Kazuyuki Nakagome

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. doi request reprint Neutrophilic inflammation in severe asthma
    Kazuyuki Nakagome
    Department of Respiratory Medicine, Saitama Medical University, Iruma gun, Saitama, Japan
    Int Arch Allergy Immunol 158:96-102. 2012
  2. pmc Antigen-sensitized CD4+CD62Llow memory/effector T helper 2 cells can induce airway hyperresponsiveness in an antigen free setting
    Kazuyuki Nakagome
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Respir Res 6:46. 2005
  3. doi request reprint IFN-gamma attenuates antigen-induced overall immune response in the airway as a Th1-type immune regulatory cytokine
    Kazuyuki Nakagome
    Department of Allergy and Rheumatology, University of Tokyo, Japan
    J Immunol 183:209-20. 2009
  4. ncbi request reprint In vivo IL-10 gene delivery suppresses airway eosinophilia and hyperreactivity by down-regulating APC functions and migration without impairing the antigen-specific systemic immune response in a mouse model of allergic airway inflammation
    Kazuyuki Nakagome
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Japan
    J Immunol 174:6955-66. 2005
  5. ncbi request reprint A novel role of hepatocyte growth factor as an immune regulator through suppressing dendritic cell function
    Katsuhide Okunishi
    Pulmonary Division, Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 175:4745-53. 2005
  6. ncbi request reprint IL-5-induced hypereosinophilia suppresses the antigen-induced immune response via a TGF-beta-dependent mechanism
    Kazuyuki Nakagome
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Immunol 179:284-94. 2007
  7. ncbi request reprint Perillyl alcohol suppresses antigen-induced immune responses in the lung
    Mitsuru Imamura
    Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 443:266-71. 2014
  8. ncbi request reprint Hepatocyte growth factor significantly suppresses collagen-induced arthritis in mice
    Katsuhide Okunishi
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 179:5504-13. 2007
  9. ncbi request reprint Splenic dendritic cells induced by oral antigen administration are important for the transfer of oral tolerance in an experimental model of asthma
    Katsuya Nagatani
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 176:1481-9. 2006
  10. doi request reprint Upregulation of lung dendritic cell functions in elastase-induced emphysema
    Hiroaki Harada
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Int Arch Allergy Immunol 149:25-30. 2009

Collaborators

Detail Information

Publications39

  1. doi request reprint Neutrophilic inflammation in severe asthma
    Kazuyuki Nakagome
    Department of Respiratory Medicine, Saitama Medical University, Iruma gun, Saitama, Japan
    Int Arch Allergy Immunol 158:96-102. 2012
    ..As inhaled corticosteroids are known to be less effective for controlling neutrophilic inflammation, a more effective therapeutic strategy for neutrophil-dominant asthma should still be elucidated...
  2. pmc Antigen-sensitized CD4+CD62Llow memory/effector T helper 2 cells can induce airway hyperresponsiveness in an antigen free setting
    Kazuyuki Nakagome
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Respir Res 6:46. 2005
    ..In the present study, we examined this possibility by cell transfer experiment, and then analyzed which cell source was essential for this process...
  3. doi request reprint IFN-gamma attenuates antigen-induced overall immune response in the airway as a Th1-type immune regulatory cytokine
    Kazuyuki Nakagome
    Department of Allergy and Rheumatology, University of Tokyo, Japan
    J Immunol 183:209-20. 2009
    ..They also suggest that delivery of IFN-gamma could be an effective strategy for regulating Ag-induced immune responses in the lung...
  4. ncbi request reprint In vivo IL-10 gene delivery suppresses airway eosinophilia and hyperreactivity by down-regulating APC functions and migration without impairing the antigen-specific systemic immune response in a mouse model of allergic airway inflammation
    Kazuyuki Nakagome
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Japan
    J Immunol 174:6955-66. 2005
    ..Therefore, if delivered selectively, IL-10 could site specifically suppress the Ag-specific immune response without affecting systemic immune responses...
  5. ncbi request reprint A novel role of hepatocyte growth factor as an immune regulator through suppressing dendritic cell function
    Katsuhide Okunishi
    Pulmonary Division, Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 175:4745-53. 2005
    ..These results demonstrated a novel, significant, and possibly therapeutic role of HGF as a potent regulator in immune-mediated disorders such as asthma...
