
    Department of Cardiovascular Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Blood 119:e45-56. 2012
  3. ncbi request reprint Follow-up study of aortic-valve replacement surgery in patients with Takayasu's disease complicated by aortic regurgitation
    Satoshi Nishimura
    Department of Cardiovascular Medicine, The Sakakibara Heart Institute, Tokyo, Japan
    Circ J 66:564-6. 2002
  4. doi request reprint CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    Satoshi Nishimura
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Nat Med 15:914-20. 2009
  5. pmc In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue
    Satoshi Nishimura
    Department of Cardiovascular Medicine and Nano Bioengineering Education Program, University of Tokyo, Tokyo, Japan
    J Clin Invest 118:710-21. 2008
  6. ncbi request reprint Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels
    Satoshi Nishimura
    Department of Cardiovascular Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Diabetes 56:1517-26. 2007
  7. ncbi request reprint Contractile dysfunction of cardiomyopathic hamster myocytes is pronounced under high load conditions
    Satoshi Nishimura
    The Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Mol Cell Cardiol 39:231-9. 2005
  8. ncbi request reprint Responses of single-ventricular myocytes to dynamic axial stretching
    Satoshi Nishimura
    Department of Cardiovascular Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo, Japan
    Prog Biophys Mol Biol 97:282-97. 2008
  9. ncbi request reprint Expression of green fluorescent protein impairs the force-generating ability of isolated rat ventricular cardiomyocytes
    Satoshi Nishimura
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7 3 1, Tokyo 113 0033, Japan
    Mol Cell Biochem 286:59-65. 2006
  10. ncbi request reprint Membrane potential of rat ventricular myocytes responds to axial stretch in phase, amplitude and speed-dependent manners
    Satoshi Nishimura
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Japan
    Cardiovasc Res 72:403-11. 2006

Collaborators

Detail Information

Publications30

  1. ncbi request reprint [In vivo imaging reveals adipose tissue inflammation in obesity and multi-cellular processes of developing thrombus]
    Satoshi Nishimura
    Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan
    Yakugaku Zasshi 132:425-31. 2012
    ....
  2. pmc In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling
    Satoshi Nishimura
    Department of Cardiovascular Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Blood 119:e45-56. 2012
    ....
  3. ncbi request reprint Follow-up study of aortic-valve replacement surgery in patients with Takayasu's disease complicated by aortic regurgitation
    Satoshi Nishimura
    Department of Cardiovascular Medicine, The Sakakibara Heart Institute, Tokyo, Japan
    Circ J 66:564-6. 2002
    ....
  4. doi request reprint CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    Satoshi Nishimura
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Nat Med 15:914-20. 2009
    ..These results support the notion that CD8(+) T cells have an essential role in the initiation and propagation of adipose inflammation...
  5. pmc In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue
    Satoshi Nishimura
    Department of Cardiovascular Medicine and Nano Bioengineering Education Program, University of Tokyo, Tokyo, Japan
    J Clin Invest 118:710-21. 2008
    ..In addition, this technique may prove to be a valuable tool to evaluate potential therapeutic interventions...
  6. ncbi request reprint Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels
    Satoshi Nishimura
    Department of Cardiovascular Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Diabetes 56:1517-26. 2007
    ..However, little is known about how adipocytes, adipocyte precursors, blood vessels, and stromal cells interact with one another to achieve adipogenesis...
  7. ncbi request reprint Contractile dysfunction of cardiomyopathic hamster myocytes is pronounced under high load conditions
    Satoshi Nishimura
    The Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Mol Cell Cardiol 39:231-9. 2005
    ..These results clearly indicate the importance of the loading conditions in evaluating the contractile function of CMP hamster myocytes, and may provide insights into the mechanism of contractile dysfunction in this disease...
  8. ncbi request reprint Responses of single-ventricular myocytes to dynamic axial stretching
    Satoshi Nishimura
    Department of Cardiovascular Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo, Japan
    Prog Biophys Mol Biol 97:282-97. 2008
    ..The amplitude may also modulate the ion selectivity of stretch-activated channels. This combination of the carbon fiber technique with fluorescence measurement could represent a powerful tool for clarifying MEF at the cellular level...
