Research Topics
Species | Akira NakajimaSummaryAffiliation: University of Miyazaki Country: Japan Publications
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Detail Information
Publications
Generation of lipid radicals in the hippocampus of neonatal rats after acute hypoxic-ischemic brain damageYuto Ueda
Department of Psychiatry, Faculty of Medicine, University of Miyazaki, Kihara 5200, 889 1692 Miyazaki, Japan
Exp Brain Res 169:117-21. 2006..We hypothesize that an increased formation of lipid radicals may participate in the cascade of reactions leading to neuronal damage in the hippocampus following ischemic-hypoxic insult in neonatal rats...- [Functional role of redox for neuronal disease]Y Ueda
No To Hattatsu 40:103-8. 2008 - [A new era of anti-epileptic drug (AED): expectation for a new-type medicine and combination therapy with existing AED]Yuto Ueda
Nippon Yakurigaku Zasshi 129:116-8. 2007 - In vivo EPR estimation of bilateral hippocampal antioxidant ability of rats with epileptogenesis induced by amygdalar FeCl3 microinjectionYuto Ueda
Section of Psychiatry, Department of Clinical Neuroscience, University of Miyazaki, Miyazaki, Japan
Epilepsia 48:1947-51. 2007.... - Functional role for redox in the epileptogenesis: molecular regulation of glutamate in the hippocampus of FeCl3-induced limbic epilepsy modelYuto Ueda
Section of Psychiatry, Department of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
Exp Brain Res 181:571-7. 2007.... 
Levetiracetam enhances endogenous antioxidant in the hippocampus of rats: in vivo evaluation by brain microdialysis combined with ESR spectroscopyYuto Ueda
Section of Psychiatry, Department of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
Brain Res 1266:1-7. 2009....- In vivo evaluation of the effect of zonisamide on the hippocampal redox state during kainic acid-induced seizure status in ratsYuto Ueda
Department of Psychiatry, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki, Japan
Neurochem Res 30:1117-21. 2005..This study is the first in vivo evaluation of the antioxidant ability of ZNS as neuroprotective role against the free radicals performed under the condition of freely moving rats during seizure status... - In vivo activation of N-methyl-D-aspartate receptors generates free radicals and reduces antioxidant ability in the rat hippocampus: experimental protocol of in vivo ESR spectroscopy and microdialysis for redox status evaluationYuto Ueda
Section of Psychiatry, Department of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki 5200 Kihara, Kiyotake, Miyazaki, 889 1692, Japan
Brain Res 1178:20-7. 2007..These results indicated that NMDA-R activation caused the shift to oxidized condition of the redox state, which subsequently leads to neuron death in the hippocampus in the model of glutamate-associated neuronal disease... - Hydrogen-related enhancement of in vivo antioxidant ability in the brain of rats fed coral calcium hydrideYuto Ueda
Department of Clinical Neuroscience, Miyazaki University, Kiyotake, Miyazaki, Japan
Neurochem Res 35:1510-5. 2010..These results clarify the mechanism that CCH may exert antioxidant activity by significantly enhancing the basal endogenous antioxidant ability in the hippocampus through a synergistic effect with α-tocopherol and ascorbic acid... - Effect of levetiracetam on molecular regulation of hippocampal glutamate and GABA transporters in rats with chronic seizures induced by amygdalar FeCl3 injectionYuto Ueda
Section of Psychiatry, Department of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
Brain Res 1151:55-61. 2007..These observations together demonstrated the critical molecular mechanism of the anti-epileptic activity of LEV... - Protective role of pentobarbital pretreatment for NMDA-R activated lipid peroxidation is derived from the synergistic effect on endogenous anti-oxidant in the hippocampus of ratsYuto Ueda
Section of Psychiatry, Department of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
Neurosci Lett 417:46-9. 2007..Our findings, therefore, suggested that PBT anesthesia not only suppresses NMDA-R activated free radical generation but also synergistically enhances the increased basal endogenous anti-oxidant ability in the hippocampus... - Kinetics of extracellular nitroxide radical and glutamate levels in the hippocampus of conscious rats: cautionary note to the application of nitroxide radical on clinical arenaYuto Ueda
Department of Psychiatry, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki 889 1692, Japan