  6. ncbi request reprint IL-5-induced hypereosinophilia suppresses the antigen-induced immune response via a TGF-beta-dependent mechanism
    Kazuyuki Nakagome
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Immunol 179:284-94. 2007
    ..Therefore, hypereosinophilia could reveal an immunosuppressive effect in the early stage of Ag-induced immune response...
  7. ncbi request reprint Perillyl alcohol suppresses antigen-induced immune responses in the lung
    Mitsuru Imamura
    Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 443:266-71. 2014
    ..Considering that it exists naturally, POH could be a novel preventive or therapeutic option for immunologic lung disorders such as asthma with minimal side effects. ..
  8. ncbi request reprint Hepatocyte growth factor significantly suppresses collagen-induced arthritis in mice
    Katsuhide Okunishi
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 179:5504-13. 2007
    ..These results indicate that HGF suppresses the development of CIA through different ways at different phases. They also suggest that HGF could be an attractive tool for treating patients with rheumatoid arthritis...
  9. ncbi request reprint Splenic dendritic cells induced by oral antigen administration are important for the transfer of oral tolerance in an experimental model of asthma
    Katsuya Nagatani
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 176:1481-9. 2006
    ..These data suggest that not only CD4+ T cells, but also CD11c+ DCs induced by Ag feeding are important for the active transfer of oral tolerance in this murine experimental model of asthma...
  10. doi request reprint Upregulation of lung dendritic cell functions in elastase-induced emphysema
    Hiroaki Harada
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Int Arch Allergy Immunol 149:25-30. 2009
    ..Although dendritic cells (DCs) are thought to play a key role in immune responses, studies investigating the role of DCs in COPD are quite limited...
  11. ncbi request reprint Changes in airway inflammation and hyperresponsiveness after inhaled corticosteroid cessation in allergic asthma
    Yotaro Takaku
    Department of Respiratory Medicine, Allergy Center, Saitama Medical University, Saitama, Japan
    Int Arch Allergy Immunol 152:41-6. 2010
    ..However, whether ICS actually induces remission of asthma remains unknown. The present study evaluates changes in airway inflammation and hyperresponsiveness in adult patients with asthma after stopping ICS...
  12. doi request reprint Intratracheal delivery of hepatocyte growth factor directly attenuates allergic airway inflammation in mice
    Katsuhide Okunishi
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Int Arch Allergy Immunol 149:14-20. 2009
    ..These results suggest that the controlled release of rhHGF protein can suppress antigen-induced allergic immune responses in the lung. Therefore, HGF could be a novel therapeutic option for asthma...
  13. doi request reprint Alendronate attenuates eosinophilic airway inflammation associated with suppression of Th2 cytokines, Th17 cytokines, and eotaxin-2
    Oh Sasaki
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Immunol 191:2879-89. 2013
    ..Although a clinical study should be conducted, ALN could be a novel therapeutic option for asthma. ..
  14. doi request reprint High expression of IL-22 suppresses antigen-induced immune responses and eosinophilic airway inflammation via an IL-10-associated mechanism
    Kazuyuki Nakagome
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 187:5077-89. 2011
    ..These findings suggested that IL-22 could have an immunosuppressive effect during the early stage of an immune response. Furthermore, IL-10 plays an important role in the immune suppression by IL-22...
  15. ncbi request reprint Phonetic mismatch negativity predicts social skills acquisition in schizophrenia
    Yuki Kawakubo
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Psychiatry Res 152:261-5. 2007
    ..Although preliminary, these results suggest that phonetic MMN could be an index of social skills acquisition in patients with schizophrenia...
  16. doi request reprint Pathogenesis of airway inflammation in bronchial asthma
    Kazuyuki Nakagome
    Department of Respiratory Medicine, Saitama Medical University, 38 Morohongo, Moroyama cho, Iruma gun, Saitama, Japan
    Auris Nasus Larynx 38:555-63. 2011
    ..In view of these mechanisms, an effective strategy for controlling asthma, especially severe asthma, should be considered...
  17. ncbi request reprint Auditory P300 latency prolongation with age in schizophrenia: gender and subcomponent effects
    Tsuyoshi Araki
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 88:217-21. 2006
    ..Our findings may provide evidence for progressive change in the brain function in schizophrenia, and this change may be slower in female than male patients. P3b may serve as a more sensitive index for cognitive decline than P3a...
