Tadao Nakazawa

Summary

Affiliation: University of Yamanashi
Country: Japan

Publications

  1. doi request reprint Global histone modification of histone H3 in colorectal cancer and its precursor lesions
    Tadao Nakazawa
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409 3898, Japan
    Hum Pathol 43:834-42. 2012
  2. ncbi request reprint Histopathology of the thyroid in amiodarone-induced hypothyroidism
    Tadao Nakazawa
    Department of Human Pathology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Yamanashi, Japan
    Pathol Int 58:55-8. 2008
  3. doi request reprint Fine-needle aspiration biopsy of low-grade cribriform cystadenocarcinoma of the salivary gland
    Tadao Nakazawa
    Department of Pathology, University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering, 1110 Shimokato, Yamanashi, Japan
    Diagn Cytopathol 39:218-22. 2011
  4. ncbi request reprint RET/PTC rearrangements arising from a small population of papillary thyroid carcinoma cells, possible candidate for passenger mutation
    Tadao Nakazawa
    Department of Pathology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, 1110 Shimokato, Chuo, Yamanashi, 409 3898, Japan
    Virchows Arch 455:35-41. 2009
  5. doi request reprint Differential distribution of blood-derived proteins in xenografted human adenocarcinoma tissues by in vivo cryotechnique and cryobiopsy
    Yuqin Bai
    Department of Anatomy and Molecular Histology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409 3898, Japan
    Med Mol Morphol 44:93-102. 2011
  6. ncbi request reprint Epigenetic silencing of TTF-1/NKX2-1 through DNA hypermethylation and histone H3 modulation in thyroid carcinomas
    Tetsuo Kondo
    Department of Pathology, University of Yamanashi, Yamanashi, Japan
    Lab Invest 89:791-9. 2009
  7. pmc Differential expression of aquaporins and its diagnostic utility in thyroid cancer
    Dongfeng Niu
    Department of Human Pathology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Yamanashi, Japan
    PLoS ONE 7:e40770. 2012
  8. doi request reprint Polyclonal origin of hormone-producing cell populations evaluated as a direct in situ demonstration in EGFP/BALB/C chimeric mice
    De Fu Ma
    Department of Pathology, University of Yamanashi, Chuo Yamanashi, Japan
    J Endocrinol 207:17-25. 2010
  9. ncbi request reprint Morphological abstraction of thyroid tumor cell nuclei using morphometry with factor analysis
    Shin Ichi Murata
    Department of Pathology, University of Yamanashi School of Medicine, Nakakoma gun, Yamanashi, Japan
    Microsc Res Tech 61:457-62. 2003
  10. doi request reprint Involvement of centrosomes in nuclear irregularity of thyroid carcinoma cells
    Dongfeng Niu
    Department of Human Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409 3898, Japan
    Virchows Arch 455:149-57. 2009

Collaborators

Detail Information

Publications42

  1. doi request reprint Global histone modification of histone H3 in colorectal cancer and its precursor lesions
    Tadao Nakazawa
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409 3898, Japan
    Hum Pathol 43:834-42. 2012
    ..These results suggest that aberration of the global H3K9me2 level is an important epigenetic event in colorectal tumorigenesis and carcinogenesis involved with gene regulation in neoplastic cells through chromatin remodeling...
  2. ncbi request reprint Histopathology of the thyroid in amiodarone-induced hypothyroidism
    Tadao Nakazawa
    Department of Human Pathology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Yamanashi, Japan
    Pathol Int 58:55-8. 2008
    ..This is the first report on the histopathological findings of thyroid tissue from a patient with amiodarone-induced hypothyroidism...
  3. doi request reprint Fine-needle aspiration biopsy of low-grade cribriform cystadenocarcinoma of the salivary gland
    Tadao Nakazawa
    Department of Pathology, University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering, 1110 Shimokato, Yamanashi, Japan
    Diagn Cytopathol 39:218-22. 2011
    ..This is the first report of the cytomorphological findings of LGCCC...
