Research Topics
| Akio NakaiSummaryAffiliation: Child Development Research Center, University of Fukui Location: Fukui, Japan URL: http://www.med.u-fukui.ac.jp/cdrc/english.html Summary: Dr. Nakai is an Associate Professor of Child Development Research Center, University of Fukui, and Department of Child and Adolescent Psychological Medicine, University of Fukui Hospital. He received M.D. in 1986 and Ph.D. in 1991, from Fukui Medical University. He studied the brain imaging of serotonin synthesis in McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Canada from 1998 to 2000. He is the council of The Japanese Society of Child Neurology. He is also the representative committee from Japan of the International Society for Research into DCD. He proceeds the several international collaborative studies of DCD with Canada, the Netherlands, Israel, and UK. Publications
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Detail Information
Publications
Urinary leukotriene E4 after exercise challenge in children with asthmaY Kikawa
Department of Pediatrics, Fukui Medical School, Japan
J Allergy Clin Immunol 89:1111-9. 1992....- Detection of heterozygotes for fructose-1,6-diphosphatase deficiency by measuring fructose-1,6-diphosphatase activity in monocytes cultured with calcitriolY Kikawa
Department of Pediatrics, Fukui Medical School, Japan
Clin Chim Acta 215:81-8. 1993..Thus, the new method using monocytes cultured with calcitriol seems more reliable for detecting heterozygotes for fructose-1,6-diphosphatase deficiency... - MRI findings of Zellweger syndromeA Nakai
Department of Pediatrics, Fukui Medical School, Japan
Pediatr Neurol 13:346-8. 1995..The patient was classified as belonging to group B of this syndrome by complementation study... - Prenatal diagnosis of organic acidemias based on amniotic fluid levels of acylcarnitinesY Shigematsu
Department of Pediatrics, Fukui Medical School, Japan
Pediatr Res 39:680-4. 1996..In addition, it is suggested that the combination of the ratios of glutarylcarnitine, isovaleryl-carnitine, and hexanoylcarnitine to propionylcarnitine may be useful for the prenatal diagnosis of glutaric aciduria type II... 
Identification of genetic mutations in Japanese patients with fructose-1,6-bisphosphatase deficiencyY Kikawa
Department of Pediatrics, Fukui Medical School, Matsuoka, Japan
Am J Hum Genet 61:852-61. 1997..Our results also indicate accurate carrier detection in eight families (73%) of 11 Japanese patients with FBPase deficiency, in whom mutations in both alleles were identified...- Localizing value of alpha-methyl-L-tryptophan PET in intractable epilepsy of neocortical originM Fedi
Department of Neurology, McGill University, Canada
Neurology 57:1629-36. 2001..7, p < 0.05). CONCLUSIONS: alpha-MTrp-PET may be of value in the localization of the epileptogenic area not only in patients with visible dysplastic lesions, but also in those with cryptogenic partial epilepsy... - alpha-[11C]-Methyl-L-tryptophan PET identifies the epileptogenic tuber and correlates with interictal spike frequencyMarco Fedi
Department of Neurology, Montreal Neurological Institute and Hospital, McGill University, Que, Montreal, Canada
Epilepsy Res 52:203-13. 2003..6; P<0.05). alpha-MTrp PET is a promising diagnostic tool in the localization of the epileptogenic area in patients with TSC... - Alpha-[11C] methyl-L-tryptophan and glucose metabolism in patients with temporal lobe epilepsyJ Natsume
Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
Neurology 60:756-61. 2003..alpha-MTrp PET studies might be useful for lateralizing the epileptic focus in TLE patients with normal hippocampal volumes... - Sex differences of brain serotonin synthesis in patients with irritable bowel syndrome using alpha-[11C]methyl-L-tryptophan, positron emission tomography and statistical parametric mappingAkio Nakai
Fukui Medical University School of Medicine, Fukui, Japan
Can J Gastroenterol 17:191-6. 2003.... - Measurement of brain regional alpha-[11C]methyl-L-tryptophan trapping as a measure of serotonin synthesis in medication-free patients with major depressionPedro Rosa-Neto
Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
Arch Gen Psychiatry 61:556-63. 2004..CONCLUSIONS: Reduction of normalized K*, an index of serotonin synthesis, in parts of the limbic and paralimbic cortices may contribute to the biochemical alterations associated with MD... - The effects of the 5-HT3 antagonist, alosetron, on brain serotonin synthesis in patients with irritable bowel syndromeA Nakai
McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A2B4
Neurogastroenterol Motil 17:212-21. 2005..The gender differences in the effect of alosetron on brain 5-HT synthesis may be related to the gender differences in the efficacy of alosetron... - Effects of anpirtoline on regional serotonin synthesis in the rat brain: an autoradiographic studyArata Watanabe
Cone Neurological Research Laboratory, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
Nucl Med Biol 33:325-32. 2006.... 
