Hironobu Naiki

Summary

Affiliation: University of Fukui
Country: Japan

Publications

  1. ncbi request reprint [Search for antiamyloidogenic compounds based on a nucleation-dependent polymerization model]
    Hironobu Naiki
    Department of Pathological Sciences, University of Fukui, Fukui, Japan
    Yakugaku Zasshi 130:503-9. 2010
  2. ncbi request reprint Molecular pathogenesis of protein misfolding diseases: pathological molecular environments versus quality control systems against misfolded proteins
    Hironobu Naiki
    Division of Molecular Pathology, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
    J Biochem 146:751-6. 2009
  3. doi request reprint Lysophospholipids induce the nucleation and extension of beta2-microglobulin-related amyloid fibrils at a neutral pH
    Tadakazu Ookoshi
    Department of Pathological Sciences, Division of Molecular Pathology, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
    Nephrol Dial Transplant 23:3247-55. 2008
  4. doi request reprint Critical role of interfaces and agitation on the nucleation of Abeta amyloid fibrils at low concentrations of Abeta monomers
    Akiyoshi Morinaga
    Division of Molecular Pathology, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
    Biochim Biophys Acta 1804:986-95. 2010
  5. ncbi request reprint The anti-amyloidogenic effect is exerted against Alzheimer's beta-amyloid fibrils in vitro by preferential and reversible binding of flavonoids to the amyloid fibril structure
    Mie Hirohata
    Division of Molecular Pathology, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
    Biochemistry 46:1888-99. 2007
  6. doi request reprint Growth of beta(2)-microglobulin-related amyloid fibrils by non-esterified fatty acids at a neutral pH
    Kazuhiro Hasegawa
    Division of Molecular Pathology, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, 23 3 Matsuokashimoaizuki, Eiheiji, Fukui 910 1193, Japan
    Biochem J 416:307-15. 2008
  7. ncbi request reprint Low concentrations of sodium dodecyl sulfate induce the extension of beta 2-microglobulin-related amyloid fibrils at a neutral pH
    Suguru Yamamoto
    Division of Molecular Pathology, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
    Biochemistry 43:11075-82. 2004
  8. ncbi request reprint Glycosaminoglycans enhance the trifluoroethanol-induced extension of beta 2-microglobulin-related amyloid fibrils at a neutral pH
    Suguru Yamamoto
    Department of Pathology, Fukui Medical University, Fukui, Japan
    J Am Soc Nephrol 15:126-33. 2004
  9. ncbi request reprint Molecular interactions in the formation and deposition of beta2-microglobulin-related amyloid fibrils
    Hironobu Naiki
    Division of Molecular Pathology, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Amyloid 12:15-25. 2005
  10. ncbi request reprint Glycosaminoglycan and proteoglycan inhibit the depolymerization of beta2-microglobulin amyloid fibrils in vitro
    Itaru Yamaguchi
    Department of Pathology, Fukui Medical University, Fukui, Japan
    Kidney Int 64:1080-8. 2003

Collaborators

  • Kazuhiro Hasegawa
  • Yuji Goto
  • Masahito Yamada
  • Kenjiro Ono
  • Hideki Kimura
  • Kazutaka Takagi
  • József Kardos
  • Satoshi Ikegaya
  • Akira Yoshida
  • Masanori Hara
  • Yoshitaka Nagai
  • Takashi Konno
  • Akihiko Takashima
  • Kunihiro Inai
  • Naoki Takahashi
  • Tadakazu Ookoshi
  • Suguru Yamamoto
  • Itaru Yamaguchi
  • Sakon Noriki
  • Daisaku Ozawa
  • Fumitake Gejyo
  • Akiyoshi Morinaga
  • Haruyoshi Yoshida
  • Masamichi Ikawa
  • Yumiko Ohhashi
  • Mie Hirohata
  • Takanori Ueda
  • Hiromi Okada
  • Shinobu Tsutsumi
  • Kazuyuki Kinoshita
  • Toyohiko Sakai
  • Akihiko Nishijima
  • Hiromichi Iwasaki
  • Masayuki Iwano
  • Daisuke Mikami
  • Minoru Yasujima
  • Hiroyuki Kurosawa
  • Kenji Kasuno
  • Shouji Tsutaya
  • Shinichi Mizuno
  • Yoshiaki Hirayama
  • Seiji Yokoi
  • Kotaro Yanagi
  • Young Ho Lee
  • Kazumasa Sakurai
  • Ryo Nomura
  • Masaru Kuriyama
  • Asuka Kazama-Suzuki
  • Akiko Matsunaga
  • Nobuo Miyashita
  • Tetsuyuki Kitamoto
  • Makoto Yoneda
  • Hiroto Nakagawa
  • Nobuo Takimoto
  • Yoshiaki Imamura
  • Ryoichi Miyazaki
  • Shinobu Tsutsumi-Yasuhara
  • Yukiya Yamaguchi
  • Hironori Suda
  • Naoki Tsuzuike
  • Masaharu Seki
  • Kouichi Seto