  4. ncbi request reprint RET/PTC rearrangements arising from a small population of papillary thyroid carcinoma cells, possible candidate for passenger mutation
    Tadao Nakazawa
    Department of Pathology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, 1110 Shimokato, Chuo, Yamanashi, 409 3898, Japan
    Virchows Arch 455:35-41. 2009
    ....
  5. doi request reprint Differential distribution of blood-derived proteins in xenografted human adenocarcinoma tissues by in vivo cryotechnique and cryobiopsy
    Yuqin Bai
    Department of Anatomy and Molecular Histology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409 3898, Japan
    Med Mol Morphol 44:93-102. 2011
    ..The interstitial tissues with augmented permeability of serum proteins would increase accessibility of tumor cells to blood-derived molecules...
  6. ncbi request reprint Epigenetic silencing of TTF-1/NKX2-1 through DNA hypermethylation and histone H3 modulation in thyroid carcinomas
    Tetsuo Kondo
    Department of Pathology, University of Yamanashi, Yamanashi, Japan
    Lab Invest 89:791-9. 2009
    ..Our data suggest that epigenetics is involved with inactivation of TTF-1 in thyroid carcinomas, and provide a possible means of using TTF-1 as a target for differentiation-inducing therapy through epigenetic modification...
  7. pmc Differential expression of aquaporins and its diagnostic utility in thyroid cancer
    Dongfeng Niu
    Department of Human Pathology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Yamanashi, Japan
    PLoS ONE 7:e40770. 2012
    ..Little is known of their expression and significance in human thyroid tissues. Thus, we examined the expression of AQP3 and AQP4 in normal, hyperplastic and neoplastic thyroid tissues in conjunction with human thyroid cancer cell lines...
  8. doi request reprint Polyclonal origin of hormone-producing cell populations evaluated as a direct in situ demonstration in EGFP/BALB/C chimeric mice
    De Fu Ma
    Department of Pathology, University of Yamanashi, Chuo Yamanashi, Japan
    J Endocrinol 207:17-25. 2010
    ..Furthermore, we clearly demonstrate that all hormone-producing cell populations are of polyclonal embryonic origin, derived from more than two progenitor cells...
  9. ncbi request reprint Morphological abstraction of thyroid tumor cell nuclei using morphometry with factor analysis
    Shin Ichi Murata
    Department of Pathology, University of Yamanashi School of Medicine, Nakakoma gun, Yamanashi, Japan
    Microsc Res Tech 61:457-62. 2003
    ..Morphological abstraction by morphometry with factor analysis may provide a practical approach to the detection of the underlying characteristics of nuclear morphology in aspiration biopsy cytology...
  10. doi request reprint Involvement of centrosomes in nuclear irregularity of thyroid carcinoma cells
    Dongfeng Niu
    Department of Human Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409 3898, Japan
    Virchows Arch 455:149-57. 2009
    ..In conclusion, we suggest that cell-to-cell contact may affect nuclear changes such as BLNs and DLNs in cancer cell lines and that centrosomes may be involved in the morphogenetic process of these nuclear changes...
  11. doi request reprint Hypoxia-inducible adenosine A2B receptor modulates proliferation of colon carcinoma cells
    De Fu Ma
    Department of Pathology, University of Yamanashi, Yamanashi, 409 3898, Japan
    Hum Pathol 41:1550-7. 2010
    ..Our data suggest that this adenosine receptor is a potential therapeutic target for colorectal cancer...
  12. ncbi request reprint Conservation and alteration of chromosome territory arrangements in thyroid carcinoma cell nuclei
    Shin Ichi Murata
    Department of Pathology, Saitama Medical University International Medical Center, Saitama, Japan
    Thyroid 17:489-96. 2007
    ..These findings indicate that alteration of CT positioning could be related to DNA amplification and, morphologically, may explain the nuclear atypia that accompanies the abnormal chromatin feature...