A case of intracranial saccular aneurysm after primary varicella zoster virus infectionMasao Kawatani
Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
Brain Dev 34:80-2. 2012..Subclinical reactivation of VZV and the segmental vascular narrowing might cause intracranial aneurysm, even in immunocompetent children...- Urinary sugar phosphates and related organic acids in fructose-1,6-diphosphatase deficiencyA Nakai
Department of Pediatrics, Fukui Medical School, Japan
J Inherit Metab Dis 16:408-14. 1993..Identification of such compounds may be useful in the early diagnosis of this disease... - Monocytes, not lymphocytes, show increased fructose-1,6-diphosphatase activity during cultureY Kikawa
Department of Pediatrics, Fukui Medical School, Japan
J Inherit Metab Dis 16:913-4. 1993 - The effects of biotin deficiency on organic acid metabolism: increase in propionyl coenzyme A-related organic acids in biotin-deficient ratsY Y Liu
Department of Pediatrics, Fukui Medical School, Japan
Metabolism 42:1392-7. 1993.... - Exercise-induced urinary excretion of leukotriene E4 in children with atopic asthmaY Kikawa
Department of Pediatrics, Fukui Medical School, Japan
Pediatr Res 29:455-9. 1991..4 +/- 17.3 versus 24.1 +/- 14.3%, p less than 0.01). Our findings suggest that exercise-induced asthma, or at least a subtype of exercise-induced asthma, may partly develop through the release of LTC4... - Pathophysiologic study on methylmalonic aciduria: decrease in liver high-energy phosphate after propionate loading in ratsA Nakai
Department of Pediatrics, Fukui Medical School, Japan
Pediatr Res 30:5-10. 1991..001). The concentrations of tricarboxylic acid cycle intermediates and related organic acids in the livers of the rats suggested that propionate inhibited NAD(+)-dependent enzymes in the cycle.(ABSTRACT TRUNCATED AT 250 WORDS).. - Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome) with hearing impairment and pupillary membrane remnantsY Shigematsu
Department of Pediatrics, Fukui Medical School, Japan
Acta Paediatr Jpn 33:476-81. 1991..Although MPS VI is characterized by normal intellectual development with normal hearing in early infancy, it is important to examine for hearing loss, especially when an infant with this disease shows developmental delay... - Growth retardation as a long-term side-effect of alpha-interferon therapyK Kikawa
Eur J Pediatr 154:591-2. 1995 - Acylcarnitine profile in tissues and body fluids of biotin-deficient rats with and without L-carnitine supplementationY Shigematsu
Department of Pediatrics, Fukui Medical School, Japan
J Inherit Metab Dis 17:678-90. 1994..These data in biotin deficiency suggest that carnitine supplementation is possibly beneficial for patients with holocarboxylase synthetase deficiency who respond incompletely to biotin therapy... - Identification of a genetic mutation in a family with fructose-1,6- bisphosphatase deficiencyY Kikawa
Department of Pediatrics, Fukui Medical School, Japan
Biochem Biophys Res Commun 210:797-804. 1995..Thus, this mutation is concluded to be responsible for fructose-1,6-bisphosphatase deficiency in this patient... - Diffuse leukodystrophy with a large-scale mitochondrial DNA deletionA Nakai
Department of Paediatrics, Fukui Medical School, Japan
Lancet 343:1397-8. 1994..Mitochondrial DNA mutation should be considered as one of the candidate causes for diffuse leukodystrophy in children... - A case of familial thyroxine binding globulin excess associated with growth hormone deficiencyA Nakai
Department of Pediatrics, Fukui Medical School, Japan
Acta Paediatr Jpn 36:408-11. 1994..8 and 8.2 ng/mL, respectively. The mean nocturnal GH concentration was 2.5 ng/mL. His growth velocity increased from 4.8 to 8.4 cm/year and his serum TBG levels decreased gradually after human growth hormone (hGH) treatment... - Uncooked cornstarch treatment for hepatic phosphorylase kinase deficiencyA Nakai
Department of Paediatrics, Fukui Medical School, Japan
Eur J Pediatr 153:581-3. 1994..These endocrinological and metabolic abnormalities and clinical symptoms were improved with uncooked cornstarch treatment. Conclusion: Uncooked cornstarch treatment may be helpful in hepatic phosphorylase deficiency... - Abnormal fatty acid composition of lymphocytes of biotin-deficient ratsY Y Liu
Department of Pediatrics, Fukui Medical School, Japan
J Nutr Sci Vitaminol (Tokyo) 40:283-8. 1994.... - cDNA sequences encoding human fructose 1,6-bisphosphatase from monocytes, liver and kidney: application of monocytes to molecular analysis of human fructose 1,6-bisphosphatase deficiencyY Kikawa
Department of Pediatrics, Fukui Medical School, Japan
Biochem Biophys Res Commun 199:687-93. 1994..Monocytes were thus useful as an alternative source for mRNA from human liver for the molecular analysis of fructose 1,6-bisphosphatase deficiency... - Free carnitine and short-chain acylcarnitines in cerebrospinal fluid of patients with disorders of propionate metabolism determined by fast atom bombardment and tandem mass spectrometryY Shigematsu
Department of Pediatrics, Fukui Medical School, Fukui, Japan
Acta Paediatr Jpn 36:112-5. 1994 - Brain regional α-[11C]methyl-L-tryptophan trapping in medication-free patients with obsessive-compulsive disorderAlexandre Berney
DERBH, Department of Psychiatry, McGill University, 1033 Pine Ave West, Montreal, QC H3A 1A1, Canada
Arch Gen Psychiatry 68:732-41. 2011..Serotonergic abnormalities in the unmedicated symptomatic state, however, remain to be fully characterized... - [Retrospective analysis of pervasive developmental disorder patients initially diagnosed with attention deficit/hyperactivity disorder]Masao Kawatani
Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui
No To Hattatsu 41:11-6. 2009..Results suggest that close evaluation of an individual's behavioral history might suggest a differential diagnosis between PDD and AD/HD... - Evaluation of the Japanese version of the Developmental Coordination Disorder Questionnaire as a screening tool for clumsiness of Japanese childrenAkio Nakai
Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
Res Dev Disabil 32:1615-22. 2011..The DCDQ-J is expected to be a useful screening tool to identify and assess motor coordination difficulties of children in Japan and enable cross-cultural comparisons...