Detail Information

Publications24

  1. ncbi request reprint [Search for antiamyloidogenic compounds based on a nucleation-dependent polymerization model]
    Hironobu Naiki
    Department of Pathological Sciences, University of Fukui, Fukui, Japan
    Yakugaku Zasshi 130:503-9. 2010
    ....
  2. ncbi request reprint Molecular pathogenesis of protein misfolding diseases: pathological molecular environments versus quality control systems against misfolded proteins
    Hironobu Naiki
    Division of Molecular Pathology, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
    J Biochem 146:751-6. 2009
    ..Protein misfolding and aggregation may be an ideal therapeutic target for protein misfolding diseases in general...
  3. doi request reprint Lysophospholipids induce the nucleation and extension of beta2-microglobulin-related amyloid fibrils at a neutral pH
    Tadakazu Ookoshi
    Department of Pathological Sciences, Division of Molecular Pathology, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
    Nephrol Dial Transplant 23:3247-55. 2008
    ....
  4. doi request reprint Critical role of interfaces and agitation on the nucleation of Abeta amyloid fibrils at low concentrations of Abeta monomers
    Akiyoshi Morinaga
    Division of Molecular Pathology, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
    Biochim Biophys Acta 1804:986-95. 2010
    ..Furthermore, elimination of AWI may be essential for proper evaluation of the roles of various biological molecules in the amyloid formation studies in vitro...
  5. ncbi request reprint The anti-amyloidogenic effect is exerted against Alzheimer's beta-amyloid fibrils in vitro by preferential and reversible binding of flavonoids to the amyloid fibril structure
    Mie Hirohata
    Division of Molecular Pathology, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
    Biochemistry 46:1888-99. 2007
    ..These findings suggest that flavonoids, especially Myr, exert an anti-amyloidogenic effect in vitro by preferentially and reversibly binding to the amyloid fibril structure of fAbeta, rather than to Abeta monomers...
  6. doi request reprint Growth of beta(2)-microglobulin-related amyloid fibrils by non-esterified fatty acids at a neutral pH
    Kazuhiro Hasegawa
    Division of Molecular Pathology, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, 23 3 Matsuokashimoaizuki, Eiheiji, Fukui 910 1193, Japan
    Biochem J 416:307-15. 2008
    ..These results suggest the involvement of NEFAs in the development of Abeta2M amyloidosis, and in the pathogenesis of Abeta2M amyloidosis...
  7. ncbi request reprint Low concentrations of sodium dodecyl sulfate induce the extension of beta 2-microglobulin-related amyloid fibrils at a neutral pH
    Suguru Yamamoto
    Division of Molecular Pathology, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
    Biochemistry 43:11075-82. 2004
    ..g., phospholipids) that affect the conformation and stability of beta2-m and amyloid fibrils will have significant effects on the kinetics of Abeta2M fibril formation...
  8. ncbi request reprint Glycosaminoglycans enhance the trifluoroethanol-induced extension of beta 2-microglobulin-related amyloid fibrils at a neutral pH
    Suguru Yamamoto
    Department of Pathology, Fukui Medical University, Fukui, Japan
    J Am Soc Nephrol 15:126-33. 2004
    ..In addition, the interference of the binding of GAG to A beta 2M amyloid fibrils may be an attractive therapeutic modality...
  9. ncbi request reprint Molecular interactions in the formation and deposition of beta2-microglobulin-related amyloid fibrils
    Hironobu Naiki
    Division of Molecular Pathology, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Amyloid 12:15-25. 2005
    ..These findings are consistent with the hypothesis that in vivo, specific molecules that affect the conformation and stability of beta2-m and amyloid fibrils will have significant effects on the deposition of A beta2M amyloid fibrils...
  10. ncbi request reprint Glycosaminoglycan and proteoglycan inhibit the depolymerization of beta2-microglobulin amyloid fibrils in vitro
    Itaru Yamaguchi
    Department of Pathology, Fukui Medical University, Fukui, Japan
    Kidney Int 64:1080-8. 2003
    ....
  11. pmc Inhibition of beta2-microglobulin amyloid fibril formation by alpha2-macroglobulin
    Daisaku Ozawa
    Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
    J Biol Chem 286:9668-76. 2011
    ....
  12. ncbi request reprint Amyloidogenic synthetic peptides of beta2-microglobulin--a role of the disulfide bond
    Kazuhiro Hasegawa
    Department of Pathology, Fukui Medical University, 910 1193, Fukui, Japan
    Biochem Biophys Res Commun 304:101-6. 2003
    ..Interestingly, the dimer formation of peptide (21-31) by the disulfide bond substantially facilitated the fibril formation, indicating that the disulfide bond is important for the structural stability of the fibrils...
  13. ncbi request reprint Establishment of a first-order kinetic model of light chain-associated amyloid fibril extension in vitro
    Naoki Takahashi
    Department of Pathology, Fukui Medical University, 23 3 Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    Biochim Biophys Acta 1601:110-20. 2002