  13. doi request reprint RET rearrangements and BRAF mutation in undifferentiated thyroid carcinomas having papillary carcinoma components
    Kunio Mochizuki
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Japan
    Histopathology 57:444-50. 2010
    ..To elucidate the genetic background of anaplastic transformation, RET rearrangements and BRAF mutation were studied in composite undifferentiated carcinomas (UCs) of the thyroid, which are UCs having papillary carcinoma (PC) components...
  14. doi request reprint Unusual thyroid carcinoma with excessive extracellular hyaline globules: a case of "hyalinizing papillary carcinoma"
    Tetsuo Kondo
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, 409 3898, Japan
    Hum Pathol 43:932-8. 2012
    ..Based on these findings, we diagnosed the present tumor as a rare morphological variation of papillary thyroid carcinoma with excessive hyaline globules consisting of basal membrane materials...
  15. ncbi request reprint Application of microscopic Forster resonance energy transfer to cytological diagnosis of the thyroid tumors
    Shin Ichi Murata
    University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering, Department of Pathology, Yamanashi, Japan
    J Biomed Opt 10:034008. 2005
    ..c) 2005 Society of Photo-Optical Instrumentation Engineers...
  16. ncbi request reprint p16(INK4a) expression analysis as an ancillary tool for cytologic diagnosis of urothelial carcinoma
    Kumiko Nakazawa
    Department of Pathology, University of Hospital, Faculty of Medicine, University of Yamanashi, Yamanashi 409 3898, Japan
    Am J Clin Pathol 132:776-84. 2009
    ..Immunocytologic analysis of p16(INK4a) expression in cytologic samples is a useful ancillary tool for detection of urothelial carcinoma with infiltrating potential...
  17. doi request reprint High-b-value diffusion-weighted MR imaging of hepatocellular lesions: estimation of grade of malignancy of hepatocellular carcinoma
    Ali Muhi
    Department of Radiology, University of Yamanashi, Yamanshi, Japan
    J Magn Reson Imaging 30:1005-11. 2009
    ..To evaluate the effectiveness of diffusion-weighted magnetic resonance imaging (DWI) in estimating the grade of malignancy of hepatocellular carcinoma...
  18. doi request reprint Application of probe electrospray ionization mass spectrometry (PESI-MS) to clinical diagnosis: solvent effect on lipid analysis
    Mridul Kanti Mandal
    Clean Energy Research Center, University of Yamanashi, Kofu, Yamanashi, Japan
    J Am Soc Mass Spectrom 23:2043-7. 2012
    ..This study paves the way for the application of PESI-MS in medical samples...
  19. doi request reprint Imaging study of early hepatocellular carcinoma: usefulness of gadoxetic acid-enhanced MR imaging
    Katsuhiro Sano
    Department of Radiology, University of Yamanashi, 1110 Shimokato, Chuo shi, Yamanashi 409 3898, Japan
    Radiology 261:834-44. 2011
    ....
  20. ncbi request reprint Laminar high shear stress up-regulates type IV collagen synthesis and down-regulates MMP-2 secretion in endothelium. A quantitative analysis
    Tetsu Yamane
    Department of Human Pathology, School of Medicine, University of Yamanashi, Yamanashi, Japan
    Cell Tissue Res 340:471-9. 2010
    ....
  21. doi request reprint Immature squamous metaplasia (focal atypical epithelial hyperplasia) of the pancreatic duct-immunohistochemical distinction from intraductal carcinoma
    Kunio Mochizuki
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    Histopathology 63:343-50. 2013
    ..The aim of this study was to analyse 20 ISMPD and 10 ICP tissue samples...
  22. ncbi request reprint Enhanced B-Raf protein expression is independent of V600E mutant status in thyroid carcinomas
    Tetsuo Kondo
    Department of Pathology, University of Yamanashi, Chuo, Yamanashi 409 3898, Japan
    Hum Pathol 38:1810-8. 2007
    ....