Neurochem Res 29:1695-701. 2004..More detailed studies on their possible toxicity of nitroxide radicals will be needed before the prospect of moving nitroxide from the experimental to the clinical arena when nitroxide radicals would be used for CNS disease in future... - An acute dysfunction of the glutamate transport activity has been shown to generate free radicals and suppress the anti-oxidant ability in the hippocampus of ratsKeiko Nagatomo
Section of Psychiatry, Department of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, Japan
Neurosci Res 57:477-80. 2007..This study provides clear evidence for the mechanisms associated with neuronal disorder in relation to glutamate... - Glutamate excess and free radical formation during and following kainic acid-induced status epilepticusYuto Ueda
Department of Psychiatry, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
Exp Brain Res 147:219-26. 2002..Further, we propose that the functional failure of glutamate transporters due to oxidative stress results in high levels of extracellular glutamate during sustained generalized seizures induced with KA... - Age-dependent changes in the hippocampal antioxidant ability of EL miceMayuko Takaki
Section of Integrative Physiology, Department of Medical Science, University of Miyazaki, Miyazaki 889 1692, Japan
Neurosci Res 58:336-8. 2007.... - Antioxidant ability and lipid peroxidation in the hippocampus with epileptogenesis induced by Fe3+ injection into the amygdaloid body of ratsYuto Ueda
Department of Psychiatry, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki, Japan
Neurochem Res 28:1895-900. 2003..This study revealed that repetitive seizures resulted in the decreased hippocampal antioxidant ability with lipid peroxidation and explained the regional vulnerability to oxidative stress in the limbic system with epileptogenesis... - EPR evidence of hydroxyl radical generation as an initiator of lipid peroxidation in amyloid beta-protein-stimulated PC12 cellsYoshihito Hayashi
Department of Psychiatry, Miyazaki Medical College, 5200 Kihara, Kiyotake cho, Miyazaki 889 1692, Japan
Brain Res 1025:29-34. 2004..These analyses showed cell damage induced by Abeta. This study provides EPR evidence that Abeta neurotoxicity is derived from hydrogen abstraction from polyunsaturated lipid acid by hydroxyl radical as a cause of lipid peroxidation... - Nitric oxide and hydroxyl radicals initiate lipid peroxidation by NMDA receptor activationYoshihito Hayashi
Department of Psychiatry, Miyazaki Medical College, 5200 Kihara, Kiyotake-cho, Miyazaki 889-1692, Japan
Brain Res 941:107-12. 2002..NO rather than from Fenton's reaction. This study verified that .OH generation from interactive reactions between .NO and O(2)(-) initiates NMDA-induced lipid peroxidation of PC12 cells... - Novel δ1-receptor agonist KNT-127 increases the release of dopamine and L-glutamate in the striatum, nucleus accumbens and median pre-frontal cortexShunsuke Tanahashi
Department of Psychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
Neuropharmacology 62:2057-67. 2012..1-receptor indirectly inhibited GABA release in NAc via activated dopaminergic transmission, while δ1-receptor indirectly enhanced GABA release in mPFC via activated glutamatergic transmission... - Mechanism of hexavalent chromium adsorption by persimmon tannin gelAkira Nakajima
Department of Chemistry, Faculty of Medicine, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki 889 1692, Japan
Water Res 38:2859-64. 2004..Through the treatment of a Cr(VI) solution with the PT gel, chromium should be recovered as a Cr(IV)-tannin complex at pH 3 or a Cr(III) solution at pH 1 or lower pH region... - Ability of water-soluble biosubstances to eliminate hydroxyl and superoxide radicals examined by spin-trapping ESR measurements: two-dimensional presentation of antioxidative abilityAkira Nakajima
Section of Obstetrics and Gynecology, Department of Reproductive and Developmental Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
Biosci Biotechnol Biochem 77:324-31. 2013..The biosubstances tested were assigned to five separate areas characterized by their functional groups on the diagram. The obtained ROS inhibitory diagram indicates the possibility for screening appropriate antioxidants... - Electron spin resonance study of copper biosorption by bacteriaAkira Nakajima
Faculty of Medicine, Department of Chemistry, Miyazaki Medical College, Kiyotake, Japan
Water Res 36:2091-7. 2002..The variation of spectral patterns among bacteria could explain as the change of ligand circumstances caused by the pH of the cell surface... - Mechanism of gold adsorption by persimmon tannin gelAkira Nakajima
