Takuro Nakamura

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi Retroviral insertional mutagenesis identifies oncogene cooperation
    Takuro Nakamura
    Department of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455
    Cancer Sci 96:7-12. 2005
  2. ncbi NUP98 fusion in human leukemia: dysregulation of the nuclear pore and homeodomain proteins
    Takuro Nakamura
    Department of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Int J Hematol 82:21-7. 2005
  3. ncbi Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation
    Miho Kawamura-Saito
    Department of Carcinogenesis, Japanese Foundation for Cancer Research, Tokyo, Japan
    Hum Mol Genet 15:2125-37. 2006
  4. ncbi Trib1 links the MEK1/ERK pathway in myeloid leukemogenesis
    Takashi Yokoyama
    Division of Carcinogenesis, The Cancer Institute, Tokyo, Japan
    Blood 116:2768-75. 2010
  5. ncbi Identification of candidate cooperative genes of the Apc mutation in transformation of the colon epithelial cell by retroviral insertional mutagenesis
    Miwa Tanaka
    Department of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, 3 10 6 Ariake, Koto ku, Tokyo 135 8550, Japan
    Cancer Sci 99:979-85. 2008
  6. ncbi Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model
    Masayuki Iwasaki
    Department of Carcinogenesis, Japanese Foundation for Cancer Research, Tokyo, Japan
    Blood 105:784-93. 2005
  7. ncbi Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia
    Takashi Yokoyama
    Division of Carcinogenesis, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Blood 119:2608-11. 2012
  8. ncbi Function of EWS-POU5F1 in sarcomagenesis and tumor cell maintenance
    Takashi Fujino
    Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 135 8550, Japan
    Am J Pathol 176:1973-82. 2010
  9. ncbi Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis
    Guang Jin
    Department of Carcinogenesis, The Cancer Institute, Genome Center, Japanese Foundation for Cancer Research, 3 10 6 Ariake, Koto ku, Tokyo 135 8550, Japan
    Blood 109:3998-4005. 2007
  10. ncbi EWSR1 is fused to POU5F1 in a bone tumor with translocation t(6;22)(p21;q12)
    Shuichi Yamaguchi
    Department of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Genes Chromosomes Cancer 43:217-22. 2005