  23. ncbi request reprint High prevalence of neuroendocrine carcinoma in breast lesions detected by the clinical symptom of bloody nipple discharge
    Tomonori Kawasaki
    Department of Pathology, University of Yamanashi, 1110, Shimokato, Chuo, Yamanashi 409 3898, Japan
    Breast 21:652-6. 2012
    ..However, the association between this symptom and breast neuroendocrine carcinomas (NECs) has not been sufficiently investigated or well understood...
  24. doi request reprint Transcription factor Runx2 is a regulator of epithelial-mesenchymal transition and invasion in thyroid carcinomas
    Dong Feng Niu
    Department of Pathology, University of Yamanashi, Yamanashi, Japan
    Lab Invest 92:1181-90. 2012
    ..Our data suggest that enhanced Runx2 is functionally linked to tumor invasion and metastasis of thyroid carcinoma by regulating EMT-related molecules, matrix metalloproteinases and angiogenic/lymphangiogenic factors...
  25. ncbi request reprint Cholangiolocellular carcinoma of the liver: imaging findings
    Utaroh Motosugi
    Department of Pathology, Saitama Medical, University, International Medical Center, 137 1 Yamane, Hidaka shi, Saitama ken 350 1298, Japan
    J Comput Assist Tomogr 33:682-8. 2009
    ..Recent study also revealed that CLC would originate from hepatic progenitor cells, which are liver-specific stem cells. We reviewed the imaging findings of CLCs, including those of intrahepatic metastases...
  26. ncbi request reprint Mucinous carcinoma (poorly differentiated carcinoma with extensive extracellular mucin deposition) of the thyroid: a case report with immunohistochemical studies
    Tetsuo Kondo
    Department of Pathology, University of Yamanashi, Yamanashi, Japan
    Hum Pathol 36:698-701. 2005
    ..The patient died of multiple metastases 4 years after the initial operation...
  27. ncbi request reprint Expression of aquaporin 3 (AQP3) in normal and neoplastic lung tissues
    Ya Lan Liu
    Department of Pathology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Yamanashi 409 3898, Japan
    Hum Pathol 38:171-8. 2007
    ....
  28. doi request reprint Neuroendocrine cells associated with neuroendocrine carcinoma of the breast: nature and significance
    Tomonori Kawasaki
    Department of Pathology, University of Yamanashi, Yamanashi, Japan
    J Clin Pathol 65:699-703. 2012
    ..The developmental mechanisms of breast neuroendocrine carcinoma (B-NEC) have not been sufficiently analysed and are not well understood...
  29. ncbi request reprint RET gene rearrangements (RET/PTC1 and RET/PTC3) in papillary thyroid carcinomas from an iodine-rich country (Japan)
    Tadao Nakazawa
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    Cancer 104:943-51. 2005
    ..The authors investigated the prevalence of RET/PTC in a large number of thyroid tumors from Japanese patients...
  30. ncbi request reprint Detection of underlying characteristics of nuclear chromatin patterns of thyroid tumor cells using texture and factor analyses
    Shin Ichi Murata
    Department of Pathology, University of Yamanashi School of Medicine, Yamanashi, Japan
    Cytometry 49:91-5. 2002
    ..In the present report, we investigated how to detect underlying chromatin characteristics of benign and malignant thyroid tumor cells by means of texture and factor analyses...
  31. ncbi request reprint Mixed papillary adenocarcinoma and transitional cell carcinoma of the uterine cervix
    Shin Ichi Murata
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Japan
    Pathol Int 54:63-6. 2004
    ..These findings indicate that the TCC component had the cellular character of AC rather than that of TCC or squamous cell carcinomas. This is thought to be the first report of a MAcTcc of the uterine cervix...
  32. ncbi request reprint Spatial distribution analysis of AT- and GC-rich regions in nuclei using corrected fluorescence resonance energy transfer
    Shin Ichi Murata
    Department of Pathology, University of Yamanashi School of Medicine, 1110 Shimokato, Tamaho cho Nakakoma gun, Yamanishi, Japan 409 3898
    J Histochem Cytochem 51:951-8. 2003
    ..Using the corrected FRET (cFRET) technique, we were able to detect early DNA separation stages in late interphase nuclei...
