Motoo Nagane

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint [Chemotherapy for malignant gliomas]
    Motoo Nagane
    Department of Neurosurgery, Kyorin University School of Medicine, Shinkawa, Mitaka shi, Tokyo, Japan
    No Shinkei Geka 35:433-50. 2007
  2. pmc Phase II study of single-agent bevacizumab in Japanese patients with recurrent malignant glioma
    Motoo Nagane
    Department of Neurosurgery, Kyorin University Faculty of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo, Japan
    Jpn J Clin Oncol 42:887-95. 2012
  3. pmc Predominant antitumor effects by fully human anti-TRAIL-receptor 2 (DR5) monoclonal antibodies in human glioma cells in vitro and in vivo
    Motoo Nagane
    Department of Neurosurgery, Kyorin University Faculty of Medicine, Mitaka, Tokyo 181 8611, Japan
    Neuro Oncol 12:687-700. 2010
  4. ncbi request reprint Prolonged and severe thrombocytopenia with pancytopenia induced by radiation-combined temozolomide therapy in a patient with newly diagnosed glioblastoma--analysis of O6-methylguanine-DNA methyltransferase status
    Motoo Nagane
    Department of Neurosurgery, Kyorin University Faculty of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo, 181 8611, Japan
    J Neurooncol 92:227-32. 2009
  5. ncbi request reprint Prognostic significance of O6-methylguanine-DNA methyltransferase protein expression in patients with recurrent glioblastoma treated with temozolomide
    Motoo Nagane
    Department of Neurosurgery, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    Jpn J Clin Oncol 37:897-906. 2007
  6. ncbi request reprint Synergistic cytotoxicity through the activation of multiple apoptosis pathways in human glioma cells induced by combined treatment with ionizing radiation and tumor necrosis factor-related apoptosis-inducing ligand
    Motoo Nagane
    Department of Neurosurgery, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    J Neurosurg 106:407-16. 2007
  7. doi request reprint Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells
    Keiichi Kobayashi
    Department of Neurosurgery, Kyorin University School of Medicine, Tokyo, Japan
    Neurosurgery 62:493-503; discussion 503-4. 2008
  8. ncbi request reprint [Chemoresistance-related genes and individualized adjuvant therapies for brain gliomas]
    Motoo Nagane
    Department of Neurosurgery, Kyorin University School of Medicine
    Nihon Rinsho 63:460-71. 2005
  9. ncbi request reprint [Genetic alterations and biomarkers for glioma]
    Motoo Nagane
    Department of Neurosurgery, Kyorin University Faculty of Medicine, Tokyo, Japan
    Brain Nerve 64:537-48. 2012
  10. ncbi request reprint [Current topics of treatment for glioma and mechanism of drug resistance]
    Motoo Nagane
    Department of Neurosurgery, Kyorin University School of Medicine, Tokyo, Japan
    Gan To Kagaku Ryoho 35:918-25. 2008