    ..These findings contribute to our understanding of the molecular mechanism underlying the pathogenesis of AL amyloidosis, and will be useful for developing a therapeutic strategy against the disease...
  14. ncbi request reprint Surface-bound basement membrane components accelerate amyloid-β peptide nucleation in air-free wells: an in vitro model of cerebral amyloid angiopathy
    Kazuhiro Hasegawa
    Department of Pathological Sciences, University of Fukui, Fukui, Japan
    Biochim Biophys Acta 1834:1624-31. 2013
    ..These data support the essential role of vascular basement membranes in the development of cerebral amyloid angiopathy. ..
  15. ncbi request reprint Kinetic modeling and determination of reaction constants of Alzheimer's beta-amyloid fibril extension and dissociation using surface plasmon resonance
    Kazuhiro Hasegawa
    Department of Pathology, Fukui Medical University, Fukui 910 1193, Japan
    Biochemistry 41:13489-98. 2002
    ..The SPR biosensor is a useful quantitative tool for the kinetic and thermodynamic study of the molecular mechanisms of f9A)beta formation in vitro...
  16. ncbi request reprint Nicotine breaks down preformed Alzheimer's beta-amyloid fibrils in vitro
    Kenjiro Ono
    Department of Pathology, Fukui Medical University, Fukui, Japan
    Biol Psychiatry 52:880-6. 2002
    ....
  17. ncbi request reprint Anionic contribution for fibrous maturation of protofibrillar assemblies of the human tau repeat domain in a fluoroalcohol solution
    Takashi Konno
    Department of Molecular Physiology and Biophysics, Faculty of Medical Sciences, University of Fukui, Matsuoka, Yoshida, Fukui 910 1193, Japan
    Biochemistry 43:13613-20. 2004
    ..The anionic environment was suggested to play a crucial role in the fibrous maturation and, therefore, could be an in vivo determinant of the morphology of the aggregates of tau...
  18. ncbi request reprint Risk factor analysis for bone marrow histiocytic hyperplasia with hemophagocytosis: an autopsy study
    Kunihiro Inai
    Division of Molecular Pathology, Department of Pathological Sciences, University of Fukui, Eiheiji, Fukui, 910 1193, Japan
    Virchows Arch 465:109-18. 2014
    ..These findings suggest that HHH is a different entity from HPS and that it preferentially develops under conditions of excessive inflammation and its associated risks, such as hematological diseases and sepsis. ..
  19. ncbi request reprint Nordihydroguaiaretic acid potently breaks down pre-formed Alzheimer's beta-amyloid fibrils in vitro
    Kenjiro Ono
    Department of Pathology, Fukui Medical University, Fukui, Japan
    J Neurochem 81:434-40. 2002
    ..Although the mechanisms by which NDGA inhibits fAbeta formation from Abeta, as well as breaking down pre-formed fAbetain vitro, are still unclear, NDGA could be a key molecule for the development of therapeutics for AD...
  20. ncbi request reprint Feasibility of liver weight estimation by postmortem computed tomography images: An autopsy study
    Kunihiro Inai
    Division of Molecular Pathology, School of Medical Sciences, University of Fukui, Fukui, Japan Division of Autopsy Imaging Center, School of Medical Sciences, University of Fukui, Fukui, Japan
    Pathol Int 64:315-24. 2014
    ..055 g/mL was highly accurate, whereas the specific gravity should be reduced by 2%-3% in patients with an HU value less than 40 due to fatty deposition. ..
  21. doi request reprint Multiple inflammatory cytokine-productive ThyL-6 cell line established from a patient with thymic carcinoma
    Kunihiro Inai
    Division of Molecular Pathology, Department of Pathological Sciences, Faculty of Medical Sciences, Univeristy of Fukui, Fukui 910 1193, Japan
    Cancer Sci 99:1778-84. 2008
    ....
  22. doi request reprint Unique clinicopathological features and PrP profiles in the first autopsied case of dura mater graft-associated Creutzfeldt-Jakob disease with codon 219 lysine allele observed in Japanese population
    Masamichi Ikawa
    Second Department of Internal Medicine Neurology, Faculty of Medical Sciences, University of Fukui, 23 3 Shimoaiduki, Matsuoka, Eiheiji cho, Yoshida gun, Fukui 910 1193, Japan
    J Neurol Sci 285:265-7. 2009
    ..Thus, these findings can be unique to dCJD with codon 219 lysine allele, and this allele may influence the clinicopathological features and PrP profiles in dCJD...
  23. ncbi request reprint Esophageal erosion as a possible bacterial entry site in an acute lymphoblastic leukemia patient with sepsis
    Satoshi Ikegaya
    Second Department of Pathology, Fukui Medical University, Yoshida gun, Fukui, Japan
    Int J Hematol 77:395-8. 2003
    ..In many patients with febrile neutropenia, the pathogenesis of infection remains unclear. Our case seems significant for clarifying the focus and pathogenesis of febrile neutropenia...
  24. doi request reprint Severe intraglomerular detachment of podocytes in a Gitelman syndrome patient
    Naoki Takahashi
    Division of Nephrology, Department of General Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Clin Exp Nephrol 16:495-500. 2012
    ..This podocyte detachment may be associated with nephron obstruction and reduced nephrin expression...