Collaborators

Detail Information

Publications24

  1. ncbi Retroviral insertional mutagenesis identifies oncogene cooperation
    Takuro Nakamura
    Department of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455
    Cancer Sci 96:7-12. 2005
    ..With use of the retrovirus mediated gene transfer system, retroviral insertional mutagenesis will provide invaluable information to understand genetic interaction in complex mechanisms of carcinogenesis...
  2. ncbi NUP98 fusion in human leukemia: dysregulation of the nuclear pore and homeodomain proteins
    Takuro Nakamura
    Department of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Int J Hematol 82:21-7. 2005
    ..Thus, the NUP98 chimera is a unique molecule that provides valuable information regarding nuclear pore function and the role of the homeobox protein in leukemogenesis/carcinogenesis...
  3. ncbi Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation
    Miho Kawamura-Saito
    Department of Carcinogenesis, Japanese Foundation for Cancer Research, Tokyo, Japan
    Hum Mol Genet 15:2125-37. 2006
    ..Moreover, the study identifies the role of DUX4 that is closely linked to facioscapulohumeral muscular dystrophy in transcriptional regulation...
  4. ncbi Trib1 links the MEK1/ERK pathway in myeloid leukemogenesis
    Takashi Yokoyama
    Division of Carcinogenesis, The Cancer Institute, Tokyo, Japan
    Blood 116:2768-75. 2010
    ..These results suggest that Trib1 may be a key mediator between the RTK-MAPK pathway and the C/EBP transcription factor in myeloid leukemogenesis...
  5. ncbi Identification of candidate cooperative genes of the Apc mutation in transformation of the colon epithelial cell by retroviral insertional mutagenesis
    Miwa Tanaka
    Department of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, 3 10 6 Ariake, Koto ku, Tokyo 135 8550, Japan
    Cancer Sci 99:979-85. 2008
    ..These data suggest the importance of cytoskeletal function in Apc-related tumor development and the usefulness of RIM in non-hematopoietic tissues, providing new insight into the early stage of colon carcinogenesis...
  6. ncbi Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model
    Masayuki Iwasaki
    Department of Carcinogenesis, Japanese Foundation for Cancer Research, Tokyo, Japan
    Blood 105:784-93. 2005
    ..These genes cooperated with NUP98-HOXA9 in transforming NIH 3T3 cells. The system described here is a powerful tool to identify cooperative oncogenes and will assist in the clarification of the multistep process of carcinogenesis...
  7. ncbi Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia
    Takashi Yokoyama
    Division of Carcinogenesis, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Blood 119:2608-11. 2012
    ..These results suggest that TRIB1 may be a novel important oncogene for Down syndrome-related acute megakaryocytic leukemia...
  8. ncbi Function of EWS-POU5F1 in sarcomagenesis and tumor cell maintenance
    Takashi Fujino
    Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 135 8550, Japan
    Am J Pathol 176:1973-82. 2010
    ..These findings reveal the functional role of the sarcoma-related chimeric protein as well as POU5F1 in the development and progression of human neoplasms...
  9. ncbi Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis
    Guang Jin
    Department of Carcinogenesis, The Cancer Institute, Genome Center, Japanese Foundation for Cancer Research, 3 10 6 Ariake, Koto ku, Tokyo 135 8550, Japan
    Blood 109:3998-4005. 2007
    ..Furthermore, Trib1 by itself is a novel myeloid oncogene, enhancing phosphorylation of ERK, resulting in inhibition of apoptosis. These results demonstrate the importance of specific oncogene interaction in myeloid leukemogenesis...
  10. ncbi EWSR1 is fused to POU5F1 in a bone tumor with translocation t(6;22)(p21;q12)
    Shuichi Yamaguchi
    Department of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Genes Chromosomes Cancer 43:217-22. 2005
    ..It is suggested that EWS-POU5F1 may act as an oncogenic transcription factor and that its expression may contribute to undifferentiated and immature phenotypes of BST...
  11. ncbi Mesenchymal to embryonic incomplete transition of human cells by chimeric OCT4/3 (POU5F1) with physiological co-activator EWS
    Hatsune Makino
    Department of Reproductive Biology, National Institute for Child Health and Development, Tokyo, 157 8535, Japan
    Exp Cell Res 315:2727-40. 2009
    ....
  12. ncbi Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15)
    Takashi Fujino
    Department of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Blood 99:1428-33. 2002
    ..These findings suggest that AbdB-type HOXA genes are common targets of t(7;11)(p15;p15) chromosomal translocations and that a single translocation can produce more than one NUP98-HOXA fusion gene, presumably because of altered splicing...
  13. ncbi Tribbles in disease: Signaling pathways important for cellular function and neoplastic transformation
    Takashi Yokoyama
    Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Cancer Sci 102:1115-22. 2011
    ....
  14. ncbi BCL11A is a SUMOylated protein and recruits SUMO-conjugation enzymes in its nuclear body
    Takeshi Kuwata
    Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Genes Cells 13:931-40. 2008
    ..These results suggest that BCL11A could be involved in the SUMO conjugation system, and that BCL11A might play an important role in protein modification...
  15. ncbi Adult Xp11 translocation renal cell carcinoma diagnosed by cytogenetics and immunohistochemistry
    Yoshinobu Komai
    Department of Urology, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Clin Cancer Res 15:1170-6. 2009
    ..To determine the incidence of Xp11 translocation renal cell carcinoma (RCC) in adult patients using cytogenetics and immunohistochemstry...
  16. ncbi Primitive neuroectodermal tumor/Ewing's sarcoma of the urinary bladder: a case report and its molecular diagnosis
    Yohei Okada
    Department of Urology, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Int J Clin Oncol 16:435-8. 2011
    ..Exact diagnosis is crucial for deciding the treatment strategy for rare bladder tumors consisting of small round cells...
  17. ncbi Identification of target genes for EWS/ATF-1 chimeric transcription factor
    Miki Jishage
    Department of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Oncogene 22:41-9. 2003
    ..Moreover, induction of POSH brought apoptotic cell death to KAS, the clear cell sarcoma (CCS) cell line, suggesting that repressed expression of POSH in CCS may be relevant to the normal signaling pathway in apoptosis...
  18. ncbi Haploinsufficiency of Runx1/AML1 promotes myeloid features and leukaemogenesis in BXH2 mice
    Namiko Yamashita
    Institute of Molecular and Cell Biology, Singapore
    Br J Haematol 131:495-507. 2005
    ..In conclusion, the BXH2-Runx1+/- system is a promising mouse model to investigate the mechanism of leukaemogenesis in FPD/AML...
  19. ncbi t(7;11)(p15;p15) Chronic myeloid leukaemia developed into blastic transformation showing a novel NUP98/HOXA11 fusion
    Akitaka Suzuki
    First Department of Internal Medicine, Tokyo Medical University, Japan
    Br J Haematol 116:170-2. 2002
    ..Although it is well known that a fusion of NUP98-HOXA9 in myeloid malignancies is created by the t(7;11)(p15;p15), this case suggests the possibility that HOXA11 might be another partner gene for NUP98 in t(7;11)(p15;p15) leukaemia...
  20. ncbi A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF-induced myeloid differentiation
    Ichiro Nishikata
    Department of Biochemistry, Miyazaki Medical College, Kiyotake, Miyazaki, 889 1692, Japan
    Blood 102:3323-32. 2003
    ..Thus, it is likely that overexpression of the zinc finger protein lacking the PR domain (EVI1 and MEL1S) in the leukemia cells is one of the causative factors in the pathogenesis of myeloid leukemia...
  21. ncbi Hematopoietic, angiogenic and eye defects in Meis1 mutant animals
    Tomoyuki Hisa
    Center for Cancer Research, Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD, USA
    EMBO J 23:450-9. 2004
    ..These and other studies showing that Meis1 is expressed at high levels in hematopoietic stem cells (HSCs) suggest that Meis1 may also be required for the proliferation/self-renewal of the HSC...
  22. ncbi Bone marrow pre-B expansion by SL/Kh-Bomb1 locus: not sufficient for lymphomagenesis
    Takuya Hiratsuka
    Department of Pathology and Biology of Diseases, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Leuk Res 32:309-14. 2008
    ..Disturbed early B cell differentiation per se is not sufficient for SL/Kh lymphomagenesis...
  23. ncbi Increased dosage of Runx1/AML1 acts as a positive modulator of myeloid leukemogenesis in BXH2 mice
    Masatoshi Yanagida
    Institute of Molecular and Cell Biology, Singapore
    Oncogene 24:4477-85. 2005
    ....
  24. ncbi [Homeobox genes and leukemia: the role of HOX-MEIS interaction]
    Takuro Nakamura
    Rinsho Ketsueki 47:1423-30. 2006