  18. ncbi request reprint Prolonged allergen challenge in murine nasal allergic rhinitis: nasal airway remodeling and adaptation of nasal airway responsiveness
    Muneo Nakaya
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Laryngoscope 117:881-5. 2007
    ..Therefore, we have undertaken this investigation to characterize nasal airway structural changes after prolonged allergen challenge and to examine the relationship between nasal airway hyperresponsivity and remodeling...
  19. doi request reprint Effect of formoterol on eosinophil trans-basement membrane migration induced by interleukin-8-stimulated neutrophils
    Akiko Kawashima
    Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan
    Int Arch Allergy Immunol 161:10-5. 2013
    ..In this study, we investigated whether formoterol modified the trans-basement membrane migration (TBM) of eosinophils stimulated with neutrophils and IL-8...
  20. doi request reprint Omalizumab attenuates airway inflammation and interleukin-5 production by mononuclear cells in patients with severe allergic asthma
    Yotaro Takaku
    Allergy Center, Saitama Medical University, Saitama, Japan
    Int Arch Allergy Immunol 161:107-17. 2013
    ..This study evaluated changes in airway inflammation and cytokine release by the peripheral blood mononuclear cells (PBMCs) of Japanese patients with severe asthma after administration of omalizumab...
  21. ncbi request reprint Noninvasive system for evaluating allergen-induced nasal hypersensitivity in murine allergic rhinitis
    Muneo Nakaya
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Lab Invest 86:917-26. 2006
    ..These results clearly demonstrate that Penh could be a useful noninvasive indicator for studying nasal hypersensitivity...
  22. ncbi request reprint Salbutamol modulates the balance of Th1 and Th2 cytokines by mononuclear cells from allergic asthmatics
    Takefumi Yamaguchi
    Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan
    Int Arch Allergy Immunol 152:32-40. 2010
    ....
  23. ncbi request reprint [Effects of educational guidance on airway inflammation of patients with severe persistent asthma]
    Yotaro Takaku
    Allergy Center, Saitama Medical University, Japan
    Arerugi 61:194-203. 2012
    ..Airway inflammation is a fundamental feature of bronchial asthma. We examined whether educational guidance using a text on pathophysiology and management of asthma modify airway inflammation of severe asthma...
  24. ncbi request reprint [A case of bronchial asthma caused by occupational exposure to trichophyton]
    Rie Hoshi
    Allergy Center, Saitama Medical University, Japan
    Arerugi 60:207-13. 2011
    ..The possibility that occupational exposure to trichophyton could exacerbate asthma symptoms needs to be kept in mind, particularly in the case of nurses who may be in contact with elderly individuals with tinea...
  25. doi request reprint Thought disorder and executive dysfunction in patients with schizophrenia
    Toshimi Owashi
    Department of Psychiatry, Showa University School of Medicine, Tokyo, Japan
    Int J Neurosci 119:105-23. 2009
    ..No significant correlations were found between parameters of positive thought disorder and executive function. Thought disorder and executive function may play different roles in the pathophysiology of schizophrenia...
  26. ncbi request reprint A novel role of cysteinyl leukotrienes to promote dendritic cell activation in the antigen-induced immune responses in the lung
    Katsuhide Okunishi
    Pulmonary Division, Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Immunol 173:6393-402. 2004
    ..These results suggested that cysLTs potentiate DC functions both in vivo and in vitro, and that LTRA could be beneficial to suppress the initial immune response in many immune-mediated disorders beyond asthma...
  27. doi request reprint Dopamine D1-like receptor antagonist attenuates Th17-mediated immune response and ovalbumin antigen-induced neutrophilic airway inflammation
    Kazuyuki Nakagome
    Department of Respiratory Medicine, Saitama Medical University, Saitama 350 0495, Japan
    J Immunol 186:5975-82. 2011
    ....
  28. pmc IFN-γ-inducible protein of 10 kDa upregulates the effector functions of eosinophils through β2 integrin and CXCR3
    Yotaro Takaku
    Department of Respiratory Medicine, Saitama Medical University, 38 Morohongo, Moroyama cho, Iruma gun, Saitama, Japan
    Respir Res 12:138. 2011
    ..The objective of this study was to examine whether CXCR3 ligands including IP-10 modify the effector functions of eosinophils...