  33. ncbi request reprint Differential tissue expression of enhanced green fluorescent protein in 'green mice'
    De Fu Ma
    Department of Human Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    Histol Histopathol 25:749-54. 2010
    ..In conclusion, our results show that EGFP is differentially expressed in organs and tissues of 'green mice', which indicates that 'green mice' may prove useful for research involving transplantation and tissue clonality...
  34. ncbi request reprint Application of cryobiopsy to morphological and immunohistochemical analyses of xenografted human lung cancer tissues and functional blood vessels
    Nobuhiko Ohno
    Department of Anatomy and Molecular Histology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan
    Cancer 113:1068-79. 2008
    ..The technical characteristics of cryobiopsy and in vivo cryotechnique (IVCT) where target organs are directly cryofixed in vivo are still unknown in practical examinations of tumor histopathology and microenvironment...
  35. doi request reprint Small invasive ductal adenocarcinoma of the pancreas associated with lymphoplasmacytic sclerosing pancreatitis
    Utaroh Motosugi
    Department of Radiology, University of Yamanashi, Chuo, Japan
    Pathol Int 59:744-7. 2009
    ..A small invasive ductal adenocarcinoma was observed in the center of the area affected by LPSP. The present case suggests that LPSP may be closely related to carcinogenesis of the pancreas...
  36. ncbi request reprint Typical fibrolamellar hepatocellular carcinoma in a Japanese boy: report of a case
    Masanori Matsuda
    First Department of Surgery, Yamanashi University School of Medicine, 1110 Shimokato, Chuo City, Yamanashi, 409 3898, Japan
    Surg Today 44:1359-66. 2014
    ..The patient was alive without recurrence 48 months after surgery. Following this case report, we summarize the clinical features of the Japanese cases documented in the literature. ..
  37. ncbi request reprint Endocervical adenocarcinomas associated with lobular endocervical glandular hyperplasia: a report of four cases with histochemical and immunohistochemical analyses
    Tetsuo Kondo
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    Mod Pathol 18:1199-210. 2005
    ..Histopathological features of the present cases suggest that some endocervical adenocarcinomas may originate from lobular endocervical glandular hyperplasia...
  38. ncbi request reprint Stromal elastosis in papillary thyroid carcinomas
    Tetsuo Kondo
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Japan
    Hum Pathol 36:474-9. 2005
    ..It is, therefore, reasonable to propose that stromal elastosis is an ancillary feature in the histopathological diagnosis of PTCs...
  39. doi request reprint Imaging of small hepatic metastases of colorectal carcinoma: how to use superparamagnetic iron oxide-enhanced magnetic resonance imaging in the multidetector-row computed tomography age?
    Utaroh Motosugi
    Department of Radiology, University of Yamanashi, Chuo shi, Yamanashi Ken, Japan
    J Comput Assist Tomogr 33:266-72. 2009
    ....
  40. ncbi request reprint Localized Langerhans cell histiocytosis of the thymus with BRAF V600E mutation: a case report with immunohistochemical and genetic analyses
    Naoki Oishi
    Department of Pathology, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409 3898, Japan
    Hum Pathol 45:1302-5. 2014
    ..At the medical follow-up, the thymic tumor had spontaneously regressed; however, identification of oncogenic BRAF mutation supports the neoplastic nature of the current case. ..
  41. ncbi request reprint Analysis of renal cell carcinoma as a first step for developing mass spectrometry-based diagnostics
    Kentaro Yoshimura
    Department of Anatomy and Cell Biology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Japan
    J Am Soc Mass Spectrom 23:1741-9. 2012
    ..These results strongly suggest that PESI-MS will be applicable to cancer diagnosis, especially when the number of data is augmented...
  42. ncbi request reprint Localized nasopharyngeal amyloidosis with remarkable early enhancement on dynamic contrast-enhanced MR imaging
    Utaroh Motosugi
    Eur Radiol 17:852-3. 2007