Affiliation: University of Tokyo
- Sugawa H, Ohno R, Shirakawa J, Nakajima A, Kanagawa A, Hirata T, et al. Eucommia ulmoides extracts prevent the formation of advanced glycation end products. Food Funct. 2016;7:2566-73 pubmed publisher..As a result, isoquercetin showed the strongest inhibitory effect of all the tested ELE components. These results indicate that the oral intake of ELE may inhibit the formation of AGEs, thereby ameliorating age-related diseases. ..
- Shirakawa J, Arakawa S, Tagawa T, Gotoh K, Oikawa N, Ohno R, et al. Salacia chinensis L. extract ameliorates abnormal glucose metabolism and improves the bone strength and accumulation of AGEs in type 1 diabetic rats. Food Funct. 2016;7:2508-15 pubmed publisher..This study provides evidence to support that SCE ameliorates diabetes-induced abnormalities by improving the uptake of glucose by various organs. ..
- Nagai R, Shirakawa J, Ohno R, Hatano K, Sugawa H, Arakawa S, et al. Antibody-based detection of advanced glycation end-products: promises vs. limitations. Glycoconj J. 2016;33:545-52 pubmed publisher..This review discusses not only the usability of anti-AGE antibodies to evaluate AGEs and disease pathology and screen AGE inhibitors, but also describes their usage. ..