Department of Chemistry, Faculty of Medicine, Miyazaki Medical College, Kiyotake, Miyazaki 889-1692, Japan
Anal Sci 19:1075-7. 2003..The gel could also adsorb colloidal Au(0) prepared independently. A model consisting of ligand exchange, Au(III) reduction to Au(0), and resulting Au(0) adsorption by PT gel was presented for the gold adsorption mechanism... - Pharmacological action of nobiletin, a component of AURANTII NOBILIS PERICARPIUM with anti-dementia activity, and its application for development of functional foodsTohru Yamakuni
Nippon Yakurigaku Zasshi 132:155-9. 2008 - Role of tumor necrosis factor-alpha in methamphetamine-induced drug dependence and neurotoxicityAkira Nakajima
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
J Neurosci 24:2212-25. 2004.... - Effect of grinding and heating on Ni2+ uptake properties of waste paper sludgeVinay Kumar Jha
Department of Metallurgy and Ceramics Science, Tokyo Institute of Technology, O-okayama, Meguro, Tokyo, Japan
J Environ Manage 80:363-71. 2006..The dry-milled and calcined at 600 degrees C sample showed the highest Ni2+ uptake (4.54 mmol/g) and an uptake rate of 3.5 micromol/(gmin)... - Interleukin-6 protects PC12 cells from 4-hydroxynonenal-induced cytotoxicity by increasing intracellular glutathione levelsAkira Nakajima
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Japan
Free Radic Biol Med 32:1324-32. 2002..These results suggest that IL-6 protects PC12 cells from HNE-induced cytotoxicity by increasing intracellular levels of GSH... - Learning and memory in two different reward tasks in a radial arm maze in ratsJue He
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8560, Japan
Behav Brain Res 134:139-48. 2002..These results suggest that different strategies are used between the FPRT and VPRT but the hippocampus plays an important role in performance of rats trained for the VPRT as well as FPRT... 
Involvement of BDNF receptor TrkB in spatial memory formationMakoto Mizuno
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya 466-8560, Japan
Learn Mem 10:108-15. 2003..The phosphorylation of Fyn and NR2B, but not TrkB, was diminished by PP2 treatment. Our findings suggest the importance of interaction between BDNF/TrkB signaling and NMDA receptors for spatial memory in the hippocampus...- An inducer for glial cell line-derived neurotrophic factor and tumor necrosis factor-alpha protects against methamphetamine-induced rewarding effects and sensitizationMinae Niwa
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
Biol Psychiatry 61:890-901. 2007.... - Utilization of steel-making slag for the uptake of ammonium and phosphate ions from aqueous solutionVinay Kumar Jha
Department of Metallurgy and Ceramics Science, Tokyo Institute of Technology, Meguro, Tokyo, Japan
J Hazard Mater 156:156-62. 2008..91 and 0.65 micro mol/(g min), respectively. It was shown that heating slag composites prior to incorporation into wastewater treatment filters resulted in an increased degree of NH(4)(+) and PO(4)(3-) uptake... - Expression of NR2B in cerebellar granule cells specifically facilitates effect of motor training on motor learningJianwei Jiao
Department of Psychiatry, University of Chicago, Chicago, Illinois, USA
PLoS ONE 3:e1684. 2008.... - Design of a photocatalyst for bromate decomposition: surface modification of TiO2 by pseudo-boehmiteHiroshi Noguchi
Research Center for Advanced Science and Technology, The University of Tokyo, 4 6 1, Komaba, Meguro ku, Tokyo 153 8904, Japan
Environ Sci Technol 37:153-7. 2003..This increase is explained by an increase in the amount of adsorbed BrO3- on the photocatalyst surface... - Nobiletin, a citrus flavonoid, improves memory impairment and Abeta pathology in a transgenic mouse model of Alzheimer's diseaseHiroshi Onozuka
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6 3 Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
J Pharmacol Exp Ther 326:739-44. 2008..These findings suggest that this natural compound has potential to become a novel drug for fundamental treatment of AD... - Tumor necrosis factor-alpha and its inducer inhibit morphine-induced rewarding effects and sensitizationMinae Niwa
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8560, Japan
Biol Psychiatry 62:658-68. 2007..In this study, we investigated the effects of TNF-alpha or Leu-Ile on morphine (MOR)-induced rewarding effects and sensitization... - Loss of presenilin function causes Alzheimer's disease-like neurodegeneration in the mouseQian Chen
Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
J Neurosci Res 86:1615-25. 2008..Most important, our results strongly suggest that to develop gamma-secretase inhibitors for the pharmacological treatment of AD may be not a reasonable strategy because antagonism of presenilin function may worsen neurodegeneration... - Fos expression associated with the discriminative stimulus effects of methamphetamine in ratsNan Zeng
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan
Ann N Y Acad Sci 1025:236-41. 2004..These results suggest that the VTA and the NAc play an important role in the discriminative stimulus effects of methamphetamine... - Genetic approaches to the molecular/neuronal mechanisms underlying learning and memory in the mouseAkira Nakajima
Department of Psychiatry, Committee on Neurobiology, The University of Chicago, Knapp Medical Research Center, Chicago, IL 60637, USA
J Pharmacol Sci 99:1-5. 2005..Studies using these techniques may eventually lead to the understanding of how new information is acquired and how learned information is memorized in the brain... - Purification, characterization, and gene cloning of glycerol dehydrogenase from Hansenula ofunaensis, and its expression for production of optically active diolKeiko Yamada-Onodera
Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma 630 0192, Japan
J Biosci Bioeng 102:545-51. 2006..Glycerol dehydrogenase from H. ofunaensis could be useful for the production of long-chain optically active secondary alcohols... - Nobiletin, a citrus flavonoid, reverses learning impairment associated with N-methyl-D-aspartate receptor antagonism by activation of extracellular signal-regulated kinase signalingAkira Nakajima
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6 6 11 404 Aoba, Aramaki, Aoba ku, Sendai 980 8579, Japan
J Pharmacol Exp Ther 321:784-90. 2007.... - Simultaneous uptake of Ni2+, NH4+ and PO4(3-) by amorphous CaO-Al2O3-SiO2 compoundsKiyoshi Okada
Department of Metallurgy and Ceramics Science, Tokyo Institute of Technology, O Okayama, Meguro, Tokyo 152 8552, Japan
J Colloid Interface Sci 305:229-38. 2007..The optimum uptake properties of the C-A-S can thus be controlled by adjusting the chemical compositions and heating conditions under which the samples are prepared... - Simultaneous uptake of ammonium and phosphate ions by compounds prepared from paper sludge ashKiyoshi Okada
Department of Metallurgy and Ceramics Science, Tokyo Institute of Technology, O Okayama, Meguro, Tokyo 152 8552, Japan
J Hazard Mater 141:622-9. 2007.... - Discriminative-stimulus effects of methamphetamine and morphine in rats are attenuated by cAMP-related compoundsYijin Yan
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan
Behav Brain Res 173:39-46. 2006..These findings suggest that the cAMP signaling cascade may play a key role in the discriminative-stimulus effects of METH and morphine and may be a potential target for the development of therapeutics to counter drugs of abuse... - Multi functional uptake behaviour of materials prepared by calcining waste paper sludgeVinay Kumar Jha
Department of Metallurgy and Ceramics Science, Tokyo Institute of Technology, O Okayama, Meguro, Tokyo 152 8552, Japan
J Environ Sci Health A Tox Hazard Subst Environ Eng 41:703-19. 2006..From an economic point of view, paper sludge is the cheapest raw material for preparing adsorbents with high uptake ability for heavy metal, phosphate and ammonium ions... - Elevated cholecystokininergic tone constitutes an important molecular/neuronal mechanism for the expression of anxiety in the mouseQian Chen
Department of Psychiatry, University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA
Proc Natl Acad Sci U S A 103:3881-6. 2006..In addition, our study has validated a robust genetic anxiety model in the mouse in terms of their face, constructive, and predictive validity... - Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in miceAkira Nakajima
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980 8578, Japan
J Pharmacol Sci 105:122-6. 2007..These results suggest that nobiletin rescues OBX-induced cholinergic neurodegeneration, accompanied by improvement of impaired memory in OBX mice... - Adult neurogenesis is functionally associated with AD-like neurodegenerationQian Chen
Department of Psychiatry, The University of Chicago, USA
Neurobiol Dis 29:316-26. 2008..Therefore, to enhance endogenous neurogenesis at early stages of neurodegeneration may be a valuable strategy to delay neurodegenerative progress...