Affiliation: University of Miyazaki
Nemoto T, Yanagita T, Kanai T, Wada A. Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: the role of GSK-3beta in the maintenance of steady-state levels of insulin receptor signaling molecules and Na(v)1.7 sodium channel in adr. J Pharmacol Sci. 2009;109:157-61 pubmed
..g., lithium) up-regulated the voltage-dependent Na(v)1.7 sodium channel. ..
Nemoto T, Yanagita T, Satoh S, Maruta T, Kanai T, Murakami M, et al
. Insulin-induced neurite-like process outgrowth: acceleration of tau protein synthesis via a phosphoinositide 3-kinase~mammalian target of rapamycin pathway. Neurochem Int. 2011;59:880-8 pubmed publisher
..Taken together, these results suggest that insulin-induced activation of PI3K?mTOR pathway up-regulated tau protein via acceleration of protein synthesis, on which insulin promoted neurite-like process outgrowth. ..
Nemoto T, Yanagita T, Maruta T, Sugita C, Satoh S, Kanai T, et al
. Endothelin-1-induced down-regulation of NaV1.7 expression in adrenal chromaffin cells: attenuation of catecholamine secretion and tau dephosphorylation. FEBS Lett. 2013;587:898-905 pubmed publisher
..These findings suggest that the endothelin-1-induced down-regulation of NaV1.7 diminishes NaV1.7-related catecholamine secretion and dephosphorylation of tau. ..