  9. ncbi request reprint Expression of green fluorescent protein impairs the force-generating ability of isolated rat ventricular cardiomyocytes
    Satoshi Nishimura
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7 3 1, Tokyo 113 0033, Japan
    Mol Cell Biochem 286:59-65. 2006
    ..Adv-GFP expression may not be an ideal control for specific gene expression experiments in myocardial tissue...
  10. ncbi request reprint Membrane potential of rat ventricular myocytes responds to axial stretch in phase, amplitude and speed-dependent manners
    Satoshi Nishimura
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Japan
    Cardiovasc Res 72:403-11. 2006
    ..However, the information to date has been limited by the technical difficulties associated with stretching single myocytes...
  11. ncbi request reprint Single cell mechanics of rat cardiomyocytes under isometric, unloaded, and physiologically loaded conditions
    Satoshi Nishimura
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Am J Physiol Heart Circ Physiol 287:H196-202. 2004
    ..In conclusion, the present results confirmed the fact that each myocyte forms the functional basis for ventricular function and that single cell mechanics can be a link between subcellular events and ventricular mechanics...
  12. pmc Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells
    Naoya Takayama
    Stem Cell Bank, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, Tokyo, Japan
    J Exp Med 207:2817-30. 2010
    ..These findings suggest that the pattern of c-MYC expression, particularly its later decline, is key to producing functional platelets from selected iPSC clones...
  13. ncbi request reprint Microtubules modulate the stiffness of cardiomyocytes against shear stress
    Satoshi Nishimura
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Japan
    Circ Res 98:81-7. 2006
    ..In the complex strain field that living myocytes experience in the body, observed changes in shear stiffness may have a significant influence on the diastolic property of the diseased heart...
  14. doi request reprint Insulin resistance is associated with coronary plaque vulnerability: insight from optical coherence tomography analysis
    Tomokazu Iguchi
    Department of Cardiovascular Medicine, Osaka City University, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Eur Heart J Cardiovasc Imaging 15:284-91. 2014
    ..The purpose of this study was to assess the relationship between insulin resistance and coronary plaque characteristics identified by optical coherence tomography (OCT)...
  15. ncbi request reprint Adipose tissue inflammation in obesity and metabolic syndrome
    Satoshi Nishimura
    Department of Cardiovascular Medicine, and Translational Systems Biology and Medicine Initiative, The University of Tokyo Graduate School of Medicine, Tokyo 112 0033, Japan
    Discov Med 8:55-60. 2009
    ..Thus clarification of the inflammatory processes ongoing in obese adipose tissue would seem essential for the understanding of metabolic syndrome and for developing novel therapeutic strategies to treat it...
  16. doi request reprint Impact of lesion length on functional significance in intermediate coronary lesions
    Tomokazu Iguchi
    Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Clin Cardiol 36:172-7. 2013
    ..Myocardial fractional flow reserve (FFR) is useful in the evaluation of coronary lesion ischemia. However, the impact of lesion length on FFR has not been adequately assessed...
  17. ncbi request reprint Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance
    Nozomu Kamei
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 281:26602-14. 2006
    ..We concluded that both paracrine and endocrine effects of MCP-1 may contribute to the development of insulin resistance in aP2-MCP-1 mice...
  18. doi request reprint Involvement of CaV3.1 T-type calcium channels in cell proliferation in mouse preadipocytes
    Atsushi Oguri
    Department of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan
    Am J Physiol Cell Physiol 298:C1414-23. 2010
    ..1 T-type Ca(2+) channel encoded by alpha(1G) subtype is the dominant Ca(V) in mouse preadipocytes and may play a role in regulating preadipocyte proliferation, a key step in adipose tissue development...
  19. pmc Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo
    Hitoshi Takizawa
    Research Institute, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku ku, Tokyo, Japan
    J Clin Invest 120:179-90. 2010
    ..Outside-in signaling modulators could represent new therapeutic targets for the prevention of cardiovascular events...
