Fumikiyo Nagawa

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi Genomic analysis of the murine odorant receptor MOR28 cluster: a possible role of gene conversion in maintaining the olfactory map
    Fumikiyo Nagawa
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, 2 11 16 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Gene 292:73-80. 2002
  2. ncbi Antigen-receptor genes of the agnathan lamprey are assembled by a process involving copy choice
    Fumikiyo Nagawa
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    Nat Immunol 8:206-13. 2007
  3. ncbi In vitro processing of the 3'-overhanging DNA in the postcleavage complex involved in V(D)J joining
    Tadashi Nishihara
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan
    Mol Cell Biol 24:3692-702. 2004
  4. ncbi Joining mutants of RAG1 and RAG2 that demonstrate impaired interactions with the coding-end DNA
    Fumikiyo Nagawa
    Department of Biophysics and Biochemistry, Graduate School of Science, and Core Research for Evolutional Science and Technology Program of the Japan Science and Technology Agency, The University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 279:38360-8. 2004
  5. ncbi RAG-heptamer interaction in the synaptic complex is a crucial biochemical checkpoint for the 12/23 recombination rule
    Tadashi Nishihara
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, 2 11 16 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 283:4877-85. 2008
  6. ncbi Regulation of antigen-receptor gene assembly in hagfish
    Natsuko Kishishita
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, 2 11 16, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    EMBO Rep 11:126-32. 2010
  7. ncbi Footprint analysis of recombination signal sequences in the 12/23 synaptic complex of V(D)J recombination
    Fumikiyo Nagawa
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan
    Mol Cell Biol 22:7217-25. 2002

Collaborators

  • Hitoshi Sakano
  • Takeshi Imai
  • Tadashi Nishihara
  • Natsuko Kishishita
  • Hirofumi Nishizumi
  • Tatsuya Matsuno
  • Hiroyuki Takaba
  • Yoshimasa Takahashi
  • Reiko Hayashi
  • Masami Kodama
  • Satoshi Hirose

Detail Information

Publications7

  1. ncbi Genomic analysis of the murine odorant receptor MOR28 cluster: a possible role of gene conversion in maintaining the olfactory map
    Fumikiyo Nagawa
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, 2 11 16 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Gene 292:73-80. 2002
    ..A possible role of gene conversion in the olfactory system is discussed in the context of the olfactory map...
  2. ncbi Antigen-receptor genes of the agnathan lamprey are assembled by a process involving copy choice
    Fumikiyo Nagawa
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    Nat Immunol 8:206-13. 2007
    ..Thus, a vast repertoire of recombinant VLR genes could be generated not only by copying of various LRR segments in diverse combinations but also by the use of multiple sites in an LRR gene segment for priming...
  3. ncbi In vitro processing of the 3'-overhanging DNA in the postcleavage complex involved in V(D)J joining
    Tadashi Nishihara
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan
    Mol Cell Biol 24:3692-702. 2004
    ..Thus, the blunt-end structure is restored for the SE and variably processed ends are generated for the synthetic CE. This 3'-processing activity is observed not only with the core RAG2 but also with the full-length protein...
  4. ncbi Joining mutants of RAG1 and RAG2 that demonstrate impaired interactions with the coding-end DNA
    Fumikiyo Nagawa
    Department of Biophysics and Biochemistry, Graduate School of Science, and Core Research for Evolutional Science and Technology Program of the Japan Science and Technology Agency, The University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 279:38360-8. 2004
    ..A possible role of this RAG coding region interaction is discussed in the context of V(D)J recombination...
  5. ncbi RAG-heptamer interaction in the synaptic complex is a crucial biochemical checkpoint for the 12/23 recombination rule
    Tadashi Nishihara
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, 2 11 16 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 283:4877-85. 2008
    ..We propose that the RAG-7-mer interaction is a critical step for coding DNA distortion and hairpin formation in the context of the 12/23 rule...
  6. ncbi Regulation of antigen-receptor gene assembly in hagfish
    Natsuko Kishishita
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, 2 11 16, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    EMBO Rep 11:126-32. 2010
    ..In fact, all VLR-assembled lymphocytes contained at least one functional VLR gene. Together, these results indicate a feedback inhibition of VLR assembly and selection of VLR-positive lymphocytes...
  7. ncbi Footprint analysis of recombination signal sequences in the 12/23 synaptic complex of V(D)J recombination
    Fumikiyo Nagawa
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan
    Mol Cell Biol 22:7217-25. 2002
    ..The present study indicates that the RAG-RSS interaction in the 7-mer region drastically changes once the synaptic complex is formed for cleavage...