Collaborators

Detail Information

Publications20

  1. ncbi request reprint [Chemotherapy for malignant gliomas]
    Motoo Nagane
    Department of Neurosurgery, Kyorin University School of Medicine, Shinkawa, Mitaka shi, Tokyo, Japan
    No Shinkei Geka 35:433-50. 2007
  2. pmc Phase II study of single-agent bevacizumab in Japanese patients with recurrent malignant glioma
    Motoo Nagane
    Department of Neurosurgery, Kyorin University Faculty of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo, Japan
    Jpn J Clin Oncol 42:887-95. 2012
    ..This single-arm, open-label, Phase II study evaluated the efficacy and safety of single-agent bevacizumab, a monoclonal antibody against vascular endothelial growth factor, in Japanese patients with recurrent malignant glioma...
  3. pmc Predominant antitumor effects by fully human anti-TRAIL-receptor 2 (DR5) monoclonal antibodies in human glioma cells in vitro and in vivo
    Motoo Nagane
    Department of Neurosurgery, Kyorin University Faculty of Medicine, Mitaka, Tokyo 181 8611, Japan
    Neuro Oncol 12:687-700. 2010
    ..Specific targeting of death receptor pathway through DR5 using fully human mAbs might provide a novel therapeutic strategy for intractable malignant gliomas...
  4. ncbi request reprint Prolonged and severe thrombocytopenia with pancytopenia induced by radiation-combined temozolomide therapy in a patient with newly diagnosed glioblastoma--analysis of O6-methylguanine-DNA methyltransferase status
    Motoo Nagane
    Department of Neurosurgery, Kyorin University Faculty of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo, 181 8611, Japan
    J Neurooncol 92:227-32. 2009
    ..This is the first report suggesting the irrelevance of MGMT status of normal hematopoietic cells to TMZ-induced severe thrombocytopenia and pancytopenia...
  5. ncbi request reprint Prognostic significance of O6-methylguanine-DNA methyltransferase protein expression in patients with recurrent glioblastoma treated with temozolomide
    Motoo Nagane
    Department of Neurosurgery, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    Jpn J Clin Oncol 37:897-906. 2007
    ....
  6. ncbi request reprint Synergistic cytotoxicity through the activation of multiple apoptosis pathways in human glioma cells induced by combined treatment with ionizing radiation and tumor necrosis factor-related apoptosis-inducing ligand
    Motoo Nagane
    Department of Neurosurgery, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    J Neurosurg 106:407-16. 2007
    ..Here, the authors show that genotoxic ionizing radiation synergistically enhances TRAIL-induced cell death in human glioma cells expressing DR5...
  7. doi request reprint Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells
    Keiichi Kobayashi
    Department of Neurosurgery, Kyorin University School of Medicine, Tokyo, Japan
    Neurosurgery 62:493-503; discussion 503-4. 2008
    ....
  8. ncbi request reprint [Chemoresistance-related genes and individualized adjuvant therapies for brain gliomas]
    Motoo Nagane
    Department of Neurosurgery, Kyorin University School of Medicine
    Nihon Rinsho 63:460-71. 2005
  9. ncbi request reprint [Genetic alterations and biomarkers for glioma]
    Motoo Nagane
    Department of Neurosurgery, Kyorin University Faculty of Medicine, Tokyo, Japan
    Brain Nerve 64:537-48. 2012
    ..Efforts to identify molecular markers that predict the benefits of novel molecularly targeted treatments will enable better patient stratification and individualization of treatment...
  10. ncbi request reprint [Current topics of treatment for glioma and mechanism of drug resistance]
    Motoo Nagane
    Department of Neurosurgery, Kyorin University School of Medicine, Tokyo, Japan
    Gan To Kagaku Ryoho 35:918-25. 2008
  11. doi request reprint Immature teratoma of the ovary with distant metastases: favorable prognosis and insights into chemotherapeutic retroconversion
    Atsushi Kurata
    Department of Pathology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka City, Tokyo, Japan
    Int J Gynecol Pathol 29:438-44. 2010
    ..The favorable prognosis of this malignant tumor even after brain metastasis was verified by the 10-year-survival of the patient...
  12. doi request reprint Predictive significance of mean apparent diffusion coefficient value for responsiveness of temozolomide-refractory malignant glioma to bevacizumab: preliminary report
    Motoo Nagane
    Department of Neurosurgery, Kyorin University Faculty of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo, 181 8611, Japan
    Int J Clin Oncol 19:16-23. 2014
    ..Here, patients with temozolomide-refractory high-grade gliomas were treated with bevacizumab (BV) and evaluated using apparent diffusion coefficient (ADC) for response...
  13. ncbi request reprint JC virus inclusions in progressive multifocal leukoencephalopathy: scaffolding promyelocytic leukemia nuclear bodies grow with cell cycle transition through an S-to-G2-like state in enlarging oligodendrocyte nuclei
    Yukiko Shishido-Hara
    From the Departments of Pathology YS H, TY, HK and Neurosurgery MN, Kyorin University School of Medicine, Shinkawa, Mitaka Laboratory of Structural Neuropathology, Tokyo Metropolitan Institute for Medical Science, Kamikitazawa, Setagaya ku YS H, TU Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima, Bunkyo ku SA S, Mku, MKi, Tokyo and Section of Pathology, Aizawa Hospital, Honjo, Matsumoto, Nagano KH, Japan
    J Neuropathol Exp Neurol 73:442-53. 2014
    ....
  14. doi request reprint Randomized trial of chemoradiotherapy and adjuvant chemotherapy with nimustine (ACNU) versus nimustine plus procarbazine for newly diagnosed anaplastic astrocytoma and glioblastoma (JCOG0305)
    Soichiro Shibui
    Department of Neurosurgery and Neuro Oncology, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Chemother Pharmacol 71:511-21. 2013
    ..Daily administration of procarbazine (PCZ) has been reported to decrease MGMT activity. This study investigated the efficacy of ACNU + PCZ compared to ACNU alone for GBM and anaplastic astrocytoma (AA)...
  15. doi request reprint ATP-binding cassette transporters in primary central nervous system lymphoma: decreased expression of MDR1 P-glycoprotein and breast cancer resistance protein in tumor capillary endothelial cells
    Seiji Sakata
    Department of Pathology, Kyorin University Faculty of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    Oncol Rep 25:333-9. 2011
    ..Thus, decreased expression may permit delivery of chemotherapeutic agents to the tumor tissues...
  16. doi request reprint Serum pentosidine, an advanced glycation end product, indicates poor outcomes after acute ischemic stroke
    Toshiki Ikeda
    Department of Neurosurgery at Akiru Municipal Medical Center, Tokyo, Japan
    J Stroke Cerebrovasc Dis 21:386-90. 2012
    ..Little is known about its relationship with cerebral ischemia. The authors investigated serum levels of pentosidine and outcomes of patients with acute ischemic stroke..
  17. ncbi request reprint Meningeal melanocytoma associated with ipsilateral nevus of Ota presenting as intracerebral hemorrhage: case report
    Ken Hino
    Department of Neurosurgery, Kyorin University School of Medicine, Tokyo, Japan
    Neurosurgery 56:E1376; discussion E1376. 2005
    ..The authors report a rare case of meningeal melanocytoma presenting with unconsciousness, which was caused by an intracerebral hematoma and associated with a history of ipsilateral nevus of Ota...
  18. pmc Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2
    Bo Hu
    Cancer Institute and Department of Medicine, University of Pittsburgh, Research Pavilion at the Hillman Cancer Center, Suite 2 19, 5117 Centre Avenue, Pittsburgh, PA 15213 1863, USA
    Proc Natl Acad Sci U S A 100:8904-9. 2003
    ..These results suggest that Ang2 plays a critical role in inducing tumor cell infiltration, and that this invasive phenotype is caused by activation of MMP-2...
  19. ncbi request reprint Mutant epidermal growth factor receptor signaling down-regulates p27 through activation of the phosphatidylinositol 3-kinase/Akt pathway in glioblastomas
    Yoshitaka Narita
    Ludwig Institute for Cancer Research, San Diego Branch, University of California at San Diego, La Jolla, California 92093 0660, USA
    Cancer Res 62:6764-9. 2002
    ..This pathway may represent another therapeutic target for treatment of those aggressive glioblastomas expressing DeltaEGFR...