  29. ncbi request reprint Phonetic mismatch negativity predicts verbal memory deficits in schizophrenia
    Yuki Kawakubo
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Neuroreport 17:1043-6. 2006
    ..These results suggest that electrophysiological auditory sensory memory dysfunction underlies the basis for neuropsychological auditory verbal memory deficits in schizophrenia...
  30. ncbi request reprint [A case of eosinophilic lung disease presenting asthma-like symptoms and centrilobular shadows in both lung fields]
    Kazuyuki Nakagome
    Department of Allergy and Rheumatology, University of Tokyo Graduate School of Medicine, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655
    Nihon Kokyuki Gakkai Zasshi 41:722-7. 2003
    ..This case showed a marked similarity to the recently reported "eosinophilic bronchiolitis", and was probably not a type of bronchial asthma...
  31. ncbi request reprint Hypofrontality in panic disorder and major depressive disorder assessed by multi-channel near-infrared spectroscopy
    Haruhisa Ohta
    Department of Neuropsychiatry, Showa University School of Medicine, Tokyo, Japan
    Depress Anxiety 25:1053-9. 2008
    ....
  32. ncbi request reprint [Role of T cells on the development of airway hyperreactivity]
    Kazuyuki Nakagome
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo
    Nihon Rinsho 63:58-62. 2005
  33. doi request reprint Allergen immunotherapy in asthma: current status and future perspectives
    Makoto Nagata
    Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan
    Allergol Int 59:15-9. 2010
    ..It is hoped that the positioning of allergen immunotherapy as a treatment option will allow the comprehensive management of symptoms in allergic individuals, and the modification of disease course...
  34. ncbi request reprint A two-way interaction between hepatocyte growth factor and interleukin-6 in tissue invasion of lung cancer cell line
    Yasuo To
    Pulmonary Section, Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Am J Respir Cell Mol Biol 27:220-6. 2002
    ..They also suggest an "autocrine circuit" among cytokines and growth factors in certain cancer cells which functions to accelerate their biologic activities such as metastatic property...
  35. ncbi request reprint Delayed automatic detection of change in speech sounds in adults with autism: a magnetoencephalographic study
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655 Tokyo, Japan
    Clin Neurophysiol 116:1655-64. 2005
    ..e. automatic change detection of speech and non-speech sounds, using magnetoencephalographic recording of mismatch response elicited by change in vowels and tones...
  36. pmc Japan useful medication program for schizophrenia (JUMPs)-long-term study on discontinuation rate, resolution and remission, and improvement in social functioning rate associated with atypical antipsychotic medications in patients with schizophrenia
    Jun Ishigooka
    Department of Psychiatry, Tokyo Women s Medical University, School of Medicine, Shinjuku ku, Tokyo, Japan
    BMC Psychiatry 13:243. 2013
    ..In Japan, no effectiveness study has been reported: thus, it is desirable to collect data that will serve as evidence for selection of the 3 SGAs approved after olanzapine...
  37. ncbi request reprint [Clinical examination of challenge test to local anesthetics]
    Takefumi Yamaguchi
    Department of Respiratory Medicine, Saitama Medical University
    Arerugi 58:657-64. 2009
    ..Although adverse reactions to local anesthetics are often diagnosed as local anesthetic allergy, there is evidence that most of these reactions occur via non-allergic mechanisms...
  38. ncbi request reprint Association between lower P300 amplitude and smaller anterior cingulate cortex volume in patients with posttraumatic stress disorder: a study of victims of Tokyo subway sarin attack
    Tsuyoshi Araki
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Neuroimage 25:43-50. 2005
    ..These results provide the first evidence that electrophysiological deficits of controlled attention observed in patients with PTSD may be linked to underlying brain morphological abnormalities...
  39. ncbi request reprint Relationships of DEX/CRH and GHRH test results to the outcome of depression--preliminary results suggest the GHRH test may predict relapse after discharge
    Toshimi Owashi
    Department of Psychiatry, Showa University School of Medicine, Tokyo, Japan
    J Psychiatr Res 42:356-64. 2008
    ..The findings of this study suggest that results of the GHRH test may be a predictor of future relapse in patients with depression...