Affiliation: University of Tokyo
- Wnt signaling inhibits cementoblast differentiation and promotes proliferationEiji Nemoto
Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, 4 1 Seiryo machi Aoba, Sendai, Japan
Bone 44:805-12. 2009..Elucidating the role of Wnt in controlling cementoblast function will provide new tools needed to improve on existing periodontal regeneration therapies...
- Cleavage of PDGF receptor on periodontal ligament cells by elastaseE Nemoto
Division of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
J Dent Res 84:629-33. 2005..These results suggest that elastase may modulate the PDGF-mediated activity of PDL cells during periodontal wound healing...
- Expression of functional Toll-like receptors and nucleotide-binding oligomerization domain proteins in murine cementoblasts and their upregulation during cell differentiationE Nemoto
Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai, Japan
J Periodontal Res 43:585-93. 2008....
- Proteolysis of human monocyte CD14 by cysteine proteinases (gingipains) from Porphyromonas gingivalis leading to lipopolysaccharide hyporesponsivenessS Sugawara
Department of Microbiology and Immunology, Tohoku University School of Dentistry, Sendai, Japan
J Immunol 165:411-8. 2000..These results suggest that gingipains preferentially cleave monocyte CD14, resulting in attenuation of the cellular recognition of bacteria, and as a consequence sustain chronic inflammation...
- Cleavage of CD14 on human gingival fibroblasts cocultured with activated neutrophils is mediated by human leukocyte elastase resulting in down-regulation of lipopolysaccharide-induced IL-8 productionE Nemoto
Division of Periodontics and Endodontics, Tohoku University Graduate School of Dentistry, Sendai, Japan
J Immunol 165:5807-13. 2000..These findings suggested that activated PMNs have a potential negative feedback mechanism for HGF function at the inflammatory site, particularly in periodontal tissues...
- Heterogeneous expression and release of CD14 by human gingival fibroblasts: characterization and CD14-mediated interleukin-8 secretion in response to lipopolysaccharideS Sugawara
Department of Microbiology and Immunology, Tohoku University School of Dentistry, Sendai, 980 8575, Japan
Infect Immun 66:3043-9. 1998..These results suggest that (i) HGF consist of populations that are heterogeneous on the basis of different levels of expression of CD14 and (ii) CD14(high) HGF secrete inflammatory cytokines in response to LPS via CD14...
- Increase of CD26/dipeptidyl peptidase IV expression on human gingival fibroblasts upon stimulation with cytokines and bacterial componentsE Nemoto
Department of Endodontics and Periodontics, Tohoku University School of Dentistry, Sendai, 980 8575, Japan
Infect Immun 67:6225-33. 1999..These results suggested that induction of CD26 on human gingival fibroblasts is regulated at the transcriptional level and is also dependent on a de novo-synthesized protein factor(s)...
- Porphyromonas gingivalis fimbriae induce unique dendritic cell subsets via Toll-like receptor 2S Kanaya
Division of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai, Japan
J Periodontal Res 44:543-9. 2009..Since Pg LPS as well as Pg fimbriae have been indicated to work as Toll-like receptor (TLR) 2 ligands, we speculate that the TLR usage of bacterial antigens may be critical for DC maturation...
- Proteolysis of ICAM-1 on human oral epithelial cells by gingipainsH Tada
Department of Microbiology and Immunology, Tohoku University Graduate School of Dentistry, Sendai, Japan
J Dent Res 82:796-801. 2003..These results indicate that gingipains cleave ICAM-1 on oral epithelial cells, consequently disrupting PMN-oral epithelial cell interaction, and are involved in immune evasion by the bacterium in periodontal tissues...
- Elevated production of interleukin 6 by hepatic MNC correlates with ICAM-1 expression on the hepatic sinusoidal endothelial cells in autoimmune MRL/lpr miceT Ohteki
Department of Microbiology, Tohoku University School of Dentistry, Sendai, Japan
Immunol Lett 36:145-52. 1993....
- Regulation of cementoblast function by P. gingivalis lipopolysaccharide via TLR2E Nemoto
Department of Periodontics, School of Dentistry, University of Washington, D322-Health Science Center Box 356365, Seattle, WA 98195-6365, USA
J Dent Res 85:733-8. 2006..These results suggest that cementoblasts participate in the recruitment of osteoclastic precursor cells by up-regulation of chemokines/cytokines...