  20. ncbi request reprint Carbon fiber technique for the investigation of single-cell mechanics in intact cardiac myocytes
    Seiryo Sugiura
    Computational Biomechanics Laboratory, Department of Human and Engineered Environmental Studies, Graduate School of Frontier Sciences, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Nat Protoc 1:1453-7. 2006
    ..In combination with other experimental procedures, this technique can also be applied to the study of mechano-transduction. This protocol can be completed in 3.5 h...
  21. doi request reprint Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle
    Tetsuya Kubota
    Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Cell Metab 13:294-307. 2011
    ..Furthermore, improving endothelial insulin signaling may serve as a therapeutic strategy for ameliorating skeletal muscle insulin resistance...
  22. pmc Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload
    Norifumi Takeda
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo, Japan
    J Clin Invest 120:254-65. 2010
    ..Modulation of cardiac fibroblast function may provide a novel strategy for treating heart failure, with KLF5 serving as an attractive target...
  23. doi request reprint Structural heterogeneity in the ventricular wall plays a significant role in the initiation of stretch-induced arrhythmias in perfused rabbit right ventricular tissues and whole heart preparations
    Kinya Seo
    Department of Human and Engineered Environmental Studies, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan
    Circ Res 106:176-84. 2010
    ..Mechanical stress is known to alter the electrophysiological properties of the myocardium and may trigger fatal arrhythmias when an abnormal load is applied to the heart...
  24. doi request reprint IFATS collection: Fibroblast growth factor-2-induced hepatocyte growth factor secretion by adipose-derived stromal cells inhibits postinjury fibrogenesis through a c-Jun N-terminal kinase-dependent mechanism
    Hirotaka Suga
    Department of Plastic Surgery, University of Tokyo, Japan
    Stem Cells 27:238-49. 2009
    ..This study revealed a functional role for ASCs in the response to injury and provides new insight into the therapeutic potential of ASCs...
  25. doi request reprint A nanoparticle system specifically designed to deliver short interfering RNA inhibits tumor growth in vivo
    Nobuhiro Yagi
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Japan
    Cancer Res 69:6531-8. 2009
    ..Our findings support the idea that siRNA/WS can be used to knock down specific genes within tumors and thereby exert therapeutic effects against cancers...
  26. ncbi request reprint Unloaded shortening increases peak of Ca2+ transients but accelerates their decay in rat single cardiac myocytes
    So ichiro Yasuda
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Am J Physiol Heart Circ Physiol 285:H470-5. 2003
    ..Our results suggest that Ca2+ transients reflect the affinity of troponin C for Ca2+, which is influenced by the change in strain on the thin filament but not by the length change per se...
  27. ncbi request reprint Detailed observation of arterial healing after stent implantation in swine arteries by using optical coherence tomography
    Satoshi Nishimura
    Department of Internal Medicine and Cardiology, Osaka City University, Graduate School of Medicine, Japan
    Osaka City Med J 58:1-11. 2012
    ..The aim of this study was to compare arterial healing images after stenting on the basis of the findings of histopathological examination, IVUS, and OCT...
  28. pmc Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis
    Yoshikazu Hirose
    Laboratory of Cell Growth and Differentiation and Laboratory of Nuclear Signaling, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 109:4263-8. 2012
    ..These results suggest that blocking Stab2 function prevents tumor metastasis by elevating circulating HA levels. Stab2 may be a potential target in antitumor therapy...
  29. ncbi request reprint Expression of Musashi-1 in human normal colon crypt cells: a possible stem cell marker of human colon epithelium
    Satoshi Nishimura
    Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto City, 602 8566, Japan
    Dig Dis Sci 48:1523-9. 2003
    ..This is the first report outlining expression of Musashi-1 in human colon crypt cells...
  30. ncbi request reprint Three-dimensional simulation of calcium waves and contraction in cardiomyocytes using the finite element method
    Jun Ichi Okada
    Core Research for Evolutional Science and Technology of the Japan Science and Technology Agency, Saitama, Japan
    Am J Physiol Cell Physiol 288:C510-22. 2005
    ..The present 3-D simulator, with its ability to study the interaction between Ca(2+) waves and contraction, will serve as a useful tool for studying the mechanism of this complex phenomenon...